Skip to content


Acta Neuropathologica Communications


Sort by
Previous Page Page 1 of 23 Next Page
  1. Content type: Research

    Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests a...

    Authors: Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S. Caron, Niels H. Skotte, Yen T. N. Nguyen, Kuljeet Vaid, Amber L. Southwell, Sabine Engemann, Sonia Franciosi and Michael R. Hayden

    Citation: Acta Neuropathologica Communications 2018 6:16

    Published on:

  2. Content type: Research

    Seeding and spread of beta-amyloid (Aβ) pathologies have been considered to be based on prion-like mechanisms. However, limited transmissibility of Aβ seeding activity upon peripheral exposure would represent ...

    Authors: Michael Burwinkel, Manuel Lutzenberger, Frank L. Heppner, Walter Schulz-Schaeffer and Michael Baier

    Citation: Acta Neuropathologica Communications 2018 6:23

    Published on:

  3. Content type: Review

    Alzheimer’s disease (AD) is conceptualized as a progressive consequence of two hallmark pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary tangles. However, over the past se...

    Authors: Sara E. Nasrabady, Batool Rizvi, James E. Goldman and Adam M. Brickman

    Citation: Acta Neuropathologica Communications 2018 6:22

    Published on:

  4. Content type: Methodology article

    All isocitrate dehydrogenase (IDH) mutant solid neoplasms exhibit highly elevated levels of D-2-hydroxyglutarate (D-2HG). Detection of 2HG in tumor tissues currently is performed by gas or liquid chromatograph...

    Authors: Rémi Longuespée, Annika K. Wefers, Elena De Vita, Aubry K. Miller, David E. Reuss, Wolfgang Wick, Christel Herold-Mende, Mark Kriegsmann, Peter Schirmacher, Andreas von Deimling and Stefan Pusch

    Citation: Acta Neuropathologica Communications 2018 6:21

    Published on:

  5. Content type: Research

    Synaptic dysfunction or loss in early stages of Alzheimer’s disease (AD) is thought to be a major structural correlate of cognitive dysfunction. Early loss of episodic memory, which occurs at the early stage o...

    Authors: M. Domínguez-Álvaro, M. Montero-Crespo, L. Blazquez-Llorca, R. Insausti, J. DeFelipe and L. Alonso-Nanclares

    Citation: Acta Neuropathologica Communications 2018 6:20

    Published on:

  6. Content type: Research

    Although the genetic causes for several rare, familial forms of Alzheimer’s disease (AD) have been identified, the etiology of the sporadic form of AD remains unclear. Here, we report a systems-level study of ...

    Authors: Qi Zhang, Cheng Ma, Marla Gearing, Peng George Wang, Lih-Shen Chin and Lian Li

    Citation: Acta Neuropathologica Communications 2018 6:19

    Published on:

  7. Content type: Research

    Despite multidisciplinary local and systemic therapeutic approaches, the prognosis for most patients with brain metastases is still dismal. The role of adaptive and innate anti-tumor response including the Hum...

    Authors: P. S. Zeiner, J. Zinke, D. J. Kowalewski, S. Bernatz, J. Tichy, M. W. Ronellenfitsch, F. Thorsen, A. Berger, M. T. Forster, A. Muller, J. P. Steinbach, R. Beschorner, J. Wischhusen, H. M. Kvasnicka, K. H. Plate, S. Stefanović…

    Citation: Acta Neuropathologica Communications 2018 6:18

    Published on:

  8. Content type: Research

    Traumatic brain injury (TBI) induces a wide variety of cellular and molecular changes that can continue for days to weeks to months, leading to functional impairments. Currently, there are no pharmacotherapies...

    Authors: Anssi Lipponen, Assam El-Osta, Antony Kaspi, Mark Ziemann, Ishant Khurana, Harikrishnan KN, Vicente Navarro-Ferrandis, Noora Puhakka, Jussi Paananen and Asla Pitkänen

    Citation: Acta Neuropathologica Communications 2018 6:17

    Published on:

  9. Content type: Research

    The therapeutic response to high-dose methotrexate (HD-MTX) therapy for primary central nervous system lymphoma (PCNSL) varies. Polyglutamylation is a reversible protein modification with a high occurrence rat...

    Authors: Naoki Shinojima, Kenji Fujimoto, Keishi Makino, Kohei Todaka, Kazumichi Yamada, Yoshiki Mikami, Kazutaka Oda, Kazumi Nakamura, Hirofumi Jono, Jun-ichi Kuratsu, Hideo Nakamura, Shigetoshi Yano and Akitake Mukasa

    Citation: Acta Neuropathologica Communications 2018 6:15

    Published on:

  10. Content type: Research

    Recent data suggest that olfactory deficits could represent an early marker and a pathogenic mechanism at the basis of cognitive decline in type 2 diabetes (T2D). However, research is needed to further charact...

    Authors: Grazyna Lietzau, William Davidsson, Claes-Göran Östenson, Fausto Chiazza, David Nathanson, Hiranya Pintana, Josefin Skogsberg, Thomas Klein, Thomas Nyström, Vladimer Darsalia and Cesare Patrone

    Citation: Acta Neuropathologica Communications 2018 6:14

    Published on:

  11. Content type: Research

    Mechanisms underlying sex differences in cancer incidence are not defined but likely involve dimorphism (s) in tumor suppressor function at the cellular and organismal levels. As an example, sexual dimorphism ...

    Authors: Najla Kfoury, Tao Sun, Kwanha Yu, Nathan Rockwell, Kelsey L. Tinkum, Zongtai Qi, Nicole M. Warrington, Peter McDonald, Anuradha Roy, Scott J. Weir, Carrie A. Mohila, Benjamin Deneen and Joshua B. Rubin

    Citation: Acta Neuropathologica Communications 2018 6:12

    Published on:

  12. Content type: Research

    Human familial prion diseases are associated with mutations at 34 different prion protein (PrP) amino acid residues. However, it is unclear whether infectious prions are found in all cases. Mutant PrP itself m...

    Authors: Brent Race, Katie Williams, Andrew G. Hughson, Casper Jansen, Piero Parchi, Annemieke J. M. Rozemuller and Bruce Chesebro

    Citation: Acta Neuropathologica Communications 2018 6:13

    Published on:

  13. Content type: Research

    Terminal complement complex deposition in endomysial capillaries detected by a C5b-9 immunostain is considered a diagnostic feature for dermatomyositis. However, we found widespread microvascular C5b-9 reactiv...

    Authors: Paul C. Yell, Dennis K. Burns, Evan G. Dittmar, Charles L. White III and Chunyu Cai

    Citation: Acta Neuropathologica Communications 2018 6:11

    Published on:

  14. Content type: Research

    Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they lack the scope of promoting CN...

    Authors: Nicolau Beckmann, Elisa Giorgetti, Anna Neuhaus, Stefan Zurbruegg, Nathalie Accart, Paul Smith, Julien Perdoux, Ludovic Perrot, Mark Nash, Sandrine Desrayaud, Peter Wipfli, Wilfried Frieauff and Derya R. Shimshek

    Citation: Acta Neuropathologica Communications 2018 6:9

    Published on:

  15. Content type: Research

    In Alzheimer disease and related disorders, the microtubule-associated protein tau aggregates and forms cytoplasmic lesions that impair neuronal physiology at many levels. In addition to affecting the host neu...

    Authors: Juan Carlos Polanco, Chuanzhou Li, Nela Durisic, Robert Sullivan and Jürgen Götz

    Citation: Acta Neuropathologica Communications 2018 6:10

    Published on:

  16. Content type: Methodology article

    The diagnosis and treatment of synucleinopathies such as Parkinson disease and dementia with Lewy bodies would be aided by the availability of assays for the pathogenic disease-associated forms of α-synuclein ...

    Authors: Bradley R. Groveman, Christina D. Orrù, Andrew G. Hughson, Lynne D. Raymond, Gianluigi Zanusso, Bernardino Ghetti, Katrina J. Campbell, Jiri Safar, Douglas Galasko and Byron Caughey

    Citation: Acta Neuropathologica Communications 2018 6:7

    Published on:

  17. Content type: Research

    In Parkinson’s disease (PD) there is widespread accumulation in the brain of abnormal α-synuclein aggregates forming intraneuronal Lewy bodies (LB). It is now well established that LB-type α-synuclein aggregat...

    Authors: Ariadna Recasens, Iria Carballo-Carbajal, Annabelle Parent, Jordi Bové, Ellen Gelpi, Eduardo Tolosa and Miquel Vila

    Citation: Acta Neuropathologica Communications 2018 6:8

    Published on:

  18. Content type: Research

    Neurodegenerative diseases are linked to a systemic enzyme resistance of toxic aggregated molecules and their pathological consequences. This paper presents a unique phenomenon that Philodina acuticornis, a bdell...

    Authors: Zsolt Datki, Zita Olah, Tibor Hortobagyi, Lilla Macsai, Katalin Zsuga, Livia Fulop, Zsolt Bozso, Bence Galik, Eva Acs, Angela Foldi, Amanda Szarvas and Janos Kalman

    Citation: Acta Neuropathologica Communications 2018 6:6

    Published on:

  19. Content type: Research

    The presence of pathology related to the deposition of amyloid-β (Aβ) has been recently reported in iatrogenic Creutzfeldt-Jakob disease (iCJD) acquired from inoculation of growth hormone (GH) extracted from h...

    Authors: Ignazio Cali, Mark L. Cohen, Stéphane Haїk, Piero Parchi, Giorgio Giaccone, Steven J. Collins, Diane Kofskey, Han Wang, Catriona A. McLean, Jean-Philippe Brandel, Nicolas Privat, Véronique Sazdovitch, Charles Duyckaerts, Tetsuyuki Kitamoto, Ermias D. Belay, Ryan A. Maddox…

    Citation: Acta Neuropathologica Communications 2018 6:5

    Published on:

  20. Content type: Research

    Proteoglycans are promising therapeutic targets in Multiple Sclerosis (MS), because they regulate many aspects of the immune response. This was studied using surfen, an agent that binds both heparan sulphate p...

    Authors: Jordan R. Warford, Anna-Claire Lamport, Derek R. Clements, Alicia Malone, Barry E. Kennedy, Youra Kim, Shashi A. Gujar, David W. Hoskin and Alexander S. Easton

    Citation: Acta Neuropathologica Communications 2018 6:4

    Published on:

  21. Content type: Research

    Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder characterized by widespread oligodendroglial cytoplasmic inclusions of filamentous α-synuclein, and neuronal loss in autonomic ...

    Authors: Violetta Refolo, Francesco Bez, Alexia Polissidis, Daniela Kuzdas-Wood, Edith Sturm, Martina Kamaratou, Werner Poewe, Leonidas Stefanis, M. Angela Cenci, Marina Romero-Ramos, Gregor K. Wenning and Nadia Stefanova

    Citation: Acta Neuropathologica Communications 2018 6:2

    Published on:

  22. Content type: Research

    Alzheimer-type neuropil threads (NTs) and neurofibrillary tangles (NFTs) are comprised of either 4 repeat (4R)-tau, 3 repeat (3R)-tau, or a mixture of both. In the hippocampus, the number of NFTs, and the prop...

    Authors: Miho Uematsu, Ayako Nakamura, Momoko Ebashi, Katsuiku Hirokawa, Ryosuke Takahashi and Toshiki Uchihara

    Citation: Acta Neuropathologica Communications 2018 6:1

    Published on:

  23. Content type: Research

    Alzheimer’s disease (AD) is the most common cause of dementia among older adults. Accumulation of amyloid-β (Aβ) in the brain is considered central in AD pathogenesis and its understanding crucial for developi...

    Authors: Maria Luisa Moro, Andrew Stephen Phillips, Katie Gaimster, Christian Paul, Amritpal Mudher, James A. R. Nicoll and Delphine Boche

    Citation: Acta Neuropathologica Communications 2018 6:3

    Published on:

  24. Content type: Review

    Emerging experimental evidence suggests that the spread of tau pathology in the brain in Tauopathies reflects the propagation of abnormal tau species along neuroanatomically connected brain areas. This propaga...

    Authors: Amrit Mudher, Morvane Colin, Simon Dujardin, Miguel Medina, Ilse Dewachter, Seyedeh Maryam Alavi Naini, Eva-Maria Mandelkow, Eckhard Mandelkow, Luc Buée, Michel Goedert and Jean-Pierre Brion

    Citation: Acta Neuropathologica Communications 2017 5:99

    Published on:

Previous Page Page 1 of 23 Next Page

2016 Journal Metrics