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  1. While Alzheimer’s disease and other neurodegenerative diseases have traditionally been viewed as brain disorders, there is growing evidence indicating their manifestation in the eyes as well. The retina, being...

    Authors: Xiaoxi Du, Jongchan Park, Ruixuan Zhao, R. Theodore Smith, Yosef Koronyo, Maya Koronyo-Hamaoui and Liang Gao
    Citation: Acta Neuropathologica Communications 2024 12:157
  2. Abnormal cytoplasmic localization and accumulation of pathological transactive response DNA binding protein of 43 kDa (TDP-43) underlies several devastating diseases such as amyotrophic lateral sclerosis (ALS)...

    Authors: Elodie Chevalier, Mickael Audrain, Monisha Ratnam, Romain Ollier, Aline Fuchs, Kasia Piorkowska, Andrea Pfeifer, Marie Kosco-Vilbois, Tamara Seredenina and Tariq Afroz
    Citation: Acta Neuropathologica Communications 2024 12:156
  3. Authors: Nobuhide Hayashi, Junya Fukai, Hirokazu Nakatogawa, Hiroshi Kawaji, Ema Yoshioka, Yoshinori Kodama, Kosuke Nakajo, Takehiro Uda, Kentaro Naito, Noriyuki Kijima, Yoshiko Okita, Naoki Kagawa, Yoshinobu Takahashi, Naoya Hashimoto, Hideyuki Arita, Koji Takano…
    Citation: Acta Neuropathologica Communications 2024 12:155

    The original article was published in Acta Neuropathologica Communications 2024 12:120

  4. Aging is the greatest known risk factor for most neurodegenerative diseases. Myelin degeneration is an early pathological indicator of these diseases and a normal part of aging; albeit, to a lesser extent. Des...

    Authors: Tyler J. McCray, Logan M. Bedford, Stephanie J. Bissel and Bruce T. Lamb
    Citation: Acta Neuropathologica Communications 2024 12:154
  5. Authors: Nathalie A. Lengacher, Julianna J. Tomlinson, Ann‑Kristin Jochum, Jonas Franz, Omar Hasan Ali, Lukas Flatz, Wolfram Jochum, Josef Penninger, Christine Stadelmann, John M. Woulfe and Michael G. Schlossmacher
    Citation: Acta Neuropathologica Communications 2024 12:153

    The original article was published in Acta Neuropathologica Communications 2024 12:70

  6. A hexanucleotide repeat expansion (HRE) in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Human brain imaging and experimental studies indicate ...

    Authors: Astrid T. van der Geest, Channa E. Jakobs, Tijana Ljubikj, Christiaan F. M. Huffels, Marta Cañizares Luna, Renata Vieira de Sá, Youri Adolfs, Marina de Wit, Daan H. Rutten, Marthe Kaal, Maria M. Zwartkruis, Mireia Carcolé, Ewout J. N. Groen, Elly M. Hol, Onur Basak, Adrian M. Isaacs…
    Citation: Acta Neuropathologica Communications 2024 12:152
  7. The characterization of genetic alterations in tumor samples has become standard practice for many human cancers to achieve more precise disease classification and guide the selection of targeted therapies. Ce...

    Authors: Richard A. Hickman, Alexandra M. Miller, Bridget M. Holle, Justin Jee, Si-Yang Liu, Dara Ross, Helena Yu, Gregory J. Riely, Christina Ombres, Alexandra N. Gewirtz, Anne S. Reiner, Subhiksha Nandakumar, Adam Price, Thomas J. Kaley, Maya S. Graham, Chad Vanderbilt…
    Citation: Acta Neuropathologica Communications 2024 12:151
  8. Glaucoma is a leading cause of blindness, affecting retinal ganglion cells (RGCs) and their axons. By 2040, it is likely to affect 110 million people. Neuroinflammation, specifically through the release of pro...

    Authors: Élodie Reboussin, Paul Bastelica, Ilyes Benmessabih, Arnaud Cordovilla, Cécile Delarasse, Annabelle Réaux-Le Goazigo, Françoise Brignole-Baudouin, Céline Olmière, Christophe Baudouin, Juliette Buffault and Stéphane Mélik Parsadaniantz
    Citation: Acta Neuropathologica Communications 2024 12:150
  9. Motor neuron loss is well recognized in amyotrophic lateral sclerosis (ALS), but research on retinal ganglion cells (RGCs) is limited. Ocular symptoms are generally not considered classic ALS symptoms, althoug...

    Authors: Yu Meng Wang, Jing Yan, Sarah K. Williams, Richard Fairless and Hilmar Bading
    Citation: Acta Neuropathologica Communications 2024 12:149
  10. Malignant transformation (MT) is commonly seen in IDH-mutant gliomas. There has been a growing research interest in revealing its underlying mechanisms and intervening prior to MT at the early stages of the tr...

    Authors: Olga Kim, Zach Sergi, Guangyang Yu, Kazutoshi Yamamoto, Martha Quezado, Zied Abdullaev, Danel R. Crooks, Shun Kishimoto, Qi Li, Peng Lu, Burchelle Blackman, Thorkell Andresson, Xiaolin Wu, Bao Tran, Jun S. Wei, Wei Zhang…
    Citation: Acta Neuropathologica Communications 2024 12:148
  11. Maladaptive changes of metabolic patterns in the lumbar dorsal root ganglion (DRG) are critical for nociceptive hypersensitivity genesis. The accumulation of branched-chain amino acids (BCAAs) in DRG has been ...

    Authors: Nan Lian, Fangzhou Li, Cheng Zhou, Yan Yin, Yi Kang, Kaiteng Luo, Su Lui, Tao Li and Peilin Lu
    Citation: Acta Neuropathologica Communications 2024 12:147
  12. Multiple sclerosis (MS) is a leading cause of non-traumatic disability in young adults. The highly dynamic nature of MS lesions has made them difficult to study using traditional histopathology due to the spec...

    Authors: Oleksandr Gakh, Jordan M. Wilkins, Yong Guo, Bogdan F. Popescu, Stephen D. Weigand, Alicja Kalinowska-Lyszczarz and Claudia F. Lucchinetti
    Citation: Acta Neuropathologica Communications 2024 12:146
  13. Pathological tau fibrils in progressive supranuclear palsy, frontotemporal dementia, chronic traumatic encephalopathy, and Alzheimer’s disease each have unique conformations, and post-translational modificatio...

    Authors: Anastasie Mate de Gerando, Anita Khasnavis, Lindsay A. Welikovitch, Harshil Bhavsar, Calina Glynn, Noe Quittot, Romain Perbet and Bradley T. Hyman
    Citation: Acta Neuropathologica Communications 2024 12:145
  14. Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease leading to motor neuron loss. Currently mutations in > 40 genes have been linked to ALS, but the contribution of many genes and g...

    Authors: Pavol Zelina, Anna Aster de Ruiter, Christy Kolsteeg, Ilona van Ginneken, Harmjan R. Vos, Laura F. Supiot, Boudewijn M. T. Burgering, Frank J. Meye, Jan H. Veldink, Leonard H. van den Berg and R. Jeroen Pasterkamp
    Citation: Acta Neuropathologica Communications 2024 12:144
  15. Neuroepithelial tumors with fusion of PLAGL1 or amplification of PLAGL1/PLAGL2 have recently been described often with ependymoma-like or embryonal histology respectively. To further evaluate emerging entities wi...

    Authors: Julieann C. Lee, Selene C. Koo, Larissa V. Furtado, Alex Breuer, Mohammad K. Eldomery, Asim K. Bag, Pat Stow, Gary Rose, Trisha Larkin, Rick Sances, Bette K. Kleinschmidt-DeMasters, Jenna L. Bodmer, Nicholas Willard, Murat Gokden, Sonika Dahiya, Kaleigh Roberts…
    Citation: Acta Neuropathologica Communications 2024 12:143
  16. Pituitary neuroendocrine tumors (PitNET) represent the vast majority of sellar masses. Some behave aggressively, growing rapidly and invading surrounding tissues, with high rates of recurrence and resistance t...

    Authors: Keiko Taniguchi-Ponciano, Silvia Hinojosa-Alvarez, Jesus Hernandez-Perez, Rocio A. Chavez-Santoscoy, Ilan Remba-Shapiro, Gerardo Guinto, Erika Magallon-Gayon, Benjamin Telles-Ramirez, Rodrigo Ponce de Leon-Conconi, Sandra Vela-Patiño, Sergio Andonegui-Elguera, Amayrani Cano-Zaragoza, Florencia Martinez-Mendoza, Jacobo Kerbel, Marco Loza-Mejia, Juan Rodrigo-Salazar…
    Citation: Acta Neuropathologica Communications 2024 12:142
  17. Research in the field of traumatic brain injury has until now heavily relied on the use of animal models to identify potential therapeutic approaches. However, a long series of failed clinical trials has broug...

    Authors: Cristina Bellotti, Samudyata Samudyata, Sebastian Thams, Carl M. Sellgren and Elham Rostami
    Citation: Acta Neuropathologica Communications 2024 12:141
  18. Wolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, diabetes insipidus, blindness, deafness, neurodegeneration and eventually early death, due to autosomal recessive mutations...

    Authors: K. Ahuja, M. Vandenabeele, F. Nami, E. Lefevere, J. Van hoecke, S. Bergmans, M. Claes, T. Vervliet, K. Neyrinck, T. Burg, D. De Herdt, P. Bhaskar, Y. Zhu, Z. J. Looser, J. Loncke, W. Gsell…
    Citation: Acta Neuropathologica Communications 2024 12:140
  19. CSF1R-related disorder (CSF1R-RD) is a neurodegenerative condition that predominantly affects white matter due to genetic alterations in the CSF1R gene, which is expressed by microglia. We studied an elderly man ...

    Authors: Jie Pan, Jaume Fores-Martos, Claire Delpirou Nouh, Tanner D. Jensen, Kristen Vallejo, Romain Cayrol, Saman Ahmadian, Euan A. Ashley, Michael D. Greicius and Inma Cobos
    Citation: Acta Neuropathologica Communications 2024 12:139
  20. Medulloblastoma, the most common malignant pediatric brain tumor, is classified into four main molecular subgroups, but group 3 and group 4 tumors are difficult to subclassify and have a poor prognosis. Rapid ...

    Authors: Kandarp Joshi, Menglang Yuan, Keisuke Katsushima, Olivier Saulnier, Animesh Ray, Ernest Amankwah, Stacie Stapleton, George Jallo, Michael D. Taylor, Charles G. Eberhart and Ranjan J. Perera
    Citation: Acta Neuropathologica Communications 2024 12:138
  21. A compromised capacity to maintain NAD pools is recognized as a key underlying pathophysiological feature of neurodegenerative diseases. NAD acts as a substrate in major cell functions including mitochondrial ...

    Authors: Gloria Cimaglia, James R. Tribble, Marcela Votruba, Pete A. Williams and James E. Morgan
    Citation: Acta Neuropathologica Communications 2024 12:137
  22. Primary familial brain calcification (PFBC) is a genetic neurological disorder characterized by symmetric brain calcifications that manifest with variable neurological symptoms. This study aimed to explore the...

    Authors: Takahiro Hobara, Yujiro Higuchi, Mari Yoshida, Masahito Suehara, Masahiro Ando, Jun-Hui Yuan, Akiko Yoshimura, Fumikazu Kojima, Eiji Matsuura, Yuji Okamoto, Jun Mitsui, Shoji Tsuji and Hiroshi Takashima
    Citation: Acta Neuropathologica Communications 2024 12:136
  23. Gliomas, particularly glioblastomas (GBMs), pose significant challenges due to their aggressiveness and poor prognosis. Early detection through biomarkers is critical for improving outcomes. This study aimed t...

    Authors: Yusuke Nakade, Masashi Kinoshita, Mitsutoshi Nakada, Hemragul Sabit, Toshiya Ichinose, Masashi Mita, Takeo Yuno, Moeko Noguchi-Shinohara, Kenjiro Ono, Yasunori Iwata and Takashi Wada
    Citation: Acta Neuropathologica Communications 2024 12:122
  24. Progressive supranuclear palsy (PSP) is a neurodegenerative movement and cognitive disorder characterized by abnormal accumulation of the microtubule-associated protein tau in the brain. Biochemically, inclusi...

    Authors: Hadley W. Ressler, Jack Humphrey, Ricardo A. Vialle, Bergan Babrowicz, Shrishtee Kandoi, Towfique Raj, Dennis W. Dickson, Nilüfer Ertekin-Taner, John F. Crary and Kurt Farrell
    Citation: Acta Neuropathologica Communications 2024 12:135
  25. Accurate and scalable quantification of amyloid-β (Aβ) pathology is crucial for deeper disease phenotyping and furthering research in Alzheimer Disease (AD). This multidisciplinary study addresses the current ...

    Authors: Rebeca Scalco, Luca C. Oliveira, Zhengfeng Lai, Danielle J. Harvey, Lana Abujamil, Charles DeCarli, Lee-Way Jin, Chen-Nee Chuah and Brittany N. Dugger
    Citation: Acta Neuropathologica Communications 2024 12:134
  26. Tumor-associated macrophages (TAMs) residing in the tumor microenvironment (TME) are characterized by their pivotal roles in tumor progression, antitumor immunity, and TME remodeling. However, a thorough compa...

    Authors: Meysam Motevasseli, Maryam Darvishi, Alireza Khoshnevisan, Mehdi Zeinalizadeh, Hiva Saffar, Shiva Bayat, Ali Najafi, Mohammad Javad Abbaspour, Ali Mamivand, Susan B. Olson and Mina Tabrizi
    Citation: Acta Neuropathologica Communications 2024 12:133
  27. Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by 4R tau deposition in neurons as well as in astrocytes and oligodendrocytes. While astrocytic tau deposits are rarely observe...

    Authors: Rosemary J. Jackson, Alexandra Melloni, Dustin P. Fykstra, Alberto Serrano-Pozo, Leslie Shinobu and Bradley T. Hyman
    Citation: Acta Neuropathologica Communications 2024 12:132
  28. Authors: Mehtap Bacioglu, Mehtap Bacioglu, Derrick Gray, Sofia Lövestam, Taxiarchis Katsinelos, Annelies Quaegebeur, John van Swieten, Zane Jaunmuktane, Stephen W. Davies, Sjors H. W. Scheres, Michel Goedert, Bernardino Ghetti and Maria Grazia Spillantini
    Citation: Acta Neuropathologica Communications 2024 12:131

    The original article was published in Acta Neuropathologica Communications 2024 12:99

  29. Optical coherence tomography (OCT) is a non-invasive technique to measure retinal layer thickness, providing insights into retinal ganglion cell integrity. Studies have shown reduced retinal nerve fibre layer ...

    Authors: Santiago Diaz-Torres, Samantha Sze-Yee Lee, Natalia S. Ogonowski, David A. Mackey, Stuart MacGregor, Puya Gharahkhani and Miguel E. Renteria
    Citation: Acta Neuropathologica Communications 2024 12:130
  30. Chordoma is a rare bone cancer with variable clinical outcomes. Here, we recruited 184 sporadic chordoma patients from the US and Canada and collected their clinical and treatment data. The average age at diag...

    Authors: Hela Koka, Weiyin Zhou, Mary L. McMaster, Jiwei Bai, Wen Luo, Alyssa Klein, Tongwu Zhang, Xing Hua, Xin Li, Difei Wang, Yujia Xiong, Kristine Jones, Aurelie Vogt, Belynda Hicks, Dilys Parry, Alisa M. Goldstein…
    Citation: Acta Neuropathologica Communications 2024 12:129
  31. Although gliomatosis cerebri (GC) has been removed as an independent tumor type from the WHO classification, its extensive infiltrative pattern may harbor a unique biological behavior. However, the clinical im...

    Authors: Ilah Shin, Yae Won Park, Yongsik Sim, Seo Hee Choi, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee and Rajan Jain
    Citation: Acta Neuropathologica Communications 2024 12:128
  32. The two types of craniopharyngioma, adamantinomatous (ACP) and papillary (PCP), are clinically relevant tumours in children and adults. Although the biology of primary craniopharyngioma is starting to be unrav...

    Authors: John R. Apps, Jose Mario Gonzalez-Meljem, Romain Guiho, Jessica C. Pickles, Eric Prince, Edward Schwalbe, Nikhil Joshi, Thomas J. Stone, Olumide Ogunbiyi, Jane Chalker, Akang Bassey, Georg Otto, Rosalind Davies, Debbie Hughes, Sebastian Brandner, Enrica Tan…
    Citation: Acta Neuropathologica Communications 2024 12:127
  33. Traumatic brain injury (TBI) survivors face debilitating long-term psychosocial consequences, including social isolation and depression. TBI modifies neurovascular physiology and behavior but the chronic physi...

    Authors: Aditya Singh, Steven Gong, Anh Vu, Scott Li and Andre Obenaus
    Citation: Acta Neuropathologica Communications 2024 12:126
  34. Sonic hedgehog subgroup of medulloblastoma (SHH-MB) is characterized by aberrant activation of the SHH signaling pathway. An inhibition of the positive SHH regulator Smoothened (SMO) has demonstrated promising cl...

    Authors: Foteini Tsiami, Chiara Lago, Noemi Pozza, Federica Piccioni, Xuesong Zhao, Fabienne Lülsberg, David E. Root, Luca Tiberi, Marcel Kool, Jens Schittenhelm, Pratiti Bandopadhayay, Rosalind A. Segal, Ghazaleh Tabatabai and Daniel J. Merk
    Citation: Acta Neuropathologica Communications 2024 12:125
  35. Epithelioid glioblastoma (eGB), a very aggressive and rare brain tumour, is associated with a dismal median overall survival. Effective therapies for patients with eGB, particularly with leptomeningeal dissemi...

    Authors: J. Steininger, C. Buszello, R. Oertel, M. Meinhardt, S. Schmid, K. Engellandt, S. Herold, S. Stasik, A. Ebrahimi, B. Renner, C. Thiede, I.Y. Eyüpoglu, G. Schackert, S. Beissert, F. Meier, J. Radke…
    Citation: Acta Neuropathologica Communications 2024 12:124
  36. Agyrophilic grains (AGs) are age-related limbic-predominant lesions in which four-repeat tau is selectively accumulated. Because previous methodologically heterogeneous studies have demonstrated inconsistent f...

    Authors: Osamu Yokota, Tomoko Miki, Hanae Nakashima-Yasuda, Hideki Ishizu, Takashi Haraguchi, Chikako Ikeda, Masato Hasegawa, Akinori Miyashita, Takeshi Ikeuchi, Naoto Nishikawa, Shintaro Takenoshita, Koichiro Sudo, Seishi Terada and Manabu Takaki
    Citation: Acta Neuropathologica Communications 2024 12:121
  37. This study aims to elucidate the clinical and molecular characteristics, treatment outcomes and prognostic factors of patients with histone H3 K27-mutant diffuse midline glioma. We retrospectively analyzed 93 ...

    Authors: Nobuhide Hayashi, Junya Fukai, Hirokazu Nakatogawa, Hiroshi Kawaji, Ema Yoshioka, Yoshinori Kodama, Kosuke Nakajo, Takehiro Uda, Kentaro Naito, Noriyuki Kijima, Yoshiko Okita, Naoki Kagawa, Yoshinobu Takahashi, Naoya Hashimoto, Hideyuki Arita, Koji Takano…
    Citation: Acta Neuropathologica Communications 2024 12:120

    The Correction to this article has been published in Acta Neuropathologica Communications 2024 12:155

  38. Background Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are found in 1% of gliomas across children and adults. TRK inhibitors are promising therapeutic agents for NTRK-fused gliomas because they a...

    Authors: Eric Eunshik Kim, Chul-Kee Park, Seung-Ki Kim, Ji Hoon Phi, Sun Ha Paek, Jung Yoon Choi, Hyoung Jin Kang, Joo Ho Lee, Jae Kyung Won, Hongseok Yun and Sung-Hye Park
    Citation: Acta Neuropathologica Communications 2024 12:118
  39. Papillary tumor of the pineal region (PTPR) is an uncommon tumor of the pineal region with distinctive histopathologic and molecular characteristics. Experience is limited with respect to its molecular heterog...

    Authors: Zhichao Wu, Karen Dazelle, Zied Abdullaev, Hye-Jung Chung, Sonika Dahiya, Matthew Wood, Han Lee, Calixto-Hope G. Lucas, Qinwen Mao, Lorraina Robinson, Igor Fernandes, Matthew McCord, Peter Pytel, Kyle S. Conway, Rebecca Yoda, Jennifer M. Eschbacher…
    Citation: Acta Neuropathologica Communications 2024 12:117
  40. Authors: Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E. Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J. O’Neill, Florian Wegner, Stefan Barghorn, Günter U. Höglinger and Roland G. Heym
    Citation: Acta Neuropathologica Communications 2024 12:115

    The original article was published in Acta Neuropathologica Communications 2023 11:181

  41. TAR DNA-Binding Protein 43 (TDP-43) pathological inclusions are a distinctive feature in dozens of neurodegenerative pathologies, including limbic-predominant age-related TDP-43 encephalopathy neuropathologic ...

    Authors: Ryan K. Shahidehpour, Peter T. Nelson and Adam D. Bachstetter
    Citation: Acta Neuropathologica Communications 2024 12:114
  42. Despite extensive studies on the neurobiological correlates of traumatic brain injury (TBI), little is known about its molecular determinants on long-term consequences, such as dementia and Alzheimer’s disease...

    Authors: Francesca Guida, Monica Iannotta, Anna Lauritano, Rosmara Infantino, Emanuela Salviati, Roberta Verde, Livio Luongo, Eduardo Maria Sommella, Fabio Arturo Iannotti, Pietro Campiglia, Sabatino Maione, Vincenzo Di Marzo and Fabiana Piscitelli
    Citation: Acta Neuropathologica Communications 2024 12:113
  43. The genetic architecture of Parkinson’s disease (PD) is complex and multiple brain cell subtypes are involved in the neuropathological progression of the disease. Here we aimed to advance our understanding of ...

    Authors: E. Keats Shwab, Daniel C. Gingerich, Zhaohui Man, Julia Gamache, Melanie E. Garrett, Gregory E. Crawford, Allison E. Ashley-Koch, Geidy E. Serrano, Thomas G. Beach, Michael W. Lutz and Ornit Chiba-Falek
    Citation: Acta Neuropathologica Communications 2024 12:111
  44. The relationship between amyloidosis and vasculature in cognitive impairment and Alzheimer’s disease (AD) pathogenesis is increasingly acknowledged. We conducted a quantitative and topographic assessment of re...

    Authors: Oana M. Dumitrascu, Jonah Doustar, Dieu-Trang Fuchs, Yosef Koronyo, Dale S. Sherman, Michelle Shizu Miller, Kenneth O. Johnson, Roxana O. Carare, Steven R. Verdooner, Patrick D. Lyden, Julie A. Schneider, Keith L. Black and Maya Koronyo-Hamaoui
    Citation: Acta Neuropathologica Communications 2024 12:109

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    Journal Impact Factor: 6.2
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    Source Normalized Impact per Paper (SNIP): 1.344
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