Fig. 4

Post-surgical effects of CSF infusion on olfactory function, forced swimming and performance in learning/memory tests. a When initially exposed to the olfactory discrimination paradigm during baseline assessment, mice assigned to receive CNS SLE CSF spent significantly more time investigating cinnamon in their first trial but performed comparably to control animals in subsequent exposures. b Following surgery, both groups seemed to habituate to repeated exposures to the cinnamon-scented filter paper. However, CNS SLE CSF-treated mice spent significantly less time investigation paprika-laced filter paper in the final (dishabituation) trial. c When forced to swim in an empty pool for 10 min, the sustained administration of CSF from CNS SLE patients reduced overall swimming distance and d increased floating. e Control animals receiving NMO CSF exhibited a significant post-surgery drop in spontaneous alternation rates in the T-maze that was not noted in animals treated with CNS SLE CSF. f Despite similar path lengths to locate the cued platform on Day 1, control animals swam longer distances to find a submerged platform on subsequent acquisition trials in the Morris water maze. g Even though NMO CSF-treated animals showed relative deficits in acquiring the location of a hidden platform, administration of CNS SLE CSF induced increased perseveration when the platform was re-located and submerged in reversal trials (n = 8 mice/group). Abbreviations: Cin – Cinnamon; Pap – Paprika; Acq – Acquisition; RevCue – Reversal Cue; RevAcq – Reversal Acquisition