Fig. 4

Cerebrospinal fluid αSyn levels in MCI-AD patients at: a baseline (non-carrier n = 7, heterozygous n = 9, homozygous n = 11), b 12-months (non-carrier n = 7, heterozygous n = 8, homozygous n = 11), and c 24-months (non-carrier n = 7, heterozygous n = 8, homozygous n = 9). P-values are presented first as uncorrected followed by Bonferroni corrected (a-c: n = 3 comparisons). In a P-values were calculated using the non-parametric Kruskal-Wallis with post-hoc testing by use of the Mann-Whitney U test. Bonferroni correction was used to account for multiple comparisons. In (b-c) P-values were calculated using the one-way ANCOVA with age entered as a covariate with post-hoc testing by use of the student’s t-test. Results are displayed without age-correction (raw data). MCI-AD = MCI patients who converted to Alzheimer’s disease at the 24-month follow up