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  1. Treatment with the alkylating agent temozolomide is known to be prognostically beneficial in a subset of glioblastoma patients. Response to such chemotherapeutic treatment and the prognostic benefit have been ...

    Authors: Henning Leske, Ulrike Camenisch Gross, Silvia Hofer, Marian Christoph Neidert, Sabine Leske, Michael Weller, Dirk Lehnick and Elisabeth Jane Rushing
    Citation: Acta Neuropathologica Communications 2023 11:139
  2. Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs), which are characterized by multiple vessel lumens enclosed in ...

    Authors: Eseosa T. Ighodaro, Ryan K. Shahidehpour, Adam D. Bachstetter, Erin L. Abner, Ruth S. Nelson, David W. Fardo, Andy Y. Shih, Roger I. Grant, Janna H. Neltner, Frederick A. Schmitt, Gregory A. Jicha, Richard J. Kryscio, Donna M. Wilcock, Linda J. Van Eldik and Peter T. Nelson
    Citation: Acta Neuropathologica Communications 2023 11:138
  3. Traumatic brain injury (TBI) initiates tissue and cellular damage to the brain that is immediately followed by secondary injury sequalae with delayed and continual damage. This secondary damage includes pathol...

    Authors: George R. Bjorklund, Jennifer Wong, David Brafman, Robert Bowser and Sarah E. Stabenfeldt
    Citation: Acta Neuropathologica Communications 2023 11:137
  4. Authors: Arnault Tauziède-Espariat, Julien Masliah-Planchon, Mamy Andrianteranagna, Philipp Sievers, Felix Sahm, Andreas von Deimling, Lauren Hasty, Olivier Delattre, Kévin Beccaria, Alice Métais, Fabrice Chrétien, Pascale Varlet and Franck Bourdeaut
    Citation: Acta Neuropathologica Communications 2023 11:136
  5. In Alzheimer’s disease (AD), reactive astrocytes produce extracellular vesicles (EVs) that affect mitochondria in neurons. Here, we show that Aβ-induced generation of the sphingolipid ceramide by acid sphingom...

    Authors: Simone M. Crivelli, Zainuddin Quadri, Hemendra J. Vekaria, Zhihui Zhu, Priyanka Tripathi, Ahmed Elsherbini, Liping Zhang, Patrick G. Sullivan and Erhard Bieberich
    Citation: Acta Neuropathologica Communications 2023 11:135
  6. Accumulating evidence suggests that type I interferon (IFN-I) signaling is a key contributor to immune cell-mediated neuropathology in neurodegenerative diseases. Recently, we demonstrated a robust upregulatio...

    Authors: Brittany P. Todd, Zili Luo, Noah Gilkes, Michael S. Chimenti, Zeru Peterson, Madison R. Mix, John T. Harty, Thomas Nickl-Jockschat, Polly J. Ferguson, Alexander G. Bassuk and Elizabeth A. Newell
    Citation: Acta Neuropathologica Communications 2023 11:134
  7. Grade 4 glioma is the most aggressive and currently incurable brain tumor with a median survival of one year in adult patients. Elucidating novel transcriptomic and epigenetic contributors to the molecular het...

    Authors: Chang Zeng, Xiao Song, Zhou Zhang, Qinyun Cai, Jiajun Cai, Craig Horbinski, Bo Hu, Shi-Yuan Cheng and Wei Zhang
    Citation: Acta Neuropathologica Communications 2023 11:133
  8. Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer’s disease pathogenesis. The endogenous inhibitor of this enzyme, cystatin B (CSTB) is encoded on chromosome 21. Thus, individ...

    Authors: Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Dinghao Luo, Floris van Dalen, Martijn Verdoes, Elizabeth M. C. Fisher and Frances K. Wiseman
    Citation: Acta Neuropathologica Communications 2023 11:132
  9. Spinocerebellar ataxia 34 (SCA34) is an autosomal dominant inherited disease characterized by age-related cerebellar degeneration and ataxia caused by mutations in the Elongation of Very Long Chain Fatty Acid-4 (

    Authors: Yeboah Kofi Gyening, Keren Boris, Mignot Cyril, Richard S. Brush, Marie-Cécile Nassogne and Martin-Paul Agbaga
    Citation: Acta Neuropathologica Communications 2023 11:131
  10. Right temporal variant frontotemporal dementia, also called right-predominant semantic dementia, often has an unclear position within the framework of the updated diagnostic criteria for behavioral variant fro...

    Authors: Kohji Mori, Kazue Shigenobu, Goichi Beck, Ryota Uozumi, Yuto Satake, Maki Suzuki, Shizuko Kondo, Shiho Gotoh, Yuki Yonenobu, Makiko Kawai, Yuki Suzuki, Yuko Saito, Eiichi Morii, Masato Hasegawa, Hideki Mochizuki, Shigeo Murayama…
    Citation: Acta Neuropathologica Communications 2023 11:130
  11. Focal Cortical Dysplasia (FCD) is a frequent cause of drug-resistant focal epilepsy in children and young adults. The international FCD classifications of 2011 and 2022 have identified several clinico-patholog...

    Authors: Dan-Dan Wang, Mitali Katoch, Samir Jabari, Ingmar Blumcke, David B. Blumenthal, De-Hong Lu, Roland Coras, Yu-Jiao Wang, Jie Shi, Wen-Jing Zhou, Katja Kobow and Yue-Shan Piao
    Citation: Acta Neuropathologica Communications 2023 11:129

    The Correction to this article has been published in Acta Neuropathologica Communications 2024 12:49

  12. Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–brain barrier impairments which play a key role in the development of white matter lesions. We hypothesised that cerebr...

    Authors: Narek Manukjan, Daria Majcher, Peter Leenders, Florian Caiment, Marcel van Herwijnen, Hubert J. Smeets, Ernst Suidgeest, Louise van der Weerd, Tim Vanmierlo, Jacobus F. A. Jansen, Walter H. Backes, Robert J. van Oostenbrugge, Julie Staals, Daniel Fulton, Zubair Ahmed, W. Matthijs Blankesteijn…
    Citation: Acta Neuropathologica Communications 2023 11:128
  13. Early pathological features of frontotemporal lobar degeneration (FTLD) due to MAPT pathogenic variants (FTLD-MAPT) are understudied, since early-stage tissue is rarely available. Here, we report unique pathologi...

    Authors: Lucia AA Giannini, Merel O Mol, Ana Rajicic, Renee van Buuren, Lana Sarkar, Sanaz Arezoumandan, Daniel T Ohm, David J Irwin, Annemieke JM Rozemuller, John C van Swieten and Harro Seelaar
    Citation: Acta Neuropathologica Communications 2023 11:126
  14. Glioblastoma (GBM) is the most frequent malignant brain tumor, the relapse of which is unavoidable following standard treatment. However, the effective treatment for recurrent GBM is lacking, necessitating the...

    Authors: Xin Wang, Qian Sun, Weiwen Wang, Baohui Liu, Ying Gu and Liang Chen
    Citation: Acta Neuropathologica Communications 2023 11:125
  15. To date, several studies on genomic events underlying medulloblastoma (MB) biology have expanded our understanding of this tumour entity and led to its division into four groups—WNT, SHH, group 3 (G3) and grou...

    Authors: Viktoria L. E. Funke, Sarah Sandmann, Viktoria Melcher, Jochen Seggewiss, Judit Horvath, Natalie Jäger, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Till Milde, Stefan Rutkowski, Martin Mynarek, Julian Varghese, Ronald Sträter, Stephan Rust, Anja Seelhöfer…
    Citation: Acta Neuropathologica Communications 2023 11:124
  16. Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts (RHI) and characterized by perivascular accumulations of hyperphosphorylated tau protei...

    Authors: Grace Rosen, Daniel Kirsch, Sarah Horowitz, Jonathan D. Cherry, Raymond Nicks, Hunter Kelley, Madeline Uretsky, Kevin Dell’Aquila, Rebecca Mathias, Kerry A. Cormier, Caroline A. Kubilus, Jesse Mez, Yorghos Tripodis, Thor D. Stein, Victor E. Alvarez, Michael L. Alosco…
    Citation: Acta Neuropathologica Communications 2023 11:123
  17. Trimethylation of lysine 27 on histone 3 (H3K27me3) loss has been implicated in worse prognoses for patients with meningiomas. However, there have been challenges in measuring H3K27me3 loss, quantifying its im...

    Authors: Gregory Cello, Ruchit V. Patel, James Tanner McMahon, Sandro Santagata and Wenya Linda Bi
    Citation: Acta Neuropathologica Communications 2023 11:122
  18. Ferroptosis is a form of lipid peroxidation-mediated cell death and damage triggered by excess iron and insufficiency in the glutathione antioxidant pathway. Oxidative stress is thought to play a crucial role ...

    Authors: Priya Jhelum, Stephanie Zandee, Fari Ryan, Juan G. Zarruk, Bernhard Michalke, Vivek Venkataramani, Laura Curran, Wendy Klement, Alexandre Prat and Samuel David
    Citation: Acta Neuropathologica Communications 2023 11:121
  19. Amyotrophic Lateral Sclerosis (ALS) is mainly characterized by the degeneration of corticospinal neurons and spinal α-motoneurons; vulnerable cells display prominent pTDP-43 inclusions. Evidence gathered from ...

    Authors: Oumayma Aousji, Simone Feldengut, Stefano Antonucci, Michael Schön, Tobias M. Boeckers, Jakob Matschke, Christian Mawrin, Albert C. Ludolph, Kelly Del Tredici, Francesco Roselli and Heiko Braak
    Citation: Acta Neuropathologica Communications 2023 11:120
  20. Post-translational modifications to the carboxyl (C) terminus domain of α-synuclein can play an important role in promoting the pathologic aggregation of α-synuclein. Various cleavages that diminish this highl...

    Authors: Grace M. Lloyd, Brooke Long, Stephan Quintin, Zachary A. Sorrentino, Kimberly-Marie M. Gorion, Brach M. Bell, Denise Carrillo, Patrick Sullivan, David Borchelt and Benoit I. Giasson
    Citation: Acta Neuropathologica Communications 2023 11:119
  21. Repetitive mild traumatic brain injury (r-mTBI) has increasingly become recognised as a risk factor for the development of neurodegenerative diseases, many of which are characterised by tau pathology, metal dy...

    Authors: Sydney M. A. Juan, Maria Daglas, Phan H. Truong, Celeste Mawal and Paul A. Adlard
    Citation: Acta Neuropathologica Communications 2023 11:118
  22. Authors: Shunsuke Koga, Aya Murakami, Alexandra I. Soto-Beasley, Ronald L. Walton, Matthew C. Baker, Monica Castanedes-Casey, Keith A. Josephs, Owen A. Ross and Dennis W. Dickson
    Citation: Acta Neuropathologica Communications 2023 11:117

    The original article was published in Acta Neuropathologica Communications 2023 11:109

  23. Authors: Berta Segura-Collar, Sara Hiller-Vallina, Olaya de Dios, Marta Caamaño-Moreno, Lucia Mondejar-Ruescas, Juan M. Sepulveda-Sanchez and Ricardo Gargini
    Citation: Acta Neuropathologica Communications 2023 11:116

    The original article was published in Acta Neuropathologica Communications 2023 11:79

  24. Bruton’s tyrosine kinase (BTK) is an emerging target in multiple sclerosis (MS). Alongside its role in B cell receptor signaling and B cell development, BTK regulates myeloid cell activation and inflammatory r...

    Authors: Kirsten Scarlett Evonuk, Sen Wang, Josh Mattie, C. J. Cracchiolo, Reine Mager, Željko Ferenčić, Ethan Sprague, Brandon Carrier, Kai Schofield, Evelyn Martinez, Zachary Stewart, Tara Petrosino, Gregory Andrew Johnson, Isharat Yusuf, Warren Plaisted, Zachary Naiman…
    Citation: Acta Neuropathologica Communications 2023 11:115
  25. Authors: Alexander H. Swan, Roland F. R. Schindler, Marco Savarese, Isabelle Mayer, Susanne Rinné, Felix Bleser, Anne Schänzer, Andreas Hahn, Mario Sabatelli, Francesco Perna, Kathryn Chapman, Mark Pfuhl, Alan C. Spivey, Niels Decher, Bjarne Udd, Giorgio Tasca…
    Citation: Acta Neuropathologica Communications 2023 11:114

    The original article was published in Acta Neuropathologica Communications 2023 11:4

  26. Chordomas are rare tumors of notochord remnants, occurring mainly in the sacrum and skull base. Despite of their unusually slow growth, chordomas are highly invasive and the involvement of adjacent critical st...

    Authors: Szymon Baluszek, Paulina Kober, Natalia Rusetska, Michał Wągrodzki, Tomasz Mandat, Jacek Kunicki and Mateusz Bujko
    Citation: Acta Neuropathologica Communications 2023 11:113
  27. Cytoplasmic aggregation and concomitant nuclear clearance of the RNA-binding protein TDP-43 are found in ~ 90% of cases of amyotrophic lateral sclerosis and ~ 45% of patients living with frontotemporal lobar d...

    Authors: Henrick Riemenschneider, Francesca Simonetti, Udit Sheth, Eszter Katona, Stefan Roth, Saskia Hutten, Daniel Farny, Meike Michaelsen, Brigitte Nuscher, Michael K. Schmidt, Andrew Flatley, Aloys Schepers, Lara A. Gruijs da Silva, Qihui Zhou, Thomas Klopstock, Arthur Liesz…
    Citation: Acta Neuropathologica Communications 2023 11:112
  28. Medulloblastoma (MB) is the most common type of malignant pediatric brain cancer. The current standard of care (SOC) involves maximal safe resection and chemoradiotherapy in individuals older than 3 years, oft...

    Authors: David Bakhshinyan, Yujin Suk, Laura Kuhlmann, Ashley A. Adile, Vladimir Ignatchenko, Stefan Custers, William D. Gwynne, Andrew Macklin, Chitra Venugopal, Thomas Kislinger and Sheila K. Singh
    Citation: Acta Neuropathologica Communications 2023 11:111

    The Correction to this article has been published in Acta Neuropathologica Communications 2023 11:169

  29. Despite tremendous research efforts, successful targeting of aberrant tumor metabolism in clinical practice has remained elusive. Tumor heterogeneity and plasticity may play a role in the clinical failure of m...

    Authors: Emma Martell, Helgi Kuzmychova, Harshal Senthil, Esha Kaul, Chirayu R. Chokshi, Chitra Venugopal, Christopher M. Anderson, Sheila K. Singh and Tanveer Sharif
    Citation: Acta Neuropathologica Communications 2023 11:110
  30. Frontotemporal lobar degeneration (FTLD) is a group of disorders characterized by degeneration of the frontal and temporal lobes, leading to progressive decline in language, behavior, and motor function. FTLD ...

    Authors: Shunsuke Koga, Aya Murakami, Alexandra I. Soto-Beasley, Ronald L. Walton, Matthew C. Baker, Monica Castanedes-Casey, Keith A. Josephs, Owen A. Ross and Dennis W. Dickson
    Citation: Acta Neuropathologica Communications 2023 11:109

    The Publisher Correction to this article has been published in Acta Neuropathologica Communications 2023 11:117

  31. Oligodendrocyte (OL) injury and loss are central features of evolving lesions in multiple sclerosis. Potential causative mechanisms of OL loss include metabolic stress within the lesion microenvironment. Here ...

    Authors: Milton Guilherme Forestieri Fernandes, Abdulshakour Mohammadnia, Florian Pernin, Laura Eleonora Schmitz-Gielsdorf, Caroline Hodgins, Qiao-Ling Cui, Moein Yaqubi, Manon Blain, Jeffery Hall, Roy Dudley, Myriam Srour, Stephanie E. J. Zandee, Wendy Klement, Alexandre Prat, Jo Anne Stratton, Moses Rodriguez…
    Citation: Acta Neuropathologica Communications 2023 11:108
  32. Evidence from animal experiments has shown that the hypothalamic paraventricular nucleus (PVN) plays a key role in regulating body weight and blood glucose levels. However, it is unclear whether neuron populat...

    Authors: Felipe Correa-da-Silva, Martin J. Kalsbeek, Femke S. Gadella, Jorn Oppersma, Wei Jiang, Samantha E. C. Wolff, Nikita L. Korpel, Dick F. Swaab, Eric Fliers, Andries Kalsbeek and Chun-Xia Yi
    Citation: Acta Neuropathologica Communications 2023 11:107
  33. Neurodegenerative diseases encompass a heterogeneous group of conditions characterised by the progressive degeneration of the structure and function of the central or peripheral nervous systems. The pathogenic...

    Authors: Katherine Fodder, Rohan de Silva, Thomas T. Warner and Conceição Bettencourt
    Citation: Acta Neuropathologica Communications 2023 11:106
  34. Despite the increasing demographic diversity of the United States’ aging population, there remain significant gaps in post-mortem research investigating the ethnoracial heterogeneity in the neuropathological l...

    Authors: Rebeca Scalco, Naomi Saito, Laurel Beckett, My-Le Nguyen, Emily Huie, Hsin-Pei Wang, Delaney A. Flaherty, Lawrence S. Honig, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Lee-Way Jin and Brittany N. Dugger
    Citation: Acta Neuropathologica Communications 2023 11:105
  35. Glioblastoma, IDH wild-type is the most common and aggressive form of glial tumors. The exact mechanisms of glioblastoma oncogenesis, including the identification of the glioma-initiating cell, are yet to be disc...

    Authors: F. Ah-Pine, M. Khettab, Y. Bedoui, Y. Slama, M. Daniel, B. Doray and P. Gasque
    Citation: Acta Neuropathologica Communications 2023 11:104
  36. Vanishing white matter (VWM) is a leukodystrophy that primarily manifests in young children. In this disease, the brain white matter is differentially affected in a predictable pattern with telencephalic brain...

    Authors: Jodie H.K. Man, Charlotte A.G.H. van Gelder, Marjolein Breur, Douwe Molenaar, Truus Abbink, Maarten Altelaar, Marianna Bugiani and Marjo S. van der Knaap
    Citation: Acta Neuropathologica Communications 2023 11:103
  37. Accumulating evidences reveal that cellular cholesterol deficiency could trigger the onset of Alzheimer’s disease (AD). As a key regulator, 24-dehydrocholesterol reductase (DHCR24) controls cellular cholestero...

    Authors: Wen-bin Zhang, Yue Huang, Xiao-rou Guo, Meng-qi Zhang, Xiang-shan Yuan and Heng-bing Zu
    Citation: Acta Neuropathologica Communications 2023 11:102
  38. Alcohol dependence is characterized by a gradual reduction in cognitive control and inflexibility to contingency changes. The neuroadaptations underlying this aberrant behavior are poorly understood. Using an ...

    Authors: Laura Pérez-Cervera, Silvia De Santis, Encarni Marcos, Zahra Ghorbanzad-Ghaziany, Alejandro Trouvé-Carpena, Mohamed Kotb Selim, Úrsula Pérez-Ramírez, Simone Pfarr, Patrick Bach, Patrick Halli, Falk Kiefer, David Moratal, Peter Kirsch, Wolfgang H. Sommer and Santiago Canals
    Citation: Acta Neuropathologica Communications 2023 11:101
  39. Multiple sclerosis (MS) pathophysiology includes inflammation, demyelination and neurodegeneration, but the exact mechanisms of disease initiation and progression are unknown. A major feature of lesions is lac...

    Authors: Wendy Oost, Allard J. Huitema, Kim Kats, Ben N. G. Giepmans, Susanne M. Kooistra, Bart J. L. Eggen and Wia Baron
    Citation: Acta Neuropathologica Communications 2023 11:100
  40. Apolipoprotein (APOE) E4 isoform is a major risk factor of Alzheimer’s disease and contributes to metabolic and neuropathological abnormalities during brain aging. To provide insights into whether APOE4 genoty...

    Authors: Tristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, Karen McFarland, Alejandra Jolie Ruiz, Gabriela P. Hery, Patrick Sullivan, David R. Borchelt, Stefan Prokop and Paramita Chakrabarty
    Citation: Acta Neuropathologica Communications 2023 11:99
  41. X-linked adrenoleukodystrophy (X-ALD), the most frequent, inherited peroxisomal disease, is caused by mutations in the ABCD1 gene encoding a peroxisomal lipid transporter importing very long-chain fatty acids (VL...

    Authors: Ksenija Martinović, Jan Bauer, Markus Kunze, Johannes Berger and Sonja Forss-Petter
    Citation: Acta Neuropathologica Communications 2023 11:98
  42. Tau deposits in astrocytes are frequently found in Alzheimer’s disease (AD) and other tauopathies. Since astrocytes do not express tau, the inclusions have been suggested to be of neuronal origin. However, the...

    Authors: Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Martin Ingelsson, Jinar Rostami, Maria Lindskog and Anna Erlandsson
    Citation: Acta Neuropathologica Communications 2023 11:97
  43. Pediatric high-grade gliomas (pHGG) are brain tumors occurring in children and adolescents associated with a dismal prognosis despite existing treatments. Therapeutic failure in both adult and pHGG has been pa...

    Authors: Marc-Antoine Da-Veiga, Natacha Coppieters, Arnaud Lombard, Bernard Rogister, Virginie Neirinckx and Caroline Piette
    Citation: Acta Neuropathologica Communications 2023 11:96
  44. Mesenchymal tumors of the central nervous system (CNS) include numerous entities, with different pathological features and biological behavior. Mesenchymal non-meningothelial tumors are rare and comprise neopl...

    Authors: Antonio d’Amati, Francesca Gianno, Luciana Scuccimarri, Michele Lastilla, Raffaella Messina, Francesco Signorelli, Domenico Sergio Zimatore, Sabina Barresi, Evelina Miele, Rita Alaggio, Sabrina Rossi, Eugenio Maiorano, Giuseppe Ingravallo, Felice Giangaspero and Manila Antonelli
    Citation: Acta Neuropathologica Communications 2023 11:95
  45. Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically involved in cognitive pro...

    Authors: Vismitha Rajeev, Yuek Ling Chai, Luting Poh, Sharmelee Selvaraji, David Y. Fann, Dong-Gyu Jo, T. Michael De Silva, Grant R. Drummond, Christopher G. Sobey, Thiruma V. Arumugam, Christopher P. Chen and Mitchell K. P. Lai
    Citation: Acta Neuropathologica Communications 2023 11:93
  46. Following traumatic brain injury (TBI), a neuroinflammatory response can persist for years and contribute to the development of chronic neurological manifestations. Complement plays a central role in post-TBI ...

    Authors: Amer Toutonji, Carsten Krieg, Davis M. Borucki, Mamatha Mandava, Silvia Guglietta and Stephen Tomlinson
    Citation: Acta Neuropathologica Communications 2023 11:92
  47. X-linked spinal and bulbar muscular atrophy (SBMA; Kennedy's disease) is a rare neuromuscular disorder characterized by adult-onset proximal muscle weakness and lower motor neuron degeneration. SBMA was the fi...

    Authors: Anastasia Gromova, Byeonggu Cha, Erica M. Robinson, Laura M. Strickland, Nhat Nguyen, Mai K. ElMallah, Constanza J. Cortes and Albert R. La Spada
    Citation: Acta Neuropathologica Communications 2023 11:90

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