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  1. B cells are attracting increasing attention in the pathogenesis of multiple sclerosis (MS). B cell-targeted therapies with monoclonal antibodies or plasmapheresis have been shown to be successful in a subset o...

    Authors: Christopher Hohmann, Bianca Milles, Michael Schinke, Michael Schroeter, Jochen Ulzheimer, Peter Kraft, Christoph Kleinschnitz, Paul V Lehmann and Stefanie Kuerten
    Citation: Acta Neuropathologica Communications 2014 2:138
  2. p25α/tubulin polymerization promoting protein (TPPP) is an oligodendroglial protein that plays crucial roles including myelination, and the stabilization of microtubules. In multiple system atrophy (MSA), TPPP...

    Authors: Kiyobumi Ota, Masato Obayashi, Kokoro Ozaki, Shizuko Ichinose, Akiyoshi Kakita, Mari Tada, Hitoshi Takahashi, Noboru Ando, Yoshinobu Eishi, Hidehiro Mizusawa and Kinya Ishikawa
    Citation: Acta Neuropathologica Communications 2014 2:136
  3. Several neurodegenerative diseases are classified as proteopathies as they are associated with the aggregation of misfolded proteins. Synucleinopathies are a group of neurodegenerative disorders associated wit...

    Authors: Irina Surgucheva, Kathy L. Newell, Jeffrey Burns and Andrei Surguchov
    Citation: Acta Neuropathologica Communications 2014 2:132
  4. Mutations in ~100 genes cause muscle diseases with complex and often unexplained genotype/phenotype correlations. Next-generation sequencing studies identify a greater-than-expected number of genetic variation...

    Authors: Marco Savarese, Giuseppina Di Fruscio, Margherita Mutarelli, Annalaura Torella, Francesca Magri, Filippo Maria Santorelli, Giacomo Pietro Comi, Claudio Bruno and Vincenzo Nigro
    Citation: Acta Neuropathologica Communications 2014 2:100
  5. Mucolipidosis IV (MLIV) is caused by mutations in the gene MCOLN1. Patients with MLIV have severe neurologic deficits and very little is known about the brain pathology in this lysosomal disease. Using an accurat...

    Authors: Yulia Grishchuk, Sarmi Sri, Nikita Rudinskiy, Weiyuan Ma, Katherine G. Stember, Matthew W. Cottle, Ellen Sapp, Marian Difiglia, Alona Muzikansky, Rebecca A. Betensky, Andrew M. S. Wong, Brian J. Bacskai, Bradley T. Hyman, Raymond J. Kelleher, Jonathan D. Cooper and Susan A. Slaugenhaupt
    Citation: Acta Neuropathologica Communications 2014 2:133
  6. Neurodegenerative diseases share common pathologic features including neuroinflammation, mitochondrial dysfunction and protein aggregation, suggesting common underlying mechanisms of neurodegeneration. We unde...

    Authors: Matthew D Li, Terry C Burns, Alexander A Morgan and Purvesh Khatri
    Citation: Acta Neuropathologica Communications 2014 2:93
  7. Hirano bodies are actin-rich intracellular inclusions found in the brains of patients with neurodegenerative conditions such as Alzheimer's disease or frontotemporal lobar degeneration-tau. While Hirano body u...

    Authors: Matthew Furgerson, Jason K. Clark, Jonathon D. Crystal, John J. Wagner, Marcus Fechheimer and Ruth Furukawa
    Citation: Acta Neuropathologica Communications 2014 2:131
  8. Alzheimer’s disease (AD) is the most common cause of dementia, and currently, there is no effective treatment. The major neuropathological lesions in AD are accumulation of amyloid β (Aβ) as amyloid plaques an...

    Authors: Henrieta Scholtzova, Peter Chianchiano, Jason Pan, Yanjie Sun, Fernando Goñi, Pankaj D Mehta and Thomas Wisniewski
    Citation: Acta Neuropathologica Communications 2014 2:101
  9. The paraffin-embedded tissue (PET) blot technique followed by limited protease digestion has been established to detect protein aggregates in prion diseases, alpha-synucleopathies, and tauopathies. We analyzed...

    Authors: Petra Steinacker, Christian Berner, Dietmar R Thal, Johannes Attems, Albert C Ludolph and Markus Otto
    Citation: Acta Neuropathologica Communications 2014 2:130
  10. A remarkable pathological difference between grey matter lesions (GML) and white matter lesions (WML) in Multiple Sclerosis (MS) patients is the paucity of infiltrating leukocytes in GML. To better understand ...

    Authors: Marloes Prins, Ranjan Dutta, Bart Baselmans, John J P Brevé, John G J M Bol, Sadie A Deckard, Paul van der Valk, Sandra Amor, Bruce D Trapp, Helga E de Vries, Benjamin Drukarch and Anne-Marie van Dam
    Citation: Acta Neuropathologica Communications 2014 2:98
  11. Alzheimer’s disease (AD) is the most common neurodegenerative disease and the leading cause of dementia. In addition to grey matter pathology, white matter changes are now recognized as an important pathologic...

    Authors: Lyndsey E Collins-Praino, Yitshak I Francis, Erica Y Griffith, Anne F Wiegman, Jonathan Urbach, Arlene Lawton, Lawrence S Honig, Etty Cortes, Jean Paul G Vonsattel, Peter D Canoll, James E Goldman and Adam M Brickman
    Citation: Acta Neuropathologica Communications 2014 2:83
  12. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) represents the most common hereditary form of cerebral small vessel disease characterized by early-onset str...

    Authors: Jessica Kast, Patrizia Hanecker, Nathalie Beaufort, Armin Giese, Anne Joutel, Martin Dichgans, Christian Opherk and Christof Haffner
    Citation: Acta Neuropathologica Communications 2014 2:96
  13. Next to α-synuclein deposition, microglial activation is a prominent pathological feature in the substantia nigra (SN) of Parkinson’s disease (PD) patients. Little is known, however, about the different phenot...

    Authors: Karlijn J Doorn, Tim Moors, Benjamin Drukarch, Wilma DJ van de Berg, Paul J Lucassen and Anne-Marie van Dam
    Citation: Acta Neuropathologica Communications 2014 2:90
  14. We explored the prevalence of syringomyelia in a series of 113 cases of fetal dysraphism and hindbrain crowding, of gestational age ranging from 17.5 to 34 weeks with the vast majority less than 26 weeks gesta...

    Authors: Anne Guo, David Chitayat, Susan Blaser, Sarah Keating and Patrick Shannon
    Citation: Acta Neuropathologica Communications 2014 2:91
  15. α-Synuclein is the major component of filamentous inclusions that constitute the defining characteristic of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy, so-called α-synucleinopat...

    Authors: Masami Masuda-Suzukake, Takashi Nonaka, Masato Hosokawa, Maki Kubo, Aki Shimozawa, Haruhiko Akiyama and Masato Hasegawa
    Citation: Acta Neuropathologica Communications 2014 2:88
  16. In Huntington’s disease (HD), the ratio between normal and mutant Huntingtin (polyQ-hHtt) is crucial in the onset and progression of the disease. As a result, addition of normal Htt was shown to improve polyQ-...

    Authors: Yoan Arribat, Yasmina Talmat-Amar, Alexia Paucard, Pierre Lesport, Nathalie Bonneaud, Caroline Bauer, Nicole Bec, Marie-Laure Parmentier, Lorraine Benigno, Christian Larroque, Patrick Maurel and Florence Maschat
    Citation: Acta Neuropathologica Communications 2014 2:86
  17. Leptomeningeal dissemination (LMD), the metastatic spread of tumor cells via the cerebrospinal fluid to the brain and spinal cord, is an ominous prognostic sign for patients with the pediatric brain tumor medu...

    Authors: Noah C Jenkins, Ricky R Kalra, Adrian Dubuc, Walavan Sivakumar, Carolyn A Pedone, Xiaochong Wu, Michael D Taylor and Daniel W Fults
    Citation: Acta Neuropathologica Communications 2014 2:85
  18. Complex cortical malformations associated with mutations in tubulin genes are commonly referred to as “Tubulinopathies”. To further characterize the mutation frequency and phenotypes associated with tubulin mu...

    Authors: Catherine Fallet-Bianco, Annie Laquerrière, Karine Poirier, Ferechte Razavi, Fabien Guimiot, Patricia Dias, Laurence Loeuillet, Karine Lascelles, Cherif Beldjord, Nathalie Carion, Aurélie Toussaint, Nicole Revencu, Marie-Claude Addor, Benoit Lhermitte, Marie Gonzales, Jelena Martinovich…
    Citation: Acta Neuropathologica Communications 2014 2:69
  19. Angiogenesis, the formation of new vessels, is found in Multiple Sclerosis (MS) demyelinating lesions following Vascular Endothelial Growth Factor (VEGF) release and the production of several other angiogenic ...

    Authors: Francesco Girolamo, Cristiana Coppola, Domenico Ribatti and Maria Trojano
    Citation: Acta Neuropathologica Communications 2014 2:84
  20. Polymicrogyria (PMG) is a complex cortical malformation which has so far defied any mechanistic or genetic explanation. Adopting a broad definition of an abnormally folded or festooned cerebral cortical neuron...

    Authors: Waney Squier and Anna Jansen
    Citation: Acta Neuropathologica Communications 2014 2:80
  21. Current consensus identifies four molecular subtypes of medulloblastoma (MB): WNT, sonic hedgehog (SHH), and groups “3/C” and “4/D”. Group 4 is not well characterized, but harbors the most frequently observed ...

    Authors: Gabriel A Bien-Willner and Robi D Mitra
    Citation: Acta Neuropathologica Communications 2014 2:74
  22. Epilepsy and psychiatric comorbidities are frequently associated, but their common biological substrate is unknown. We have previously reported altered structural elements and neurotrophins (NTs) expression in...

    Authors: Ludmyla Kandratavicius, Jaime Eduardo Hallak, Carlos Gilberto Carlotti, Joao Alberto Assirati and Joao Pereira Leite
    Citation: Acta Neuropathologica Communications 2014 2:81
  23. Synaptic dysfunction occurs early in the progression of Alzheimer’s disease (AD) and correlates with memory decline. There is emerging evidence that deregulation of Erythropoietin-producing hepatocellular (Eph...

    Authors: Andrea FN Rosenberger, Annemieke JM Rozemuller, Wiesje M van der Flier, Philip Scheltens, Saskia M van der Vies and Jeroen JM Hoozemans
    Citation: Acta Neuropathologica Communications 2014 2:79
  24. It has been shown that progranulin (PGRN) deficiency causes age-related neurodegenerative diseases such as frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL), a lysosomal storage...

    Authors: Yoshinori Tanaka, James K Chambers, Takashi Matsuwaki, Keitaro Yamanouchi and Masugi Nishihara
    Citation: Acta Neuropathologica Communications 2014 2:78
  25. In the human demyelinating central nervous system (CNS) disease multiple sclerosis, remyelination promotes recovery and limits neurodegeneration, but this is inefficient and always ultimately fails. Furthermor...

    Authors: Eva Jolanda Münzel, Catherina G Becker, Thomas Becker and Anna Williams
    Citation: Acta Neuropathologica Communications 2014 2:77
  26. Mutagenic loss of the NF2 tumor suppressor gene encoded protein merlin is known to provoke the hereditary neoplasia syndrome, Neurofibromatosis type 2 (NF2). In addition to glial cell-derived tumors in the PNS an...

    Authors: Alexander Schulz, Ansgar Zoch and Helen Morrison
    Citation: Acta Neuropathologica Communications 2014 2:82
  27. Activation of the mTOR pathway has been linked to the cytopathology and epileptogenicity of malformations, specifically Focal Cortical Dysplasia (FCD) and Tuberous Sclerosis (TSC). Experimental and clinical tr...

    Authors: Joan Liu, Cheryl Reeves, Zuzanna Michalak, Antonietta Coppola, Beate Diehl, Sanjay M Sisodiya and Maria Thom
    Citation: Acta Neuropathologica Communications 2014 2:71
  28. Alzheimer’s disease is caused by increased production or reduced clearance of amyloid-β, which results in the formation amyloid-β plaques and triggers a cascade of downstream events leading to progressive neur...

    Authors: Marlene J Végh, Céline M Heldring, Willem Kamphuis, Sara Hijazi, Arie J Timmerman, Ka Wan Li, Pim van Nierop, Huibert D Mansvelder, Elly M Hol, August B Smit and Ronald E van Kesteren
    Citation: Acta Neuropathologica Communications 2014 2:76
  29. Accumulation of β-amyloid (Aβ) in the brain is essential to Alzheimer’s disease (AD) pathogenesis. Carriers of the apolipoprotein E (APOE) ε4 allele demonstrate greatly increased AD risk and enhanced brain Aβ ...

    Authors: Joanna E Pankiewicz, Maitea Guridi, Jungsu Kim, Ayodeji A Asuni, Sandrine Sanchez, Patrick M Sullivan, David M Holtzman and Martin J Sadowski
    Citation: Acta Neuropathologica Communications 2014 2:75
  30. A hexanucleotide (GGGGCC) expansion in C9ORF72 gene is the most common genetic change seen in familial Frontotemporal Lobar Degeneration (FTLD) and familial Motor Neurone Disease (MND). Pathologically, expansion ...

    Authors: Yvonne S Davidson, Holly Barker, Andrew C Robinson, Jennifer C Thompson, Jenny Harris, Claire Troakes, Bradley Smith, Safa Al-Saraj, Chris Shaw, Sara Rollinson, Masami Masuda-Suzukake, Masato Hasegawa, Stuart Pickering-Brown, Julie S Snowden and David M Mann
    Citation: Acta Neuropathologica Communications 2014 2:70
  31. We evaluated the prognostic and predictive value of a range of molecular changes in the setting of a randomised trial comparing standard PCV (procarbazine, CCNU (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea) a...

    Authors: Vincent Peter Collins, Koichi Ichimura, Ying Di, Danita Pearson, Ray Chan, Lindsay C Thompson, Rhian Gabe, Michael Brada and Sally P Stenning
    Citation: Acta Neuropathologica Communications 2014 2:68
  32. Blast-related traumatic brain injury (TBI) is a common cause of injury in the military operations in Iraq and Afghanistan. How the primary blast wave affects the brain is not well understood. The aim of the pr...

    Authors: Miguel A Gama Sosa, Rita De Gasperi, Pierce L Janssen, Frank J Yuk, Pamela C Anazodo, Paul E Pricop, Alejandro J Paulino, Bridget Wicinski, Michael C Shaughness, Eric Maudlin-Jeronimo, Aaron A Hall, Dara L Dickstein, Richard M McCarron, Mikulas Chavko, Patrick R Hof, Stephen T Ahlers…
    Citation: Acta Neuropathologica Communications 2014 2:67
  33. Progressive supranuclear palsy (PSP) is a neurodegenerative tauopathy which is primarily defined by the deposition of tau into globose-type neurofibrillary tangles (NFT). Tau in its native form has important f...

    Authors: Julia E Gerson, Urmi Sengupta, Cristian A Lasagna-Reeves, Marcos J Guerrero-Muñoz, Juan Troncoso and Rakez Kayed
    Citation: Acta Neuropathologica Communications 2014 2:73
  34. In epilepsy, the diagnosis of mild Malformation of Cortical Development type II (mMCD II) predominantly relies on the histopathological assessment of heterotopic neurons in the white matter. The exact diagnost...

    Authors: Joan YW Liu, Matthew Ellis, Hannah Brooke-Ball, Jane de Tisi, Sofia H Eriksson, Sebastian Brandner, Sanjay M Sisodiya and Maria Thom
    Citation: Acta Neuropathologica Communications 2014 2:72
  35. Hallmarks of CNS inflammation, including microglial and astrocyte activation, are prominent features in post-mortem tissue from amyotrophic lateral sclerosis (ALS) patients and in mice overexpressing mutant super...

    Authors: Matthew C Evans, Pieter J Gaillard, Marco de Boer, Chantal Appeldoorn, Rick Dorland, Nicola R Sibson, Martin R Turner, Daniel C Anthony and Helen B Stolp
    Citation: Acta Neuropathologica Communications 2014 2:66
  36. Mid-life obesity and type 2 diabetes mellitus (T2DM) confer a modest, increased risk for Alzheimer’s disease (AD), though the underlying mechanisms are unknown. We have created a novel mouse model that recapit...

    Authors: Dana M Niedowicz, Valerie L Reeves, Thomas L Platt, Katharina Kohler, Tina L Beckett, David K Powell, Tiffany L Lee, Travis R Sexton, Eun Suk Song, Lawrence D Brewer, Caitlin S Latimer, Susan D Kraner, Kara L Larson, Sabire Ozcan, Christopher M Norris, Louis B Hersh…
    Citation: Acta Neuropathologica Communications 2014 2:64
  37. Intraneuronal neurofibrillary tangles (NFTs) – a characteristic pathological feature of Alzheimer’s and several other neurodegenerative diseases – are considered a major target for drug development. Tangle loa...

    Authors: Nikita Rudinskiy, Jonathan M Hawkes, Susanne Wegmann, Kishore V Kuchibhotla, Alona Muzikansky, Rebecca A Betensky, Tara L Spires-Jones and Bradley T Hyman
    Citation: Acta Neuropathologica Communications 2014 2:63
  38. Cancer pain creates a poor quality of life and decreases survival. The basic neurobiology of cancer pain is poorly understood. Adenosine triphosphate (ATP) and the ATP ionotropic receptor subunits, P2X2 and P2...

    Authors: Yi Ye, Kentaro Ono, Daniel G Bernabé, Chi T Viet, Victoria Pickering, John C Dolan, Markus Hardt, Anthony P Ford and Brian L Schmidt
    Citation: Acta Neuropathologica Communications 2014 2:62
  39. Numerous studies have implicated the abnormal accumulation of intraneuronal amyloid-β (Aβ) as an important contributor to Alzheimer’s disease (AD) pathology, capable of triggering neuroinflammation, tau hyperp...

    Authors: M Florencia Iulita, Simon Allard, Luise Richter, Lisa-Marie Munter, Adriana Ducatenzeiler, Christoph Weise, Sonia Do Carmo, William L Klein, Gerhard Multhaup and A Claudio Cuello
    Citation: Acta Neuropathologica Communications 2014 2:61
  40. The pathogenesis of heart failure (HF) in diabetic individuals, called “diabetic cardiomyopathy”, is only partially understood. Alterations in the cardiac autonomic nervous system due to oxidative stress have ...

    Authors: Chantalle E Menard, Melanie Durston, Elena Zherebitskaya, Darrell R Smith, Darren Freed, Gordon W Glazner, Ganghong Tian, Paul Fernyhough and Rakesh C Arora
    Citation: Acta Neuropathologica Communications 2014 2:60
  41. Diffuse intrinsic pontine glioma (DIPG) is a malignant pediatric brain tumor associated with dismal outcome. Recent high-throughput molecular studies have shown a high frequency of mutations in histone-encodin...

    Authors: Sama Ahsan, Eric H Raabe, Michael C Haffner, Ajay Vaghasia, Katherine E Warren, Martha Quezado, Leomar Y Ballester, Javad Nazarian, Charles G Eberhart and Fausto J Rodriguez
    Citation: Acta Neuropathologica Communications 2014 2:59
  42. Mutations in isocitrate dehydrogenase genes IDH1 or IDH2 are frequent in glioma, and IDH mutation status is a strong diagnostic and prognostic marker. Current IDH mutation screening is performed with an immunohis...

    Authors: Aurélie Catteau, Hélène Girardi, Florence Monville, Cécile Poggionovo, Sabrina Carpentier, Véronique Frayssinet, Jesse Voss, Robert Jenkins, Blandine Boisselier, Karima Mokhtari, Marc Sanson, Hélène Peyro-Saint-Paul and Caterina Giannini
    Citation: Acta Neuropathologica Communications 2014 2:58
  43. Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients. We analysed whether circumve...

    Authors: Ramadhan T Othman, Ioanna Kimishi, Tracey D Bradshaw, Lisa CD Storer, Andrey Korshunov, Stefan M Pfister, Richard G Grundy, Ian D Kerr and Beth Coyle
    Citation: Acta Neuropathologica Communications 2014 2:57
  44. Pathological aggregation of the microtubule-associated protein tau and subsequent accumulation of neurofibrillary tangles (NFTs) or other tau-containing inclusions are defining histopathological features of ma...

    Authors: Cristian A Lasagna-Reeves, Urmi Sengupta, Diana Castillo-Carranza, Julia E Gerson, Marcos Guerrero-Munoz, Juan C Troncoso, George R Jackson and Rakez Kayed
    Citation: Acta Neuropathologica Communications 2014 2:56
  45. Greater than 160 missense mutations in copper-zinc superoxide dismutase-1 (SOD1) can cause amyotrophic lateral sclerosis (ALS). These mutations produce conformational changes that reveal novel antibody binding ep...

    Authors: Jacob I Ayers, Guilian Xu, Olga Pletnikova, Juan C Troncoso, P John Hart and David R Borchelt
    Citation: Acta Neuropathologica Communications 2014 2:55
  46. The neuronal ceroid lipofuscinoses constitute a group of fatal inherited lysosomal storage diseases that manifest in profound neurodegeneration in the CNS. Visual impairment usually is an early symptom and sel...

    Authors: Janos Groh, David Stadler, Mathias Buttmann and Rudolf Martini
    Citation: Acta Neuropathologica Communications 2014 2:54
  47. Inflammation and complement activation are firmly implicated in the pathology of multiple sclerosis; however, the extent and nature of their involvement in specific pathological processes such as axonal damage...

    Authors: Gillian Ingram, Sam Loveless, Owain W Howell, Svetlana Hakobyan, Bethan Dancey, Claire L Harris, Neil P Robertson, James W Neal and B Paul Morgan
    Citation: Acta Neuropathologica Communications 2014 2:53
  48. Acute hemorrhagic leukoencephalitis (AHL) is a fulminant demyelinating disease of unknown etiology. Most cases are fatal within one week from onset. AHL pathology varies with the acuteness of disease. Hemorrha...

    Authors: Christopher A Robinson, Reginald C Adiele, Mylyne Tham, Claudia F Lucchinetti and Bogdan FGh Popescu
    Citation: Acta Neuropathologica Communications 2014 2:52

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