Skip to main content

Articles

Page 1 of 27

  1. Pleomorphic xanthoastrocytoma (PXA) in its classic manifestation exhibits distinct morphological features and is assigned to CNS WHO grade 2 or grade 3. Distinction from glioblastoma variants and lower grade g...

    Authors: Azadeh Ebrahimi, Andrey Korshunov, Guido Reifenberger, David Capper, Joerg Felsberg, Elena Trisolini, Bianca Pollo, Chiara Calatozzolo, Marco Prinz, Ori Staszewski, Leonille Schweizer, Jens Schittenhelm, Patrick N. Harter, Werner Paulus, Christian Thomas, Patricia Kohlhof-Meinecke…

    Citation: Acta Neuropathologica Communications 2022 10:5

    Content type: Research

    Published on:

  2. The Bridging Integrator 1 (BIN1) gene is a major susceptibility gene for Alzheimer’s disease (AD). Deciphering its pathophysiological role is challenging due to its numerous isoforms. Here we observed in Drosophi...

    Authors: Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, Julien Chapuis…

    Citation: Acta Neuropathologica Communications 2022 10:4

    Content type: Research

    Published on:

  3. Recent studies highlight phosphorylated tau (p-tau) at threonine tau 217 (p-tau217) as a new promising plasma biomarker for pathological changes implicated in Alzheimer’s disease (AD), but the specific brain p...

    Authors: Malin Wennström, Shorena Janelidze, K. Peter R. Nilsson, Geidy E. Serrano, Thomas G. Beach, Jeffrey L. Dage and Oskar Hansson

    Citation: Acta Neuropathologica Communications 2022 10:3

    Content type: Research

    Published on:

  4. The increased life expectancy of individuals with Down syndrome (DS) is associated with increased prevalence of trisomy 21–linked early-onset Alzheimer’s disease (EOAD) and dementia. The aims of this study of ...

    Authors: Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Jarek Wegiel, Shuang Yong Ma, Nanbert Zhong, Teresa Wierzba Bobrowicz, Mony de Leon, Florence Lai, Wayne P. Silverman and Thomas Wisniewski

    Citation: Acta Neuropathologica Communications 2022 10:2

    Content type: Research

    Published on:

  5. We previously identified matrix metalloproteinase 2 (MMP2) and MMP9 plasma levels as candidate biomarkers of bevacizumab activity in patients with recurrent glioblastoma. The aim of this study was to assess th...

    Authors: Carine Jiguet-Jiglaire, Sebastien Boissonneau, Emilie Denicolai, Victoria Hein, Romain Lasseur, Josep Garcia, Sylvie Romain, Romain Appay, Thomas Graillon, Warren Mason, Antoine F. Carpentier, Alba A. Brandes, L.’Houcine Ouafik, Wolfgang Wick, Ania Baaziz, Julien P. Gigan…

    Citation: Acta Neuropathologica Communications 2022 10:1

    Content type: Research

    Published on:

  6. Amyloid beta (Aβ) is thought to play a critical role in the pathogenesis of Alzheimer’s disease (AD). Prion-like Aβ polymorphs, or “strains”, can have varying pathogenicity and may underlie the phenotypic hete...

    Authors: Alison M. Maxwell, Peng Yuan, Brianna M. Rivera, Wilder Schaaf, Mihovil Mladinov, Vee P. Prasher, Andrew C. Robinson, William F. DeGrado and Carlo Condello

    Citation: Acta Neuropathologica Communications 2021 9:201

    Content type: Research

    Published on:

  7. Giant cell glioblastoma (GC-GBM) is a rare variant of IDH-wt GBM histologically characterized by the presence of numerous multinucleated giant cells and molecularly considered a hybrid between IDH-wt and IDH-muta...

    Authors: Valeria Barresi, Michele Simbolo, Andrea Mafficini, Maurizio Martini, Martina Calicchia, Maria Liliana Piredda, Chiara Ciaparrone, Giada Bonizzato, Serena Ammendola, Maria Caffo, Giampietro Pinna, Francesco Sala, Rita Teresa Lawlor, Claudio Ghimenton and Aldo Scarpa

    Citation: Acta Neuropathologica Communications 2021 9:200

    Content type: Research

    Published on:

  8. Apolipoprotein E ε4 allele (APOE4) has been shown to associate with increased susceptibility to SARS-CoV-2 infection and COVID-19 mortality in some previous genetic studies, but information on the role of APOE4 o...

    Authors: Samu N. Kurki, Jonas Kantonen, Karri Kaivola, Laura Hokkanen, Mikko I. Mäyränpää, Henri Puttonen, Juha Martola, Minna Pöyhönen, Mia Kero, Jarno Tuimala, Olli Carpén, Anu Kantele, Olli Vapalahti, Marjaana Tiainen, Pentti J. Tienari, Kai Kaila…

    Citation: Acta Neuropathologica Communications 2021 9:199

    Content type: Research

    Published on:

  9. Socioeconomic disadvantage is associated with greater risk of dementia. This has been theorised to reflect inequalities in cognitive reserve, healthcare access, lifestyle, and other health factors which may co...

    Authors: Calum A. Hamilton, Fiona E. Matthews, Daniel Erskine, Johannes Attems and Alan J. Thomas

    Citation: Acta Neuropathologica Communications 2021 9:198

    Content type: Research

    Published on:

  10. Mild traumatic brain injuries (mTBIs) are a prevalent form of injury that can result in persistent neurological impairments. Microglial activation has become increasingly recognized as a key process regulating...

    Authors: Prashanth S. Velayudhan, Nicole Schwab, Lili-Naz Hazrati and Anne L. Wheeler

    Citation: Acta Neuropathologica Communications 2021 9:197

    Content type: Review

    Published on:

  11. The SorLA protein, encoded by the SORL1 gene, is a major player in Alzheimer’s disease (AD) pathophysiology. Functional and genetic studies demonstrated that SorLA deficiency results in increased production of Aβ...

    Authors: Anne Rovelet-Lecrux, Sebastien Feuillette, Laetitia Miguel, Catherine Schramm, Ségolène Pernet, Olivier Quenez, Isabelle Ségalas-Milazzo, Laure Guilhaudis, Stéphane Rousseau, Gaëtan Riou, Thierry Frébourg, Dominique Campion, Gaël Nicolas and Magalie Lecourtois

    Citation: Acta Neuropathologica Communications 2021 9:196

    Content type: Research

    Published on:

  12. Haploinsufficiency of chromosome 17p and c-Myc amplification distinguish group 3 medulloblastomas which are associated with early metastasis, rapid recurrence, and swift mortality. Tumor suppressor genes on th...

    Authors: Naveenkumar Perumal, Ranjana K. Kanchan, David Doss, Noah Bastola, Pranita Atri, Ramakanth Chirravuri-Venkata, Ishwor Thapa, Raghupathy Vengoji, Shailendra K. Maurya, David Klinkebiel, Geoffrey A. Talmon, Mohd W. Nasser, Surinder K. Batra and Sidharth Mahapatra

    Citation: Acta Neuropathologica Communications 2021 9:195

    Content type: Research

    Published on:

  13. Pathogenic variants in SETX cause two distinct neurological diseases, a loss-of-function recessive disorder, ataxia with oculomotor apraxia type 2 (AOA2), and a dominant gain-of-function motor neuron disorder, am...

    Authors: Aristides Hadjinicolaou, Kathie J. Ngo, Daniel Y. Conway, John P. Provias, Steven K. Baker, Lauren I. Brady, Craig L. Bennett, Albert R. La Spada, Brent L. Fogel and Grace Yoon

    Citation: Acta Neuropathologica Communications 2021 9:194

    Content type: Case report

    Published on:

  14. Previous reports indicate a potential role for signal transducer and activator of transcription 3 (STAT3) in amyloid-β (Aβ) processing and neuritic plaque pathogenesis. In the present study, the impact of STAT...

    Authors: Jogender Mehla, Itender Singh, Deepti Diwan, James W. Nelson, Molly Lawrence, Eunjae Lee, Adam Q. Bauer, David M. Holtzman and Gregory J. Zipfel

    Citation: Acta Neuropathologica Communications 2021 9:193

    Content type: Research

    Published on:

  15. Primary spinal cord tumors contribute to ≤ 10% of central nervous system tumors in individuals of pediatric or adolescent age. Among intramedullary tumors, spinal ependymomas make up ~ 30% of this rare tumor p...

    Authors: Margaret Shatara, Kathleen M. Schieffer, Darren Klawinski, Diana L. Thomas, Christopher R. Pierson, Eric A. Sribnick, Jeremy Jones, Diana P. Rodriguez, Carol Deeg, Elizabeth Hamelberg, Stephanie LaHaye, Katherine E. Miller, James Fitch, Benjamin Kelly, Kristen Leraas, Ruthann Pfau…

    Citation: Acta Neuropathologica Communications 2021 9:192

    Content type: Case report

    Published on:

  16. Knowledge of 1p/19q-codeletion and IDH1/2 mutational status is necessary to interpret any investigational study of diffuse gliomas in the modern era. While DNA sequencing is the gold standard for determining IDH ...

    Authors: Nicholas Nuechterlein, Linda G. Shapiro, Eric C. Holland and Patrick J. Cimino

    Citation: Acta Neuropathologica Communications 2021 9:191

    Content type: Research

    Published on:

  17. Authors: Marco J. Russo, Christina D. Orru, Luis Concha-Marambio, Simone Giaisi, Bradley R. Groveman, Carly M. Farris, Bret Holguin, Andrew G. Hughson, David-Erick LaFontant, Chelsea Caspell-Garcia, Christopher S. Cofey, Jennifer Mollon, Samantha J. Hutten, Kalpana Merchant, Roland G. Heym, Claudio Soto…

    Citation: Acta Neuropathologica Communications 2021 9:190

    Content type: Correction

    Published on:

    The original article was published in Acta Neuropathologica Communications 2021 9:179

  18. Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). Th...

    Authors: Jennifer A. Macdonald, John L. Chen, Masami Masuda-Suzukake, Manuel Schweighauser, Zane Jaunmuktane, Thomas Warner, Janice L. Holton, Annabelle Grossman, Richard Berks, Isabelle Lavenir and Michel Goedert

    Citation: Acta Neuropathologica Communications 2021 9:189

    Content type: Research

    Published on:

  19. Lewy bodies (LBs) are complex, intracellular inclusions that are common pathological features of many neurodegenerative diseases. They consist largely of aggregated forms of the protein alpha-Synuclein (α-Syn)...

    Authors: Nicholas P. Marotta, Jahan Ara, Norihito Uemura, Marshall G. Lougee, Emily S. Meymand, Bin Zhang, E. James Petersson, John Q. Trojanowski and Virginia M.-Y. Lee

    Citation: Acta Neuropathologica Communications 2021 9:188

    Content type: Research

    Published on:

  20. In sporadic Creutzfeldt–Jakob disease (sCJD), the pathological changes appear to be restricted to the central nervous system. Only involvement of the trigeminal ganglion is widely accepted. The present study s...

    Authors: Anna Hofmann, Arne Wrede, Wiebke M. Jürgens-Wemheuer and Walter J. Schulz-Schaeffer

    Citation: Acta Neuropathologica Communications 2021 9:187

    Content type: Research

    Published on:

  21. The type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel on the sarcoplasmic/endoplasmic reticulum that is required for skeletal muscle contraction. RyR1 channel activity is modulat...

    Authors: Qi Yuan, Haikel Dridi, Oliver B. Clarke, Steven Reiken, Zephan Melville, Anetta Wronska, Alexander Kushnir, Ran Zalk, Leah Sittenfeld and Andrew R. Marks

    Citation: Acta Neuropathologica Communications 2021 9:186

    Content type: Research

    Published on:

  22. LIN28A overexpression has been identified in malignant brain tumors called embryonal tumors with multilayered rosettes (ETMR) but its specific role during brain development remains largely unknown. Radial glia...

    Authors: Maximilian Middelkamp, Lisa Ruck, Christoph Krisp, Piotr Sumisławski, Behnam Mohammadi, Matthias Dottermusch, Valerie Meister, Lukas Küster, Hartmut Schlüter, Sabine Windhorst and Julia E. Neumann

    Citation: Acta Neuropathologica Communications 2021 9:185

    Content type: Research

    Published on:

  23. Alzheimer’s disease (AD) is associated with inner retina (nerve fiber and ganglion cell layers) thinning. In contrast, we have seen outer retina thinning driven by photoreceptor outer nuclear layer (ONL) thinn...

    Authors: Benjamin J. Kim, Vivian Lee, Edward B. Lee, Adrienne Saludades, John Q. Trojanowski, Joshua L. Dunaief, Murray Grossman and David J. Irwin

    Citation: Acta Neuropathologica Communications 2021 9:184

    Content type: Case report

    Published on:

  24. Sensory neurons have recently emerged as components of the tumor microenvironment. Nevertheless, whether sensory neuronal activity is important for tumor progression remains unknown. Here we used Designer Rece...

    Authors: Pedro A. C. Costa, Walison N. Silva, Pedro H. D. M. Prazeres, Caroline C. Picoli, Gabriela D. A. Guardia, Alinne C. Costa, Mariana A. Oliveira, Pedro P. G. Guimarães, Ricardo Gonçalves, Mauro C. X. Pinto, Jaime H. Amorim, Vasco A. C. Azevedo, Rodrigo R. Resende, Remo C. Russo, Thiago M. Cunha, Pedro A. F. Galante…

    Citation: Acta Neuropathologica Communications 2021 9:183

    Content type: Research

    Published on:

  25. Serine 129 (S129) phosphorylation of α-synuclein (αSyn) is a central feature of Lewy body (LB) disease pathology. Although the neighboring tyrosine residues Y125, Y133, and Y136 are also phosphorylation sites,...

    Authors: Kazunori Sano, Yasushi Iwasaki, Yuta Yamashita, Keiichi Irie, Masato Hosokawa, Katsuya Satoh and Kenichi Mishima

    Citation: Acta Neuropathologica Communications 2021 9:182

    Content type: Research

    Published on:

  26. Pituitary neuroendocrine tumors (PitNETs) are common, generally benign tumors with complex clinical characteristics related to hormone hypersecretion and/or growing sellar tumor mass. PitNETs can be classified...

    Authors: Abdellah Tebani, Jelena Jotanovic, Neda Hekmati, Åsa Sivertsson, Olafur Gudjonsson, Britt Edén Engström, Johan Wikström, Mathias Uhlèn, Olivera Casar-Borota and Fredrik Pontén

    Citation: Acta Neuropathologica Communications 2021 9:181

    Content type: Research

    Published on:

  27. Pathologic inclusions composed of α-synuclein called Lewy pathology are hallmarks of Parkinson’s Disease (PD). Dominant inherited mutations in leucine rich repeat kinase 2 (LRRK2) are the most common genetic c...

    Authors: Charlotte F. Brzozowski, Baraa A. Hijaz, Vijay Singh, Nolwazi Z. Gcwensa, Kaela Kelly, Edward S. Boyden, Andrew B. West, Deblina Sarkar and Laura A. Volpicelli-Daley

    Citation: Acta Neuropathologica Communications 2021 9:180

    Content type: Research

    Published on:

  28. Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for Parkinson’s disease (PD) and related synucleinopathies. They enable detection of seeding-competent alpha-synuclein aggre...

    Authors: Marco J. Russo, Christina D. Orru, Luis Concha-Marambio, Simone Giaisi, Bradley R. Groveman, Carly M. Farris, Bret Holguin, Andrew G. Hughson, David-Erick LaFontant, Chelsea Caspell-Garcia, Christopher S. Coffey, Jennifer Mollon, Samantha J. Hutten, Kalpana Merchant, Roland G. Heym, Claudio Soto…

    Citation: Acta Neuropathologica Communications 2021 9:179

    Content type: Research

    Published on:

    The Correction to this article has been published in Acta Neuropathologica Communications 2021 9:190

  29. Diffuse intrinsic pontine gliomas (DIPGs) are high-grade tumors of the brainstem that often occur in children, with a median overall survival of less than one year. Given the fact that DIPGs are resistant to c...

    Authors: Cheng Xu, Heng Liu, Christopher J. Pirozzi, Lee H. Chen, Paula K. Greer, Bill H. Diplas, Liwei Zhang, Matthew S. Waitkus, Yiping He and Hai Yan

    Citation: Acta Neuropathologica Communications 2021 9:178

    Content type: Research

    Published on:

  30. In Alzheimer’s disease and related tauopathies, trans-synaptic transfer and accumulation of pathological tau from donor to recipient neurons is thought to contribute to disease progression, but the underlying ...

    Authors: François-Xavier Blaudin de Thé, Benjamin Lassus, Ari W. Schaler, Stephanie L. Fowler, Chris N. Goulbourne, Ross Jeggo, Clotilde Mannoury la Cour, Mark J. Millan and Karen E. Duff

    Citation: Acta Neuropathologica Communications 2021 9:177

    Content type: Research

    Published on:

  31. Authors: Arnault Tauziède-Espariat, Gaëlle Pierron, Delphine Guillemot, Dorian Bochaton, Sarah Watson, Julien Masliah-Planchon, Alexandre Vasiljevic, Alexandra Meurgey, Guillaume Chotard, Lauren Hasty, Ellen Wahler, Emmanuèle Lechapt, Fabrice Chrétien, Jacques Grill, Franck Bourdeaut, Yassine Bouchoucha…

    Citation: Acta Neuropathologica Communications 2021 9:176

    Content type: Letter to the Editor

    Published on:

  32. The clinicopathological heterogeneity in Lewy-body diseases (LBD) highlights the need for pathology-driven biomarkers in-vivo. Misfolded alpha-synuclein (α-Syn) is a lead candidate based on its crucial role in di...

    Authors: Kathrin Brockmann, Corinne Quadalti, Stefanie Lerche, Marcello Rossi, Isabel Wurster, Simone Baiardi, Benjamin Roeben, Angela Mammana, Milan Zimmermann, Ann-Kathrin Hauser, Christian Deuschle, Claudia Schulte, Katharina Waniek, Ingolf Lachmann, Simon Sjödin, Ann Brinkmalm…

    Citation: Acta Neuropathologica Communications 2021 9:175

    Content type: Research

    Published on:

  33. A novel histomolecular tumor of the central nervous system, the “intracranial mesenchymal tumor (IMT), FET-CREB fusion-positive” has recently been identified in the literature and will be added to the 2021 World ...

    Authors: Arnault Tauziède-Espariat, Gaëlle Pierron, Delphine Guillemot, Philipp Sievers, Dominique Cazals-Hatem, Thierry Faillot, Alexandre Roux, Joseph Benzakoun, Sophie Bockel, Nicolas Weinbreck, Lauren Hasty, Emmanuèle Lechapt, Fabrice Chrétien and Pascale Varlet

    Citation: Acta Neuropathologica Communications 2021 9:174

    Content type: Case report

    Published on:

  34. Tau neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer’s disease (AD). To elucidate ...

    Authors: Sadhana Ravikumar, Laura E. M. Wisse, Sydney Lim, Ranjit Ittyerah, Long Xie, Madigan L. Bedard, Sandhitsu R. Das, Edward B. Lee, M. Dylan Tisdall, Karthik Prabhakaran, Jacqueline Lane, John A. Detre, Gabor Mizsei, John Q. Trojanowski, John L. Robinson, Theresa Schuck…

    Citation: Acta Neuropathologica Communications 2021 9:173

    Content type: Research

    Published on:

  35. Spinocerebellar ataxia type 34 (SCA34) is an autosomal dominant inherited ataxia due to mutations in ELOVL4, which encodes one of the very long-chain fatty acid elongases. SCA38, another spinocerebellar ataxia, i...

    Authors: Kokoro Ozaki, Takashi Irioka, Toshiki Uchihara, Akane Yamada, Ayako Nakamura, Takamasa Majima, Susumu Igarashi, Hiroshi Shintaku, Mayumi Yakeishi, Yukio Tsuura, Yasushi Okazaki, Kinya Ishikawa and Takanori Yokota

    Citation: Acta Neuropathologica Communications 2021 9:172

    Content type: Case report

    Published on:

  36. The extracellular matrix (ECM) of the cerebral vasculature provides a pathway for the flow of interstitial fluid (ISF) and solutes out of the brain by intramural periarterial drainage (IPAD). Failure of IPAD l...

    Authors: Matthew MacGregor Sharp, Jordan Cassidy, Thomas Thornton, James Lyles, Abby Keable, Maureen Gatherer, Masato Yasui, Yoichiro Abe, Shinsuke Shibata, Roy O. Weller, Dariusz C. Górecki and Roxana O. Carare

    Citation: Acta Neuropathologica Communications 2021 9:171

    Content type: Research

    Published on:

  37. Although pathology of tauopathies is characterized by abnormal tau protein aggregation in both gray and white matter regions of the brain, neuropathological investigations have generally focused on abnormaliti...

    Authors: Anthony R. Vega, Rati Chkheidze, Vipul Jarmale, Ping Shang, Chan Foong, Marc I. Diamond, Charles L. White III and Satwik Rajaram

    Citation: Acta Neuropathologica Communications 2021 9:170

    Content type: Research

    Published on:

  38. Amyloid precursor protein (APP) metabolism is central to Alzheimer’s disease (AD) pathogenesis, but the key etiological driver remains elusive. Recent failures of clinical trials targeting amyloid-β (Aβ) pepti...

    Authors: Suman Rimal, Yu Li, Rasika Vartak, Ji Geng, Ishaq Tantray, Shuangxi Li, Sungun Huh, Hannes Vogel, Charles Glabe, Lea T. Grinberg, Salvatore Spina, William W. Seeley, Su Guo and Bingwei Lu

    Citation: Acta Neuropathologica Communications 2021 9:169

    Content type: Research

    Published on:

  39. Progressive accumulation of Amyloid-β (Aβ) deposits in the brain is a characteristic neuropathological hallmark of Alzheimer’s disease (AD). During disease progression, extracellular Aβ plaques undergo specifi...

    Authors: Pranav Joshi, Florian Riffel, Sathish Kumar, Nàdia Villacampa, Sandra Theil, Samira Parhizkar, Christian Haass, Marco Colonna, Michael T. Heneka, Thomas Arzberger, Jochen Herms and Jochen Walter

    Citation: Acta Neuropathologica Communications 2021 9:168

    Content type: Research

    Published on:

  40. Cerebral vascular injury as a consequence of blast-induced traumatic brain injury is primarily the result of blast wave-induced mechanical disruptions within the neurovascular unit. In rodent models of blast-i...

    Authors: Miguel A. Gama Sosa, Rita De Gasperi, Dylan Pryor, Georgina S. Perez Garcia, Gissel M. Perez, Rania Abutarboush, Usmah Kawoos, Seth Hogg, Benjamin Ache, William G. Janssen, Allison Sowa, Timothy Tetreault, David G. Cook, Susan J. Tappan, Sam Gandy, Patrick R. Hof…

    Citation: Acta Neuropathologica Communications 2021 9:167

    Content type: Research

    Published on:

  41. Osteopontin (OPN) is a matricellular protein that mediates various physiological functions and is implicated in neuroinflammation, myelination, and perinatal brain injury. However, its expression in associatio...

    Authors: Gisela Nilsson, Ana A. Baburamani, Mary A. Rutherford, Changlian Zhu, Carina Mallard, Henrik Hagberg, Regina Vontell and Xiaoyang Wang

    Citation: Acta Neuropathologica Communications 2021 9:166

    Content type: Research

    Published on:

  42. Amyloid-β (Aβ) pathology transmission has been described in patients following iatrogenic exposure to compounds contaminated with Aβ proteins. It can induce cerebral Aβ angiopathy resulting in brain hemorrhage...

    Authors: Suzanne Lam, Fanny Petit, Anne-Sophie Hérard, Susana Boluda, Sabiha Eddarkaoui, Martine Guillermier, Luc Buée, Charles Duyckaerts, Stéphane Haïk, Jean-Luc Picq and Marc Dhenain

    Citation: Acta Neuropathologica Communications 2021 9:165

    Content type: Research

    Published on:

  43. Tauopathies are heterogeneous neurodegenerative diseases defined by progressive brain accumulation of tau aggregates. The most common tauopathy, sporadic Alzheimer’s disease (AD), involves progressive tau depo...

    Authors: Barbara E. Stopschinski, Kelly Del Tredici, Sandi-Jo Estill-Terpack, Estifanos Ghebremdehin, Fang F. Yu, Heiko Braak and Marc I. Diamond

    Citation: Acta Neuropathologica Communications 2021 9:164

    Content type: Research

    Published on:

  44. Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid β (Aβ) and neurofibrillary tangles. The last decade, it became increasingly clear that neuroinflamma...

    Authors: Junhua Xie, Nina Gorlé, Charysse Vandendriessche, Griet Van Imschoot, Elien Van Wonterghem, Caroline Van Cauwenberghe, Eef Parthoens, Evelien Van Hamme, Saskia Lippens, Lien Van Hoecke and Roosmarijn E. Vandenbroucke

    Citation: Acta Neuropathologica Communications 2021 9:163

    Content type: Research

    Published on:

  45. Mutations in the presenilin (PS/PSEN) genes encoding the catalytic components of γ-secretase accelerate amyloid-β (Aβ) and tau pathologies in familial Alzheimer’s disease (AD). Although the mechanisms by which th...

    Authors: Carlos M. Soto-Faguás, Paula Sanchez-Molina and Carlos A. Saura

    Citation: Acta Neuropathologica Communications 2021 9:162

    Content type: Research

    Published on:

  46. Authors: David I. Finkelstein, Jessica L. Billings, Paul A. Adlard, Scott Ayton, Amelia Sedjahtera, Colin L. Masters, Simon Wilkins, David M. Shackleford, Susan A. Charman, Wojciech Bal, Izabela A. Zawisza, Ewa Kurowska, Andrew L. Gundlach, Sheri Ma, Ashley I. Bush, Dominic J. Hare…

    Citation: Acta Neuropathologica Communications 2021 9:161

    Content type: Correction

    Published on:

    The original article was published in Acta Neuropathologica Communications 2017 5:53

  47. Infratentorial oligodendrogliomas, a rare pathological entity, are generally considered metastatic lesions from supratentorial primary tumors. Here, we report the case of a 23-year-old man presenting with a hi...

    Authors: Alexander H. C. W. Agopyan-Miu, Matei A. Banu, Michael L. Miller, Christopher Troy, Gunnar Hargus, Peter Canoll, Tony J. C. Wang, Neil Feldstein, Aya Haggiagi and Guy M. McKhann II

    Citation: Acta Neuropathologica Communications 2021 9:160

    Content type: Case report

    Published on:

  48. The pathogenetic mechanisms underlying neuronal death and dysfunction in Alzheimer’s disease (AD) remain unclear. However, chronic neuroinflammation has been implicated in stimulating or exacerbating neuronal ...

    Authors: Anusha Jayaraman, Thein Than Htike, Rachel James, Carmen Picon and Richard Reynolds

    Citation: Acta Neuropathologica Communications 2021 9:159

    Content type: Research

    Published on:

  49. Chronic wasting disease (CWD) is a cervid prion disease caused by the accumulation of an infectious misfolded conformer (PrPSc) of cellular prion protein (PrPC). It has been spreading rapidly in North America and...

    Authors: Zerui Wang, Kefeng Qin, Manuel V. Camacho, Ignazio Cali, Jue Yuan, Pingping Shen, Justin Greenlee, Qingzhong Kong, James A. Mastrianni and Wen-Quan Zou

    Citation: Acta Neuropathologica Communications 2021 9:158

    Content type: Research

    Published on:

  50. Prion diseases or prionoses are a group of rapidly progressing and invariably fatal neurodegenerative diseases. The pathogenesis of prionoses is associated with self-replication and connectomal spread of PrPSc, a...

    Authors: Joanna E. Pankiewicz, Anita M. Lizińczyk, Leor A. Franco, Jenny R. Diaz, Mitchell Martá-Ariza and Martin J. Sadowski

    Citation: Acta Neuropathologica Communications 2021 9:157

    Content type: Research

    Published on:

Annual Journal Metrics