Fig. 8

CSF αSyn levels quantified in participants from the DIAN cohort. a CSF αSyn levels grouped by ADAD gene mutation. b CSF αSyn in ADAD non-mutation carriers versus asymptomatic and symptomatic ADAD mutation carriers. Data point coloring represents the three ADAD genes as shown in (a). P-values are presented first as uncorrected followed by Bonferroni corrected (a-b: n = 3 comparisons). P-values calculated using the non-parametric Kruskal-Wallis test and a Bonferroni correction was used to account for multiple comparisons. c Correlation between CSF αSyn and the estimated years from symptom onset (EYO) in ADAD mutation carriers and non-mutation carriers; correlations are calculated using Pearson’s correlation test after log-transformation of the CSF αSyn data and results are displayed without log-transformation or age-correction (raw data)