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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Effects of sustained i.c.v. infusion of lupus CSF and autoantibodies on behavioral phenotype and neuronal calcium signaling

Fig. 5

Behavioral effects of anti-NR2A antibody administration. a This treatment resulted in a significant reduction in time spent exploring cinnamon and paprika in the olfactory discrimination task. These results suggest that anti-NMDA receptor binding attenuates responsiveness to previously presented scents. b Spatial learning/memory assessment in MWM revealed similar performance outcomes in cued and hidden versions of the test. However, when the platform was relocated to the opposite quadrant, mice administered anti-NR2A antibodies exhibited significantly shorter path lengths to locate it. c They also swam shorter distances in an empty pool devoid of a platform during probe and extinction trials (n = 12 mice/group). Abbreviations: Cin – Cinnamon; Pap – Paprika; Acq – Acquisition; RevCue – Reversal Cue; RevAcq – Reversal Acquisition; Ext – Extinction

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Acta Neuropathologica Communications

ISSN: 2051-5960

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