Fig. 2

CSF αSyn measured in APOEε4-positive versus APOEε4-negative sporadic MCI patients. a-c CSF αSyn quantified in MCI patients at baseline, 12- and 24-months respectively. APOEε4-positive patients are shown as grey shaded boxes, APOEε4-negative patients are white boxes. Orange data points represent patients longitudinally diagnosed as MCI-AD, brown points represent MCI-MCI patients. d-f CSF αSyn quantified in MCI-AD diagnosed patients at baseline, 12- and 24-months respectively. P-values were calculated using the one-way ANCOVA of log-transformed data, with age entered as a covariate with post-hoc testing by use of the student’s t-test. Results are displayed without log-transformation or age-correction (raw data). MCI-AD = MCI patients who converted to Alzheimer’s disease at the 24-month follow up