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Table 1 Overview of included subjects

From: Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis

NBB no.

Sex

Age

PMD

pH

MS/C

Onset

Duration

Time to EDSS6

Type

EDSS

Death cause

96–026

F

69

9:15

6.40

MS

44

25

16

SP

9

respiratory insufficiency

96–074

F

40

7:00

6.74

MS

26

14

11

SP

8–9

dehydration

96–076

F

81

4:15

6.93

MS

32

49

44

SP

6

cachexia

96–121

F

53

7:15

6.54

MS

35

18

8

SP

9

pneumonia

97–006

F

62

6:45

6.49

MS

33

29

22

SP

9

cardiac asthma

97–160

F

40

7:00

6.33

MS

29

11

8

SP

9

aspiration pneumonia with cardiac decompensation

98–009

F

70

6:30

6.30

MS

38

32

n/a

SP

9

cardiac arrest

98–158

F

76

14:15

5.93

MS

23

53

24

SP

9

respiratory insufficiency

99–025

F

64

7:45

6.22

MS

29

35

21

SP

9

pneumonia and dehydration

99–054

F

58

8:10

6.30

MS

38

20

13

SP

9

legal euthanasia

99–073

F

71

8:00

6.80

MS

47

24

30

SP

9

pneumonia

99–086

F

71

10:25

6.35

MS

47

24

22

SP

9

respiratory insufficiency

99–119

F

38

5:15

6.55

MS

28

10

n/a

RR

3

cardiac arrest

00–120

F

69

13:20

6.12

MS

43

26

10

SP

9

probable viral infection

01–018

F

48

8:10

6.55

MS

40

8

7

SP

6.5

legal euthanasia

01–093

F

66

6:20

6.44

MS

23

43

30

SP

9

liver failure due to cancer metastases

01–126

F

80

9:35

6.20

MS

21

59

51

SP

9

acute leukemia

02–053

F

48

5:50

6.64

MS

27

21

14

SP

8

heart failure

95–078

F

74

6:40

6.70

C

–

–

–

–

–

cachexia

96–014

F

54

8:00

6.45

C

–

–

–

–

–

acute renal failure

00–025

F

68

5:45

6.97

C

–

–

–

–

–

legal euthanasia

01–069

F

41

13:30

–

C

–

–

–

–

–

pulmonary artery hemorrhage

97–068

F

61

7:15

7.20

C

–

–

–

–

–

cachexia

97–042

F

65

12:50

6.90

C

–

–

–

–

–

cardiac arrest

97–005

F

69

7:10

9.80

C

–

–

–

–

–

respiratory insufficiency

96–051

F

71

4:50

6.70

C

–

–

–

–

–

cardiac arrest

00–050

F

52

6:30

7.20

C

–

–

–

–

–

metastasized leiomyosarcoma

  1. NBB no. = donor registration number of the Netherlands Brain Bank
  2. Age age at death (years), PMD post-mortem delay (hours:minutes), pH pH of CSF, MS/C MS or control subject, Onset age of disease onset (years), Duration disease duration (years), Time to EDSS6 time to EDSS6 (years), Type clinical subtype of MS, F female, SP secondary progressive MS, RR relapsing-remitting MS, n/a not available