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  1. Low-level blast exposure can result in neurological impairment for military personnel. Currently, there is a lack of experimental data using sex as a biological variable in neurovascular outcomes following bla...

    Authors: W. Brad Hubbard, Gopal V. Velmurugan, Emily P. Brown and Patrick G. Sullivan
    Citation: Acta Neuropathologica Communications 2022 10:93
  2. The two main histopathological hallmarks that characterize Alzheimer’s Disease are the presence of amyloid plaques and neurofibrillary tangles. One of the current approaches to studying the consequences of amy...

    Authors: S. Tok, H. Maurin, C. Delay, D. Crauwels, N. V. Manyakov, W. Van Der Elst, D. Moechars and W. H. I. M. Drinkenburg
    Citation: Acta Neuropathologica Communications 2022 10:92
  3. Aberrant cortisol and activation of the glucocorticoid receptor (GR) play an essential role in age-related progression of Alzheimer's disease (AD). However, the GR pathways required for influencing the pathobi...

    Authors: Yann Dromard, Margarita Arango-Lievano, Amelie Borie, Maheva Dedin, Pierre Fontanaud, Joan Torrent, Michael J. Garabedian, Stephen D. Ginsberg and Freddy Jeanneteau
    Citation: Acta Neuropathologica Communications 2022 10:91
  4. Currently, there is a need for diagnostic markers in Lewy body disorders (LBD). α-synuclein (αSyn) RT-QuIC has emerged as a promising assay to detect misfolded αSyn in clinically or neuropathologically establi...

    Authors: Sara Hall, Christina D. Orrù, Geidy E. Serrano, Douglas Galasko, Andrew G. Hughson, Bradley R. Groveman, Charles H. Adler, Thomas G. Beach, Byron Caughey and Oskar Hansson
    Citation: Acta Neuropathologica Communications 2022 10:90
  5. Authors: Dahyun Yu, Nicole Zarate, Angel White, De’jah Coates, Wei Tsai, Carmen Nanclares, Francesco Cuccu, Johnny S. Yue, Taylor G. Brown, Rachel H. Mansky, Kevin Jiang, Hyuck Kim, Tessa Nichols‑Meade, Sarah N. Larson, Katherine Gundry, Ying Zhang…
    Citation: Acta Neuropathologica Communications 2022 10:89

    The original article was published in Acta Neuropathologica Communications 2022 10:83

  6. Desmoplastic infantile astrocytoma (DIA) is rare, cystic and solid tumor of infants usually found in superficial cerebral hemispheres. Although DIA is usually benign, uncommon cases bearing malignant histologi...

    Authors: Javier Megías, Teresa San-Miguel, Mirian Sánchez, Lara Navarro, Daniel Monleón, Silvia Calabuig-Fariñas, José Manuel Morales, Lisandra Muñoz-Hidalgo, Pedro Roldán, Miguel Cerdá-Nicolás and Concha López-Ginés
    Citation: Acta Neuropathologica Communications 2022 10:88
  7. Thalamic volume is associated with clinical disability in multiple sclerosis (MS) and is vulnerable to secondary neurodegeneration due to its extensive connectivity throughout the central nervous system (CNS)....

    Authors: Gabrielle M. Mey, Kirsten S. Evonuk, McKenzie K. Chappell, Laura M. Wolfe, Rupesh Singh, Julia C. Batoki, Minzhong Yu, Neal S. Peachey, Bela Anand-Apte, Robert Bermel, Daniel Ontaneda, Kunio Nakamura, Kedar R. Mahajan and Tara M. DeSilva
    Citation: Acta Neuropathologica Communications 2022 10:87
  8. Although Down syndrome (DS), the most common developmental genetic cause of intellectual disability, displays proliferation and migration deficits in the prenatal frontal cortex (FC), a knowledge gap exists on...

    Authors: Emma C. Utagawa, David G. Moreno, Kristian T. Schafernak, Nicoleta C. Arva, Michael H. Malek-Ahmadi, Elliott J. Mufson and Sylvia E. Perez
    Citation: Acta Neuropathologica Communications 2022 10:86
  9. Inclusion body myositis (IBM) is the most prevalent idiopathic inflammatory myopathy (IIM) affecting older adults. The pathogenic hallmark of IBM is chronic inflammation of skeletal muscle. At present, we do n...

    Authors: Christopher Nelke, Felix Kleefeld, Corinna Preusse, Tobias Ruck and Werner Stenzel
    Citation: Acta Neuropathologica Communications 2022 10:84
  10. Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the HTT gene for which no therapies are available. HTT mutation causes protein misfolding and aggregatio...

    Authors: Dahyun Yu, Nicole Zarate, Angel White, De’jah Coates, Wei Tsai, Carmen Nanclares, Francesco Cuccu, Johnny S. Yue, Taylor G. Brown, Rachel H. Mansky, Kevin Jiang, Hyuck Kim, Tessa Nichols-Meade, Sarah N. Larson, Katherine Gundry, Ying Zhang…
    Citation: Acta Neuropathologica Communications 2022 10:83

    The Correction to this article has been published in Acta Neuropathologica Communications 2022 10:89

  11. Based on immunostainings and biochemical analyses, certain post-translationally modified alpha-synuclein (aSyn) variants, including C-terminally truncated (CTT) and Serine-129 phosphorylated (pSer129) aSyn, ar...

    Authors: Tim E. Moors, Daniel Mona, Stefan Luehe, Gonzalo Duran-Pacheco, Liz Spycher, Olaf Mundigl, Klaus Kaluza, Sylwia Huber, Melanie N. Hug, Thomas Kremer, Mirko Ritter, Sebastian Dziadek, Gregor Dernick, Wilma D. J. van de Berg and Markus Britschgi
    Citation: Acta Neuropathologica Communications 2022 10:82
  12. The International Society for the Study of Vascular Anomalies (ISSVA) has defined four vascular lesions in the central nervous system (CNS): arteriovenous malformations, cavernous angiomas (also known as cereb...

    Authors: Arnault Tauziède-Espariat, Thibaut Pierre, Michel Wassef, David Castel, Florence Riant, Jacques Grill, Alexandre Roux, Johan Pallud, Edouard Dezamis, Damien Bresson, Sandro Benichi, Thomas Blauwblomme, Djallel Benzohra, Guillaume Gauchotte, Celso Pouget, Sophie Colnat-Coulbois…
    Citation: Acta Neuropathologica Communications 2022 10:81
  13. The majority of diffuse midline gliomas, H3 K27-altered (DMG-H3 K27-a), are infiltrating pediatric brain tumors that arise in the pons with no effective treatment. To understand how clonal evolution contribute...

    Authors: Sasi Arunachalam, Karol Szlachta, Samuel W. Brady, Xiaotu Ma, Bensheng Ju, Bridget Shaner, Heather L. Mulder, John Easton, Benjamin J. Raphael, Matthew Myers, Christopher Tinkle, Sariah J. Allen, Brent A. Orr, Cynthia J. Wetmore, Suzanne J. Baker and Jinghui Zhang
    Citation: Acta Neuropathologica Communications 2022 10:80
  14. Recently, inspired by the similar clinical and pathological features shared with fragile X-associated tremor/ataxia syndrome (FXTAS), abnormal expansion of CGG repeats in the 5’ untranslated region has been fo...

    Authors: Tongling Liufu, Yilei Zheng, Jiaxi Yu, Yun Yuan, Zhaoxia Wang, Jianwen Deng and Daojun Hong
    Citation: Acta Neuropathologica Communications 2022 10:79
  15. Genetic and neuropathological evidence strongly implicates aberrant forms of α-synuclein in neurodegeneration. Antibodies specific for α-synuclein phosphorylated at serine 129 (pS129) are selective for the pat...

    Authors: Rose B. Creed, Adeel A. Memon, Sindhu P. Komaragiri, Sandeep K. Barodia and Matthew S. Goldberg
    Citation: Acta Neuropathologica Communications 2022 10:78
  16. NF2 alteration is the most commonly–found genetic abnormality in meningiomas and is known to initiate events for aggressive-type meningiomas. Whereas the prognosis of meningiomas differs depending on their epigen...

    Authors: Yu Teranishi, Atsushi Okano, Satoru Miyawaki, Kenta Ohara, Daiichiro Ishigami, Hiroki Hongo, Shogo Dofuku, Hirokazu Takami, Jun Mitsui, Masako Ikemura, Daisuke Komura, Hiroto Katoh, Tetsuo Ushiku, Shumpei Ishikawa, Masahiro Shin, Hirofumi Nakatomi…
    Citation: Acta Neuropathologica Communications 2022 10:76
  17. In the intermediate stages of amyotrophic lateral sclerosis (ALS), surviving motor neurons (MNs) that show intrinsic resistance to TDP-43 proteinopathy can partially compensate for the loss of their more disea...

    Authors: Seong Kwon Hur, Mandana Hunter, Myrna A. Dominique, Madona Farag, Dejania Cotton-Samuel, Tahiyana Khan, John Q. Trojanowski, Krista J. Spiller and Virginia M.-Y. Lee
    Citation: Acta Neuropathologica Communications 2022 10:75
  18. Prenatal alcohol exposure is a major cause of neurobehavioral disabilities. MRI studies in humans have shown that alcohol is associated with white matter microstructural anomalies but these studies focused on ...

    Authors: Florent Marguet, Mélanie Brosolo, Gaëlle Friocourt, Fanny Sauvestre, Pascale Marcorelles, Céline Lesueur, Stéphane Marret, Bruno J. Gonzalez and Annie Laquerrière
    Citation: Acta Neuropathologica Communications 2022 10:74
  19. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the viability of upper and lower motor neurons. Current options for treatment are limited, necessitating deeper understandi...

    Authors: Anna Westerhaus, Thea Joseph, Alison J. Meyers, Yura Jang, Chan Hyun Na, Clinton Cave and Shanthini Sockanathan
    Citation: Acta Neuropathologica Communications 2022 10:73
  20. Clinico-pathological correlation studies show that some otherwise healthy elderly individuals who never developed cognitive impairment harbor a burden of Alzheimer’s disease lesions (plaques and tangles) that ...

    Authors: Raquel N. Taddei, Maria V. Sanchez-Mico, Orla Bonnar, Theresa Connors, Angelica Gaona, Dominique Denbow, Matthew P. Frosch and Teresa Gómez-Isla
    Citation: Acta Neuropathologica Communications 2022 10:72
  21. DNA methylation of cytosines in CpG sites throughout the genome is an epigenetic mark contributing to gene expression regulation. DNA methylation patterns are specific to tissue type, conserved throughout life...

    Authors: Kristyn Galbraith and Matija Snuderl
    Citation: Acta Neuropathologica Communications 2022 10:71
  22. Diffusely infiltrative low-grade gliomas (LGG) are primary brain tumours that arise predominantly in the cerebral hemispheres of younger adults. LGG can display either astrocytic or oligodendroglial histology ...

    Authors: Derek Wong, Tae Hoon Lee, Amy Lum, Valerie Lan Tao and Stephen Yip
    Citation: Acta Neuropathologica Communications 2022 10:70
  23. Microglia are implicated in Alzheimer’s Disease (AD) pathogenesis. In a middle-aged cohort enriched for neuroinflammation, we asked whether microgliosis was related to neocortical amyloid beta (A

    Authors: Jacinta Murray, Gregory Meloni, Etty P. Cortes, Ariadna KimSilva, Michelle Jacobs, Alyssa Ramkissoon, John F. Crary and Susan Morgello
    Citation: Acta Neuropathologica Communications 2022 10:69
  24. Risk factors such as dysregulation of Insulin-like growth factor (IGF) signaling have been linked to Alzheimer’s disease. Here we show that Insulin-like Growth Factor Binding Protein 5 (Igfbp5), an inhibitory ...

    Authors: Stefanie Rauskolb, Thomas Andreska, Sophie Fries, Cora Ruedt von Collenberg, Robert Blum, Camelia-Maria Monoranu, Carmen Villmann and Michael Sendtner
    Citation: Acta Neuropathologica Communications 2022 10:68
  25. Damage to long axons in white matter tracts is a major pathology in closed head traumatic brain injury (TBI). Acute TBI treatments are needed that protect against axon damage and promote recovery of axon funct...

    Authors: Kryslaine L. Radomski, Xiaomei Zi, Fritz W. Lischka, Mark D. Noble, Zygmunt Galdzicki and Regina C. Armstrong
    Citation: Acta Neuropathologica Communications 2022 10:67
  26. Pathologists can label pathologies differently, making it challenging to yield consistent assessments in the absence of one ground truth. To address this problem, we present a deep learning (DL) approach that ...

    Authors: Daniel R. Wong, Ziqi Tang, Nicholas C. Mew, Sakshi Das, Justin Athey, Kirsty E. McAleese, Julia K. Kofler, Margaret E. Flanagan, Ewa Borys, Charles L. White III, Atul J. Butte, Brittany N. Dugger and Michael J. Keiser
    Citation: Acta Neuropathologica Communications 2022 10:66
  27. Glioblastoma (GBM) is characterized by a particularly invasive phenotype, supported by oncogenic signals from the fibroblast growth factor (FGF)/ FGF receptor (FGFR) network. However, a possible role of FGFR4 ...

    Authors: Lisa Gabler, Carola Nadine Jaunecker, Sonja Katz, Sushilla van Schoonhoven, Bernhard Englinger, Christine Pirker, Thomas Mohr, Petra Vician, Mirjana Stojanovic, Valentin Woitzuck, Anna Laemmerer, Dominik Kirchhofer, Lisa Mayr, Mery LaFranca, Friedrich Erhart, Sarah Grissenberger…
    Citation: Acta Neuropathologica Communications 2022 10:65
  28. We present the case of a 41-year-old man who developed worsening mid-thoracic back pain and imaging revealed a well-circumscribed intramedullary tumor in the thoracic spinal cord. Subtotal resection was perfor...

    Authors: Michael G. Argenziano, Julia L. Furnari, Michael L. Miller, Yu Sun, Matei A. Banu, Justin A. Neira, Matija Snuderl, Jeffrey N. Bruce, Mary Welch, Paul McCormick and Peter Canoll
    Citation: Acta Neuropathologica Communications 2022 10:64
  29. Authors: Lindsey N. Campion, Alan Mejia Maza, Rachita Yadav, Ellen B. Penney, Micaela G. Murcar, Kevin Correia, Tammy Gillis, Cara Fernandez-Cerado, M. Salvie Velasco-Andrada, G. Paul Legarda, Niecy G. Ganza-Bautista, J. Benedict B. Lagarde, Patrick J. Acuña, Trisha Multhaupt-Buell, Gabrielle Aldykiewicz, Melanie L. Supnet…
    Citation: Acta Neuropathologica Communications 2022 10:62

    The original article was published in Acta Neuropathologica Communications 2022 10:49

  30. A central event in the pathogenesis of motor neuron disease (MND) is the loss of neuromuscular junctions (NMJs), yet the mechanisms that lead to this event in MND remain to be fully elucidated. Maintenance of ...

    Authors: Qiao Ding, Kaamini Kesavan, Kah Meng Lee, Elyse Wimberger, Thomas Robertson, Melinder Gill, Dominique Power, Jeryn Chang, Atefeh T. Fard, Jessica C. Mar, Robert D. Henderson, Susan Heggie, Pamela A. McCombe, Rosalind L. Jeffree, Michael J. Colditz, Massimo A. Hilliard…
    Citation: Acta Neuropathologica Communications 2022 10:61
  31. Duchenne muscular dystrophy (DMD) is a fatal muscle-wasting disorder caused by mutations in the Dystrophin gene and for which there is currently no cure. To bridge the gap between preclinical and therapeutic e...

    Authors: Valentina Taglietti, Kaouthar Kefi, Iwona Bronisz-Budzyńska, Busra Mirciloglu, Mathilde Rodrigues, Nastasia Cardone, Fanny Coulpier, Baptiste Periou, Christel Gentil, Melissa Goddard, François-Jérôme Authier, France Pietri-Rouxel, Edoardo Malfatti, Peggy Lafuste, Laurent Tiret and Frederic Relaix
    Citation: Acta Neuropathologica Communications 2022 10:60
  32. Acquired brain injuries due to trauma damage the cortical vasculature, which in turn impairs blood flow to injured tissues. There are reports of vascular morphological recovery following traumatic brain injury...

    Authors: Xiaoxiao Lin, Lujia Chen, Amandine Jullienne, Hai Zhang, Arjang Salehi, Mary Hamer, Todd C. Holmes, Andre Obenaus and Xiangmin Xu
    Citation: Acta Neuropathologica Communications 2022 10:59
  33. Authors: Bongyong Lee, Iqbal Mahmud, Rudramani Pokhrel, Rabi Murad, Menglang Yuan, Stacie Stapleton, Chetan Bettegowda, George Jallo, Charles G. Eberhart, Timothy Garrett and Ranjan J. Perera
    Citation: Acta Neuropathologica Communications 2022 10:58

    The original article was published in Acta Neuropathologica Communications 2022 10:25

  34. Apolipoprotein (APOE) is a major risk factor of Alzheimer’s disease (AD), with the E2, E3 and E4 isoforms differentially regulating the burden of AD-associated neuropathologies, such as amyloid β and tau. In A...

    Authors: Tristan Williams, Alejandra Jolie Ruiz, Angelica Maria Ruiz, Quan Vo, Wangchen Tsering, Guilian Xu, Karen McFarland, Benoit I. Giasson, Patrick Sullivan, David R. Borchelt and Paramita Chakrabarty
    Citation: Acta Neuropathologica Communications 2022 10:57
  35. Chordoid meningioma is a morphological variant of meningioma designated as WHO grade 2. However, the recurrence rates varied widely in different case series, and to date, a unifying molecular genetic signature...

    Authors: Elena V. Daoud, Kelsey Zhu, Bruce Mickey, Hussein Mohamed, Mandisa Wen, Michael Delorenzo, Ivy Tran, Jonathan Serrano, Kimmo J. Hatanpaa, Jack M. Raisanen, Matija Snuderl and Chunyu Cai
    Citation: Acta Neuropathologica Communications 2022 10:56
  36. Huntington disease is characterized by progressive neurodegeneration, especially of the striatum, and the presence of polyglutamine huntingtin (HTT) inclusions. Although HTT inclusions are most abundant in the...

    Authors: Richard A. Hickman, Phyllis L. Faust, Karen Marder, Ai Yamamoto and Jean-Paul Vonsattel
    Citation: Acta Neuropathologica Communications 2022 10:55
  37. Mutations in the RYR1 gene, encoding ryanodine receptor 1 (RyR1), are a well-known cause of Central Core Disease (CCD) and Multi-minicore Disease (MmD). We screened a cohort of 153 patients carrying an histopatho...

    Authors: Aurora Fusto, Denise Cassandrini, Chiara Fiorillo, Valentina Codemo, Guja Astrea, Adele D’Amico, Lorenzo Maggi, Francesca Magri, Marika Pane, Giorgio Tasca, Daniele Sabbatini, Luca Bello, Roberta Battini, Pia Bernasconi, Fabiana Fattori, Enrico Silvio Bertini…
    Citation: Acta Neuropathologica Communications 2022 10:54
  38. Amyloid plaques contain many proteins in addition to beta amyloid (Aβ). Previous studies examining plaque-associated proteins have shown these additional proteins are important; they provide insight into the f...

    Authors: Eleanor Drummond, Tomas Kavanagh, Geoffrey Pires, Mitchell Marta-Ariza, Evgeny Kanshin, Shruti Nayak, Arline Faustin, Valentin Berdah, Beatrix Ueberheide and Thomas Wisniewski
    Citation: Acta Neuropathologica Communications 2022 10:53
  39. Exposure to military blast and repetitive head impacts (RHI) in contact sports is associated with increased risk of long-term neurobehavioral sequelae and cognitive deficits, and the neurodegenerative disease ...

    Authors: Katharine J. Babcock, Bobak Abdolmohammadi, Patrick T. Kiernan, Ian Mahar, Jonathan D. Cherry, Victor E. Alvarez, Lee E. Goldstein, Thor D. Stein, Ann C. McKee and Bertrand R. Huber
    Citation: Acta Neuropathologica Communications 2022 10:52
  40. Recent studies suggest that metabolic changes and oxygen deficiency in the central nervous system play an important role in the pathophysiology of multiple sclerosis (MS). In our present study, we investigated...

    Authors: Marta Ramos-Vega, Pontus Kjellman, Mihail Ivilinov Todorov, Tekla Maria Kylkilahti, B. Thomas Bäckström, Ali Ertürk, Chris Denis Madsen and Iben Lundgaard
    Citation: Acta Neuropathologica Communications 2022 10:51
  41. Traumatic brain injury (TBI) is associated with the development of a range of neurodegenerative pathologies, including chronic traumatic encephalopathy (CTE). Current consensus diagnostic criteria define the p...

    Authors: Kamar E. Ameen-Ali, Abigail Bretzin, Edward B. Lee, Rebecca Folkerth, Lili-Naz Hazrati, Diego Iacono, C. Dirk Keene, Julia Kofler, Gabor G. Kovacs, Amber Nolan, Daniel P. Perl, David S. Priemer, Douglas H. Smith, Douglas J. Wiebe and William Stewart
    Citation: Acta Neuropathologica Communications 2022 10:50
  42. X-linked dystonia-parkinsonism (XDP) is a progressive adult-onset neurodegenerative disorder caused by insertion of a SINE-VNTR-Alu (SVA) retrotransposon in the TAF1 gene. The SVA retrotransposon contains a CCCTC...

    Authors: Lindsey N. Campion, Alan Mejia Maza, Rachita Yadav, Ellen B. Penney, Micaela G. Murcar, Kevin Correia, Tammy Gillis, Cara Fernandez-Cerado, M. Salvie Velasco-Andrada, G. Paul Legarda, Niecy G. Ganza-Bautista, J. Benedict B. Lagarde, Patrick J. Acuña, Trisha Multhaupt-Buell, Gabrielle Aldykiewicz, Melanie L. Supnet…
    Citation: Acta Neuropathologica Communications 2022 10:49

    The Correction to this article has been published in Acta Neuropathologica Communications 2022 10:62

  43. Becker muscular dystrophy (BMD) is a severe X-linked muscle disease. Age of onset, clinical variability, speed of progression and affected tissues display wide variability, making a clinical trial design for d...

    Authors: Michela Ripolone, Daniele Velardo, Stefania Mondello, Simona Zanotti, Francesca Magri, Elisa Minuti, Sara Cazzaniga, Francesco Fortunato, Patrizia Ciscato, Francesca Tiberio, Monica Sciacco, Maurizio Moggio, Paolo Bettica and Giacomo P. Comi
    Citation: Acta Neuropathologica Communications 2022 10:48
  44. Pediatric high-grade gliomas, specifically diffuse midline gliomas, account for only 20% of clinical cases but are 100% fatal. A majority of the DMG cases are characterized by the signature K27M mutation in hi...

    Authors: Swati Dhar, Samantha Gadd, Priyam Patel, Jake Vaynshteyn, G. Praveen Raju, Rintaro Hashizume, Daniel J. Brat and Oren J. Becher
    Citation: Acta Neuropathologica Communications 2022 10:47
  45. The mechanisms by which vertically transmitted Zika virus (ZIKV) causes postnatal brain development abnormalities and congenital disease remain poorly understood. Here, we optimized the established anti-IFNAR1...

    Authors: Clayton W. Winkler, Chad S. Clancy, Rebecca Rosenke and Karin E. Peterson
    Citation: Acta Neuropathologica Communications 2022 10:46
  46. Amyloid-beta (Aβ) and tau protein are both involved in the pathogenesis of Alzheimer’s disease. Aβ produces synaptic deficits in wild-type mice that are not seen in Mapt−/− mice, suggesting that tau protein is re...

    Authors: Olivia A. Shipton, Clara S. Tang, Ole Paulsen and Mariana Vargas-Caballero
    Citation: Acta Neuropathologica Communications 2022 10:45
  47. Tau accumulation is clearly linked to pathogenesis in Alzheimer’s disease and other Tauopathies. However, processes leading to Tau fibrillization and reasons for its pathogenicity remain largely elusive. Mical...

    Authors: Engie Prifti, Eleni N. Tsakiri, Ergina Vourkou, George Stamatakis, Martina Samiotaki, Efthimios M. C. Skoulakis and Katerina Papanikolopoulou
    Citation: Acta Neuropathologica Communications 2022 10:44

    The Correction to this article has been published in Acta Neuropathologica Communications 2022 10:63

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