Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis

Table 3 Genes with the strongest connectivity to the modules identified by WGCNA

	Lightgreen module				Pink module					Tan module			Yellow module
	Gene	Corr	P		Gene	Corr	P		Gene	Corr	P		Gene	Corr	P
1	ASPM	0.97	4.2E-15	1	CHORDC1	0.96	2.7E-14	1	MAGED1	0.92	4.8E-11	1	PPP2R3A	0.96	5.7E-14
2	CST7	0.95	1.7E-13	2	CACYBP	0.95	2.9E-13	2	SARS2	0.90	6.5E-10	2	CNP	0.95	1.8E-13
3	DEFA4	0.95	1.1E-12	3	DNAJA4	0.94	1.4E-12	3	PRMT7	0.90	1.2E-09	3	VPS4B	0.95	4.0E-13
4	VSTM1	0.94	1.2E-12	4	HSPH1	0.94	1.6E-12	4	NAT6	0.88	6.4E-09	4	TMEM209	0.95	5.0E-13
5	BPI	0.94	4.2E-12	5	HSPA4L	0.94	1.9E-12	5	NFU1	0.87	1.1E-08	5	ITCH	0.94	1.8E-12
6	DLGAP5	0.93	1.2E-11	6	DNAJB4	0.94	2.1E-12	6	COG1	0.87	1.2E-08	6	ENDOD1	0.94	2.0E-12
7	S100P	0.93	1.6E-11	7	P4HA2	0.94	3.2E-12	7	THNSL1	0.87	1.5E-08	7	PCBP4	0.94	3.1E-12
8	WISP3	0.93	1.7E-11	8	HSPD1	0.93	8.1E-12	8	RTF1	0.87	2.1E-08	8	ATPGD1	0.94	5.6E-12
9	NLRP12	0.93	2.1E-11	9	HSPE1	0.93	9.5E-12	9	STOML1	0.87	2.2E-08	9	CUEDC1	0.94	6.1E-12
10	RGL4	0.93	3.0E-11	10	ACRC	0.93	1.1E-11	10	NIT2	0.87	2.3E-08	10	CA14	0.94	6.2E-12

Corr correlation to the principal component of the module, which represents the connectivity of each gene to the module; P = p-value

ISSN: 2051-5960