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Table 4 DIAN cohort CSF αSyn correlation analysesa

From: The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease

  Non- mutation carriers APP mutation carriers   PSEN1 mutation carriers PSEN2 mutation carriers
Asym
(n = 15)
Sym
(n = 9)
  Asym
(n = 29)
Sym
(n = 21)
Asym
(n = 16)
Sym
(n = 2)
CSF Aβ1–42 0.595***   ¤
CSF Aβ1–40 0.744*** 0.610* 0.717*   0.526** 0.788*** ¤
CSF Aβ42/40 −0.800**   −0.464* ¤
CSF t-tau 0.716*** 0.676* 0.917***   0.943*** 0.664*** 0.736** ¤
CSF p-tau 0.544***   0.809*** 0.662*** ¤
  1. a = All correlations calculated using the Spearman’s rank correlation test
  2. Asym = asymptomatic Sym = symptomatic
  3. ¤ = not determined * = p ≤ 0.05 ** = p ≤ 0.01 *** = p ≤ 0.001