Abbott NJ, Mendonca LL, Dolman DE (2003) The blood-brain barrier in systemic lupus erythematosus. Lupus 12:908–915. doi: 10.1191/0961203303lu501oa
Article
CAS
PubMed
Google Scholar
ACR ad hoc committee (1999) The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum 42:599–608
Article
Google Scholar
Alexander JJ, Quigg RJ (2007) Systemic lupus erythematosus and the brain: what mice are telling us. Neurochem Int 50:5–11
Article
CAS
PubMed
Google Scholar
Anisman H, Hayley S, Kelly O, Borowski T, Merali Z (2001) Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: mouse strain-dependent outcomes. Behav Neurosci 115:443–454
Article
CAS
PubMed
Google Scholar
Appenzeller S, Cendes F, Costallat LT (2004) Epileptic seizures in systemic lupus erythematosus. Neurology 63:1808–1812
Article
PubMed
Google Scholar
Arinuma Y, Yanagida T, Hirohata S (2008) Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. Arthritis Rheum 58:1130–1135. doi: 10.1002/art.23399
Article
CAS
PubMed
Google Scholar
Asgari N, Khorooshi R, Lillevang ST, Owens T (2013) Complement-dependent pathogenicity of brain-specific antibodies in cerebrospinal fluid. J Neuroimmunol 254:76–82. doi: 10.1016/j.jneuroim.2012.09.010
Article
CAS
PubMed
Google Scholar
Ballok DA, Millward JM, Sakic B (2003) Neurodegeneration in autoimmune MRL-lpr mice as revealed by Fluoro Jade B staining. Brain Res 964:200–210
Article
CAS
PubMed
Google Scholar
Ballok DA, Szechtman H, Sakic B (2003) Taste responsiveness and diet preference in autoimmune MRL mice. Behav Brain Res 140:119–130
Article
PubMed
Google Scholar
Ballok DA, Woulfe J, Sur M, Cyr M, Sakic B (2004) Hippocampal damage in mouse and human forms of systemic autoimmune disease. Hippocampus 14:649–661. doi: 10.1002/hipo.10205
Article
PubMed
PubMed Central
Google Scholar
Bennett JL, Lam C, Kalluri SR, Saikali P, Bautista K, Dupree C, Glogowska M, Case D, Antel JP, Owens GP et al (2009) Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol 66:617–629. doi: 10.1002/ana.21802
Article
CAS
PubMed
PubMed Central
Google Scholar
Bertsias GK, Boumpas DT (2010) Pathogenesis, diagnosis and management of neuropsychiatric SLE manifestations. Nat Rev Rheumatol 6:358–367. doi: 10.1038/nrrheum.2010.62
Article
PubMed
Google Scholar
Bluestein HG, Williams GW, Steinberg AD (1981) Cerebrospinal fluid antibodies to neuronal cells: association with neuropsychiatric manifestations of systemic lupus erythematosus. Am J Med 70:240–246
Article
CAS
PubMed
Google Scholar
Bravo-Zehnder M, Toledo EM, Segovia-Miranda F, Serrano FG, Benito MJ, Metz C, Retamal C, Alvarez A, Massardo L, Inestrosa NC et al (2015) Anti-ribosomal P protein autoantibodies from patients with neuropsychiatric lupus impair memory in mice. Arthritis Rheumatol 67:204–214. doi: 10.1002/art.38900
Article
CAS
PubMed
Google Scholar
Bresnihan B, Hohmeister R, Cutting J, Travers RL, Waldburger M, Black C, Jones T, Hughes GR (1979) The neuropsychiatric disorder in systemic lupus erythematosus: evidence for both vascular and immune mechanisms. Ann Rheum Dis 38:301–306
Article
CAS
PubMed
PubMed Central
Google Scholar
Brimberg L, Mader S, Jeganathan V, Berlin R, Coleman TR, Gregersen PK, Huerta PT, Volpe BT, Diamond B (2016) Caspr2-reactive antibody cloned from a mother of an ASD child mediates an ASD-like phenotype in mice. Mol Psychiatry 21:1663–1671. doi: 10.1038/mp.2016.165
Article
CAS
PubMed
PubMed Central
Google Scholar
Brimberg L, Sadiq A, Gregersen PK, Diamond B (2013) Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder. Mol Psychiatry 18:1171–1177. doi: 10.1038/mp.2013.101
Article
CAS
PubMed
Google Scholar
Colasanti T, Delunardo F, Margutti P, Vacirca D, Piro E, Siracusano A, Ortona E (2009) Autoantibodies involved in neuropsychiatric manifestations associated with systemic lupus erythematosus. J Neuroimmunol 212:3–9. doi: 10.1016/j.jneuroim.2009.05.003
Article
CAS
PubMed
Google Scholar
Covelo A, Araque A (2016) Lateral regulation of synaptic transmission by astrocytes. Neuroscience 323:62–66. doi: 10.1016/j.neuroscience.2015.02.036
Article
CAS
PubMed
Google Scholar
Cronin ME, Biswas RM, Van der Straeton C, Fleisher TA, Klippel JH (1988) IgG and IgM anticardiolipin antibodies in patients with lupus with anticardiolipin antibody associated clinical syndromes. J Rheumatol 15:795–798
CAS
PubMed
Google Scholar
D’Cruz DP, Khamashta MA, Hughes GR (2007) Systemic lupus erythematosus. Lancet 369:587–596. doi: 10.1016/S0140-6736(07)60279-7
Article
PubMed
Google Scholar
Dalmau J, Geis C, Graus F (2017) Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev 97:839–887. doi: 10.1152/physrev.00010.2016
Article
PubMed
Google Scholar
Deacon RM, Rawlins JN (2006) T-maze alternation in the rodent. Nat Protoc 1:7–12. doi: 10.1038/nprot.2006.2
Article
PubMed
Google Scholar
DeGiorgio LA, Konstantinov KN, Lee SC, Hardin JA, Volpe BT, Diamond B (2001) A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med 7:1189–1193. doi: 10.1038/nm1101-1189
Article
CAS
PubMed
Google Scholar
Diamond B, Honig G, Mader S, Brimberg L, Volpe BT (2013) Brain-reactive antibodies and disease. Annu Rev Immunol 31:345–385. doi: 10.1146/annurev-immunol-020711-075041
Article
CAS
PubMed
PubMed Central
Google Scholar
Diamond B, Kowal C, Huerta PT, Aranow C, Mackay M, DeGiorgio LA, Lee J, Triantafyllopoulou A, Cohen-Solal J, Volpe BT (2006) Immunity and acquired alterations in cognition and emotion: lessons from SLE. Adv Immunol 89:289–320. doi: 10.1016/S0065-2776(05)89007-8
Article
CAS
PubMed
Google Scholar
During MJ, Symes CW, Lawlor PA, Lin J, Dunning J, Fitzsimons HL, Poulsen D, Leone P, Xu R, Dicker BL et al (2000) An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy. Science 287:1453–1460
Article
CAS
PubMed
Google Scholar
Efthimiou P, Blanco M (2009) Pathogenesis of neuropsychiatric systemic lupus erythematosus and potential biomarkers. Mod Rheumatol 19:457–468. doi: 10.1007/s10165-009-0198-5
Article
CAS
PubMed
Google Scholar
Ernerudh J, Olsson T, Lindstrom F, Skogh T (1985) Cerebrospinal fluid immunoglobulin abnormalities in systemic lupus erythematosus. J Neurol Neurosurg Psychiatry 48:807–813
Article
CAS
PubMed
PubMed Central
Google Scholar
Faust TW, Chang EH, Kowal C, Berlin R, Gazaryan IG, Bertini E, Zhang J, Sanchez-Guerrero J, Fragoso-Loyo HE, Volpe BT et al (2010) Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms. Proc Natl Acad Sci U S A 107:18569–18574. doi: 10.1073/pnas.1006980107
Article
CAS
PubMed
PubMed Central
Google Scholar
Feeney DM, Gonzalez A, Law WA (1982) Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury. Science 217:855–857
Article
CAS
PubMed
Google Scholar
Fraussen J, Claes N, de Bock L, Somers V (2014) Targets of the humoral autoimmune response in multiple sclerosis. Autoimmun Rev 13:1126–1137. doi: 10.1016/j.autrev.2014.07.002
Article
CAS
PubMed
Google Scholar
Ganor Y, Goldberg-Stern H, Lerman-Sagie T, Teichberg VI, Levite M (2005) Autoimmune epilepsy: distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA. Epilepsy Res 65:11–22. doi: 10.1016/j.eplepsyres.2005.03.011
Article
CAS
PubMed
Google Scholar
Geis C, Ritter C, Ruschil C, Weishaupt A, Grunewald B, Stoll G, Holmoy T, Misu T, Fujihara K, Hemmer B et al (2015) The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model. Exp Neurol 265:8–21. doi: 10.1016/j.expneurol.2014.12.015
Article
CAS
PubMed
Google Scholar
Golombek SJ, Graus F, Elkon KB (1986) Autoantibodies in the cerebrospinal fluid of patients with systemic lupus erythematosus. Arthritis Rheum 29:1090–1097
Article
CAS
PubMed
Google Scholar
Gono T, Takarada T, Fukumori R, Kawaguchi Y, Kaneko H, Hanaoka M, Katsumata Y, Yoneda Y, Yamanaka H (2011) NR2-reactive antibody decreases cell viability through augmentation of Ca(2+) influx in systemic lupus erythematosus. Arthritis Rheum 63:3952–3959
Article
CAS
PubMed
Google Scholar
Greenwood DL, Gitlits VM, Alderuccio F, Sentry JW, Toh BH (2002) Autoantibodies in neuropsychiatric lupus. Autoimmunity 35:79–86
Article
CAS
PubMed
Google Scholar
Gulinello M, Chen F, Dobrenis K (2008) Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal storage disorder, Sandhoff disease. Behav Brain Res 193:315–319. doi: 10.1016/j.bbr.2008.06.016
Article
PubMed
PubMed Central
Google Scholar
Hanly JG (2014) Diagnosis and management of neuropsychiatric SLE. Nat Rev Rheumatol 10:338–347. doi: 10.1038/nrrheum.2014.15
Article
CAS
PubMed
Google Scholar
Hanly JG (2005) Neuropsychiatric lupus. Rheum Dis Clin N Am 31:273–298 vi
Article
Google Scholar
Hanly JG, Hong C, Smith S, Fisk JD (1999) A prospective analysis of cognitive function and anticardiolipin antibodies in systemic lupus erythematosus. Arthritis Rheum 42:728–734. doi: 10.1002/1529-0131(199904)42:4<728::AID-ANR16>3.0.CO;2-O
Article
CAS
PubMed
Google Scholar
Hanly JG, Robichaud J, Fisk JD (2006) Anti-NR2 glutamate receptor antibodies and cognitive function in systemic lupus erythematosus. J Rheumatol 33:1553–1558
CAS
PubMed
Google Scholar
Hanly JG, Urowitz MB, Siannis F, Farewell V, Gordon C, Bae SC, Isenberg D, Dooley MA, Clarke A, Bernatsky S et al (2008) Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis: results from an international inception cohort study. Arthritis Rheum 58:843–853
Article
CAS
PubMed
PubMed Central
Google Scholar
Harada K, Kamiya T, Tsuboi T (2015) Gliotransmitter Release from Astrocytes: Functional, Developmental, and Pathological Implications in the Brain. Front Neurosci 9:499. doi: 10.3389/fnins.2015.00499
PubMed
Google Scholar
Harrison MJ, Ravdin LD, Lockshin MD (2006) Relationship between serum NR2a antibodies and cognitive dysfunction in systemic lupus erythematosus. Arthritis Rheum 54:2515–2522. doi: 10.1002/art.22030
Article
CAS
PubMed
Google Scholar
Hess DC, Taormina M, Thompson J, Sethi KD, Diamond B, Rao R, Chamberlain CR, Feldman DS (1993) Cognitive and neurologic deficits in the MRL/lpr mouse: a clinicopathologic study. J Rheumatol 20:610–617
CAS
PubMed
Google Scholar
Hickey WF, Lassmann S, Cross AH (1997) Lymphocyte entry and the initiation of inflammation in the central nervous system. In: Keane RW, Hickey WF (eds) Immunology of the Nervous System. New York: Oxford University Press; pp 200–225
Hinson SR, McKeon A, Fryer JP, Apiwattanakul M, Lennon VA, Pittock SJ (2009) Prediction of neuromyelitis optica attack severity by quantitation of complement-mediated injury to aquaporin-4-expressing cells. Arch Neurol 66:1164–1167. doi: 10.1001/archneurol.2009.188
Article
PubMed
Google Scholar
Hirohata S, Hirose S, Miyamoto T (1985) Cerebrospinal fluid IgM, IgA, and IgG indexes in systemic lupus erythematosus. Their use as estimates of central nervous system disease activity. Arch Intern Med 145:1843–1846
Article
CAS
PubMed
Google Scholar
Hirohata S, Sakuma Y, Yanagida T, Yoshio T (2014) Association of cerebrospinal fluid anti-Sm antibodies with acute confusional state in systemic lupus erythematosus. Arthritis Res Ther 16:450. doi: 10.1186/s13075-014-0450-z
Article
PubMed
PubMed Central
CAS
Google Scholar
Hoffman SA, Sakic B (2008) Autoimmunity and Brain Dysfunction. In: Siegel A, Zalcman S (eds) The Neuroimmunological Basis of Behavior and Mental Disorders. New York: Springer-Verlag
Huerta PT, Kowal C, DeGiorgio LA, Volpe BT, Diamond B (2006) Immunity and behavior: antibodies alter emotion. Proc Natl Acad Sci U S A 103:678–683. doi: 10.1073/pnas.0510055103
Article
CAS
PubMed
PubMed Central
Google Scholar
Jarius S, Probst C, Borowski K, Franciotta D, Wildemann B, Stoecker W, Wandinger KP (2010) Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen. J Neurol Sci 291:52–56. doi: 10.1016/j.jns.2010.01.002
Article
CAS
PubMed
Google Scholar
Jarius S, Wildemann B (2010) AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance. Nat Rev Neurol 6:383–392. doi: 10.1038/nrneurol.2010.72
Article
CAS
PubMed
Google Scholar
Jennekens FG, Kater L (2002) The central nervous system in systemic lupus erythematosus. Part 2. Pathogenetic mechanisms of clinical syndromes: a literature investigation. Rheumatology (Oxford) 41:619–630
Article
CAS
Google Scholar
Johansson P, Almqvist EG, Johansson JO, Mattsson N, Andreasson U, Hansson O, Wallin A, Blennow K, Zetterberg H, Svensson J (2013) Cerebrospinal fluid (CSF) 25-hydroxyvitamin D concentration and CSF acetylcholinesterase activity are reduced in patients with Alzheimer’s disease. PLoS One 8:e81989. doi: 10.1371/journal.pone.0081989
Article
PubMed
PubMed Central
CAS
Google Scholar
Kapadia M, Stanojcic M, Earls AM, Pulapaka S, Lee J, Sakic B (2012) Altered olfactory function in the MRL model of CNS lupus. Behav Brain Res 234:303–311. doi: 10.1016/j.bbr.2012.07.005
Article
PubMed
Google Scholar
Kapadia M, Xu J, Sakic B (2016) The water maze paradigm in experimental studies of chronic cognitive disorders: Theory, protocols, analysis, and inference. Neurosci Biobehav Rev 68:195–217. doi: 10.1016/j.neubiorev.2016.05.016
Article
PubMed
Google Scholar
Kapadia M, Zhao H, Ma D, Hatkar R, Marchese M, Sakic B (2014) Zoopharmacognosy in diseased laboratory mice: conflicting evidence. PLoS One 9:e100684. doi: 10.1371/journal.pone.0100684
Article
PubMed
PubMed Central
Google Scholar
Kapadia M, Zhao H, Ma D, Sakic B (2017) Sustained Immunosuppression Alters Olfactory Function in the MRL Model of CNS Lupus. J NeuroImmune Pharmacol 12:555–564. doi: 10.1007/s11481-017-9745-6
Article
PubMed
Google Scholar
Katzav A, Ben-Ziv T, Blank M, Pick CG, Shoenfeld Y, Chapman J (2014) Antibody-specific behavioral effects: intracerebroventricular injection of antiphospholipid antibodies induces hyperactive behavior while anti-ribosomal-P antibodies induces depression and smell deficits in mice. J Neuroimmunol 272:10–15
Article
CAS
PubMed
Google Scholar
Katzav A, Ben-Ziv T, Chapman J, Blank M, Reichlin M, Shoenfeld Y (2008) Anti-P ribosomal antibodies induce defect in smell capability in a model of CNS -SLE (depression). J Autoimmun 31:393–398. doi: 10.1016/j.jaut.2008.09.002
Article
CAS
PubMed
Google Scholar
Katzav A, Solodeev I, Brodsky O, Chapman J, Pick CG, Blank M, Zhang W, Reichlin M, Shoenfeld Y (2007) Induction of autoimmune depression in mice by anti-ribosomal P antibodies via the limbic system. Arthritis Rheum 56:938–948. doi: 10.1002/art.22419
Article
CAS
PubMed
Google Scholar
Kivity S, Tsarfaty G, Agmon-Levin N, Blank M, Manor D, Konen E, Chapman J, Reichlin M, Wasson C, Shoenfeld Y et al (2010) Abnormal olfactory function demonstrated by manganese-enhanced MRI in mice with experimental neuropsychiatric lupus. Ann N Y Acad Sci 1193:70–77. doi: 10.1111/j.1749-6632.2009.05302.x
Article
PubMed
Google Scholar
Konsman JP, Parnet P, Dantzer R (2002) Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci 25:154–159
Article
CAS
PubMed
Google Scholar
Kowal C, Degiorgio LA, Lee JY, Edgar MA, Huerta PT, Volpe BT, Diamond B (2006) Human lupus autoantibodies against NMDA receptors mediate cognitive impairment. Proc Natl Acad Sci U S A 103:19854–19859. doi: 10.1073/pnas.0608397104
Article
CAS
PubMed
PubMed Central
Google Scholar
Kowal C, DeGiorgio LA, Nakaoka T, Hetherington H, Huerta PT, Diamond B, Volpe BT (2004) Cognition and immunity; antibody impairs memory. Immunity 21:179–188. doi: 10.1016/j.immuni.2004.07.011
Article
CAS
PubMed
Google Scholar
Kozora E, West SG, Maier SF, Filley CM, Arciniegas DB, Brown M, Miller D, Grimm A, Zhang L (2010) Antibodies against N-methyl-D-aspartate receptors in patients with systemic lupus erythematosus without major neuropsychiatric syndromes. J Neurol Sci 295:87–91
Article
CAS
PubMed
PubMed Central
Google Scholar
Lapteva L, Nowak M, Yarboro CH, Takada K, Roebuck-Spencer T, Weickert T, Bleiberg J, Rosenstein D, Pao M, Patronas N et al (2006) Anti-N-methyl-D-aspartate receptor antibodies, cognitive dysfunction, and depression in systemic lupus erythematosus. Arthritis Rheum 54:2505–2514. doi: 10.1002/art.22031
Article
CAS
PubMed
Google Scholar
Lauvsnes MB, Omdal R (2012) Systemic lupus erythematosus, the brain, and anti-NR2 antibodies. J Neurol 259:622–629. doi: 10.1007/s00415-011-6232-5
Article
CAS
PubMed
Google Scholar
Lefranc D, Launay D, Dubucquoi S, de Seze J, Dussart P, Vermersch M, Hachulla E, Hatron PY, Vermersch P, Mouthon L et al (2007) Characterization of discriminant human brain antigenic targets in neuropsychiatric systemic lupus erythematosus using an immunoproteomic approach. Arthritis Rheum 56:3420–3432
Article
CAS
PubMed
Google Scholar
Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR (2005) IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 202:473–477. doi: 10.1084/jem.20050304
Article
CAS
PubMed
PubMed Central
Google Scholar
Loheswaran G, Stanojcic M, Xu L, Sakic B (2010) Autoimmunity as a principal pathogenic factor in the refined model of neuropsychiatric lupus. Clin Exp Neuroimmunol 1:141–152
Article
CAS
Google Scholar
Love PE, Santoro SA (1990) Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Prevalence and clinical significance. Ann Intern Med 112:682–698
Article
CAS
PubMed
Google Scholar
Lu XY, Chen XX, Huang LD, Zhu CQ, Gu YY, Ye S (2010) Anti-alpha-internexin autoantibody from neuropsychiatric lupus induce cognitive damage via inhibiting axonal elongation and promote neuron apoptosis. PLoS One 5:e11124. doi: 10.1371/journal.pone.0011124
Article
PubMed
PubMed Central
CAS
Google Scholar
Marchese M, Cowan D, Head E, Ma D, Karimi K, Ashthorpe V, Kapadia M, Zhao H, Davis P, Sakic B (2014) Autoimmune manifestations in the 3xTg-AD model of Alzheimer’s disease. J Alzheimers Dis 39:191–210. doi: 10.3233/JAD-131490
CAS
PubMed
PubMed Central
Google Scholar
Marcinko K, Parsons T, Lerch JP, Sled JG, Sakic B (2013) Effects of prolonged treatment with memantine in the MRL model of CNS lupus. Clin Exp Neuroimmunol 3:116–128
Article
CAS
Google Scholar
Maric D, Millward JM, Ballok DA, Szechtman H, Denburg JA, Barker JL, Sakic B (2001) Neurotoxic properties of cerebrospinal fluid from behaviorally impaired autoimmune mice. Brain Res 920:183–193
Article
CAS
PubMed
Google Scholar
Matus S, Burgos PV, Bravo-Zehnder M, Kraft R, Porras OH, Farias P, Barros LF, Torrealba F, Massardo L, Jacobelli S et al (2007) Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis. J Exp Med 204:3221–3234. doi: 10.1084/jem.20071285
Article
CAS
PubMed
PubMed Central
Google Scholar
McGaugh JL (1989) Involvement of hormonal and neuromodulatory systems in the regulation of memory storage. Annu Rev Neurosci 12:255–287. doi: 10.1146/annurev.ne.12.030189.001351
Article
CAS
PubMed
Google Scholar
McLean BN, Miller D, Thompson EJ (1995) Oligoclonal banding of IgG in CSF, blood-brain barrier function, and MRI findings in patients with sarcoidosis, systemic lupus erythematosus, and Behcet’s disease involving the nervous system. J Neurol Neurosurg Psychiatry 58:548–554
Article
CAS
PubMed
PubMed Central
Google Scholar
Menachem A, Chapman J, Deri Y, Pick CG, Katzav A (2013) Immunoglobulin-mediated neuro-cognitive impairment: new data and a comprehensive review. Clin Rev Allergy Immunol 45:248–255. doi: 10.1007/s12016-013-8357-z
Article
CAS
PubMed
Google Scholar
Menon S, Jameson-Shortall E, Newman SP, Hall-Craggs MR, Chinn R, Isenberg DA (1999) A longitudinal study of anticardiolipin antibody levels and cognitive functioning in systemic lupus erythematosus. Arthritis Rheum 42:735–741. doi: 10.1002/1529-0131(199904)42:4<735::AID-ANR17>3.0.CO;2-L
Article
CAS
PubMed
Google Scholar
Ndhlovu M, Preuss BE, Dengjel J, Stevanovic S, Weiner SM, Klein R (2011) Identification of alpha-tubulin as an autoantigen recognized by sera from patients with neuropsychiatric systemic lupus erythematosus. Brain Behav Immun 25:279–285. doi: 10.1016/j.bbi.2010.09.019
Article
CAS
PubMed
Google Scholar
Omdal R, Brokstad K, Waterloo K, Koldingsnes W, Jonsson R, Mellgren SI (2005) Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors. Eur J Neurol 12:392–398. doi: 10.1111/j.1468-1331.2004.00976.x
Article
CAS
PubMed
Google Scholar
Petri M, Naqibuddin M, Sampedro M, Omdal R, Carson KA (2011) Memantine in systemic lupus erythematosus: a randomized, double-blind placebo-controlled trial. Semin Arthritis Rheum 41:194–202. doi: 10.1016/j.semarthrit.2011.02.005
Article
CAS
PubMed
PubMed Central
Google Scholar
Porsolt RD, Bertin A, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229:327–336
CAS
PubMed
Google Scholar
Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC (2010) Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain 133:349–361. doi: 10.1093/brain/awp309
Article
PubMed
PubMed Central
Google Scholar
Sabater L, Giralt A, Boronat A, Hankiewicz K, Blanco Y, Llufriu S, Alberch J, Graus F, Saiz A (2009) Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: an in vitro study. J Neuroimmunol 215:31–35. doi: 10.1016/j.jneuroim.2009.07.014
Article
CAS
PubMed
Google Scholar
Sakic B, Cooper MP, Taylor SE, Stojanovic M, Zagorac B, Kapadia M (2015) Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST). J Vis Exp. doi: 10.3791/51524
Sakic B, Denburg JA, Denburg SD, Szechtman H (1996) Blunted sensitivity to sucrose in autoimmune MRL-lpr mice: a curve-shift study. Brain Res Bull 41:305–311
Article
CAS
PubMed
Google Scholar
Sakic B, Kirkham DL, Ballok DA, Mwanjewe J, Fearon IM, Macri J, Yu G, Sidor MM, Denburg JA, Szechtman H et al (2005) Proliferating brain cells are a target of neurotoxic CSF in systemic autoimmune disease. J Neuroimmunol 169:68–85. doi: 10.1016/j.jneuroim.2005.08.010
Article
CAS
PubMed
PubMed Central
Google Scholar
Sakic B, Szechtman H, Denburg JA (1997) Neurobehavioral alteration in autoimmune mice. Neurosci Biobehav Rev 21:327–340
Article
CAS
PubMed
Google Scholar
Sakic B, Szechtman H, Denburg S, Carbotte R, Denburg JA (1993) Brain-reactive antibodies and behavior of autoimmune MRL-lpr mice. Physiol Behav 54:1025–1029
Article
CAS
PubMed
Google Scholar
Sakic B, Szechtman H, Denburg S, Carbotte R, Denburg JA (1993) Spatial learning during the course of autoimmune disease in MRL mice. Behav Brain Res 54:57–66
Article
CAS
PubMed
Google Scholar
Sakic B, Szechtman H, Keffer M, Talangbayan H, Stead R, Denburg JA (1992) A behavioral profile of autoimmune lupus-prone MRL mice. Brain Behav Immun 6:265–285
Article
CAS
PubMed
Google Scholar
Sakic B, Szechtman H, Stead RH, Denburg JA (1996) Joint pathology and behavioral performance in autoimmune MRL-lpr Mice. Physiol Behav 60:901–905
Article
CAS
PubMed
Google Scholar
Sakic B, Szechtman H, Talangbayan H, Denburg SD, Carbotte RM, Denburg JA (1994) Disturbed emotionality in autoimmune MRL-lpr mice. Physiol Behav 56:609–617
Article
CAS
PubMed
Google Scholar
Sanna G, Bertolaccini ML, Cuadrado MJ, Laing H, Khamashta MA, Mathieu A, Hughes GR (2003) Neuropsychiatric manifestations in systemic lupus erythematosus: prevalence and association with antiphospholipid antibodies. J Rheumatol 30:985–992
PubMed
Google Scholar
Sanna G, Piga M, Terryberry JW, Peltz MT, Giagheddu S, Satta L, Ahmed A, Cauli A, Montaldo C, Passiu G et al (2000) Central nervous system involvement in systemic lupus erythematosus: cerebral imaging and serological profile in patients with and without overt neuropsychiatric manifestations. Lupus 9:573–583
Article
CAS
PubMed
Google Scholar
Santer DM, Yoshio T, Minota S, Moller T, Elkon KB (2009) Potent induction of IFN-alpha and chemokines by autoantibodies in the cerebrospinal fluid of patients with neuropsychiatric lupus. J Immunol 182:1192–1201
Article
CAS
PubMed
PubMed Central
Google Scholar
Segovia-Miranda F, Serrano F, Dyrda A, Ampuero E, Retamal C, Bravo-Zehnder M, Parodi J, Zamorano P, Valenzuela D, Massardo L et al (2015) Pathogenicity of lupus anti-ribosomal P antibodies: role of cross-reacting neuronal surface P antigen in glutamatergic transmission and plasticity in a mouse model. Arthritis Rheumatol 67:1598–1610. doi: 10.1002/art.39081
Article
CAS
PubMed
Google Scholar
Sibbitt WL Jr, Brooks WM, Kornfeld M, Hart BL, Bankhurst AD, Roldan CA (2010) Magnetic resonance imaging and brain histopathology in neuropsychiatric systemic lupus erythematosus. Semin Arthritis Rheum 40:32–52. doi: 10.1016/j.semarthrit.2009.08.005
Article
PubMed
Google Scholar
Stanley JL, Lincoln RJ, Brown TA, McDonald LM, Dawson GR, Reynolds DS (2005) The mouse beam walking assay offers improved sensitivity over the mouse rotarod in determining motor coordination deficits induced by benzodiazepines. J Psychopharmacol 19:221–227. doi: 10.1177/0269881105051524
Article
CAS
PubMed
Google Scholar
Steiner J, Walter M, Glanz W, Sarnyai Z, Bernstein HG, Vielhaber S, Kastner A, Skalej M, Jordan W, Schiltz K et al (2013) Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis. JAMA Psychiat 70:271–278. doi: 10.1001/2013.jamapsychiatry.86
Article
Google Scholar
Steup-Beekman G, Steens S, van Buchem M, Huizinga T (2007) Anti-NMDA receptor autoantibodies in patients with systemic lupus erythematosus and their first-degree relatives. Lupus 16:329–334
Article
CAS
PubMed
Google Scholar
Stojanovich L, Smiljanich-Miljkovich D, Omdal R, Sakic B (2009) Neuropsychiatric lupus and association with cerebrospinal fluid immunoglobulins: a pilot study. Isr Med Assoc J 11:359–362
PubMed
PubMed Central
Google Scholar
Szechtman H, Sakic B, Denburg JA (1997) Behaviour of MRL mice: an animal model of disturbed behaviour in systemic autoimmune disease. Lupus 6:223–229. doi: 10.1177/096120339700600302
Article
CAS
PubMed
Google Scholar
Takahashi T, Fujihara K, Nakashima I, Misu T, Miyazawa I, Nakamura M, Watanabe S, Shiga Y, Kanaoka C, Fujimori J et al (2007) Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. Brain 130:1235–1243. doi: 10.1093/brain/awm062
Article
PubMed
Google Scholar
Venero JL, Vizuete ML, Ilundain AA, Machado A, Echevarria M, Cano J (1999) Detailed localization of aquaporin-4 messenger RNA in the CNS: preferential expression in periventricular organs. Neuroscience 94:239–250
Article
CAS
PubMed
Google Scholar
Wang GM, Tian XB, Chen JP, Yang SB, Gao F, Yang H, An K, Tian YK (2007) Prevention of neuropathic pain in an animal model of spare nerve injury following oral immunization with recombinant adenovirus serotype 5-mediated NR2B gene transfer. Gene Ther 14:1681–1687. doi: 10.1038/sj.gt.3303025
Article
CAS
PubMed
Google Scholar
Weiner SM, Klein R, Berg PA (2000) A longitudinal study of autoantibodies against central nervous system tissue and gangliosides in connective tissue diseases. Rheumatol Int 19:83–88
Article
CAS
PubMed
Google Scholar
Williams RC Jr, Sugiura K, Tan EM (2004) Antibodies to microtubule-associated protein 2 in patients with neuropsychiatric systemic lupus erythematosus. Arthritis Rheum 50:1239–1247. doi: 10.1002/art.20156
Article
CAS
PubMed
Google Scholar
Winfield JB, Shaw M, Silverman LM, Eisenberg RA, Wilson HA 3rd, Koffler D (1983) Intrathecal IgG synthesis and blood-brain barrier impairment in patients with systemic lupus erythematosus and central nervous system dysfunction. Am J Med 74:837–844
Article
CAS
PubMed
Google Scholar
Yang M, Crawley JN (2009) Simple behavioral assessment of mouse olfaction. Curr Protoc Neurosci Chapter 8:Unit 8 24. doi: 10.1002/0471142301.ns0824s48
PubMed
Google Scholar
Yaniv G, Twig G, Shor DB, Furer A, Sherer Y, Mozes O, Komisar O, Slonimsky E, Klang E, Lotan E et al (2015) A volcanic explosion of autoantibodies in systemic lupus erythematosus: a diversity of 180 different antibodies found in SLE patients. Autoimmun Rev 14:75–79
Article
CAS
PubMed
Google Scholar
Yoshio T, Hirata D, Onda K, Nara H, Minota S (2005) Antiribosomal P protein antibodies in cerebrospinal fluid are associated with neuropsychiatric systemic lupus erythematosus. J Rheumatol 32:34–39
CAS
PubMed
Google Scholar
Yoshio T, Onda K, Nara H, Minota S (2006) Association of IgG anti-NR2 glutamate receptor antibodies in cerebrospinal fluid with neuropsychiatric systemic lupus erythematosus. Arthritis Rheum 54:675–678. doi: 10.1002/art.21547
Article
CAS
PubMed
Google Scholar
Zandman-Goddard G, Chapman J, Shoenfeld Y (2007) Autoantibodies involved in neuropsychiatric SLE and antiphospholipid syndrome. Semin Arthritis Rheum 36:297–315. doi: 10.1016/j.semarthrit.2006.11.003
Article
CAS
PubMed
Google Scholar
Živković I, Rajnpreht I, Minić R, Mitić K, Aleksić I, Kadrić J, Petrušić V (2016) Characterization of Intor: Swiss Albino Mice Adopted in the Institute of Virology, Vaccines and Sera–Torlak, Belgrade in the Early Twentieth Century. Acta Vet Brno 66:279–293
Google Scholar
Zvaifler NJ, Bluestein HG (1982) The pathogenesis of central nervous system manifestations of systemic lupus erythematosus. Arthritis Rheum 25:862–866
Article
CAS
PubMed
Google Scholar