Arai Y, Yamazaki M, Mori O, Muramatsu H, Asano G, Katayama Y (2001) α-Synuclein-positive structures in cases with sporadic Alzheimer’s disease: morphology and its relationship to tau aggregation. Brain Res 888:287–296 Elsevier
Article
CAS
Google Scholar
Bachhuber T, Katzmarski N, McCarter JF, Loreth D, Tahirovic S, Kamp F et al (2015) Inhibition of amyloid-β plaque formation by α-synuclein. Nat Med 21:802–807 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved
Article
CAS
Google Scholar
Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM et al (2011) Autosomal-dominant Alzheimer’s disease: a review and proposal for the prevention of Alzheimer’s disease. Alzheimers Res Ther 3:1 BioMed Central
Article
Google Scholar
Bateman RJ, Xiong C, Benzinger TLS, Fagan AM, Goate A, Fox NC et al (2012) Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. N Engl J Med 367:795–804 Massachusetts Medical Society
Article
CAS
Google Scholar
Berge G, Lauridsen C, Sando SB, Holder DJ, Møller I, Aasly JO et al (2015) Effect of Tween-20 on Core biomarkers measured in cerebrospinal fluid from patients with Alzheimer’s disease, mild cognitive impairment, or healthy control individuals. J Alzheimer’s Dis 49:493–502 IOS Press
Article
Google Scholar
Berge G, Sando SB, Albrektsen G, Lauridsen C, Møller I, Grøntvedt GR et al (2016) Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer’s disease, mild cognitive impairment, or healthy controls: a two year follow-up study. BMC Neurol BioMed Central 16:180
Article
Google Scholar
Berge G, Sando SB, Rongve A, Aarsland D, White LR (2014) Apolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort. J Neurol Neurosurg Psychiatry 85:1227–1231 BMJ Publishing Group Ltd
Article
Google Scholar
Chow VW, Mattson MP, Wong PC, Gleichmann M (2010) An overview of APP processing enzymes and products. NeuroMolecular Med 12:1–12 Humana Press Inc
Article
CAS
Google Scholar
Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM (2010) Synergistic interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci 30:7281–7289
Article
CAS
Google Scholar
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW et al (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261:921–923 American Association for the Advancement of Science
Article
CAS
Google Scholar
Eisenstein SA, Koller JM, Piccirillo M, Kim A, Antenor-Dorsey JAV, Videen TO et al (2012) Characterization of extrastriatal D2 in vivo specific binding of [18F](N-methyl)benperidol using PET. Synapse 66:770–780 NIH Public Access
Article
CAS
Google Scholar
Emmanouilidou E, Melachroinou K, Roumeliotis T, Garbis SD, Ntzouni M, Margaritis LH et al (2010) Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci 30:6838–6851 Society for Neuroscience
Article
CAS
Google Scholar
Fagan AM, Mintun MA, Mach RH, Lee S-Y, Dence CS, Shah AR et al (2006) Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ 42 in humans. Ann Neurol 59:512–519 Wiley-Blackwell
Article
CAS
Google Scholar
Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C et al (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33:341–355
Article
CAS
Google Scholar
Gąssowska M, Czapski GA, Pająk B, Cieślik M, Lenkiewicz AM, Adamczyk A. Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells. Paudel HK, editor. PLoS One. 2014;9:e94259 Public Library of Science
Hamilton RL (2000) Lewy bodies in Alzheimer’s disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathol 10:378–384
Article
CAS
Google Scholar
Hansen LA, Masliah E, Galasko D, Terry RD (1993) Plaque-only Alzheimer disease is usually the lewy body variant, and vice versa. J Neuropathol Exp Neurol 52:648–654
Article
CAS
Google Scholar
Hong Z, Shi M, Chung KA, Quinn JF, Peskind ER, Galasko D et al (2010) DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease. Brain 133:713–726 Oxford University Press
Article
Google Scholar
Irwin DJ, Lee VM-Y, Trojanowski JQ (2013) Parkinson’s disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies. Nat Rev Neurosci NIH Public Access 14:626–636
Article
CAS
Google Scholar
Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L (1995) Rohan de Silva H., et al. the precursor protein of non-Aβ component of Alzheimer’s disease amyloid is a presynaptic protein of the central nervous system. Neuron 14:467–475
Article
CAS
Google Scholar
Jack CR, Bernstein MA, Borowski BJ, Gunter JL, Fox NC, Thompson PM et al (2010) Update on the magnetic resonance imaging core of the Alzheimer’s disease neuroimaging initiative. Alzheimers Dement 6:212–220 NIH Public Access
Article
Google Scholar
Jack CR, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D et al (2008) The Alzheimer’s Disease Neuroimaging Initiative (ADNI): MRI methods. J Magn Reson Imaging 27:685–691 NIH Public Access
Article
Google Scholar
Kallhoff V, Peethumnongsin E, Zheng H (2007) Lack of α-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer’s disease. Mol Neurodegener BioMed Central 2:6
Article
Google Scholar
Kasuga K, Tokutake T, Ishikawa A, Uchiyama T, Tokuda T, Onodera O et al (2010) Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer’s disease. J Neurol Neurosurg Psychiatry 81:608–610 BMJ Publishing Group Ltd
Article
Google Scholar
Kawakami F, Suzuki M, Shimada N, Kagiya G, Ohta E, Tamura K et al (2011) Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β. FEBS J 278(10.1111):4895–4904 Wiley/Blackwell
Article
CAS
Google Scholar
Korff A, Liu C, Ginghina C, Shi M, Zhang J (2013) α-Synuclein in cerebrospinal fluid of Alzheimer’s disease and mild cognitive impairment. J Alzheimer’s Dis 36:679–688 IOS Press
Article
CAS
Google Scholar
Larson ME, Greimel SJ, Amar F, LaCroix M, Boyle G, Sherman MA et al (2017) Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits. Proc Natl Acad Sci 114:E4648–E4657 National Academy of Sciences
Article
CAS
Google Scholar
Larson ME, Sherman MA, Greimel S, Kuskowski M, Schneider JA, Bennett DA et al (2012) Soluble alpha-Synuclein is a novel modulator of Alzheimer’s disease pathophysiology. J Neurosci 32:10253–10266
Article
CAS
Google Scholar
Leverenz JB, Fishel MA, Peskind ER, Montine TJ, Nochlin D, Steinbart E et al (2006) Lewy Body Pathology in Familial Alzheimer Disease. Arch Neurol 63:370 American Medical Association
Article
Google Scholar
Li YJ, Hauser MA, Scott WK, Martin ER, Booze MW, Qin XJ et al (2004) Apolipoprotein E controls the risk and age at onset of Parkinson disease. Neurology 62:2005–2009
Article
CAS
Google Scholar
Lippa CF, Fujiwara H, Mann DMA, Giasson B, Baba M, Schmidt ML et al (1998) Lewy bodies contain altered α-Synuclein in brains of many familial Alzheimer’s disease patients with mutations in Presenilin and amyloid precursor protein genes. Am J Pathol 153:1365–1370
Article
CAS
Google Scholar
Liu C-C, Liu C-C, Kanekiyo T, Xu H, Bu G (2013) Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol 9:106–118 NIH Public Access
Article
CAS
Google Scholar
Masliah E, Iwai A, Mallory M, Uéda K, Saitoh T (1996) Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer’s disease. Am J Pathol 148:201–210 American Society for Investigative Pathology
CAS
PubMed
PubMed Central
Google Scholar
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology 34:939–944 American Academy of Neurology
Article
CAS
Google Scholar
McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawas CH et al (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7:263–269 Elsevier
Article
Google Scholar
Mintun MA, LaRossa GN, Sheline YI, Dence CS, Lee SY, Mach RH et al (2006) [11C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease. Neurology 67:446–452
Article
CAS
Google Scholar
Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I et al (2008) Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Exp Neurol 213:315–325 Academic Press
Article
CAS
Google Scholar
Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I et al (2008) Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Exp Neurol 213:315–325
Article
CAS
Google Scholar
Mollenhauer B, Locascio JJ, Schulz-Schaeffer W, Sixel-Döring F, Trenkwalder C, Schlossmacher MG (2011) α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study. Lancet Neurol. Elsevier 10:230–240
CAS
Google Scholar
Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM et al (2010) APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann Neurol 67:122–131 NIH Public Access
Article
CAS
Google Scholar
Mueller C, Ballard C, Corbett A, Aarsland D (2017) The prognosis of dementia with Lewy bodies. Lancet Neurol 16:390–398
Article
Google Scholar
Ogaki K, Martens YA, Heckman MG, Koga S, Labbé C, Lorenzo-Betancor O et al (2018) Multiple system atrophy and apolipoprotein E. Mov Disord 33(4):647–650
Article
CAS
Google Scholar
Öhrfelt A, Grognet P, Andreasen N, Wallin A, Vanmechelen E, Blennow K et al (2009) Cerebrospinal fluid α-synuclein in neurodegenerative disorders—a marker of synapse loss? Neurosci Lett 450:332–335 Elsevier
Article
Google Scholar
Palmqvist S, Schöll M, Strandberg O, Mattsson N, Stomrud E, Zetterberg H et al (2017) Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity. Nat Commun 8:1214 Nat Nature Publishing Group
Article
Google Scholar
Patra K, Soosaipillai A, Sando SB, Lauridsen C, Berge G, Møller I et al (2018) Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer’s disease. Alzheimers Res Ther 10:9 BioMed Central
Article
Google Scholar
Pletnikova O, West N, Lee MK, Rudow GL, Skolasky RL, Dawson TM et al (2005) Aβ deposition is associated with enhanced cortical α-synuclein lesions in Lewy body diseases. Neurobiol Aging 26:1183–1192
Article
CAS
Google Scholar
Rosén C, Hansson O, Blennow K, Zetterberg H (2013) Fluid biomarkers in Alzheimer’s disease – current concepts. Mol Neurodegener 8:20
Article
Google Scholar
Rousset OG, Ma Y, Evans AC (1998) Correction for partial volume effects in PET: principle and validation. J Nucl Med 39:904–911
CAS
PubMed
Google Scholar
Rowland DJ, Garbow JR, Laforest R, Snyder AZ, Xu S, Zanzonico PB et al (2005) Registration of [18F]FDG microPET and small-animal MRI. Nucl Med Biol 32:567–572 Elsevier
Article
CAS
Google Scholar
Saint-Aubert L, Lemoine L, Chiotis K, Leuzy A, Rodriguez-Vieitez E, Nordberg A (2017) Tau PET imaging: present and future directions. Mol Neurodegener 12:19 BioMed Central
Article
Google Scholar
Saman S, Kim W, Raya M, Visnick Y, Miro S, Saman S et al (2012) Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J Biol Chem 287:3842–3849 American Society for Biochemistry and Molecular Biology
Article
CAS
Google Scholar
Spencer B, Michael S, Shen J, Kosberg K, Rockenstein E, Patrick C et al (2013) Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD. Mol Ther 21:31–41 Elsevier
Article
CAS
Google Scholar
Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N et al (2016) Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group. PLoS One 11:e0152082 Herholz K, editor. Public Library of Science
Article
Google Scholar
Su Y, D’Angelo GM, Vlassenko AG, Zhou G, Snyder AZ, Marcus DS et al (2013) Quantitative Analysis of PiB-PET with FreeSurfer ROIs. PLoS One 8:e73377 Chen K, editor. Public Library of Science
Article
CAS
Google Scholar
Tatebe H, Watanabe Y, Kasai T, Mizuno T, Nakagawa M, Tanaka M et al (2010) Extracellular neurosin degrades α-synuclein in cultured cells. Neurosci Res 67:341–346 Elsevier
Article
CAS
Google Scholar
Tateno F, Sakakibara R, Kawai T, Kishi M, Murano T (2012) Alpha-synuclein in the cerebrospinal fluid differentiates Synucleinopathies (Parkinson disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease. Alzheimer Dis Assoc Disord 26:213–216
Article
CAS
Google Scholar
Tokuda T, Salem SA, Allsop D, Mizuno T, Nakagawa M, Qureshi MM et al (2006) Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease. Biochem Biophys Res Commun 349:162–166 Academic Press
Article
CAS
Google Scholar
Uéda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M et al (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 90:11282–11286
Article
Google Scholar
Vergallo A, Bun R-S, Toschi N, Baldacci F, Zetterberg H, Blennow K et al (2018) Association of cerebrospinal fluid α-synuclein with total and phospho-tau 181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer’s disease biomarkers. Alzheimers Dement:1–9. https://doi.org/10.1016/j.jalz.2018.06.3053.
Wang H, Stewart T, Toledo JB, Ginghina C, Tang L, Atik A et al (2018) A longitudinal study of Total and phosphorylated α-Synuclein with other biomarkers in cerebrospinal fluid of Alzheimer’s disease and mild cognitive impairment. J Alzheimer’s Dis 61:1541–1553 IOS Press
Article
CAS
Google Scholar
Wennström M, Londos E, Minthon L, Nielsen HM (2012) Altered CSF orexin and α-synuclein levels in dementia patients. J Alzheimers Dis 29:125–132
Article
Google Scholar
Wennström M, Surova Y, Hall S, Nilsson C, Minthon L, Boström F et al (2013) Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy. PLoS One 8:e53250 Public Library of Science
Article
Google Scholar
Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L (2004) Mild cognitive impairment – beyond controversies, towards a consensus : report of the International Working Group on Mild Cognitive Impairment, pp 240–246
Google Scholar
Winslow AR, Moussaud S, Zhu L, Post KL, Post KL, Dickson DW et al (2014) Convergence of pathology in dementia with Lewy bodies and Alzheimer’s disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease. Brain Oxford 137:1958–1970 University Press
Article
Google Scholar
Wirths O, Weickert S, Majtenyi K, Havas L, Kahle PJ, Okochi M et al (2000) Lewy body variant of Alzheimer’s disease: alpha-synuclein in dystrophic neurites of a beta plaques. Neuroreport 11:3737–3741
Article
CAS
Google Scholar
Wong YC, Krainc D (2017) Α-Synuclein Toxicity in Neurodegeneration: Mechanism and Therapeutic Strategies. Nat Med 23:1–13 Nature Publishing Group
Article
CAS
Google Scholar
Xia M, Wang J, He Y (2013) BrainNet Viewer: A Network Visualization Tool for Human Brain Connectomics. PLoS One 8:e68910 Csermely P, editor. Public Library of Science
Article
CAS
Google Scholar
Zetterberg H, Petzold M, Magdalinou N (2014) Cerebrospinal fluid α-synuclein levels in Parkinson’s disease - changed or unchanged? Eur J Neurol 21(10.1111):365–367 Wiley/Blackwell
Article
CAS
Google Scholar