From: The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease
Non-Mutation Carriers | All Mutation Carriers | APP Mutation Carriers | PSEN1 Mutation Carriers | PSEN2 Mutation Carriers | p-valuea | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
All | Asym | Sym | All | Asym | Sym | All | Asym | Sym | ||||
N | 50 | 92 | 24 | 15 | 9 | 50 | 29 | 21 | 18 | 16 | 2 | |
Sex (% f/m) | 56/44 | 55/45 | 63/37 | 67/33 | 56/44 | 60/40 | 52/48 | 71/29 | 33/66 | 32/68 | 50/50 | – |
Age at examination (yrs) | 40 ± 11 | 40 ± 10 | 42 ± 11 | 39 ± 12 | 49 ± 6 | 39 ± 10 | 34 ± 9 | 46 ± 8 | 40 ± 10 | 38 ± 9 | 57 | ***c |
EYO | −9 ± 11 | −7 ± 12 | 5 ± 11 | −11 ± 11 | 4±3 | −6 ± 12 | −14 ± 10 | 5 ± 4 | −13 ± 11 | −15 ± 9 | 7 | – |
MMSE§ | 29 ± 1 | 27 ± 5 | 27 ± 5 | 29 ± 1 | 23 ± 7 | 26 ± 6 | 29 ± 1 | 21 ± 7 | 29 ± 3 | 30 ± 1 | 20 | *c |
CDR | 0 ± 0 | 0.3 ± 0.6 | 0.3 ± 0.5 | 0 ± 0 | 1 ± 0.5 | 0.4 ± 0.7 | 0 ± 0 | 1 ± 0.8 | 0.1 ± 0.5 | 0 ± 0 | 1 | -d |
APOEε4 carrier (%) | 36 | 27 | 25 | 20 | 33 | 18 | 14 | 24 | 56 | 50 | 100 | **e |
CSF Aβ1–42 (pg/mL) | 858 ±264 | 613 ± 320 (n = 89) | 613 ± 353 (n = 23) | 734 ± 393 (n = 14) | 425 ± 164 | 621 ± 335 (n = 49) | 770 ± 318 (n = 28) | 422 ± 243 | 592 ± 233 (n = 17) | 596 ± 249 (n = 15) | 565 | -c |
CSF Aβ1–40 (pg/mL) | 8173 ± 2751 | 7477 ± 3146 (n = 89) | 6639 ± 3278 (n = 23) | 6302 ± 3494 (n = 14) | 7162 ± 3033 | 7563 ± 2785 (n = 49) | 8313 ± 2918 (n = 28) | 6563 ± 2300 | 8363 ± 3810 (n = 17) | 8811 ± 3776 (n = 15) | 5005 | -c |
CSF Aβ42/40 | 0.115 ± 0.045 | 0.092 ± 0.052 (n = 89) | 0.106 ± 0.065 (n = 23) | 0.128 ± 0.066 (n = 14) | 0.072 ± 0.049 | 0.088 ± 0.048 (n = 49) | 0.102 ± 0.047 (n = 28) | 0.070 ± 0.045 | 0.082 ± 0.037 (n = 17) | 0.076 ± 0.031 (n = 15) | 0.129 | -c |
CSF t-tau (pg/mL) | 56 ± 26 (n = 49) | 106 ± 73 (n = 87) | 90 ± 64 (n = 23) | 60 ± 30 (n = 14) | 137 ± 76 | 124 ± 82 (n = 47) | 94 ± 56 (n = 26) | 162 ± 94 | 75 ± 39 (n = 17) | 72 ± 40 (n = 15) | 98 | *c |
CSF p-tau (pg/mL) | 29 ± 14 (n = 49) | 54 ± 34 (n = 89) | 46 ± 25 (n = 23) | 32 ± 11 (n = 14) | 69 ± 24 | 60 ± 37 (n = 49) | 45 ± 28 (n = 28) | 81 ± 38 | 45 ± 31 (n = 17) | 48 ± 32 (n = 15) | 29 | -c |