The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease

Table 5 Linear regression models relating mean cortical ¹¹C-Pittsburgh Compound-B uptake and αSyn in ADAD mutation carriers

Model (PiB-positive asymptomatic mutation carriers): Mean cortical PiB ~ αSyn + EYO
Independent predictors	Standardized β	Std. Error	t value	p value
αSyn	0.375	0.00047	2.348	0.027
EYO	0.444	0.00676	2.780	0.010
Model (all mutation carriers): Mean cortical PiB ~ αSyn + APOEε4 + EYO + αSyn*APOEε4
Independent predictors	Estimate	Std. Error	t value	p value
αSyn	−0.00038	0.00039	−0.970	0.335
APOEε4	−0.98698	0.44767	−2.205	0.030
EYO	0.02682	0.00435	6.164	0.000
αSyn*APOEε4	0.00244	0.00099	2.468	0.016
Model (APOEε4-positive mutation carriers): Mean cortical PiB ~ αSyn + EYO
Independent predictors	Standardized β	Std. Error	t value	p value
αSyn	0.393	0.00088	2.321	0.032
EYO	0.533	0.00864	3.147	0.005

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