Allen IC, Wilson JE, Schneider M et al (2012) NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity 36(5):742–754
Article
CAS
PubMed
PubMed Central
Google Scholar
Arthur JC, Lich JD, Aziz RK, Kotb M, Ting JP-Y (2007) Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase. J Immunol 179(9):6291–6296
Article
CAS
PubMed
Google Scholar
Baillet A, Trocmé C, Berthier S et al (2010) Synovial fluid proteomic fingerprint: S100A8, S100A9 and S100A12 proteins discriminate rheumatoid arthritis from other inflammatory joint diseases. Rheumatology 49(4):671–682
Article
CAS
PubMed
Google Scholar
Berilgen MS, Bulut S, Ustundag B, Tekatas A, Ayar A (2005) Patients with multiple sclerosis have higher levels of serum ghrelin. Neuro Endocrinol Lett 26(6):819–822
CAS
PubMed
Google Scholar
Bielekova B, Kadom N, Fisher E et al (2005) MRI as a marker for disease heterogeneity in multiple sclerosis. Neurology 65(7):1071–1076
Article
CAS
PubMed
Google Scholar
Brucklacher-Waldert V, Stuerner K, Kolster M, Wolthausen J, Tolosa E (2009) Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 132(Pt 12):3329–3341
Article
PubMed
Google Scholar
Burguillos MA, Deierborg T, Kavanagh E et al (2011) Caspase signalling controls microglia activation and neurotoxicity. Nature 472(7343):319–324
Article
CAS
PubMed
Google Scholar
Butovsky O, Jedrychowski MP, Moore CS et al (2014) Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat Neurosci 17(1):131–143
Article
CAS
PubMed
Google Scholar
Calza L, Fernandez M, Giuliani A, Aloe L, Giardino L (2002) Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis. Proc Natl Acad Sci U S A 99(5):3258–3263
Article
CAS
PubMed
PubMed Central
Google Scholar
Carrette F, Surh CD (2012) IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis. Semin Immunol 24(3):209–217
Article
CAS
PubMed
PubMed Central
Google Scholar
Chandler S, Coates R, Gearing A, Lury J, Wells G, Bone E (1995) Matrix metalloproteinases degrade myelin basic protein. Neurosci Lett 201(3):223–226
Article
CAS
PubMed
Google Scholar
Chen W, Jin W, Hardegen N, Lei K-J, Li L, Marinos N, McGrady G, Wahl SM (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198(12):1875–1886
Article
CAS
PubMed
PubMed Central
Google Scholar
Cheng P, Corzo CA, Luetteke N et al (2008) Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 205(10):2235–2249
Article
CAS
PubMed
PubMed Central
Google Scholar
Cid C, Alvarez-Cermeño JC, Camafeita E, Salinas M, Alcázar A (2004) Antibodies reactive to heat shock protein 90 induce oligodendrocyte precursor cell death in culture. Implications for demyelination in multiple sclerosis. FASEB J 18(2):409–411
Article
CAS
PubMed
Google Scholar
Coombes JL, Siddiqui KRR, Arancibia-Cárcamo CV, Hall J, Sun C-M, Belkaid Y, Powrie F (2007) A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204(8):1757–1764
Article
CAS
PubMed
PubMed Central
Google Scholar
de Groot M, Verhaaren BFJ, de Boer R, Klein S, Hofman A, van der Lugt A, Ikram MA, Niessen WJ, Vernooij MW (2013) Changes in normal-appearing white matter precede development of white matter lesions. Stroke 44(4):1037–1042
Article
PubMed
Google Scholar
DeBoy CA, Rus H, Tegla C, Cudrici C, Jones MV, Pardo CA, Small D, Whartenby KA, Calabresi PA (2010) FLT-3 expression and function on microglia in multiple sclerosis. Exp Mol Pathol 89(2):109–116
Article
CAS
PubMed
PubMed Central
Google Scholar
Denning TL, Wang Y-C, Patel SR, Williams IR, Pulendran B (2007) Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8(10):1086–1094
Article
CAS
PubMed
Google Scholar
Elias KM, Laurence A, Davidson TS, Stephens G, Kanno Y, Shevach EM, O'Shea JJ (2008) Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 111(3):1013–1020
Article
CAS
PubMed
PubMed Central
Google Scholar
Elliott C, Lindner M, Arthur A et al (2012) Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain 135(Pt 6):1819–1833
Article
PubMed
PubMed Central
Google Scholar
Foell D, Wittkowski H, Vogl T, Roth J (2007) S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biol 81(1):28–37
Article
CAS
PubMed
Google Scholar
Fujino S, Andoh A, Bamba S, Ogawa A, Hata K, Araki Y, Bamba T, Fujiyama Y (2003) Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52(1):65–70
Article
CAS
PubMed
PubMed Central
Google Scholar
Galon J, Franchimont D, Hiroi N, Frey G, Boettner A, Ehrhart-Bornstein M, O'Shea JJ, Chrousos GP, Bornstein SR (2002) Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J 16(1):61–71
Article
CAS
PubMed
Google Scholar
Gillett A, Thessen Hedreul M, Khademi M, Espinosa A, Beyeen AD, Jagodic M, Kockum I, Harris RA, Olsson T (2010) Interleukin 18 receptor 1 expression distinguishes patients with multiple sclerosis. Mult Scler 16(9):1056–1065
Article
CAS
PubMed
Google Scholar
Gold SM, Raji A, Huitinga I, Wiedemann K, Schulz K-H, Heesen C (2005) Hypothalamo-pituitary-adrenal axis activity predicts disease progression in multiple sclerosis. J Neuroimmunol 165(1–2):186–191
Article
CAS
PubMed
Google Scholar
Grasser A, Möller A, Backmund H, Yassouridis A, Holsboer F (1996) Heterogeneity of hypothalamic-pituitary-adrenal system response to a combined dexamethasone-CRH test in multiple sclerosis. Exp Clin Endocrinol Diabetes 104(1):31–37
Article
CAS
PubMed
Google Scholar
Gray E, Thomas TL, Betmouni S, Scolding N, Love S (2008) Elevated myeloperoxidase activity in white matter in multiple sclerosis. Neurosci Lett 444(2):195–198
Article
CAS
PubMed
Google Scholar
Gregory SG, Schmidt S, Seth P et al (2007) Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 39(9):1083–1091
Article
CAS
PubMed
Google Scholar
Gutcher I, Urich E, Wolter K, Prinz M, Becher B (2006) Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammation. Nat Immunol 7(9):946–953
Article
CAS
PubMed
Google Scholar
Hametner S, Wimmer I, Haider L, Pfeifenbring S, Brück W, Lassmann H (2013) Iron and neurodegeneration in the multiple sclerosis brain. Ann Neurol 74(6):848–861
Article
CAS
PubMed
PubMed Central
Google Scholar
Hanafy KA, Sloane JA (2011) Regulation of remyelination in multiple sclerosis. FEBS Lett 585(23):3821–3828
Article
CAS
PubMed
Google Scholar
Heesen C, Gold SM, Raji A, Wiedemann K, Schulz K-H (2002) Cognitive impairment correlates with hypothalamo-pituitary-adrenal axis dysregulation in multiple sclerosis. Psychoneuroendocrinology 27(4):505–517
Article
CAS
PubMed
Google Scholar
Hendrickx DAE, Koning N, Schuurman KG, van Strien ME, van Eden CG, Hamann J, Huitinga I (2013) Selective upregulation of scavenger receptors in and around demyelinating areas in multiple sclerosis. J Neuropathol Exp Neurol 72(2):106–118
Article
CAS
PubMed
Google Scholar
Hsu K, Passey RJ, Endoh Y, Rahimi F, Youssef P, Yen T, Geczy CL (2005) Regulation of S100A8 by glucocorticoids. J Immunol 174(4):2318–2326
Article
CAS
PubMed
Google Scholar
Huitinga I, Erkut ZA, van Beurden D, Swaab DF (2004) Impaired hypothalamus-pituitary-adrenal axis activity and more severe multiple sclerosis with hypothalamic lesions. Ann Neurol 55(1):37–45
Article
PubMed
Google Scholar
International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, Sawcer S et al (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476(7359):214–219
Article
CAS
Google Scholar
Jéru I, Duquesnoy P, Fernandes-Alnemri T et al (2008) Mutations in NALP12 cause hereditary periodic fever syndromes. Proc Natl Acad Sci U S A 105(5):1614–1619
Article
PubMed
PubMed Central
Google Scholar
Jha S, Srivastava SY, Brickey WJ, Iocca H, Toews A, Morrison JP, Chen VS, Gris D, Matsushima GK, Ting JP-Y (2010) The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18. J Neurosci 30(47):15811–15820
Article
CAS
PubMed
PubMed Central
Google Scholar
Kehlen A, Pachnio A, Thiele K, Langner J (2003) Gene expression induced by interleukin-17 in fibroblast-like synoviocytes of patients with rheumatoid arthritis: upregulation of hyaluronan-binding protein TSG-6. Arthritis Res Ther 5(4):R186–R192
Article
CAS
PubMed
PubMed Central
Google Scholar
Koning N, Bö L, Hoek RM, Huitinga I (2007) Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions. Ann Neurol 62(5):504–514
Article
CAS
PubMed
Google Scholar
Kreft KL, Verbraak E, Wierenga-Wolf AF, van Meurs M, Oostra BA, Laman JD, Hintzen RQ (2012) The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis. J Immunol 188(4):1874–1883
Article
CAS
PubMed
Google Scholar
Kuruto R, Nozawa R, Takeishi K, Arai K, Yokota T, Takasaki Y (1990) Myeloid calcium binding proteins: expression in the differentiated HL-60 cells and detection in sera of patients with connective tissue diseases. J Biochem 108(4):650–653
Article
CAS
PubMed
Google Scholar
La Russa A, Cittadella R, De Marco EV, Valentino P, Andreoli V, Trecroci F, Latorre V, Gambardella A, Quattrone A (2010) Single nucleotide polymorphism in the MMP-9 gene is associated with susceptibility to develop multiple sclerosis in an Italian case-control study. J Neuroimmunol 225(1–2):175–179
Article
CAS
PubMed
Google Scholar
Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9(1):559
Article
CAS
PubMed
PubMed Central
Google Scholar
Lassmann H, Ransohoff RM (2004) The CD4-Th1 model for multiple sclerosis: a critical [correction of crucial] re-appraisal. Trends Immunol 25(3):132–137
Article
CAS
PubMed
Google Scholar
Lawrance IC, Fiocchi C, Chakravarti S (2001) Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Hum Mol Genet 10(5):445–456
Article
CAS
PubMed
Google Scholar
Lawson BR, Gonzalez-Quintial R, Eleftheriadis T, Farrar MA, Miller SD, Sauer K, McGavern DB, Kono DH, Baccala R, Theofilopoulos AN (2015) Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation. Clin Immunol 161(2):260–269
Article
CAS
PubMed
PubMed Central
Google Scholar
Lei X, Cai S, Chen Y, Cui J, Wang Y, Li Z, Li Y (2017) Down-regulation of interleukin 7 receptor (IL-7R) contributes to central nervous system demyelination. Oncotarget 8(17):28395–28407
Article
PubMed
PubMed Central
Google Scholar
Li YJ, Higgins RR, Pak BJ, Shivdasani RA, Ney PA, Archer M, Ben-David Y (2001) p45(NFE2) is a negative regulator of erythroid proliferation which contributes to the progression of friend virus-induced erythroleukemias. Mol Cell Biol 21(1):73–80
Article
CAS
PubMed
PubMed Central
Google Scholar
Lich JD, Williams KL, Moore CB, Arthur JC, Davis BK, Taxman DJ, Ting JP-Y (2007) Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes. J Immunol 178(3):1256–1260
Article
CAS
PubMed
Google Scholar
Lock C, Hermans G, Pedotti R et al (2002) Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 8(5):500–508
Article
CAS
PubMed
Google Scholar
Lou N, Takano T, Pei Y, Xavier AL, Goldman SA, Nedergaard M (2016) Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier. Proc Natl Acad Sci U S A 113(4):1074–1079
Article
CAS
PubMed
PubMed Central
Google Scholar
Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H (2000) Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47(6):707–717
Article
CAS
PubMed
Google Scholar
Luchetti S, Fransen NL, van Eden CG, Ramaglia V, Mason M, Huitinga I (2018) Progressive multiple sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis. Acta Neuropathol 135(4) 511–528.
Ma J, Tanaka KF, Shimizu T, Bernard CCA, Kakita A, Takahashi H, Pfeiffer SE, Ikenaka K (2011) Microglial cystatin F expression is a sensitive indicator for ongoing demyelination with concurrent remyelination. J Neurosci Res 89(5):639–649
Article
CAS
PubMed
Google Scholar
Massacesi L, Abbamondi AL, Giorgi C, Sarlo F, Lolli F, Amaducci L (1987) Suppression of experimental allergic encephalomyelitis by retinoic acid. J Neurol Sci 80(1):55–64
Article
CAS
PubMed
Google Scholar
McGahan MC, Harned J, Mukunnemkeril M, Goralska M, Fleisher L, Ferrell JB (2005) Iron alters glutamate secretion by regulating cytosolic aconitase activity. Am J Phys Cell Physiol 288(5):C1117–C1124
Article
CAS
Google Scholar
Melief J, de Wit SJ, van Eden CG, Teunissen C, Hamann J, Uitdehaag BM, Swaab D, Huitinga I (2013) HPA axis activity in multiple sclerosis correlates with disease severity, lesion type and gene expression in normal-appearing white matter. Acta Neuropathol 126(2):237–249
Article
PubMed
Google Scholar
Melief J, Koning N, Schuurman KG, van de Garde MDB, Smolders J, Hoek RM, van Eijk M, Hamann J, Huitinga I (2012) Phenotyping primary human microglia: tight regulation of LPS responsiveness. Glia 60(10):1506–1517
Article
PubMed
Google Scholar
Melief J, Schuurman KG, van de Garde MDB, Smolders J, van Eijk M, Hamann J, Huitinga I (2013) Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed. Glia 61(11):1848–1861
Article
PubMed
Google Scholar
Miller JA, Horvath S, Geschwind DH (2010) Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proc Natl Acad Sci U S A 107(28):12698–12703
Article
PubMed
PubMed Central
Google Scholar
Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H (2007) Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317(5835):256–260
Article
CAS
PubMed
Google Scholar
Nacken W, Roth J, Sorg C, Kerkhoff C (2003) S100A9/S100A8: myeloid representatives of the S100 protein family as prominent players in innate immunity. Microsc Res Tech 60(6):569–580
Article
CAS
PubMed
Google Scholar
Olesch C, Ringel C, Brüne B, Weigert A (2017) Beyond immune cell migration: the emerging role of the Sphingosine-1-phosphate receptor S1PR4 as a modulator of innate immune cell activation. Mediat Inflamm 2017:1–12
Article
CAS
Google Scholar
Peferoen LAN, Gerritsen WH, Breur M, Ummenthum KMD, Peferoen-Baert RMB, van der Valk P, van Noort JM, Amor S (2015) Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter. Acta Neuropathol Commun 3(1):132
Article
CAS
Google Scholar
Picard D, Yamamoto KR (1987) Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J 6(11):3333–3340
Article
CAS
PubMed
PubMed Central
Google Scholar
Pieragostino D, Del Boccio P, Di Ioia M et al (2013) Oxidative modifications of cerebral transthyretin are associated with multiple sclerosis. Proteomics 13(6):1002–1009
Article
CAS
PubMed
Google Scholar
Pitt D, Werner P, Raine CS (2000) Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med 6(1):67–70
Article
CAS
PubMed
Google Scholar
Pribiag H, Stellwagen D (2014) Neuroimmune regulation of homeostatic synaptic plasticity. Neuropharmacology 78:13–22
Article
CAS
PubMed
Google Scholar
Proost P, Vandamme J, Opdenakker G (1993) Leukocyte gelatinase B cleavage releases Encephalitogens from human myelin basic protein. Biochem Biophys Res Commun 192(3):1175–1181
Article
CAS
PubMed
Google Scholar
Reed KE, Westphale EM, Larson DM, Wang HZ, Veenstra RD, Beyer EC (1993) Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein. J Clin Invest 91(3):997–1004
Article
CAS
PubMed
PubMed Central
Google Scholar
Rice CM, Sun M, Kemp K, Gray E, Wilkins A, Scolding NJ (2012) Mitochondrial sirtuins--a new therapeutic target for repair and protection in multiple sclerosis. Eur J Neurosci 35(12):1887–1893
Article
CAS
PubMed
Google Scholar
Savinko T, Karisola P, Lehtimäki S, Lappeteläinen A-M, Haapakoski R, Wolff H, Lauerma A, Alenius H (2013) ST2 regulates allergic airway inflammation and T-cell polarization in epicutaneously sensitized mice. J Invest Dermatol 133(11):2522–2529
Article
CAS
PubMed
Google Scholar
Schulze T, Golfier S, Tabeling C, Räbel K, Gräler MH, Witzenrath M, Lipp M (2011) Sphingosine-1-phospate receptor 4 (S1P4) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model. FASEB J 25(11):4024–4036
Article
CAS
PubMed
Google Scholar
Schumann EM, Kümpfel T, Then Bergh F, Trenkwalder C, Holsboer F, Auer DP (2002) Activity of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: correlations with gadolinium-enhancing lesions and ventricular volume. Ann Neurol 51(6):763–767
Article
PubMed
Google Scholar
Sipe GO, Lowery RL, Tremblay ME, Kelly EA, Lamantia CE, Majewska AK (2016) Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex. Nat Commun 7:10905
Article
CAS
PubMed
PubMed Central
Google Scholar
Song W-C (2006) Complement regulatory proteins and autoimmunity. Autoimmunity 39(5):403–410
Article
CAS
PubMed
Google Scholar
Sun C-M, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR, Belkaid Y (2007) Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 204(8):1775–1785
Article
CAS
PubMed
PubMed Central
Google Scholar
Theil M-M, Miyake S, Mizuno M et al (2009) Suppression of experimental autoimmune encephalomyelitis by ghrelin. J Immunol 183(4):2859–2866
Article
CAS
PubMed
Google Scholar
Van de Garde MDB, Martinez FO, Melgert BN, Hylkema MN, Jonkers RE, Hamann J (2014) Chronic exposure to fluticasone propionate shapes gene expression and modulates innate and adaptive activation pathways in human macrophages. J Immunol 192(3):1196–1208
Article
CAS
PubMed
Google Scholar
van Eden W, van der Zee R, Prakken B (2005) Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat Rev Immunol 5(4):318–330
Article
CAS
PubMed
Google Scholar
van Horssen J, Singh S, van der Pol S et al (2012) Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation. J Neuroinflammation 9:156
PubMed
PubMed Central
Google Scholar
van Strien ME, de Vries HE, Chrobok NL et al (2015) Tissue transglutaminase contributes to experimental multiple sclerosis pathogenesis and clinical outcome by promoting macrophage migration. Brain Behav Immun 50:141–154
Article
CAS
PubMed
Google Scholar
Weiner HL (2009) The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease? Ann Neurol 65(3):239–248
Article
CAS
PubMed
Google Scholar
Weissbach H, Resnick L, Brot N (2005) Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage. Biochim Biophys Acta 1703(2):203–212
Article
CAS
PubMed
Google Scholar
Williams KL, Lich JD, Duncan JA et al (2005) The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J Biol Chem 280(48):39914–39924
Article
CAS
PubMed
Google Scholar
Wong CW, Christen T, Roth I, Chadjichristos CE, Derouette J-P, Foglia BF, Chanson M, Goodenough DA, Kwak BR (2006) Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nat Med 12(8):950–954
Article
CAS
PubMed
Google Scholar
Xu D, Hopf C, Reddy R, Cho RW, Guo L, Lanahan A, Petralia RS, Wenthold RJ, O'Brien RJ, Worley P (2003) Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity. Neuron 39(3):513–528
Article
CAS
PubMed
Google Scholar
Zeis T, Graumann U, Reynolds R, Schaeren-Wiemers N (2008) Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection. Brain 131(Pt 1):288–303
PubMed
Google Scholar