Patients – Controls | ||
 | GO class | Genes present |
Up | Positive regulation of apoptosis (GO:0043065) | SIVA1, HTATIP2, ZAK, PML, TNFSF14, RPS27L, TLR4, ITSN1, CTNNBL1, RPS3, CASP3, HTRA2, CD44, CDKN2C, RPS3A, SOS1, MTCH1, TGM2, AATF, RUNX3, RPS27A, DEDD2, CEBPG, FADD, BAD, SOD1, TXNDC12, EI24, RNF7, NAIF1, HSPD1 |
Activation of caspase activity (GO:0006919) | SIVA1, MTCH1, PML, HSPE1, HSPD1, RPS3 | |
Regulation of T cell activation (GO:0050863) | CD47, CASP3, IL6ST, NCK1, TGFBR2, TNFSF14, BAD, HSPD1, SOD1 | |
Cytokine binding (GO:0019955) | TNFRSF1A, ACVRL1, IL10RB, IL6ST, LEPR, TGFBR2, ENG, IFNAR1, ACVR1 | |
Down | Neuron differentiation (GO:003082) | EGR2, GNAO1, ATL1, TBCE, NTNG2, DSCAML1, APP, RASGRF1, GHRL, MAPK8IP3, SEMA3B, NTM, C17ORF28 |
Cell projection (GO:0042995) | RTN4, MYO5A, BBS5, KIAA1598, SSH1, ATL1, NEDD9, GIPC1, DNAH2, CPEB1, APP, CTTN, DNAI1, ARHGEF4, DBNL, ARHGEF7, FSCN1, LDB3, DNAI2, PCM1, CAMK2N1, RASGRF1, IFT172, MAPK8IP3, GHRL, SPEF1 | |
Regulation of lipid metabolic process (GO:0019216) | TNF, DHCR7, SF1, ACACB, PPARGC1A | |
MS High Cortisol – Low Cortisol | ||
 | GO class | Genes present |
Up | Immune response (GO:0006955) | LAIR1, CEBPB, IL1RL1, IFITM2, TLR2, TNFSF14, CALCOCO2, SLC11A1, C1QB, UNC13D, APOL1, XBP1, LILRB3, IL4R, BCL3, HSPD1, VSIG4 |
Regulation of cytokine production (GO:0001817) | INHBA, SLC11A1, CEBPB, TLR2, BCL3, NFKB1, BCL6, HSPD1, VSIG4, SRGN | |
Myeloid cell differentiation (GO:0030099) | INHBA, RPS19, JMJD6, RPS14, BCL6, ZBTB16, RUNX1, CBFB, TIMP1 | |
Negative regulation of myeloid cell differentiation (GO:0045638) | INHBA, NFKBIA, ZBTB16, RUNX1 | |
Down | Apoptosis (GO:0006915) | RTN4, CKAP2, POLR2G, DNM1L, TM2D1, EGLN3, RRAGA, PIGT, BAG1, NGFRAP1, EIF2AK2, MAGEH1, NDUFS1, PUF60, ZIM2 |
Negative regulation of neurogenesis (GO:0050768) | RTN4, NOG, NF1, OMG | |
MS Mild Disease – Severe Disease | ||
 | GO class | Genes present |
Up | Neuron projection development (GO:0031175) | APP, GNAO1, EGR2, ATL1, RASGRF1, TBCE, MAPK8IP3, NTNG2, DSCAML1, GHRL, SEMA3B |
Neuron differentiation (GO:0030182) | EGR2, GNAO1, ATL1, TBCE, NTNG2, DSCAML1, APP, RASGRF1, GHRL, MAPK8IP3, SEMA3B, NTM, C17ORF28 | |
Inflammatory response (GO:0006954) | HDAC5, YWHAZ, TNF, NDST1, TOLLIP, CCL3L3, ITIH4, CCL4L1, CCL4 | |
Down | Lysosome (GO:0005764) | HGSNAT, SGSH, NAGLU, MFSD8, LIPA, GM2A, PPT1, CD63, ASAH1 |
Steroid metabolic process (GO:0008202) | HSD17B11, MBTPS2, LIPA, CYB5R2, INSIG2, PRKAA1, CLN6 |