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Table 2 Longitudinal cohort CSF αSyn correlation analysesǂ

From: The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease

Time Longitudinal diagnosis MMSE CSF
1-42
CSF
1-40
CSF
42/40
CSF
t-tau
CSF
p-tau
Baseline Control
(n=57)
- -
(n=41)
0.616***
(n=37)
-0.542***
(n=37)
0.871***
(n=42)
0.766***
(n=42)
MCI-MCI
(n=27)
- - 0.472**
(n=26)
-
(n=26)
0.577*** 0.651***
MCI-AD
(n=27)
-0.605*** - 0.640***
(n=23)
-0.457*
(n=23)
0.736*** 0.694***
AD
(n=27)
- - 0.758***
(n=26)
-
(n=26)
0.722*** 0.738***
12-months MCI-MCI
(n=27)
- -
(n=15)
0.703***
(n=15)
-0.575*
(n=15)
0.804***
(n=15)
0.849***
(n=15)
MCI-AD
(n=25)
- -
(n=19)
0.863***
(n=18)
-0.732***
(n=18)
0.913***
(n=19)
0.927***
(n=19)
AD
(n=24)
- -
(n=18)
0.691***
(n=18)
-
(n=18)
0.804***
(n=18)
0.770***
(n=18)
24-months MCI-MCI
(n=24)
- -
(n=14)
0.925***
(n=14)
-
(n=14)
0.782***
(n=14)
0.924***
(n=14)
MCI-AD
(n=24)
- -
(n=18)
0.716***
(n=17)
-0.556*
(n=17)
0.902***
(n=18)
0.919***
(n=18)
AD
(n=18)
- 0.662**
(n=16)
0.585*
(n=16)
-
(n=16)
0.741**
(n=16)
0.650**
(n=16)
  1. ǂAll correlations calculated using the Spearman’s rank correlation test
  2. MCI-MCI= MCI patients who remained MCI at the 24-month follow up
  3. MCI-AD= MCI patients who converted to Alzheimer’s disease at the 24-month follow up
  4. AD patients diagnosed with Alzheimer’s disease at baseline, MMSE Mini-Mental State Examination score
  5. *p ≤0.05, **p ≤0.01, ***p ≤0.001