Table 4 DIAN cohort CSF αSyn correlation analysesa
From: The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease
Non- mutation carriers | APP mutation carriers | PSEN1 mutation carriers | PSEN2 mutation carriers | |||||
|---|---|---|---|---|---|---|---|---|
Asym (n = 15) | Sym (n = 9) | Asym (n = 29) | Sym (n = 21) | Asym (n = 16) | Sym (n = 2) | |||
CSF Aβ1–42 | 0.595*** | – | – | – | – | – | ¤ | |
CSF Aβ1–40 | 0.744*** | 0.610* | 0.717* | 0.526** | 0.788*** | – | ¤ | |
CSF Aβ42/40 | – | – | −0.800** | – | −0.464* | – | ¤ | |
CSF t-tau | 0.716*** | 0.676* | 0.917*** | 0.943*** | 0.664*** | 0.736** | ¤ | |
CSF p-tau | 0.544*** | – | – | 0.809*** | 0.662*** | – | ¤ | |