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Table 3 DIAN cohort baseline characteristics

From: The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease

  Non-Mutation Carriers All Mutation Carriers APP
Mutation Carriers
  PSEN1
Mutation Carriers
  PSEN2
Mutation Carriers
p-valuea
  All Asym Sym All Asym Sym All Asym Sym
N 50 92 24 15 9 50 29 21 18 16 2  
Sex (% f/m) 56/44 55/45 63/37 67/33 56/44 60/40 52/48 71/29 33/66 32/68 50/50
Age at examination (yrs) 40 ± 11 40 ± 10 42 ± 11 39 ± 12 49 ± 6 39 ± 10 34 ± 9 46 ± 8 40 ± 10 38 ± 9 57 ***c
EYO −9 ± 11 −7 ± 12 5 ± 11 −11 ± 11 4±3 −6 ± 12 −14 ± 10 5 ± 4 −13 ± 11 −15 ± 9 7
MMSE§ 29 ± 1 27 ± 5 27 ± 5 29 ± 1 23 ± 7 26 ± 6 29 ± 1 21 ± 7 29 ± 3 30 ± 1 20 *c
CDR 0 ± 0 0.3 ± 0.6 0.3 ± 0.5 0 ± 0 1 ± 0.5 0.4 ± 0.7 0 ± 0 1 ± 0.8 0.1 ± 0.5 0 ± 0 1 -d
APOEε4 carrier (%) 36 27 25 20 33 18 14 24 56 50 100 **e
CSF Aβ1–42 (pg/mL) 858 ±264 613 ± 320
(n = 89)
613 ± 353
(n = 23)
734 ± 393
(n = 14)
425 ± 164 621 ± 335
(n = 49)
770 ± 318
(n = 28)
422 ± 243 592 ± 233
(n = 17)
596 ± 249
(n = 15)
565 -c
CSF Aβ1–40 (pg/mL) 8173 ± 2751 7477 ± 3146
(n = 89)
6639 ± 3278
(n = 23)
6302 ± 3494
(n = 14)
7162 ± 3033 7563 ± 2785
(n = 49)
8313 ± 2918
(n = 28)
6563 ± 2300 8363 ± 3810
(n = 17)
8811 ± 3776
(n = 15)
5005 -c
CSF Aβ42/40 0.115 ± 0.045 0.092 ± 0.052
(n = 89)
0.106 ± 0.065
(n = 23)
0.128 ± 0.066
(n = 14)
0.072 ± 0.049 0.088 ± 0.048
(n = 49)
0.102 ± 0.047
(n = 28)
0.070 ± 0.045 0.082 ± 0.037
(n = 17)
0.076 ± 0.031
(n = 15)
0.129 -c
CSF t-tau (pg/mL) 56 ± 26
(n = 49)
106 ± 73
(n = 87)
90 ± 64
(n = 23)
60 ± 30
(n = 14)
137 ± 76 124 ± 82
(n = 47)
94 ± 56
(n = 26)
162 ± 94 75 ± 39
(n = 17)
72 ± 40
(n = 15)
98 *c
CSF p-tau (pg/mL) 29 ± 14
(n = 49)
54 ± 34
(n = 89)
46 ± 25
(n = 23)
32 ± 11
(n = 14)
69 ± 24 60 ± 37
(n = 49)
45 ± 28
(n = 28)
81 ± 38 45 ± 31
(n = 17)
48 ± 32
(n = 15)
29 -c
  1. Asym = asymptomatic Sym = symptomatic EYO = estimated yeats from symptom onset MMSE = Mini-Mental State Exam scorre
  2. CDR = Clinical Dementia Rating score a = p-value versus all mutation carriers c = Kruskal-Wallis test d = Mann-Whitney U test e = χ2 test § = non-normally distributed data presented at mean ± standard deviation in order to maintain patient anonymity
  3. - = non-significant * = p ≤ 0.05 ** = p ≤ 0.01 *** = p ≤ 0.001