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  1. Leber’s hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressive retinal ganglion cell dysfunction usually in the absence of extra-ophthalmic symptoms. Ther...

    Authors: Amin Otmani, Gauti Jóhannesson, Rune Brautaset, James R. Tribble and Pete A. Williams
    Citation: Acta Neuropathologica Communications 2024 12:37
  2. Tauopathies are neurodegenerative diseases that typically require postmortem examination for a definitive diagnosis. Detecting neurotoxic tau fragments in cerebrospinal fluid (CSF) and serum provides an opport...

    Authors: Liara Rizzi and Lea T. Grinberg
    Citation: Acta Neuropathologica Communications 2024 12:36
  3. Immunotherapies with antibody–drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better...

    Authors: Kelin Gonçalves de Oliveira, Anna Bång-Rudenstam, Sarah Beyer, Axel Boukredine, Hugo Talbot, Valeria Governa, Maria C. Johansson, Ann-Sofie Månsson, Karin Forsberg-Nilsson, Johan Bengzon, Johan Malmström, Charlotte Welinder and Mattias Belting
    Citation: Acta Neuropathologica Communications 2024 12:35
  4. Accumulating evidence highlights the involvement of astrocytes in Alzheimer’s disease (AD) progression. We have previously demonstrated that human iPSC-derived astrocytes ingest and modify synthetic tau fibril...

    Authors: Khalid Eltom, Tobias Mothes, Sylwia Libard, Martin Ingelsson and Anna Erlandsson
    Citation: Acta Neuropathologica Communications 2024 12:34
  5. Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are clinically linked major neurodegenerative diseases. Notably, TAR DNA-binding protein-43 (TDP43) accumulations are hallmark pathologies ...

    Authors: Andrea Markovinovic, Sandra M. Martín-Guerrero, Gábor M. Mórotz, Shaakir Salam, Patricia Gomez-Suaga, Sebastien Paillusson, Jenny Greig, Younbok Lee, Jacqueline C. Mitchell, Wendy Noble and Christopher C.J. Miller
    Citation: Acta Neuropathologica Communications 2024 12:32
  6. Pick’s disease (PiD) is a subtype of the tauopathy form of frontotemporal lobar degeneration (FTLD-tau) characterized by intraneuronal 3R-tau inclusions. PiD can underly various dementia syndromes, including p...

    Authors: Allegra Kawles, Rachel Keszycki, Grace Minogue, Antonia Zouridakis, Ivan Ayala, Nathan Gill, Alyssa Macomber, Vivienne Lubbat, Christina Coventry, Emily Rogalski, Sandra Weintraub, Qinwen Mao, Margaret E. Flanagan, Hui Zhang, Rudolph Castellani, Eileen H. Bigio…
    Citation: Acta Neuropathologica Communications 2024 12:31
  7. Neurovascular unit mural cells called ‘pericytes’ maintain the blood-brain barrier and local cerebral blood flow. Pathological changes in the hippocampus predispose to cognitive impairment and dementia. The ro...

    Authors: Yoshiki Hase, Dan Jobson, Jeremy Cheong, Kelvin Gotama, Luciana Maffei, Mai Hase, Alhafidz Hamdan, Ren Ding, Tuomo Polivkoski, Karen Horsburgh and Raj N. Kalaria
    Citation: Acta Neuropathologica Communications 2024 12:29
  8. Dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD), and Parkinson’s disease (PD) collectively known as Lewy body diseases (LBDs) are neuropathologically characterised by α-synuclein deposits (...

    Authors: Lauren Walker, Harry Simpson, Alan J. Thomas and Johannes Attems
    Citation: Acta Neuropathologica Communications 2024 12:28
  9. Authors: Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian‑Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez‑Pinilla and Zhen Zhao
    Citation: Acta Neuropathologica Communications 2024 12:27

    The original article was published in Acta Neuropathologica Communications 2021 9:74

  10. Authors: Sonia George, Annica Rönnbäck, Gunnar K. Gouras, Géraldine H. Petit, Fiona Grueninger, Bengt Winblad, Caroline Graff and Patrik Brundin
    Citation: Acta Neuropathologica Communications 2024 12:26

    The original article was published in Acta Neuropathologica Communications 2014 2:17

  11. Alzheimer’s disease (AD), characterized by the deposition of amyloid-β (Aβ) in senile plaques and neurofibrillary tangles of phosphorylated tau (pTau), is increasingly recognized as a complex disease with mult...

    Authors: Ana-Caroline Raulin, Sydney V. Doss, Michael G. Heckman, Emily C. Craver, Zonghua Li, Tadafumi C. Ikezu, Hiroaki Sekiya, Chia-Chen Liu, Yuka A. Martens, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Michael DeTure, R. Ross Reichard, Aivi T. Nguyen, Eleni Constantopoulos, Rachel A. Larsen…
    Citation: Acta Neuropathologica Communications 2024 12:25
  12. Myelin sheath abnormality is the cause of various neurodegenerative diseases (NDDs). G-proteins and their coupled receptors (GPCRs) play the important roles in myelination. Gnao1, encoding the major Gα protein...

    Authors: Jinghui Xu, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Wenfeng Su, Gang Chen, Hualin Sun, Changlai Zhu and Yun Gu
    Citation: Acta Neuropathologica Communications 2024 12:24
  13. Glaucoma is one of the leading causes of irreversible blindness worldwide and vision loss in the disease results from the deterioration of retinal ganglion cells (RGC) and their axons. Metabolic dysfunction of...

    Authors: Huilan Zeng, Jordan E. Mayberry, David Wadkins, Nathan Chen, Daniel W. Summers and Markus H. Kuehn
    Citation: Acta Neuropathologica Communications 2024 12:23
  14. Deposition of amyloid beta (Aβ) into plaques is a major hallmark of Alzheimer’s disease (AD). Different amyloid precursor protein (APP) mutations cause early-onset AD by altering the production or aggregation pro...

    Authors: María Pagnon de la Vega, Stina Syvänen, Vilmantas Giedraitis, Monique Hooley, Evangelos Konstantinidis, Silvio R. Meier, Johanna Rokka, Jonas Eriksson, Ximena Aguilar, Tara L. Spires-Jones, Lars Lannfelt, Lars N. G. Nilsson, Anna Erlandsson, Greta Hultqvist, Martin Ingelsson and Dag Sehlin
    Citation: Acta Neuropathologica Communications 2024 12:22
  15. The abnormal aggregation of TDP-43 into cytoplasmic inclusions in affected neurons is a major pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although TDP-43 is ...

    Authors: Tetsuhiro Ueda, Toshihide Takeuchi, Nobuhiro Fujikake, Mari Suzuki, Eiko N. Minakawa, Morio Ueyama, Yuzo Fujino, Nobuyuki Kimura, Seiichi Nagano, Akio Yokoseki, Osamu Onodera, Hideki Mochizuki, Toshiki Mizuno, Keiji Wada and Yoshitaka Nagai
    Citation: Acta Neuropathologica Communications 2024 12:20
  16. Tissue injury and tumorigenesis share many cellular and molecular features, including immune cell (T cells, monocytes) infiltration and inflammatory factor (cytokines, chemokines) elaboration. Their common pat...

    Authors: Jit Chatterjee, Joshua P. Koleske, Astoria Chao, Andrew D. Sauerbeck, Ji-Kang Chen, Xuanhe Qi, Megan Ouyang, Lucy G. Boggs, Rujuta Idate, Lara Isabel Marco Y Marquez, Terrence T. Kummer and David H. Gutmann
    Citation: Acta Neuropathologica Communications 2024 12:21
  17. Excitotoxicity from the impairment of glutamate uptake constitutes an important mechanism in neurodegenerative diseases such as Alzheimer’s, multiple sclerosis, and Parkinson's disease. Within the eye, excitot...

    Authors: Da Ma, Wenyu Deng, Zain Khera, Thajunnisa A. Sajitha, Xinlei Wang, Gadi Wollstein, Joel S. Schuman, Sieun Lee, Haolun Shi, Myeong Jin Ju, Joanne Matsubara, Mirza Faisal Beg, Marinko Sarunic, Rebecca M. Sappington and Kevin C. Chan
    Citation: Acta Neuropathologica Communications 2024 12:19
  18. In men, reduced levels of testosterone are associated with the prevalence and progression of multiple sclerosis (MS), a chronic and disabling demyelinating disorder. Testosterone has been shown to promote myel...

    Authors: Narimène Asbelaoui, Charly Abi-Ghanem, Géraldine Schlecht-Louf, Hania Oukil, Michael Schumacher and Abdel Mouman Ghoumari
    Citation: Acta Neuropathologica Communications 2024 12:18
  19. Intracranial mesenchymal tumor (IMT), FET::CREB fusion-positive is a provisional tumor type in the 2021 WHO classification of central nervous system tumors with limited information available. Herein, we describe ...

    Authors: Frank M. Mezzacappa, Frankie K. Smith, Weiwei Zhang, Andrew Gard, Fatmagul Kusku Cabuk, Ignancio Gonzalez-Gomez, Hector L. Monforte, Jiancong Liang, Omkar Singh, Martha M. Quezado, Kenneth D. Aldape, Murat Gokden, Julia A. Bridge and Jie Chen
    Citation: Acta Neuropathologica Communications 2024 12:17
  20. The human hypothalamus modulates mental health by balancing interactions between hormonal fluctuations and stress responses. Stress-induced progesterone release activates progesterone receptors (PR) in the hum...

    Authors: Lin Zhang, Ronald W.H. Verwer, Joop van Heerikhuize, Paul J. Lucassen, Peter W. Nathanielsz, Elly M. Hol, Eleonora Aronica, Waljit S. Dhillo, Gerben Meynen and Dick F. Swaab
    Citation: Acta Neuropathologica Communications 2024 12:16
  21. Brain metastases occur in 1% of sarcoma cases and are associated with a median overall survival of 6 months. We report a rare case of a brain metastasis with unique radiologic and histopathologic features in a...

    Authors: David Rogawski, Joshua Wheeler, Esther Nie, William Zhu, Eleanor Villanueva, Gwen Coffey, Qian Ma, Kristen Ganjoo, Nancy Fischbein, Michael Iv, Hannes Vogel and Seema Nagpal
    Citation: Acta Neuropathologica Communications 2024 12:15
  22. Neurocutaneous melanosis (NCM) is a rare congenital neurocutaneous syndrome characterized by congenital melanocytic nevus of skin and abnormal proliferation of leptomeningeal melanocytes. Early acquisition of ...

    Authors: Haruhiko Takahashi, Manabu Natsumeda, Norikazu Hara, Akihide Koyama, Hiroshi Shimizu, Akinori Miyashita, Daiken Satake, Yoshihiro Mouri, Jun Tsukano, Keita Kawabe, Yoshihiro Tsukamoto, Masayasu Okada, Ryosuke Ogura, Akihiko Yuki, Hajime Umezu, Akiyoshi Kakita…
    Citation: Acta Neuropathologica Communications 2024 12:14
  23. Cerebrospinal fluid (CSF) analysis is underutilized in patients with glioblastoma (GBM), partly due to a lack of studies demonstrating the clinical utility of CSF biomarkers. While some studies show the utilit...

    Authors: Daniel H. Wang, Yoko Fujita, Antonio Dono, Ana G. Rodriguez Armendariz, Mauli Shah, Nagireddy Putluri, Pavel S. Pichardo-Rojas, Chirag B. Patel, Jay-Jiguang Zhu, Jason T. Huse, Brittany C. Parker Kerrigan, Frederick F. Lang, Yoshua Esquenazi and Leomar Y. Ballester
    Citation: Acta Neuropathologica Communications 2024 12:13
  24. Erythroblastic sarcoma (ES) (previously called chloroma or granulocytic sarcoma) are rare hematological neoplams characterized by the proliferation of myeloid blasts at extramedullary sites, and primarily invo...

    Authors: Arnault Tauziède-Espariat, Lucille Lew-Derivry, Samuel Abbou, Alice Métais, Gaëlle Pierron, Stéphanie Reynaud, Julien Masliah-Planchon, Cassandra Mariet, Lauren Hasty, Volodia Dangouloff-Ros, Nathalie Boddaert, Marie Csanyi, Aude Aline-Fardin, Claire Lamaison, Fabrice Chrétien, Kévin Beccaria…
    Citation: Acta Neuropathologica Communications 2024 12:12
  25. Multiple system atrophy (MSA) is a rare and fatal synucleinopathy characterized by insoluble alpha-synuclein (α-syn) cytoplasmic inclusions located within oligodendroglia. Neuroinflammation, demyelination, and...

    Authors: Nicole J. Corbin-Stein, Gabrielle M. Childers, Jhodi M. Webster, Asta Zane, Ya-Ting Yang, Nikhita Mudium, Rajesh Gupta, Fredric P. Manfredsson, Jeffrey H. Kordower and Ashley S. Harms
    Citation: Acta Neuropathologica Communications 2024 12:11
  26. Mesencephalic astrocyte-derived neurotrophic factor (MANF) has cytoprotective effects on various injuries, including cerebral ischemia, and it can promote recovery even when delivered intracranially several da...

    Authors: Jenni E. Anttila, Olli S. Mattila, Hock-Kean Liew, Kert Mätlik, Eero Mervaala, Päivi Lindholm, Maria Lindahl, Perttu J. Lindsberg, Kuan-Yin Tseng and Mikko Airavaara
    Citation: Acta Neuropathologica Communications 2024 12:10
  27. DNA methylation analysis has become a powerful tool in neuropathology. Although DNA methylation-based classification usually shows high accuracy, certain samples cannot be classified and remain clinically chal...

    Authors: Richard Drexler, Florian Brembach, Jennifer Sauvigny, Franz L. Ricklefs, Alicia Eckhardt, Helena Bode, Jens Gempt, Katrin Lamszus, Manfred Westphal, Ulrich Schüller and Malte Mohme
    Citation: Acta Neuropathologica Communications 2024 12:9
  28. The fifth edition of the World Health Organization (WHO) classification of central nervous system (CNS) tumors introduced the new tumor type CNS tumor with BCOR internal tandem duplication (ITD), characterized by...

    Authors: Valeria Barresi, Antonello Cardoni, Evelina Miele, Lucia Pedace, Barbara Masotto, Claudia Nardini, Sabina Barresi and Sabrina Rossi
    Citation: Acta Neuropathologica Communications 2024 12:8
  29. Mitosis is a critical criterion for meningioma grading. However, pathologists’ assessment of mitoses is subject to significant inter-observer variation due to challenges in locating mitosis hotspots and accura...

    Authors: Hongyan Gu, Chunxu Yang, Issa Al-kharouf, Shino Magaki, Nelli Lakis, Christopher Kazu Williams, Sallam Mohammad Alrosan, Ellie Kate Onstott, Wenzhong Yan, Negar Khanlou, Inma Cobos, Xinhai Robert Zhang, Neda Zarrin-Khameh, Harry V. Vinters, Xiang Anthony Chen and Mohammad Haeri
    Citation: Acta Neuropathologica Communications 2024 12:7
  30. Cerebral amyloid angiopathy (CAA) is a form of small vessel disease characterised by the progressive deposition of amyloid β protein in the cerebral vasculature, inducing symptoms including cognitive impairmen...

    Authors: Marc Vervuurt, Joseph M. Schrader, Anna M. de Kort, Iris Kersten, Hans J. C. T. Wessels, Catharina J. M. Klijn, Floris H. B. M. Schreuder, H. Bea Kuiperij, Jolein Gloerich, William E. Van Nostrand and Marcel M. Verbeek
    Citation: Acta Neuropathologica Communications 2024 12:6
  31. Parthanatos represents a critical molecular aspect of Parkinson's disease, wherein AIMP2 aberrantly activates PARP-1 through direct physical interaction. Although AIMP2 ought to be a therapeutic target for the...

    Authors: Min Hak Lee, Ki-Hwan Um, Seok Won Lee, Ye Ji Sun, Da-Hye Gu, Young Ok Jo, Sung Hyun Kim, Wongi Seol, Hyorin Hwang, Kyunghwa Baek and Jin Woo Choi
    Citation: Acta Neuropathologica Communications 2024 12:5
  32. Regional differences in synaptic degeneration may underlie differences in clinical presentation and neuropathological disease progression in Parkinson’s Disease (PD) and Dementia with Lewy bodies (DLB). Here, ...

    Authors: Irene Frigerio, Maud M. A. Bouwman, Ruby T. G. M. M. Noordermeer, Ema Podobnik, Marko Popovic, Evelien Timmermans, Annemieke J. M. Rozemuller, Wilma D. J. van de Berg and Laura E. Jonkman
    Citation: Acta Neuropathologica Communications 2024 12:4
  33. Alzheimer’s Disease (AD) is a disorder characterized by cognitive decline, neurodegeneration, and accumulation of amyloid plaques and tau neurofibrillary tangles in the brain. Dysregulation of epigenetic histo...

    Authors: Daniel C. Xu, Hanna Sas-Nowosielska, Greg Donahue, Hua Huang, Naemeh Pourshafie, Charly R. Good and Shelley L. Berger
    Citation: Acta Neuropathologica Communications 2024 12:3
  34. Authors: Huihui Luo, Emil K. Gustavsson, Hannah Macpherson, Natalia Dominik, Kristina Zhelcheska, Kylie Montgomery, Claire Anderson, Wai Yan Yau, Stephanie Efthymiou, Chris Turner, Michael DeTure, Dennis W. Dickson, Keith A. Josephs, Tamas Revesz, Tammaryn Lashley, Glenda Halliday…
    Citation: Acta Neuropathologica Communications 2024 12:2
  35. The growing recognition of a dichotomous role of astrocytes in neurodegenerative processes has heightened the need for unraveling distinct astrocytic subtypes in neurological disorders. In multiple system atro...

    Authors: Y. Schneider, C. Gauer, M. Andert, A. Hoffmann, M. J. Riemenschneider, W. Krebs, N. Chalmers, C. Lötzsch, U. J. Naumann, W. Xiang, V. Rothhammer, R. Beckervordersandforth, J. C. M. Schlachetzki and J. Winkler
    Citation: Acta Neuropathologica Communications 2024 12:1
  36. Amyotrophic lateral sclerosis (ALS) displays considerable clinical and genetic heterogeneity. Machine learning approaches have previously been utilised for patient stratification in ALS as they can disentangle...

    Authors: Heather Marriott, Renata Kabiljo, Guy P Hunt, Ahmad Al Khleifat, Ashley Jones, Claire Troakes, Abigail L Pfaff, John P Quinn, Sulev Koks, Richard J Dobson, Patrick Schwab, Ammar Al-Chalabi and Alfredo Iacoangeli
    Citation: Acta Neuropathologica Communications 2023 11:208
  37. Authors: Hideki Hayashi, Rie Saito, Hidetomo Tanaka, Norikazu Hara, Shin Koide, Yosuke Yonemochi, Tetsuo Ozawa, Mariko Hokari, Yasuko Toyoshima, Akinori Miyashita, Osamu Onodera, Kouichirou Okamoto, Takeshi Ikeuchi, Takashi Nakajima and Akiyoshi Kakita
    Citation: Acta Neuropathologica Communications 2023 11:207
  38. Traumatic brain injury (TBI), particularly when moderate-to-severe and repetitive, is a strong environmental risk factor for several progressive neurodegenerative disorders. Mislocalization and deposition of t...

    Authors: Elif O. Dogan, James Bouley, Jianjun Zhong, Ashley L. Harkins, Allison M. Keeler, Daryl A. Bosco, Robert H. Brown Jr. and Nils Henninger
    Citation: Acta Neuropathologica Communications 2023 11:206
  39. Apolipoprotein E ε4 allele (APOE-ε4) is the main genetic risk factor for late-onset Alzheimer’s disease (AD) and may impact cognitive function also via other neuropathological lesions. However, there is limite...

    Authors: Regina Silva Paradela, Alberto Fernando Oliveira Justo, Vítor Ribeiro Paes, Renata E. P. Leite, Carlos A. Pasqualucci, Lea T. Grinberg, Michel Satya Naslavsky, Mayana Zatz, Ricardo Nitrini, Wilson Jacob-Filho and Claudia Kimie Suemoto
    Citation: Acta Neuropathologica Communications 2023 11:205
  40. Vascular risk factors such as chronic hypertension are well-established major modifiable factors for the development of cerebral small vessel disease (cSVD). In the present study, our focus was the investigati...

    Authors: Lorena Morton, Philipp Arndt, Alejandra P. Garza, Solveig Henneicke, Hendrik Mattern, Marilyn Gonzalez, Alexander Dityatev, Deniz Yilmazer-Hanke, Stefanie Schreiber and Ildiko R. Dunay
    Citation: Acta Neuropathologica Communications 2023 11:204
  41. The prognosis of childhood medulloblastoma (MB) is often poor, and it usually requires aggressive therapy that adversely affects quality of life. microRNA-211 (miR-211) was previously identified as an importan...

    Authors: Menglang Yuan, Iqbal Mahmud, Keisuke Katsushima, Kandarp Joshi, Olivier Saulnier, Rudramani Pokhrel, Bongyong Lee, Wathsala Liyanage, Haritha Kunhiraman, Stacie Stapleton, Ignacio Gonzalez-Gomez, Rangaramanujam M. Kannan, Tanja Eisemann, Elayaraja Kolanthai, Sudipta Seal, Timothy J. Garrett…
    Citation: Acta Neuropathologica Communications 2023 11:203
  42. Machine learning (ML) has increasingly been used to assist and expand current practices in neuropathology. However, generating large imaging datasets with quality labels is challenging in fields which demand h...

    Authors: Juan C. Vizcarra, Thomas M. Pearce, Brittany N. Dugger, Michael J. Keiser, Marla Gearing, John F. Crary, Evan J. Kiely, Meaghan Morris, Bartholomew White, Jonathan D. Glass, Kurt Farrell and David A. Gutman
    Citation: Acta Neuropathologica Communications 2023 11:202
  43. Autosomal dominant pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). The most common mutation, G2019S-LRRK2, increases the kinase activity of LRRK2 causing hyper-phos...

    Authors: Vijay Singh, Marissa A. Menard, Geidy E. Serrano, Thomas G. Beach, Hien T. Zhao, Alexis Riley-DiPaolo, Nitya Subrahmanian, Matthew J. LaVoie and Laura A. Volpicelli-Daley
    Citation: Acta Neuropathologica Communications 2023 11:201
  44. TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma/Translocated in Sarcoma (FUS) are ribonucleoproteins associated with pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degene...

    Authors: Beibei Zhao, Catherine M. Cowan, Juliane A. Coutts, Darren D. Christy, Ananya Saraph, Shawn C. C. Hsueh, Stephen S. Plotkin, Ian R. Mackenzie, Johanne M. Kaplan and Neil R. Cashman
    Citation: Acta Neuropathologica Communications 2023 11:200
  45. The hypomethylation of fused in sarcoma (FUS) in frontotemporal lobar degeneration promotes the formation of irreversible condensates of FUS. However, the mechanisms by which these hypomethylated FUS condensat...

    Authors: Seung Chan Kim, Scott J. Mitchell, Seema Qamar, Daniel J. Whitcomb, Marc-David Ruepp, Peter St George-Hyslop and Kwangwook Cho
    Citation: Acta Neuropathologica Communications 2023 11:199
  46. Meningiomas are the most common intracranial brain tumours. These tumours are heterogeneous and encompass a wide spectrum of clinical aggressivity. Treatment options are limited to surgery and radiotherapy and...

    Authors: Laurien L. van de Weijer, Emanuela Ercolano, Ting Zhang, Maryam Shah, Matthew C. Banton, Juri Na, Claire L. Adams, David Hilton, Kathreena M. Kurian and C. Oliver Hanemann
    Citation: Acta Neuropathologica Communications 2023 11:198
  47. In sporadic Alzheimer’s disease (sAD) specific regions, layers and neurons accumulate hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even in advanced disease. ApoER2-Dab1 si...

    Authors: Christopher E. Ramsden, Daisy Zamora, Mark S. Horowitz, Jahandar Jahanipour, Elizabeth Calzada, Xiufeng Li, Gregory S. Keyes, Helen C. Murray, Maurice A. Curtis, Richard M. Faull, Andrea Sedlock and Dragan Maric
    Citation: Acta Neuropathologica Communications 2023 11:197
  48. Tau (Tubulin associated unit) protein is a major hallmark of Alzheimer’s disease (AD) and tauopathies. Tau is predominantly an axonal protein with a crucial role in the stabilization and dynamics of the microt...

    Authors: Neelam Younas, Tayyaba Saleem, Abrar Younas and Inga Zerr
    Citation: Acta Neuropathologica Communications 2023 11:196

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