Fig. 7

Behavioral effects of sustained anti-α-tubulin antibody administration. a Prolonged infusion of anti-α-tubulin antibodies increased post-surgical home-cage activity, as measured by increased number of running wheel rotations, b more time spent in the running wheel, and c less time spent in the shelter. d In the MWM, mice had similar latencies to locate cued and hidden platforms. However, relocation of the platform in reversal acquisition trials resulted in significantly shorter escape latencies in mice treated with anti-cytoskeletal antibodies. Together with home-cage behavior, these results suggest that sustained administration of anti-α-tubulin antibodies has a stimulatory effect on certain behaviors (n = 12 mice/group). Abbreviations: INBEST – Integrated Behavioral Station; Acq – Acquisition; RevCue – Reversal Cue; RevAcq – Reversal Acquisition