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  1. Content type: Research

    Doublecortin (DCX) is widely regarded as a marker of immature and migrating neurons during development. While DCX expression persists in adults, particularly in the temporal lobe and neurogenic regions, it is ...

    Authors: Joan Y. W. Liu, Mar Matarin, Cheryl Reeves, Andrew W. McEvoy, Anna Miserocchi, Pamela Thompson, Sanjay M. Sisodiya and Maria Thom

    Citation: Acta Neuropathologica Communications 2018 6:60

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  2. Content type: Research

    One of the earliest pathological features characterizing Alzheimer’s disease (AD) is the loss of dendritic spines. Among the many factors potentially mediating this loss of neuronal connectivity, the contribut...

    Authors: Mirta Borin, Claudia Saraceno, Marcella Catania, Erika Lorenzetto, Valeria Pontelli, Anna Paterlini, Silvia Fostinelli, Anna Avesani, Giuseppe Di Fede, Gianluigi Zanusso, Luisa Benussi, Giuliano Binetti, Simone Zorzan, Roberta Ghidoni, Mario Buffelli and Silvia Bolognin

    Citation: Acta Neuropathologica Communications 2018 6:61

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  3. Content type: Research

    Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viab...

    Authors: Jeroen van Ameijde, Rosa Crespo, Roosmarijn Janson, Jarek Juraszek, Berdien Siregar, Hanneke Verveen, Imke Sprengers, Tariq Nahar, Jeroen J. Hoozemans, Stefan Steinbacher, Roland Willems, Lore Delbroek, Marianne Borgers, Koen Dockx, Kristof Van Kolen, Marc Mercken…

    Citation: Acta Neuropathologica Communications 2018 6:59

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  4. Content type: Research

    Differentiated neurons established via iPSCs from patients that suffer from familial Parkinson’s disease (PD) have allowed insights into the mechanisms of neurodegeneration. In the larger cohort of patients wi...

    Authors: Markus Schulze, Annika Sommer, Sonja Plötz, Michaela Farrell, Beate Winner, Janina Grosch, Jürgen Winkler and Markus J. Riemenschneider

    Citation: Acta Neuropathologica Communications 2018 6:58

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  5. Content type: Research

    Parkinson’s disease is diagnosed upon the presentation of motor symptoms, resulting from substantial degeneration of dopaminergic neurons in the midbrain. Prior to diagnosis, there is a lengthy prodromal stage...

    Authors: Leah C. Beauchamp, Jacky Chan, Lin W. Hung, Benjamin S. Padman, Laura J. Vella, Xiang M. Liu, Bradley Coleman, Ashley I. Bush, Michael Lazarou, Andrew F. Hill, Laura Jacobson and Kevin J. Barnham

    Citation: Acta Neuropathologica Communications 2018 6:57

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  6. Content type: Research

    While post mortem studies have identified the major cell types and functional systems affected in Alzheimer’s disease (AD) the initial sites and molecular characteristics of pathology are still unclear. Becaus...

    Authors: Yvonne S. Davidson, Andrew Robinson, Vee P. Prasher and David M. A. Mann

    Citation: Acta Neuropathologica Communications 2018 6:56

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  7. Content type: Research

    A hexanucleotide (GGGGCC) repeat expansion in C9ORF72 is the most common genetic contributor to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Reduced expression of the C9ORF72 ...

    Authors: Daniel A. Mordes, Mercedes Prudencio, Lindsey D. Goodman, Joseph R. Klim, Rob Moccia, Francesco Limone, Olli Pietilainen, Kaitavjeet Chowdhary, Dennis W. Dickson, Rosa Rademakers, Nancy M. Bonini, Leonard Petrucelli and Kevin Eggan

    Citation: Acta Neuropathologica Communications 2018 6:55

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  8. Content type: Research

    Parkinson disease (PD) is the second most common neurodegenerative disorder and the leading neurodegenerative cause of motor disability. Pathologic accumulation of aggregated alpha synuclein (AS) protein in br...

    Authors: Asad Jan, Brandon Jansonius, Alberto Delaidelli, Forum Bhanshali, Yi Andy An, Nelson Ferreira, Lisa M. Smits, Gian Luca Negri, Jens C. Schwamborn, Poul H. Jensen, Ian R. Mackenzie, Stefan Taubert and Poul H. Sorensen

    Citation: Acta Neuropathologica Communications 2018 6:54

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  9. Content type: Research

    Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of progressive supranuclear palsy (PSP) cases. To confirm the binding target of rad...

    Authors: Aiko Ishiki, Ryuichi Harada, Hideaki Kai, Naomi Sato, Tomoko Totsune, Naoki Tomita, Shoichi Watanuki, Kotaro Hiraoka, Yoichi Ishikawa, Yoshihito Funaki, Ren Iwata, Shozo Furumoto, Manabu Tashiro, Hironobu Sasano, Tetsuyuki Kitamoto, Yukitsuka Kudo…

    Citation: Acta Neuropathologica Communications 2018 6:53

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  10. Content type: Research

    Alzheimer’s disease is characterized by accumulation of amyloid plaques and tau aggregates in several cortical brain regions. Tau phosphorylation causes formation of neurofibrillary tangles and neuropil thread...

    Authors: Joerg Neddens, Magdalena Temmel, Stefanie Flunkert, Bianca Kerschbaumer, Christina Hoeller, Tina Loeffler, Vera Niederkofler, Guenther Daum, Johannes Attems and Birgit Hutter-Paier

    Citation: Acta Neuropathologica Communications 2018 6:52

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  11. Content type: Research

    Diffuse intrinsic pontine glioma (DIPG) is a universally fatal malignancy of the childhood central nervous system, with a median overall survival of 9–11 months. We have previously shown that primary DIPG tiss...

    Authors: Grant L. Lin, Surya Nagaraja, Mariella G. Filbin, Mario L. Suvà, Hannes Vogel and Michelle Monje

    Citation: Acta Neuropathologica Communications 2018 6:51

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  12. Content type: Research

    Aging-related tau astrogliopathy (ARTAG) describes tau pathology in astrocytes in different locations and anatomical regions. In the present study we addressed the question of whether sequential distribution p...

    Authors: Gabor G. Kovacs, Sharon X. Xie, John L. Robinson, Edward B. Lee, Douglas H. Smith, Theresa Schuck, Virginia M.-Y. Lee and John Q. Trojanowski

    Citation: Acta Neuropathologica Communications 2018 6:50

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  13. Content type: Research

    Oligodendrogliomas are primary human brain tumors with a characteristic 1p/19q co-deletion of important prognostic relevance, but little is known about the pathology of this chromosomal mutation. We developed ...

    Authors: Josef Gladitz, Barbara Klink and Michael Seifert

    Citation: Acta Neuropathologica Communications 2018 6:49

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  14. Content type: Research

    Genomic characterization has begun to redefine diagnostic classifications of cancers. However, it remains a challenge to infer disease phenotypes from genomic alterations alone. To help realize the promise of ...

    Authors: Samuel Rivero-Hinojosa, Ling San Lau, Mojca Stampar, Jerome Staal, Huizhen Zhang, Heather Gordish-Dressman, Paul A. Northcott, Stefan M. Pfister, Michael D. Taylor, Kristy J. Brown and Brian R. Rood

    Citation: Acta Neuropathologica Communications 2018 6:48

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  15. Content type: Research

    Ganglioglioma is the most common epilepsy-associated neoplasm that accounts for approximately 2% of all primary brain tumors. While a subset of gangliogliomas are known to harbor the activating p.V600E mutatio...

    Authors: Melike Pekmezci, Javier E. Villanueva-Meyer, Benjamin Goode, Jessica Van Ziffle, Courtney Onodera, James P. Grenert, Boris C. Bastian, Gabriel Chamyan, Ossama M. Maher, Ziad Khatib, Bette K. Kleinschmidt-DeMasters, David Samuel, Sabine Mueller, Anuradha Banerjee, Jennifer L. Clarke, Tabitha Cooney…

    Citation: Acta Neuropathologica Communications 2018 6:47

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  16. Content type: Research

    Alzheimer’s disease (AD) is characterized by amyloid beta (Aβ) deposits as plaques in the parenchyma and in the walls of cortical and leptomeningeal blood vessels of the brain called cerebral amyloid angiopath...

    Authors: David C. Hondius, Kristel N. Eigenhuis, Tjado H. J. Morrema, Roel C. van der Schors, Pim van Nierop, Marianna Bugiani, Ka Wan Li, Jeroen J. M. Hoozemans, August B. Smit and Annemieke J. M. Rozemuller

    Citation: Acta Neuropathologica Communications 2018 6:46

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  17. Content type: Research

    Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer’s Disease (AD). By interrogating IgG+ memory B cells from asymptomatic donors with tau peptides, we hav...

    Authors: Adrian Apetri, Rosa Crespo, Jarek Juraszek, Gabriel Pascual, Roosmarijn Janson, Xueyong Zhu, Heng Zhang, Elissa Keogh, Trevin Holland, Jay Wadia, Hanneke Verveen, Berdien Siregar, Michael Mrosek, Renske Taggenbrock, Jeroenvan Ameijde, Hanna Inganäs…

    Citation: Acta Neuropathologica Communications 2018 6:43

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  18. Content type: Research

    Mutations in leucine-rich repeat kinase (LRRK2) are the most common cause of heritable Parkinson’s disease (PD), and the most common mutations in LRRK2 lead to elevated kinase activity. For these reasons, inhi...

    Authors: Michael X. Henderson, Chao Peng, John Q. Trojanowski and Virginia M. Y. Lee

    Citation: Acta Neuropathologica Communications 2018 6:45

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  19. Content type: Research

    Several studies suggest that women have a higher risk to develop Alzheimer’s disease (AD) than men. In particular, the number of pregnancies was shown to be a risk factor for AD and women with several pregnanc...

    Authors: Stephanie Ziegler-Waldkirch, Karin Marksteiner, Johannes Stoll, Paolo d´Errico, Marina Friesen, Denise Eiler, Lea Neudel, Verena Sturn, Isabel Opper, Moumita Datta, Marco Prinz and Melanie Meyer-Luehmann

    Citation: Acta Neuropathologica Communications 2018 6:44

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  20. Content type: Research

    Loss-of-function mutations in progranulin (GRN) and a non-coding (GGGGCC)n hexanucleotide repeat expansions in C9ORF72 are the two most common genetic causes of frontotemporal lobar degeneration with aggregates o...

    Authors: Alexandra M. Nicholson, Xiaolai Zhou, Ralph B. Perkerson, Tammee M. Parsons, Jeannie Chew, Mieu Brooks, Mariely DeJesus-Hernandez, NiCole A. Finch, Billie J. Matchett, Aishe Kurti, Karen R. Jansen-West, Emilie Perkerson, Lillian Daughrity, Monica Castanedes-Casey, Linda Rousseau, Virginia Phillips…

    Citation: Acta Neuropathologica Communications 2018 6:42

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  21. Content type: Research

    Nemaline myopathies are heterogeneous congenital muscle disorders causing skeletal muscle weakness and, in some cases, death soon after birth. Mutations in nebulin, encoding a large sarcomeric protein required fo...

    Authors: Tamar E. Sztal, Emily A. McKaige, Caitlin Williams, Viola Oorschot, Georg Ramm and Robert J. Bryson-Richardson

    Citation: Acta Neuropathologica Communications 2018 6:40

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  22. Content type: Letter to the Editor

    Authors: Clémence Fournier, Vincent Anquetil, Agnès Camuzat, Sandrine Stirati-Buron, Véronique Sazdovitch, Laura Molina-Porcel, Sabrina Turbant, Daisy Rinaldi, Raquel Sánchez-Valle, Mathieu Barbier, Morwena Latouche, Giovanni Stevanin, Danielle Seilhean, Alexis Brice, Charles Duyckaerts and Isabelle Le Ber

    Citation: Acta Neuropathologica Communications 2018 6:41

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  23. Content type: Research

    Degeneration of noradrenergic locus coeruleus neurons occurs during the prodromal phase of Parkinson’s disease and contributes to a variety of non-motor symptoms, e.g. depression, anxiety and REM sleep behavio...

    Authors: Martin Timo Henrich, Fanni Fruzsina Geibl, Bolam Lee, Wei-Hua Chiu, James Benjamin Koprich, Jonathan Michael Brotchie, Lars Timmermann, Niels Decher, Lina Anita Matschke and Wolfgang Hermann Oertel

    Citation: Acta Neuropathologica Communications 2018 6:39

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  24. Content type: Research

    Astroyctes serve myriad functions but are especially critical in white matter tracts, where energy-demanding axons propagate action potentials great distances between neurons. Axonal dependence on astrocytes f...

    Authors: Melissa L. Cooper, John W. Collyer and David J. Calkins

    Citation: Acta Neuropathologica Communications 2018 6:38

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  25. Content type: Research

    In Alzheimer’s disease (AD) and related tauopathies, the microtubule-associated protein tau is highly phosphorylated and aggregates to form neurofibrillary tangles that are characteristic of these neurodegener...

    Authors: Caterina Giacomini, Chuay-Yeng Koo, Natalia Yankova, Ignatius A. Tavares, Selina Wray, Wendy Noble, Diane P. Hanger and Jonathan D. H. Morris

    Citation: Acta Neuropathologica Communications 2018 6:37

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