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  1. Content type: Review

    Ubiquilin-2 (UBQLN2) is a member of the ubiquilin family, actively implicated in the degradation of misfolded and redundant proteins through the ubiquitin-proteasome system and macroautophagy. UBQLN2 received ...

    Authors: Laurence Renaud, Vincent Picher-Martel, Philippe Codron and Jean-Pierre Julien

    Citation: Acta Neuropathologica Communications 2019 7:103

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  2. Content type: Research

    The exact mechanisms and temporal sequence of neurodegeneration in multiple sclerosis are still unresolved. The visual pathway including its unmyelinated retinal axons, can serve as a prototypic model of neuro...

    Authors: Praveena Manogaran, Marijana Samardzija, Anaïs Nura Schad, Carla Andrea Wicki, Christine Walker-Egger, Markus Rudin, Christian Grimm and Sven Schippling

    Citation: Acta Neuropathologica Communications 2019 7:116

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  3. Content type: Research

    The expansion of a hexanucleotide repeat GGGGCC in C9orf72 is the most common known cause of ALS accounting for ~ 40% familial cases and ~ 7% sporadic cases in the European population. In most people, the repe...

    Authors: Alfredo Iacoangeli, Ahmad Al Khleifat, Ashley R. Jones, William Sproviero, Aleksey Shatunov, Sarah Opie-Martin, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, Isabella Fogh, Richard J. Dobson, Stephen J. Newhouse and Ammar Al-Chalabi

    Citation: Acta Neuropathologica Communications 2019 7:115

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  4. Content type: Research

    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons in the brainstem, spinal cord and motor cortex. ALS is characterized by genetic and clinical heterogeneity, s...

    Authors: Laura Rué, Patrick Oeckl, Mieke Timmers, Annette Lenaerts, Jasmijn van der Vos, Silke Smolders, Lindsay Poppe, Antina de Boer, Ludo Van Den Bosch, Philip Van Damme, Jochen H. Weishaupt, Albert C. Ludolph, Markus Otto, Wim Robberecht and Robin Lemmens

    Citation: Acta Neuropathologica Communications 2019 7:114

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  5. Content type: Research

    Cellular injury in AQP4-IgG seropositive neuromyelitis spectrum disorder (herein called NMO) involves AQP4-IgG binding to astrocytes, resulting in astrocyte injury by complement-dependent cytotoxicity (CDC) an...

    Authors: Tianjiao Duan, Alex J. Smith and Alan S. Verkman

    Citation: Acta Neuropathologica Communications 2019 7:112

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  6. Content type: Research

    Acetylsalicylic acid has been linked to a lower risk for different cancer types, presumably through its inhibitory effect on cyclooxygenase 2. This has also been investigated in vestibular schwannomas with pro...

    Authors: Felix Behling, Vanessa Ries, Marco Skardelly, Irina Gepfner-Tuma, Martin Schuhmann, Florian-Heinrich Ebner, Ghazaleh Tabatabai, Antje Bornemann, Jens Schittenhelm and Marcos Tatagiba

    Citation: Acta Neuropathologica Communications 2019 7:105

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  7. Content type: Review

    Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of aggregated tau and include diseases such as Alzheimer’s disease (AD), progressive supranuclear palsy and chronic traum...

    Authors: Thomas Vogels, Adriana-Natalia Murgoci and Tomáš Hromádka

    Citation: Acta Neuropathologica Communications 2019 7:109

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  8. Content type: Research

    We explored the immune neuropathology underlying multi-day relief from neuropathic pain in a rat model initiated at the sciatic nerve, by using a nanoemulsion-based nanomedicine as a biological probe. The nano...

    Authors: Muzamil Saleem, Brooke Deal, Emily Nehl, Jelena M. Janjic and John A. Pollock

    Citation: Acta Neuropathologica Communications 2019 7:108

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  9. Content type: Research

    Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In many models of neurodegeneration, global histone acetylat...

    Authors: Elisabeth Rossaert, Eveliina Pollari, Tom Jaspers, Lawrence Van Helleputte, Matthew Jarpe, Philip Van Damme, Katrien De Bock, Matthieu Moisse and Ludo Van Den Bosch

    Citation: Acta Neuropathologica Communications 2019 7:107

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  10. Content type: Letter to the Editor

    Authors: Marius Schwabenland, Omar Mossad, Adam G. Peres, Franziska Kessler, Feres Jose Mocayar Maron, Laura-Adela Harsan, Thomas Bienert, Dominik von Elverfeldt, Klaus-Peter Knobeloch, Ori Staszewski, Frank L. Heppner, Marije E. C. Meuwissen, Grazia M. S. Mancini, Marco Prinz and Thomas Blank

    Citation: Acta Neuropathologica Communications 2019 7:106

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  11. Content type: Research

    Age is the most robust risk factor for Alzheimer’s dementia, however there is little data on the relation of age to Alzheimer’s disease (AD) and other common neuropathologies that contribute to Alzheimer’s dem...

    Authors: Jose M. Farfel, Lei Yu, Patricia A. Boyle, Sue Leurgans, Raj C. Shah, Julie A. Schneider and David A. Bennett

    Citation: Acta Neuropathologica Communications 2019 7:104

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  12. Content type: Letter to the Editor Response

    Citation: Acta Neuropathologica Communications 2019 7:102

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    The original article was published in Acta Neuropathologica Communications 2019 7:101

  13. Content type: Letter to the Editor

    Citation: Acta Neuropathologica Communications 2019 7:101

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    The original article was published in Acta Neuropathologica Communications 2019 7:45

    The Letter to the Editor Response to this article has been published in Acta Neuropathologica Communications 2019 7:102

  14. Content type: Research

    The transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein involved in RNA splicing. Abnormally deposited TDP-43 is found in the brains of patients with frontotemporal lobar deg...

    Authors: Keith A. Josephs, Yong-Jie Zhang, Matthew Baker, Rosa Rademakers, Leonard Petrucelli and Dennis W. Dickson

    Citation: Acta Neuropathologica Communications 2019 7:100

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  15. Content type: Research

    The diagnosis and prognostication of glioblastoma (GBM) remain to be solely dependent on histopathological findings and few molecular markers, despite the clinical heterogeneity in this entity. To address this...

    Authors: Toru Umehara, Hideyuki Arita, Ema Yoshioka, Tomoko Shofuda, Daisuke Kanematsu, Manabu Kinoshita, Yoshinori Kodama, Masayuki Mano, Naoki Kagawa, Yasunori Fujimoto, Yoshiko Okita, Masahiro Nonaka, Kosuke Nakajo, Takehiro Uda, Naohiro Tsuyuguchi, Junya Fukai…

    Citation: Acta Neuropathologica Communications 2019 7:99

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  16. Content type: Research

    For the transmissible, neurogenerative family of prion diseases, few human models of infection exist and none represent structured neuronal tissue. Human cerebral organoids are self-organizing, three-dimension...

    Authors: Bradley R. Groveman, Simote T. Foliaki, Christina D. Orru, Gianluigi Zanusso, James A. Carroll, Brent Race and Cathryn L. Haigh

    Citation: Acta Neuropathologica Communications 2019 7:90

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  17. Content type: Research

    Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease resulting from motor neuron degeneration that causes muscle weakness, paralysis, and eventually respiratory failure. We investigated whether...

    Authors: Sang Hwan Lee, Subin Kim, Nayeon Lee, Junghun Lee, Seung Shin Yu, Jin Hong Kim and Sunyoung Kim

    Citation: Acta Neuropathologica Communications 2019 7:96

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  18. Content type: Research

    Mitochondria are critical for the function and maintenance of myelinated axons notably through Adenosine triphosphate (ATP) production. A direct by-product of this ATP production is reactive oxygen species (RO...

    Authors: Gerben van Hameren, Graham Campbell, Marie Deck, Jade Berthelot, Benoit Gautier, Patrice Quintana, Roman Chrast and Nicolas Tricaud

    Citation: Acta Neuropathologica Communications 2019 7:86

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  19. Content type: Research

    It has been reported that neutrophil extracellular traps (NETs) play important roles in non-infectious diseases. In ischemic stroke, neutrophils infiltrate damaged brain tissue soon after injury and aggravate ...

    Authors: Seung-Woo Kim, Hahnbie Lee, Hye-Kyung Lee, Il-Doo Kim and Ja-Kyeong Lee

    Citation: Acta Neuropathologica Communications 2019 7:94

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  20. Content type: Research

    Since the discovery that IDH1/2 mutations confer a significantly better prognosis in astrocytomas, much work has been done to identify other molecular signatures to help further stratify lower-grade astrocytomas ...

    Authors: Kanish Mirchia, Adwait Amod Sathe, Jamie M. Walker, Yelena Fudym, Kristyn Galbraith, Mariano S. Viapiano, Robert J. Corona, Matija Snuderl, Chao Xing, Kimmo J. Hatanpaa and Timothy E. Richardson

    Citation: Acta Neuropathologica Communications 2019 7:92

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  21. Content type: Research

    Alzheimer’s disease neuropathologic change (ADNC) is defined by progressive accumulation of β-amyloid plaques and hyperphosphorylated tau (pTau) neurofibrillary tangles across diverse regions of brain. Non-dem...

    Authors: Caitlin S. Latimer, Bridget T. Burke, Nicole F. Liachko, Heather N. Currey, Mitchell D. Kilgore, Laura E. Gibbons, Jonathan Henriksen, Martin Darvas, Kimiko Domoto-Reilly, Suman Jayadev, Tom J. Grabowski, Paul K. Crane, Eric B. Larson, Brian C. Kraemer, Thomas D. Bird and C. Dirk Keene

    Citation: Acta Neuropathologica Communications 2019 7:91

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  22. Content type: Research

    Methylation of the O(6)-Methylguanine-DNA methyltransferase (MGMT) promoter is predictive for treatment response in glioblastoma patients. However, precise predictive cutoff values to distinguish “MGMT methylated...

    Authors: Josefine Radke, Arend Koch, Fabienne Pritsch, Elisa Schumann, Martin Misch, Claudia Hempt, Klaus Lenz, Franziska Löbel, Fabienne Paschereit, Frank L. Heppner, Peter Vajkoczy, Randi Koll and Julia Onken

    Citation: Acta Neuropathologica Communications 2019 7:89

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  23. Content type: Methodology article

    Therapeutic developments for neurodegenerative disorders are redirecting their focus to the mechanisms that contribute to neuronal connectivity and the loss thereof. Using a high-throughput microscopy pipeline...

    Authors: Marlies Verschuuren, Peter Verstraelen, Gerardo García-Díaz Barriga, Ines Cilissen, Emma Coninx, Mieke Verslegers, Peter H. Larsen, Rony Nuydens and Winnok H. De Vos

    Citation: Acta Neuropathologica Communications 2019 7:93

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  24. Content type: Research

    The study of survival outliers of glioblastoma can provide important clues on gliomagenesis as well as on the ways to alter clinical course of this almost uniformly lethal cancer type. However, there has been ...

    Authors: Taeyoung Hwang, Dimitrios Mathios, Kerrie L. McDonald, Irene Daris, Sung-Hye Park, Peter C. Burger, Sojin Kim, Yun-Sik Dho, Hruban Carolyn, Chetan Bettegowda, Joo Heon Shin, Michael Lim and Chul-Kee Park

    Citation: Acta Neuropathologica Communications 2019 7:88

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  25. Content type: Research

    It is currently accepted that the human brain has a limited neurogenic capacity and an impaired regenerative potential. We have previously shown the existence of CD271-expressing neural stem cells (NSCs) in th...

    Authors: Vanessa Donega, Saskia M. Burm, Miriam E. van Strien, Emma J. van Bodegraven, Iryna Paliukhovich, Hanneke Geut, Wilma D. J. van de Berg, Ka Wan Li, August B. Smit, Onur Basak and Elly M. Hol

    Citation: Acta Neuropathologica Communications 2019 7:84

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  26. Content type: Research

    Here, we assessed unique brain tissue samples, obtained from living subjects with idiopathic Normal Pressure Hydrocephalus (iNPH). Our cohort of 95 subjects with age ranging from 75 to 79 years, displayed a hi...

    Authors: Sylwia Libard and Irina Alafuzoff

    Citation: Acta Neuropathologica Communications 2019 7:98

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  27. Content type: Research

    Choroid plexus tumours (CPTs) account for 2–5% of brain tumours in children. They can spread along the neuraxis and can recur after treatment. Little is known about the molecular mechanisms underlying their fo...

    Authors: Ashirwad Merve, Xinyu Zhang, Nicola Pomella, Serena Acquati, Joerg D. Hoeck, Anaelle Dumas, Gabriel Rosser, Yichen Li, Jennie Jeyapalan, Silvia Vicenzi, Qianhai Fan, Zeng Jie Yang, Arianna Sabò, Denise Sheer, Axel Behrens and Silvia Marino

    Citation: Acta Neuropathologica Communications 2019 7:95

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  28. Content type: Research

    Despite their phenotypic heterogeneity, most human prion diseases belong to two broadly defined groups: Creutzfeldt-Jakob disease (CJD) and Gerstmann-Sträussler-Scheinker disease (GSS). While the structural ch...

    Authors: Laura Cracco, Xiangzhu Xiao, Satish K. Nemani, Jody Lavrich, Ignazio Cali, Bernardino Ghetti, Silvio Notari, Witold K. Surewicz and Pierluigi Gambetti

    Citation: Acta Neuropathologica Communications 2019 7:85

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  29. Content type: Research

    Astrogliosis and activation of microglia are hallmarks of prion diseases in humans and animals. Both were viewed to be rather independent events in disease pathophysiology, with proinflammatory microglia consi...

    Authors: Kristin Hartmann, Diego Sepulveda-Falla, Indigo V. L. Rose, Charlotte Madore, Christiane Muth, Jakob Matschke, Oleg Butovsky, Shane Liddelow, Markus Glatzel and Susanne Krasemann

    Citation: Acta Neuropathologica Communications 2019 7:83

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  30. Content type: Research

    Microglia affect Alzheimer’s disease (AD) pathogenesis in opposing manners, by protecting against amyloid accumulation in early phases of the disease and promoting neuropathology in advanced stages. Recent res...

    Authors: T. L. Stephen, M. Cacciottolo, D. Balu, T. E. Morgan, M. J. LaDu, C. E. Finch and C. J. Pike

    Citation: Acta Neuropathologica Communications 2019 7:82

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  31. Content type: Research

    Glial cytoplasmic inclusions (GCIs) containing aggregated and hyperphosphorylated α-synuclein are the signature neuropathological hallmark of multiple system atrophy (MSA). Native α-synuclein can adopt a prion...

    Authors: Zuzana Krejciova, George A. Carlson, Kurt Giles and Stanley B. Prusiner

    Citation: Acta Neuropathologica Communications 2019 7:81

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  32. Content type: Research

    α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central nervous system (CNS) inoculation studies using...

    Authors: Jess-Karan S. Dhillon, Jorge A. Trejo-Lopez, Cara Riffe, Yona Levites, Amanda N. Sacino, David R. Borchelt, Anthony Y. Yachnis and Benoit I. Giasson

    Citation: Acta Neuropathologica Communications 2019 7:80

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  33. Content type: Research

    Pathogenic variants of the huntingtin (HTT) protein and their aggregation have been investigated in great detail in brains of Huntington’s disease patients and HTT-transgenic animals. However, little is known ...

    Authors: Maike Hartlage-Rübsamen, Veronika Ratz, Ulrike Zeitschel, Lukas Finzel, Lisa Machner, Janett Köppen, Anja Schulze, Hans-Ulrich Demuth, Stephan von Hörsten, Corinna Höfling and Steffen Roßner

    Citation: Acta Neuropathologica Communications 2019 7:79

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  34. Content type: Case report

    The recently described malignant neuro-epithelial tumors with histone H3F3A point mutations at G34 (NET-H3-G34) occur most often in cerebral hemispheres of teenagers and young adults, and have a generally adverse...

    Authors: Felipe Andreiuolo, Tomo Lisner, Jozef Zlocha, Christof Kramm, Arend Koch, Brigitte Bison, Albane Gareton, Marc Zanello, Andreas Waha, Pascale Varlet and Torsten Pietsch

    Citation: Acta Neuropathologica Communications 2019 7:78

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  35. Content type: Research

    The maintenance of genomic integrity is essential for normal cellular functions. However, it is difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA damage increases with ag...

    Authors: Niraj M. Shanbhag, Mark D. Evans, Wenjie Mao, Alissa L. Nana, William W. Seeley, Anthony Adame, Robert A. Rissman, Eliezer Masliah and Lennart Mucke

    Citation: Acta Neuropathologica Communications 2019 7:77

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  36. Content type: Research

    Diffuse intrinsic pontine glioma (DIPG), an infiltrative, high grade glioma (HGG) affecting young children, has the highest mortality rate of all pediatric cancers. Despite treatment, average survival is less ...

    Authors: J. Qi, D. R. Esfahani, T. Huang, P. Ozark, E. Bartom, R. Hashizume, E. R. Bonner, S. An, C. M. Horbinski, C. D. James and A. M. Saratsis

    Citation: Acta Neuropathologica Communications 2019 7:75

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  37. Content type: Research

    Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of Alzheimer’s disease (AD) and other neurol...

    Authors: Alex J. Smith, Tianjiao Duan and Alan S. Verkman

    Citation: Acta Neuropathologica Communications 2019 7:74

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  38. Content type: Research

    Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 ...

    Authors: Gábor M. Mórotz, Elizabeth B. Glennon, Patricia Gomez-Suaga, Dawn H. W. Lau, Eleanor D. Robinson, Éva Sedlák, Alessio Vagnoni, Wendy Noble and Christopher C. J. Miller

    Citation: Acta Neuropathologica Communications 2019 7:73

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  39. Content type: Research

    Tau is a microtubule stabilizing protein that forms aggregates in Alzheimer’s disease (AD). Tau derived from AD patients’ brains induces tau aggregation in a prion-like manner when injected into susceptible mo...

    Authors: Zhiva Skachokova, Alfonso Martinisi, Martin Flach, Frederik Sprenger, Yvonne Naegelin, Viviane Steiner-Monard, Marc Sollberger, Andreas U. Monsch, Michel Goedert, Markus Tolnay and David T. Winkler

    Citation: Acta Neuropathologica Communications 2019 7:72

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  40. Content type: Research

    Neurofibrillary tangles (NFTs), are shared between progressive supranuclear palsy (PSP) and Alzheimer disease (AD). Histological distinction of PSP and AD is possible based on the distribution of NFTs. However...

    Authors: Momoko Ebashi, Yoshinori Ito, Miho Uematsu, Ayako Nakamura, Katsuiku Hirokawa, Satoshi Kamei and Toshiki Uchihara

    Citation: Acta Neuropathologica Communications 2019 7:71

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  41. Content type: Letter to the Editor

    Authors: Giorgio Giaccone, Emanuela Maderna, Gianluca Marucci, Marcella Catania, Alessandra Erbetta, Luisa Chiapparini, Antonio Indaco, Paola Caroppo, Anna Bersano, Eugenio Parati, Giuseppe Di Fede and Luigi Caputi

    Citation: Acta Neuropathologica Communications 2019 7:70

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  42. Content type: Research

    Pituicytoma is a rare, poorly characterized tumor of the sellar region that is thought to be derived from neurohypophyseal pituicytes. Resection of pituicytomas is often associated with significant morbidity i...

    Authors: Angela N. Viaene, Edward B. Lee, Jason N. Rosenbaum, Ilya M. Nasrallah and MacLean P. Nasrallah

    Citation: Acta Neuropathologica Communications 2019 7:69

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  43. Content type: Research

    Accumulating evidence indicates that endoplasmic reticulum (ER) stress is a common feature of Parkinson’s disease (PD) and further suggests that several PD-related genes are responsible for ER dysfunction. How...

    Authors: Jee Hoon Lee, Ji-hye Han, Hyunmi Kim, Sang Myun Park, Eun-hye Joe and Ilo Jou

    Citation: Acta Neuropathologica Communications 2019 7:68

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  44. Content type: Research

    Meningiomas are the most common primary brain tumor of adults. The majority are benign (WHO grade I), with a mostly indolent course; 20% of them (WHO grade II and III) are, however, considered aggressive and r...

    Authors: Angela N. Viaene, Bo Zhang, Maria Martinez-Lage, Chaomei Xiang, Umberto Tosi, Jayesh P. Thawani, Busra Gungor, Yuankun Zhu, Laura Roccograndi, Logan Zhang, Robert L. Bailey, Phillip B. Storm, Donald M. O’Rourke, Adam C. Resnick, M. Sean Grady and Nadia Dahmane

    Citation: Acta Neuropathologica Communications 2019 7:67

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