Fig. 6

Behavioral effects of sustained anti-RPLP0 antibody administration. a Administration of anti-RPLP0 antibodies into the brains of healthy mice led to a transient decrease in water consumption that was prominent on the last day of INBEST testing. b These mice also displayed a transient, but significant reduction in preference for 8% sucrose solution, as compared to their baseline performance. c When exposed to the MWM, no group differences were detected in the latency to locate a cued or hidden platform in acquisition and reversal trials. d However, ARPA-treated mice displayed poorer recall when the platform was removed from the pool during the probe trial (n = 12 mice/group). Note: Eight animals had to be excluded from the analysis of the probe and extinction trials due to a technical error with video-tracking software. Abbreviations: INBEST – Integrated Behavioral Station; Acq – Acquisition; RevCue – Reversal Cue; RevAcq – Reversal Acquisition