Fig. 1

CSF αSyn levels in sporadic MCI and Alzheimer’s disease cohort. Quantification of CSF αSyn levels at (a) baseline, (b) 12-months and (c) 24-months in the four longitudinally diagnosed patient groups: control = cognitively healthy controls, MCI-MCI = MCI patients who remained MCI at the 24-month follow up, MCI-AD = MCI patients who converted to Alzheimer’s disease at the 24-month follow up, AD = patients diagnosed with AD at baseline. P-values were calculated using a one-way ANCOVA of log-transformed data with age entered as a covariate with post-hoc testing by use of the student’s t-test. Bonferroni correction was used to account for multiple comparisons (a: n = 6 comparisons, b-c: n = 3 comparisons). Results are displayed without log-transformation or age-correction (raw data)