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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis

Fig. 2

Module trait relationships. Overview of the modules generated by the WCGNA and their relationship with parameters for HPA-axis activity and disease severity. On the left are the names of the modules, the digits between square brackets indicating the number of genes present. The scale on the right indicates the actual values belonging to the coefficients of correlations between the module eigengenes and the studied traits. Underlined are the modules with strongest positive (lightgreen and pink) and negative (tan and yellow) correlations to one or more traits, which were therefore further analyzed and described in the text. Note the positive correlation of the lightgreen module with CSF cortisol levels, disease duration and time to EDSS6. ME = module eigengene; Cortisol = cortisol level in cerebrospinal fluid; CRH = number of neurons expressing corticotropin-releasing hormone; Duration = disease duration; EDSS6 = time to EDSS6

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Acta Neuropathologica Communications

ISSN: 2051-5960

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