Skip to main content

Articles

Page 1 of 27

  1. Amyloid precursor protein (APP) metabolism is central to Alzheimer’s disease (AD) pathogenesis, but the key etiological driver remains elusive. Recent failures of clinical trials targeting amyloid-β (Aβ) pepti...

    Authors: Suman Rimal, Yu Li, Rasika Vartak, Ji Geng, Ishaq Tantray, Shuangxi Li, Sungun Huh, Hannes Vogel, Charles Glabe, Lea T. Grinberg, Salvatore Spina, William W. Seeley, Su Guo and Bingwei Lu

    Citation: Acta Neuropathologica Communications 2021 9:169

    Content type: Research

    Published on:

  2. Progressive accumulation of Amyloid-β (Aβ) deposits in the brain is a characteristic neuropathological hallmark of Alzheimer’s disease (AD). During disease progression, extracellular Aβ plaques undergo specifi...

    Authors: Pranav Joshi, Florian Riffel, Sathish Kumar, Nàdia Villacampa, Sandra Theil, Samira Parhizkar, Christian Haass, Marco Colonna, Michael T. Heneka, Thomas Arzberger, Jochen Herms and Jochen Walter

    Citation: Acta Neuropathologica Communications 2021 9:168

    Content type: Research

    Published on:

  3. Cerebral vascular injury as a consequence of blast-induced traumatic brain injury is primarily the result of blast wave-induced mechanical disruptions within the neurovascular unit. In rodent models of blast-i...

    Authors: Miguel A. Gama Sosa, Rita De Gasperi, Dylan Pryor, Georgina S. Perez Garcia, Gissel M. Perez, Rania Abutarboush, Usmah Kawoos, Seth Hogg, Benjamin Ache, William G. Janssen, Allison Sowa, Timothy Tetreault, David G. Cook, Susan J. Tappan, Sam Gandy, Patrick R. Hof…

    Citation: Acta Neuropathologica Communications 2021 9:167

    Content type: Research

    Published on:

  4. Osteopontin (OPN) is a matricellular protein that mediates various physiological functions and is implicated in neuroinflammation, myelination, and perinatal brain injury. However, its expression in associatio...

    Authors: Gisela Nilsson, Ana A. Baburamani, Mary A. Rutherford, Changlian Zhu, Carina Mallard, Henrik Hagberg, Regina Vontell and Xiaoyang Wang

    Citation: Acta Neuropathologica Communications 2021 9:166

    Content type: Research

    Published on:

  5. Amyloid-β (Aβ) pathology transmission has been described in patients following iatrogenic exposure to compounds contaminated with Aβ proteins. It can induce cerebral Aβ angiopathy resulting in brain hemorrhage...

    Authors: Suzanne Lam, Fanny Petit, Anne-Sophie Hérard, Susana Boluda, Sabiha Eddarkaoui, Martine Guillermier, Luc Buée, Charles Duyckaerts, Stéphane Haïk, Jean-Luc Picq and Marc Dhenain

    Citation: Acta Neuropathologica Communications 2021 9:165

    Content type: Research

    Published on:

  6. Tauopathies are heterogeneous neurodegenerative diseases defined by progressive brain accumulation of tau aggregates. The most common tauopathy, sporadic Alzheimer’s disease (AD), involves progressive tau depo...

    Authors: Barbara E. Stopschinski, Kelly Del Tredici, Sandi-Jo Estill-Terpack, Estifanos Ghebremdehin, Fang F. Yu, Heiko Braak and Marc I. Diamond

    Citation: Acta Neuropathologica Communications 2021 9:164

    Content type: Research

    Published on:

  7. Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid β (Aβ) and neurofibrillary tangles. The last decade, it became increasingly clear that neuroinflamma...

    Authors: Junhua Xie, Nina Gorlé, Charysse Vandendriessche, Griet Van Imschoot, Elien Van Wonterghem, Caroline Van Cauwenberghe, Eef Parthoens, Evelien Van Hamme, Saskia Lippens, Lien Van Hoecke and Roosmarijn E. Vandenbroucke

    Citation: Acta Neuropathologica Communications 2021 9:163

    Content type: Research

    Published on:

  8. Mutations in the presenilin (PS/PSEN) genes encoding the catalytic components of γ-secretase accelerate amyloid-β (Aβ) and tau pathologies in familial Alzheimer’s disease (AD). Although the mechanisms by which th...

    Authors: Carlos M. Soto-Faguás, Paula Sanchez-Molina and Carlos A. Saura

    Citation: Acta Neuropathologica Communications 2021 9:162

    Content type: Research

    Published on:

  9. Authors: David I. Finkelstein, Jessica L. Billings, Paul A. Adlard, Scott Ayton, Amelia Sedjahtera, Colin L. Masters, Simon Wilkins, David M. Shackleford, Susan A. Charman, Wojciech Bal, Izabela A. Zawisza, Ewa Kurowska, Andrew L. Gundlach, Sheri Ma, Ashley I. Bush, Dominic J. Hare…

    Citation: Acta Neuropathologica Communications 2021 9:161

    Content type: Correction

    Published on:

    The original article was published in Acta Neuropathologica Communications 2017 5:53

  10. Infratentorial oligodendrogliomas, a rare pathological entity, are generally considered metastatic lesions from supratentorial primary tumors. Here, we report the case of a 23-year-old man presenting with a hi...

    Authors: Alexander H. C. W. Agopyan-Miu, Matei A. Banu, Michael L. Miller, Christopher Troy, Gunnar Hargus, Peter Canoll, Tony J. C. Wang, Neil Feldstein, Aya Haggiagi and Guy M. McKhann II

    Citation: Acta Neuropathologica Communications 2021 9:160

    Content type: Case report

    Published on:

  11. The pathogenetic mechanisms underlying neuronal death and dysfunction in Alzheimer’s disease (AD) remain unclear. However, chronic neuroinflammation has been implicated in stimulating or exacerbating neuronal ...

    Authors: Anusha Jayaraman, Thein Than Htike, Rachel James, Carmen Picon and Richard Reynolds

    Citation: Acta Neuropathologica Communications 2021 9:159

    Content type: Research

    Published on:

  12. Chronic wasting disease (CWD) is a cervid prion disease caused by the accumulation of an infectious misfolded conformer (PrPSc) of cellular prion protein (PrPC). It has been spreading rapidly in North America and...

    Authors: Zerui Wang, Kefeng Qin, Manuel V. Camacho, Ignazio Cali, Jue Yuan, Pingping Shen, Justin Greenlee, Qingzhong Kong, James A. Mastrianni and Wen-Quan Zou

    Citation: Acta Neuropathologica Communications 2021 9:158

    Content type: Research

    Published on:

  13. Prion diseases or prionoses are a group of rapidly progressing and invariably fatal neurodegenerative diseases. The pathogenesis of prionoses is associated with self-replication and connectomal spread of PrPSc, a...

    Authors: Joanna E. Pankiewicz, Anita M. Lizińczyk, Leor A. Franco, Jenny R. Diaz, Mitchell Martá-Ariza and Martin J. Sadowski

    Citation: Acta Neuropathologica Communications 2021 9:157

    Content type: Research

    Published on:

  14. Lewy bodies (LBs) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common in older persons and associated with cognitive impairment. However, little is known about ...

    Authors: Sonal Agrawal, Lei Yu, Sukriti Nag, Konstantinos Arfanakis, Lisa L. Barnes, David A. Bennett and Julie A. Schneider

    Citation: Acta Neuropathologica Communications 2021 9:156

    Content type: Research

    Published on:

  15. The ryanodine receptor RyR1 is the main sarcoplasmic reticulum Ca2+ channel in skeletal muscle and acts as a connecting link between electrical stimulation and Ca2+-dependent muscle contraction. Abnormal RyR1 act...

    Authors: Valérie Biancalana, John Rendu, Annabelle Chaussenot, Helen Mecili, Eric Bieth, Mélanie Fradin, Sandra Mercier, Maud Michaud, Marie-Christine Nougues, Laurent Pasquier, Sabrina Sacconi, Norma B. Romero, Pascale Marcorelles, François Jérôme Authier, Antoinette Gelot Bernabe, Emmanuelle Uro-Coste…

    Citation: Acta Neuropathologica Communications 2021 9:155

    Content type: Case report

    Published on:

  16. Brain accumulation of amyloid-beta (Aβ) is a crucial feature in Alzheimer´s disease (AD) and cerebral amyloid angiopathy (CAA), although the pathophysiological relationship between these diseases remains uncle...

    Authors: Paula Marazuela, Montse Solé, Anna Bonaterra-Pastra, Jesús Pizarro, Jessica Camacho, Elena Martínez-Sáez, H. Bea Kuiperij, Marcel M. Verbeek, Anna M. de Kort, Floris H. B. M. Schreuder, Catharina J. M. Klijn, Laura Castillo-Ribelles, Olalla Pancorbo, David Rodríguez-Luna, Francesc Pujadas, Pilar Delgado…

    Citation: Acta Neuropathologica Communications 2021 9:154

    Content type: Research

    Published on:

  17. Recent studies suggest that brain cell type specific intracellular environments may play important roles in the generation of structurally different protein aggregates that define neurodegenerative diseases. U...

    Authors: Nadja Gustavsson, Ekaterina Savchenko, Oxana Klementieva and Laurent Roybon

    Citation: Acta Neuropathologica Communications 2021 9:153

    Content type: Case report

    Published on:

  18. Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is the most prevalent subtype of TDP-43 proteinopathy, affecting up to 1/3rd of aged persons. LATE-NC often co-occurs with ...

    Authors: Adam J. Dugan, Peter T. Nelson, Yuriko Katsumata, Lincoln M. P. Shade, Kevin L. Boehme, Merilee A. Teylan, Matthew D. Cykowski, Shubhabrata Mukherjee, John S. K. Kauwe, Timothy J. Hohman, Julie A. Schneider and David W. Fardo

    Citation: Acta Neuropathologica Communications 2021 9:152

    Content type: Research

    Published on:

  19. Little is known about the effects of parenchymal or vascular amyloid β peptide (Aβ) deposition in the brain. We hypothesized that Aβ strain-specific information defines whether Aβ deposits on the brain parench...

    Authors: Tsuyoshi Hamaguchi, Jee Hee Kim, Akane Hasegawa, Ritsuko Goto, Kenji Sakai, Kenjiro Ono, Yoshinori Itoh and Masahito Yamada

    Citation: Acta Neuropathologica Communications 2021 9:151

    Content type: Research

    Published on:

  20. Dystrophic neuronal processes harboring neuritic plaque (NP) tau pathology are found in association with Aβ plaques in Alzheimer’s disease (AD) brain. Microglia are also in proximity to these plaques and micro...

    Authors: Argyro Thalia Delizannis, Annelies Nonneman, Wangchen Tsering, An De Bondt, Ilse Van den Wyngaert, Bin Zhang, Emily Meymand, Modupe F. Olufemi, Pyry Koivula, Shaniya Maimaiti, John Q. Trojanowski, Virginia M.-Y. Lee and Kurt R. Brunden

    Citation: Acta Neuropathologica Communications 2021 9:150

    Content type: Research

    Published on:

  21. In this review, we discuss the synaptic aspects of Tau pathology occurring during Alzheimer’s disease (AD) and how this may relate to memory impairment, a major hallmark of AD. Whilst the clinical diagnosis of...

    Authors: Miranda Robbins, Emma Clayton and Gabriele S. Kaminski Schierle

    Citation: Acta Neuropathologica Communications 2021 9:149

    Content type: Review

    Published on:

  22. It is recognized that the tumor microenvironment (TME) plays a critical role in the biology of cancer. To better understand the role of immune cell components in CNS tumors, we applied a deconvolution approach...

    Authors: Omkar Singh, Drew Pratt and Kenneth Aldape

    Citation: Acta Neuropathologica Communications 2021 9:148

    Content type: Research

    Published on:

  23. Diffuse leptomeningeal glioneuronal tumours (DLGNT) represent rare enigmatic CNS tumours of childhood. Most patients with this disease share common radiological and histopathological features but the clinical ...

    Authors: Neevika Manoharan, Pamela Ajuyah, Akanksha Senapati, Marie Wong, Anna Mullins, Michael Rodriguez, Helen Doyle, Geoff McCowage, Loretta M. S. Lau, Paul G. Ekert and David S. Ziegler

    Citation: Acta Neuropathologica Communications 2021 9:147

    Content type: Case report

    Published on:

  24. Synucleinopathies, including Parkinson’s disease (PD), Lewy body dementia (LBD), Alzheimer’s disease with amygdala restricted Lewy bodies (AD/ALB), and multiple system atrophy (MSA) comprise a spectrum of neur...

    Authors: Ethan W. Hass, Zachary A. Sorrentino, Yuxing Xia, Grace M. Lloyd, John Q. Trojanowski, Stefan Prokop and Benoit I. Giasson

    Citation: Acta Neuropathologica Communications 2021 9:146

    Content type: Research

    Published on:

  25. Treatment with human pituitary-derived growth hormone (hGH) was responsible for a significant proportion of iatrogenic Creutzfeldt–Jakob disease (iCJD) cases. France and the UK experienced the largest case num...

    Authors: Jean-Yves Douet, Alvina Huor, Hervé Cassard, Séverine Lugan, Naïma Aron, Chloé Mesic, Didier Vilette, Tomás Barrio, Nathalie Streichenberger, Armand Perret-Liaudet, Marie-Bernadette Delisle, Patrice Péran, Jean-Philippe Deslys, Emmanuel Comoy, Jean-Luc Vilotte, Katayoun Goudarzi…

    Citation: Acta Neuropathologica Communications 2021 9:145

    Content type: Research

    Published on:

  26. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving progressive degeneration of upper and lower motor neurons. The pattern of lower motor neuron loss along the spinal cord follow...

    Authors: Sarah Waters, Molly E. V. Swanson, Birger V. Dieriks, Yibin B. Zhang, Natasha L. Grimsey, Helen C. Murray, Clinton Turner, Henry J. Waldvogel, Richard L. M. Faull, Jiyan An, Robert Bowser, Maurice A. Curtis, Mike Dragunow and Emma Scotter

    Citation: Acta Neuropathologica Communications 2021 9:144

    Content type: Research

    Published on:

  27. Increasing evidence indicates that extracellular vesicles (EVs) play an important role in the pathogenesis of Alzheimer’s disease (AD). We previously reported that the blood–cerebrospinal fluid (CSF) interface...

    Authors: Charysse Vandendriessche, Sriram Balusu, Caroline Van Cauwenberghe, Marjana Brkic, Marie Pauwels, Nele Plehiers, Arnout Bruggeman, Pieter Dujardin, Griet Van Imschoot, Elien Van Wonterghem, An Hendrix, Femke Baeke, Riet De Rycke, Kris Gevaert and Roosmarijn E. Vandenbroucke

    Citation: Acta Neuropathologica Communications 2021 9:143

    Content type: Research

    Published on:

  28. The blood–brain barrier (BBB) plays important roles in brain tumor pathogenesis and treatment response, yet our understanding of its function and heterogeneity within or across brain tumor types remains poorly...

    Authors: Xin Wei, Michaël H. Meel, Marjolein Breur, Marianna Bugiani, Esther Hulleman and Timothy N. Phoenix

    Citation: Acta Neuropathologica Communications 2021 9:142

    Content type: Research

    Published on:

  29. Traditionally, analysis of neuropathological markers in neurodegenerative diseases has relied on visual assessments of stained sections. Resulting semiquantitative scores often vary between individual raters a...

    Authors: Valentina Perosa, Ashley A. Scherlek, Mariel G. Kozberg, Lindsey Smith, Thomas Westerling-Bui, Corinne A. Auger, Serge Vasylechko, Steven M. Greenberg and Susanne J. van Veluw

    Citation: Acta Neuropathologica Communications 2021 9:141

    Content type: Methodology article

    Published on:

  30. The microglial reaction is a hallmark of neurodegenerative conditions, and elements thereof may exert differential effects on disease progression, either worsening or ameliorating severity. In amyotrophic late...

    Authors: Mandana Hunter, Krista J. Spiller, Myrna A. Dominique, Hong Xu, Francis W. Hunter, Terry C. Fang, Rebecca G. Canter, Christopher J. Roberts, Richard M. Ransohoff, John Q. Trojanowski and Virginia M.-Y. Lee

    Citation: Acta Neuropathologica Communications 2021 9:140

    Content type: Research

    Published on:

  31. The etiology of sporadic Parkinson’s disease (PD) remains uncertain, but genetic, epidemiological, and physiological overlap between PD and inflammatory bowel disease suggests that gut inflammation could promo...

    Authors: Madelyn C. Houser, W. Michael Caudle, Jianjun Chang, George T. Kannarkat, Yuan Yang, Sean D. Kelly, Danielle Oliver, Valerie Joers, Kathleen M. Shannon, Ali Keshavarzian and Malú Gámez Tansey

    Citation: Acta Neuropathologica Communications 2021 9:139

    Content type: Research

    Published on:

  32. Traumatic brain injury (TBI) causes acute and subacute tissue damage, but is also associated with chronic inflammation and progressive loss of brain tissue months and years after the initial event. The trigger...

    Authors: Antonia Clarissa Wehn, Igor Khalin, Marco Duering, Farida Hellal, Carsten Culmsee, Peter Vandenabeele, Nikolaus Plesnila and Nicole Angela Terpolilli

    Citation: Acta Neuropathologica Communications 2021 9:138

    Content type: Research

    Published on:

  33. Down syndrome (DS) is the leading genetic cause of intellectual disability and causes early-onset dementia and cerebellar hypoplasia. The prevalence of attention deficit hyperactivity disorder is elevated in c...

    Authors: Feng J. Gao, Donna Klinedinst, Fabian-Xosé Fernandez, Bei Cheng, Alena Savonenko, Benjamin Devenney, Yicong Li, Dan Wu, Martin G. Pomper and Roger H. Reeves

    Citation: Acta Neuropathologica Communications 2021 9:137

    Content type: Research

    Published on:

  34. Degeneration of motor neurons, glial cell reactivity, and vascular alterations in the CNS are important neuropathological features of amyotrophic lateral sclerosis (ALS). Immune cells trafficking from the bloo...

    Authors: Mariángeles Kovacs, Catalina Alamón, Cecilia Maciel, Valentina Varela, Sofía Ibarburu, Lucas Tarragó, Peter H. King, Ying Si, Yuri Kwon, Olivier Hermine, Luis Barbeito and Emiliano Trias

    Citation: Acta Neuropathologica Communications 2021 9:136

    Content type: Research

    Published on:

  35. The cIMPACT-NOW Update 7 has replaced the WHO nosology of “ependymoma, RELA fusion positive” by “Supratentorial-ependymoma, C11orf95-fusion positive”. This modification reinforces the idea that supratentorial-epe...

    Authors: Arnault Tauziède-Espariat, Aurore Siegfried, Yvan Nicaise, Thomas Kergrohen, Philipp Sievers, Alexandre Vasiljevic, Alexandre Roux, Edouard Dezamis, Chiara Benevello, Marie-Christine Machet, Sophie Michalak, Chloe Puiseux, Francisco Llamas-Gutierrez, Pierre Leblond, Franck Bourdeaut, Jacques Grill…

    Citation: Acta Neuropathologica Communications 2021 9:135

    Content type: Research

    Published on:

  36. Primary age-related tauopathy (PART) is a form of Alzheimer-type neurofibrillary degeneration occurring in the absence of amyloid-beta (Aβ) plaques. While PART shares some features with Alzheimer disease (AD),...

    Authors: Megan A. Iida, Kurt Farrell, Jamie M. Walker, Timothy E. Richardson, Gabriel A. Marx, Clare H. Bryce, Dushyant Purohit, Gai Ayalon, Thomas G. Beach, Eileen H. Bigio, Etty P. Cortes, Marla Gearing, Vahram Haroutunian, Corey T. McMillan, Edward B. Lee, Dennis W. Dickson…

    Citation: Acta Neuropathologica Communications 2021 9:134

    Content type: Research

    Published on:

  37. The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Im...

    Authors: Cristina Cudalbu, Pierre Bady, Marta Lai, Lijing Xin, Olga Gusyatiner, Marie-France Hamou, Mario Lepore, Jean-Philippe Brouland, Roy T. Daniel, Andreas F. Hottinger and Monika E. Hegi

    Citation: Acta Neuropathologica Communications 2021 9:133

    Content type: Research

    Published on:

  38. We identified an autosomal dominant progranulin mutation carrier without symptoms of dementia in her lifetime (Reduced Penetrance Mutation Carrier, RedPenMC). This resistance to develop expected pathology present...

    Authors: Karthick Natarajan, Jesper Eisfeldt, Maria Hammond, José Miguel Laffita-Mesa, Kalicharan Patra, Behzad Khoshnood, Linn Öijerstedt and Caroline Graff

    Citation: Acta Neuropathologica Communications 2021 9:132

    Content type: Case report

    Published on:

  39. Although the right temporal variant frontotemporal dementia (rtvFTD) is characterised by distinct clinical and radiological features, its underlying histopathology remains elusive. Being considered a right-sid...

    Authors: Hulya Ulugut, Anke A. Dijkstra, Marta Scarioni, Frederik Barkhof, Philip Scheltens, Annemieke J. M. Rozemuller and Yolande A. L. Pijnenburg

    Citation: Acta Neuropathologica Communications 2021 9:131

    Content type: Case report

    Published on:

  40. Cerebral pericytes are an integral component of the neurovascular unit, which governs the blood–brain barrier. There is paucity of knowledge on cortical pericytes across different dementias. We quantified cort...

    Authors: Ren Ding, Yoshiki Hase, Matthew Burke, Vincent Foster, William Stevenson, Tuomo Polvikoski and Raj N. Kalaria

    Citation: Acta Neuropathologica Communications 2021 9:130

    Content type: Research

    Published on:

  41. The pathogenic mechanisms underlying the development of Alzheimer’s disease (AD) remain elusive and to date there are no effective prevention or treatment for AD. Farnesyltransferase (FT) catalyzes a key postt...

    Authors: Angela Jeong, Shaowu Cheng, Rui Zhong, David A. Bennett, Martin O. Bergö and Ling Li

    Citation: Acta Neuropathologica Communications 2021 9:129

    Content type: Research

    Published on:

  42. The medial temporal lobe (MTL) is a nidus for neurodegenerative pathologies and therefore an important region in which to study polypathology. We investigated associations between neurodegenerative pathologies...

    Authors: L. E. M. Wisse, S. Ravikumar, R. Ittyerah, S. Lim, J. Lane, M. L. Bedard, L. Xie, S. R. Das, T. Schuck, M. Grossman, E. B. Lee, M. D. Tisdall, K. Prabhakaran, J. A. Detre, G. Mizsei, J. Q. Trojanowski…

    Citation: Acta Neuropathologica Communications 2021 9:128

    Content type: Research

    Published on:

  43. Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon...

    Authors: Alyssa N. Coyne and Jeffrey D. Rothstein

    Citation: Acta Neuropathologica Communications 2021 9:127

    Content type: Research

    Published on:

  44. Activation of the complement system propagates neuroinflammation and brain damage early and chronically after traumatic brain injury (TBI). The complement system is complex and comprises more than 50 component...

    Authors: Amer Toutonji, Mamatha Mandava, Silvia Guglietta and Stephen Tomlinson

    Citation: Acta Neuropathologica Communications 2021 9:126

    Content type: Research

    Published on:

  45. Peripheral nerve injury is a serious health problem and repairing long nerve deficits remains a clinical challenge nowadays. Nerve guidance conduit (NGC) serves as the most promising alternative therapy strate...

    Authors: Feixiang Chen, Weihuang Liu, Qiang Zhang, Ping Wu, Ao Xiao, Yanan Zhao, Ying Zhou, Qiaona Wang, Yun Chen and Zan Tong

    Citation: Acta Neuropathologica Communications 2021 9:125

    Content type: Research

    Published on:

  46. The cellular and molecular mechanisms that drive neurodegeneration remain poorly defined. Recent clinical trial failures, difficult diagnosis, uncertain etiology, and lack of curative therapies prompted us to ...

    Authors: Pooja Jadiya, Joanne F. Garbincius and John W. Elrod

    Citation: Acta Neuropathologica Communications 2021 9:124

    Content type: Review

    Published on:

  47. Spinal muscular atrophy (SMA) is a neuromuscular genetic disease caused by reduced survival motor neuron (SMN) protein. SMN is ubiquitous and deficient levels cause spinal cord motoneurons (MNs) degeneration a...

    Authors: Alba Sansa, Ivan Hidalgo, Maria P. Miralles, Sandra de la Fuente, M. Jose Perez-Garcia, Francina Munell, Rosa M. Soler and Ana Garcera

    Citation: Acta Neuropathologica Communications 2021 9:122

    Content type: Research

    Published on:

  48. Up to one person in a population of 10,000 is diagnosed once in lifetime with an encephalitis, in 50–70% of unknown origin. Recognized causes amount to 20–50% viral infections. Approximately one third of affec...

    Authors: Justus B. H. Wilke, Martin Hindermann, Amir Moussavi, Umer Javed Butt, Rakshit Dadarwal, Stefan A. Berghoff, Aref Kalantari Sarcheshmeh, Anja Ronnenberg, Svenja Zihsler, Sahab Arinrad, Rüdiger Hardeland, Jan Seidel, Fred Lühder, Klaus-Armin Nave, Susann Boretius and Hannelore Ehrenreich

    Citation: Acta Neuropathologica Communications 2021 9:121

    Content type: Research

    Published on:

  49. Primary spinal cord astrocytomas are rare, hence few data exist about the prognostic significance of molecular markers. Here we analyze a panel of molecular alterations in association with the clinical course....

    Authors: Annamaria Biczok, Felix L. Strübing, Julia M. Eder, Rupert Egensperger, Oliver Schnell, Stefan Zausinger, Julia E. Neumann, Jochen Herms, Joerg-Christian Tonn and Mario M. Dorostkar

    Citation: Acta Neuropathologica Communications 2021 9:119

    Content type: Research

    Published on:

Annual Journal Metrics