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  1. Content type: Research

    Degeneration of noradrenergic locus coeruleus neurons occurs during the prodromal phase of Parkinson’s disease and contributes to a variety of non-motor symptoms, e.g. depression, anxiety and REM sleep behavio...

    Authors: Martin Timo Henrich, Fanni Fruzsina Geibl, Bolam Lee, Wei-Hua Chiu, James Benjamin Koprich, Jonathan Michael Brotchie, Lars Timmermann, Niels Decher, Lina Anita Matschke and Wolfgang Hermann Oertel

    Citation: Acta Neuropathologica Communications 2018 6:39

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  2. Content type: Research

    Astroyctes serve myriad functions but are especially critical in white matter tracts, where energy-demanding axons propagate action potentials great distances between neurons. Axonal dependence on astrocytes f...

    Authors: Melissa L. Cooper, John W. Collyer and David J. Calkins

    Citation: Acta Neuropathologica Communications 2018 6:38

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  3. Content type: Research

    In Alzheimer’s disease (AD) and related tauopathies, the microtubule-associated protein tau is highly phosphorylated and aggregates to form neurofibrillary tangles that are characteristic of these neurodegener...

    Authors: Caterina Giacomini, Chuay-Yeng Koo, Natalia Yankova, Ignatius A. Tavares, Selina Wray, Wendy Noble, Diane P. Hanger and Jonathan D. H. Morris

    Citation: Acta Neuropathologica Communications 2018 6:37

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  4. Content type: Research

    The complement system is a key driver of neuroinflammation. Activation of complement by all pathways, results in the formation of the anaphylatoxin C5a and the membrane attack complex (MAC). Both initiate pro-...

    Authors: Iliana Michailidou, Aldo Jongejan, Jeroen P. Vreijling, Theodosia Georgakopoulou, Marit B. de Wissel, Ruud A. Wolterman, Patrick Ruizendaal, Ngaisah Klar-Mohamad, Anita E. Grootemaat, Daisy I. Picavet, Vinod Kumar, Cees van Kooten, Trent M. Woodruff, B. Paul Morgan, Nicole N. van der Wel, Valeria Ramaglia…

    Citation: Acta Neuropathologica Communications 2018 6:36

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  5. Content type: Research

    TDP-43 pathology was investigated in the anterior temporal pole cortex (ATPC) and orbital frontal cortex (OFC), regions often degenerated in frontotemporal lobar degenerations (FTLD), in aging and Alzheimer’s ...

    Authors: Sukriti Nag, Lei Yu, Patricia A. Boyle, Sue E. Leurgans, David A. Bennett and Julie A. Schneider

    Citation: Acta Neuropathologica Communications 2018 6:33

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  6. Content type: Research

    Imaging of pathological tau with positron emission tomography (PET) has the potential to allow early diagnosis of the dementias and monitoring of disease progression, including assessment of therapeutic interv...

    Authors: Melissa C. Wren, Tammaryn Lashley, Erik Årstad and Kerstin Sander

    Citation: Acta Neuropathologica Communications 2018 6:34

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  7. Content type: Research

    Neuronal inclusions composed of α-synuclein (α-syn) characterize Parkinson’s Disease (PD) and Dementia with Lewy bodies (DLB). Cognitive dysfunction defines DLB, and up to 80% of PD patients develop dementia. ...

    Authors: Jessica M. Froula, Benjamin W. Henderson, Jose Carlos Gonzalez, Jada H. Vaden, John W. Mclean, Yumei Wu, Gokulakrishna Banumurthy, Linda Overstreet-Wadiche, Jeremy H. Herskowitz and Laura A. Volpicelli-Daley

    Citation: Acta Neuropathologica Communications 2018 6:35

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  8. Content type: Research

    Heterozygous mutations in glucocerebrosidase 1 (GBA1) are a major genetic risk factor for Parkinson’s disease and Dementia with Lewy bodies. Mutations in GBA1 leads to GBA1 enzyme deficiency, and GBA1-associated ...

    Authors: Donghoon Kim, Heehong Hwang, Seulah Choi, Sang Ho Kwon, Suhyun Lee, Jae Hong Park, SangMin Kim and Han Seok Ko

    Citation: Acta Neuropathologica Communications 2018 6:32

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  9. Content type: Research

    Although there is a strong association between osteoporosis and skeletal muscle atrophy/dysfunction, the functional relevance of a particular biological pathway that regulates synchronously bone and skeletal m...

    Authors: Sébastien S. Dufresne, Antoine Boulanger-Piette, Sabrina Bossé, Anteneh Argaw, Dounia Hamoudi, Laetitia Marcadet, Daniel Gamu, Val A. Fajardo, Hideo Yagita, Josef M. Penninger, A. Russell Tupling and Jérôme Frenette

    Citation: Acta Neuropathologica Communications 2018 6:31

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  10. Content type: Research

    Transmissible spongiform encephalopathies, also known as prion diseases, are a group of fatal neurodegenerative disorders affecting both humans and animals. The central pathogenic event in prion disease is the...

    Authors: Fei Wang, Xinhe Wang, Romany Abskharon and Jiyan Ma

    Citation: Acta Neuropathologica Communications 2018 6:30

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  11. Content type: Research

    The concept that abnormal protein aggregates show prion-like propagation between cells has been considered to explain the onset and progression of many neurodegenerative diseases. Indeed, both synthetic amyloi...

    Authors: Airi Tarutani, Tetsuaki Arai, Shigeo Murayama, Shin-ichi Hisanaga and Masato Hasegawa

    Citation: Acta Neuropathologica Communications 2018 6:29

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  12. Content type: Research

    Muscle atrophy with weakness is a core feature of amyotrophic lateral sclerosis (ALS) that has long been attributed to motor neuron loss alone. However, several studies in ALS patients, and more so in animal m...

    Authors: Matthew D. Cykowski, Suzanne Z. Powell, Joan W. Appel, Anithachristy S. Arumanayagam, Andreana L. Rivera and Stanley H. Appel

    Citation: Acta Neuropathologica Communications 2018 6:28

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  13. Content type: Research

    Duchenne muscular dystrophy (DMD) is the most common inherited muscle disorder that causes severe disability and death of young men. This disease is characterized by progressive muscle degeneration aggravated ...

    Authors: Rasha Al-Khalidi, Chiara Panicucci, Paul Cox, Natalia Chira, Justyna Róg, Christopher N. J. Young, Rhiannon E. McGeehan, Kameshwari Ambati, Jayakrishna Ambati, Krzysztof Zabłocki, Elisabetta Gazzerro, Stephen Arkle, Claudio Bruno and Dariusz C. Górecki

    Citation: Acta Neuropathologica Communications 2018 6:27

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  14. Content type: Research

    Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid (Aβ) peptides and hyperphosphorylated tau protein accompanied by neuronal loss. Aβ accumulation has been associated with an impaired s...

    Authors: Gaëlle Dominguez, Marie-Lise Maddelein, Mélanie Pucelle, Yvan Nicaise, Claude-Alain Maurage, Charles Duyckaerts, Olivier Cuvillier and Marie-Bernadette Delisle

    Citation: Acta Neuropathologica Communications 2018 6:25

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  15. Content type: Research

    The amyloid cascade hypothesis posits that the initiating event in Alzheimer’s disease (AD) is the aggregation and deposition of the β-amyloid (Aβ) peptide, which is a proteolytic cleavage product of the amylo...

    Authors: Alejandro Ruiz-Riquelme, Heather H. C. Lau, Erica Stuart, Adrienn N. Goczi, Zhilan Wang, Gerold Schmitt-Ulms and Joel C. Watts

    Citation: Acta Neuropathologica Communications 2018 6:26

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  16. Content type: Research

    Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests a...

    Authors: Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S. Caron, Niels H. Skotte, Yen T. N. Nguyen, Kuljeet Vaid, Amber L. Southwell, Sabine Engemann, Sonia Franciosi and Michael R. Hayden

    Citation: Acta Neuropathologica Communications 2018 6:16

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  17. Content type: Research

    Seeding and spread of beta-amyloid (Aβ) pathologies have been considered to be based on prion-like mechanisms. However, limited transmissibility of Aβ seeding activity upon peripheral exposure would represent ...

    Authors: Michael Burwinkel, Manuel Lutzenberger, Frank L. Heppner, Walter Schulz-Schaeffer and Michael Baier

    Citation: Acta Neuropathologica Communications 2018 6:23

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  18. Content type: Review

    Alzheimer’s disease (AD) is conceptualized as a progressive consequence of two hallmark pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary tangles. However, over the past se...

    Authors: Sara E. Nasrabady, Batool Rizvi, James E. Goldman and Adam M. Brickman

    Citation: Acta Neuropathologica Communications 2018 6:22

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  19. Content type: Methodology article

    All isocitrate dehydrogenase (IDH) mutant solid neoplasms exhibit highly elevated levels of D-2-hydroxyglutarate (D-2HG). Detection of 2HG in tumor tissues currently is performed by gas or liquid chromatograph...

    Authors: Rémi Longuespée, Annika K. Wefers, Elena De Vita, Aubry K. Miller, David E. Reuss, Wolfgang Wick, Christel Herold-Mende, Mark Kriegsmann, Peter Schirmacher, Andreas von Deimling and Stefan Pusch

    Citation: Acta Neuropathologica Communications 2018 6:21

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  20. Content type: Research

    Synaptic dysfunction or loss in early stages of Alzheimer’s disease (AD) is thought to be a major structural correlate of cognitive dysfunction. Early loss of episodic memory, which occurs at the early stage o...

    Authors: M. Domínguez-Álvaro, M. Montero-Crespo, L. Blazquez-Llorca, R. Insausti, J. DeFelipe and L. Alonso-Nanclares

    Citation: Acta Neuropathologica Communications 2018 6:20

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  21. Content type: Research

    Although the genetic causes for several rare, familial forms of Alzheimer’s disease (AD) have been identified, the etiology of the sporadic form of AD remains unclear. Here, we report a systems-level study of ...

    Authors: Qi Zhang, Cheng Ma, Marla Gearing, Peng George Wang, Lih-Shen Chin and Lian Li

    Citation: Acta Neuropathologica Communications 2018 6:19

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  22. Content type: Research

    Despite multidisciplinary local and systemic therapeutic approaches, the prognosis for most patients with brain metastases is still dismal. The role of adaptive and innate anti-tumor response including the Hum...

    Authors: P. S. Zeiner, J. Zinke, D. J. Kowalewski, S. Bernatz, J. Tichy, M. W. Ronellenfitsch, F. Thorsen, A. Berger, M. T. Forster, A. Muller, J. P. Steinbach, R. Beschorner, J. Wischhusen, H. M. Kvasnicka, K. H. Plate, S. Stefanović…

    Citation: Acta Neuropathologica Communications 2018 6:18

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  23. Content type: Research

    Traumatic brain injury (TBI) induces a wide variety of cellular and molecular changes that can continue for days to weeks to months, leading to functional impairments. Currently, there are no pharmacotherapies...

    Authors: Anssi Lipponen, Assam El-Osta, Antony Kaspi, Mark Ziemann, Ishant Khurana, Harikrishnan KN, Vicente Navarro-Ferrandis, Noora Puhakka, Jussi Paananen and Asla Pitkänen

    Citation: Acta Neuropathologica Communications 2018 6:17

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  24. Content type: Research

    Recent data suggest that olfactory deficits could represent an early marker and a pathogenic mechanism at the basis of cognitive decline in type 2 diabetes (T2D). However, research is needed to further charact...

    Authors: Grazyna Lietzau, William Davidsson, Claes-Göran Östenson, Fausto Chiazza, David Nathanson, Hiranya Pintana, Josefin Skogsberg, Thomas Klein, Thomas Nyström, Vladimer Darsalia and Cesare Patrone

    Citation: Acta Neuropathologica Communications 2018 6:14

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