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Table 5 Linear regression models relating mean cortical 11C-Pittsburgh Compound-B uptake and αSyn in ADAD mutation carriers

From: The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease

Model (PiB-positive asymptomatic mutation carriers): Mean cortical PiB ~ αSyn + EYO
Independent predictors Standardized β Std. Error t value p value
 αSyn 0.375 0.00047 2.348 0.027
 EYO 0.444 0.00676 2.780 0.010
Model (all mutation carriers): Mean cortical PiB ~ αSyn + APOEε4 + EYO + αSyn*APOEε4
Independent predictors Estimate Std. Error t value p value
 αSyn −0.00038 0.00039 −0.970 0.335
APOEε4 −0.98698 0.44767 −2.205 0.030
 EYO 0.02682 0.00435 6.164 0.000
 αSyn*APOEε4 0.00244 0.00099 2.468 0.016
Model (APOEε4-positive mutation carriers): Mean cortical PiB ~ αSyn + EYO
Independent predictors Standardized β Std. Error t value p value
 αSyn 0.393 0.00088 2.321 0.032
 EYO 0.533 0.00864 3.147 0.005
  1. PiB = 11C-Pittsburgh Compound-B EYO = estimated years from symptom onset