Table 1 Longitudinal cohort baseline characteristics

N

57

54

27

27

Sex (% f/m)

65/35

53/47

44/56

59/41

52/48

- ^d

Age at examination (yrs)^a

68 ± 5

65 ± 6

66 ± 6

64 ± 4

64 ± 6

** ^e

MMSE^b

30 (28–30)

28 (23–30)

28 (25–30)

27 (23–29)

23 (16–27)

*** ^f

APOEε4 carrier (%)

38 (n = 55)

66

63

74

81

*** ^d

CSF

969.7

546.5

574.3

539.0

476.8

*** ^f

Aβ_1–42

(500–1674)

(173–1269)

(173–1269)

(283–1060)

(212–1092)

(pg/mL)^b

CSF

17.1

13.5

12.9

14.2

14.9

** ^f

Aβ_1–40

(11–41)

(4–31)

(4–31)

(8–23)

(7–29)

(ng/mL) ^b

(n = 26)

(n = 23)

(n = 26)

CSF

0.059

0.042

0.049

0.039

0.034

*** ^f

Aβ_42/40 ^b

(0.013–0.096)

(0.008–0.118)

(0.008–0.118)

(0.012–0.088)

(0.007–0.080)

(n = 26)

(n = 23)

(n = 26)

CSF

269.0

447.9

315.2

550.8

624.2

*** ^f

t-tau

(138–1314)

(99–2325)

(99–1057)

(163–2325)

(177–1540)

(pg/mL)^b

CSF

53.5

69.9

53.0

85.6

90.8

*** ^f

p-tau

(33–135)

(16–169)

(16–131)

(37–169)

(28–157)

(pg/mL)^b