Amorini AM, Nociti V, Petzold A, Gasperini C, Quartuccio E, Lazzarino G, et al. Serum lactate as a novel potential biomarker in multiple sclerosis. Biochim Biophys Acta (BBA) - Mol Basis Dis. 2014;1842:1137–43.
Article
CAS
Google Scholar
Baynes JW, Dominiczak MH. Medical biochemistry. Philadelphia: Mosby elsevier; 2009.
Becher B, Giacomini PS, Pelletier D, McCrea E, Prat A, Antel JP. Interferon-gamma secretion by peripheral blood T-cell subsets in multiple sclerosis: correlation with disease phase and interferon-beta therapy. Ann Neurol. 1999;45:247–50.
Article
CAS
PubMed
Google Scholar
Bélanger M, Allaman I, Magistretti PJ. Differential effects of pro- and anti-inflammatory cytokines alone or in combinations on the metabolic profile of astrocytes. J Neurochem. 2011;116:564–76.
Article
PubMed
Google Scholar
Bigl M, Bruckner MK, Arendt T, Bigl V, Eschrich K. Activities of key glycolytic enzymes in the brains of patients with Alzheimer’s disease. J Neural Transm. 1999;106:499–511.
Article
CAS
PubMed
Google Scholar
Bitsch A, Kuhlmann T, Da CC, Bunkowski S, Polak T, Bruck W. Tumour necrosis factor alpha mRNA expression in early multiple sclerosis lesions: correlation with demyelinating activity and oligodendrocyte pathology. Glia. 2000;29:366–75.
Article
CAS
PubMed
Google Scholar
Brooks WM, Lynch PJ, Ingle CC, Hatton A, Emson PC, Faull RLM, et al. Gene expression profiles of metabolic enzyme transcripts in Alzheimer’s disease. Brain Res. 2007;1127:127–35.
Article
CAS
PubMed
Google Scholar
Campbell GR, Ziabreva I, Reeve AK, Krishnan KJ, Reynolds R, Howell O, et al. Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis. Ann Neurol. 2010;69.
Chieco P, Jonker A, De Boer BA, Ruijter JM, Van Noorden CJF. Image Cytometry: Protocols for 2D and 3D Quantification in Microscopic Images. Prog Histochem Cytochem. 2013;47:211–333.
Article
PubMed
Google Scholar
Chinopoulos C. Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex. J Neurosci Res. 2013;91:1030–43.
Article
CAS
PubMed
Google Scholar
Cunnane S, Nugent S, Roy M, Courchesne-Loyer A, Croteau E, Tremblay S, et al. Brain fuel metabolism, aging, and Alzheimers disease. Nutrition. 2011;27:3–20.
Article
PubMed Central
CAS
PubMed
Google Scholar
Durrenberger P, Fernando F, Magliozzi R, Kashefi S, Bonnert T, Ferrer I, et al. Selection of novel reference genes for use in the human central nervous system: a BrainNet Europe Study. Acta Neuropathol. 2012;124:893–903.
Article
PubMed
Google Scholar
Dutta R, Trapp BD. Pathogenesis of axonal and neuronal damage in multiple sclerosis. Neurology. 2007;68:S22–31.
Article
PubMed
Google Scholar
Fischer MT, Sharma R, Lim JL, Haider L, Frischer JM, Drexhage J, et al. NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain. 2012;135:886–99.
Article
PubMed Central
PubMed
Google Scholar
Frohman EM, Racke MK, Raine CS. Multiple sclerosis--the plaque and its pathogenesis. N Engl J Med. 2006;354:942–55.
Article
CAS
PubMed
Google Scholar
Funfschilling U, Supplie LM, Mahad D, Boretius S, Saab AS, Edgar J, et al. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature. 2012;485:517–21.
PubMed Central
PubMed
Google Scholar
Gibson GE, Park LCH, Sheu KFR, Blass JP, Calingasan NY. The alpha-ketoglutarate dehydrogenase complex in neurodegeneration. Neurochem Int. 2000;36:97–112.
Article
CAS
PubMed
Google Scholar
Gibson G, Blass J, Beal MF, Bunik V. The alpha-ketoglutarate-dehydrogenase complex. Mol Neurobiol. 2005;31:43–63.
Article
CAS
PubMed
Google Scholar
Gietl C. Malate dehydrogenase isoenzymes: cellular locations and role in the flow of metabolites between the cytoplasm and cell organelles. Biochim Biophys Acta. 1992;1100:217–34.
Article
CAS
PubMed
Google Scholar
Gouarne C, Gl T, Tracz J, Latyszenok V, Michaud M, Clemens LE, et al. Early Deficits in Glycolysis Are Specific to Striatal Neurons from a Rat Model of Huntington Disease. PLoS One. 2013;8, e81528.
Article
PubMed Central
PubMed
Google Scholar
Kiss G, Konrad C, Doczi J, Starkov AA, Kawamata H, Manfredi G, et al. The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation. FASEB J. 2013;27:2392–406.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lee Y, Morrison BM, Li Y, Lengacher S, Farah MH, Hoffman PN, et al. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature. 2012;487:443–8.
Article
PubMed Central
CAS
PubMed
Google Scholar
Li Q, Lau A, Morris TJ, Guo L, Fordyce CB, Stanley EF. A Syntaxin 1, Galpha-o, and N-Type Calcium Channel Complex at a Presynaptic Nerve Terminal: Analysis by Quantitative Immunocolocalization. J Neurosci. 2004;24:4070–81.
Article
CAS
PubMed
Google Scholar
Mahad DJ, Ziabreva I, Campbell G, Lax N, White K, Hanson PS, et al. Mitochondrial changes within axons in multiple sclerosis. Brain. 2009;132:1161–74.
Article
PubMed Central
PubMed
Google Scholar
Mahad DH, Trapp BD, Lassmann H. Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol. 2015;14:183–93.
Article
CAS
PubMed
Google Scholar
Markert CL, Shaklee JB, Whitt GS. Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation. Science. 1975;189:102–14.
Article
CAS
PubMed
Google Scholar
McLain AL, Szweda PA, Szweda LI. alpha-Ketoglutarate dehydrogenase: A mitochondrial redox sensor. Free Radic Res. 2010;45:29–36.
Article
PubMed Central
PubMed
Google Scholar
Molenaar RJ, Botman D, Smits MA, Hira VV, van Lith SA, Stap J et al.(2015). Radioprotection of IDH1-mutated cancer cells by the IDH1-mutant inhibitor AGI-5198. Cancer Res. 2015;75;4790–802
Nijland PG, Michailidou I, Witte ME, Mizee MR, van der Pol SMA, van het Hof B, et al. Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions. Glia. 2014;62:1125–41.
Article
PubMed
Google Scholar
Nikic I, Merkler D, Sorbara C, Brinkoetter M, Kreutzfeldt M, Bareyre FM, et al. A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med. 2011;17:495–9.
Article
CAS
PubMed
Google Scholar
O’Neill LAJ, Hardie DG. Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature. 2013;493:346–55.
Article
PubMed
Google Scholar
Patel KP, O’Brien TW, Subramony SH, Shuster J, Stacpoole PW. The spectrum of pyruvate dehydrogenase complex deficiency: Clinical, biochemical and genetic features in 371 patients. Mol Genet Metab. 2012;105:34–43.
Article
PubMed Central
CAS
PubMed
Google Scholar
Patel MS, Roche TE. Molecular biology and biochemistry of pyruvate dehydrogenase complexes. FASEB J. 1990;4:3224–33.
CAS
PubMed
Google Scholar
Pellerin L, Magistretti PJ. Sweet sixteen for ANLS. J Cereb Blood Flow Metab. 2012;32:1152–66.
Article
PubMed Central
CAS
PubMed
Google Scholar
Petzold A, Nijland PG, Balk LJ, Amorini AM, Lazzarino G, Wattjes MP, et al. Visual pathway neurodegeneration winged by mitochondrial dysfunction. Ann Clin Transl Neurol. 2015;2:140–50.
Article
PubMed Central
PubMed
Google Scholar
Pierre K, Pellerin L. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem. 2005;94:1–14.
Article
CAS
PubMed
Google Scholar
Rex Sheu KF, Kim YT, Blass JP, Weksler ME. An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer’s disease brain. Ann Neurol. 1985;17:444–9.
Article
Google Scholar
Rodriguez-Rodriguez P, Fernandez E, Almeida A, Bolanos JP. Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration. Cell Death Differ. 2012;19:1582–9.
Article
PubMed Central
CAS
PubMed
Google Scholar
Schiepers C, Van Hecke P, Vandenberghe R, Van Oostende S, Dupont P, Demaerel P, et al. Positron emission tomography, magnetic resonance imaging and proton NMR spectroscopy of white matter in multiple sclerosis. Mult Scler. 1997;3:8–17.
Article
CAS
PubMed
Google Scholar
Schocke MFH, Berger T, Felber SR, Wolf C, Deisenhammer F, Kremser C, et al. Serial contrast-enhanced magnetic resonance imaging and spectroscopic imaging of acute multiple sclerosis lesions under high-dose methylprednisolone therapy. Neuroimage. 2003;20:1253–63.
Article
PubMed
Google Scholar
Simone IL, Tortorella C, Federico F, Liguori M, Lucivero V, Giannini P, et al. Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study. J Neurol Sci. 2001;182(2):143–50.
Article
CAS
PubMed
Google Scholar
Trapp BD, Stys PK. Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis. Lancet Neurol. 2009;8:280–91.
Article
CAS
PubMed
Google Scholar
Trofimova LK, Araujo WL, Strokina AA, Fernie AR, Bettendorff L, Bunik VI. Consequences of the alpha-ketoglutarate dehydrogenase inhibition for neuronal metabolism and survival: implications for neurodegenerative diseases. Curr Med Chem. 2012;19:5895–906.
Article
CAS
PubMed
Google Scholar
Wang J, Li G, Wang Z, Zhang X, Yao L, Wang F, et al. High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes. Neuroscience. 2012;202:58–68.
Article
CAS
PubMed
Google Scholar
Warburg O. On the Origin of Cancer Cells. Science. 1956;123:309–14.
Article
CAS
PubMed
Google Scholar
Witte ME, Bo L, Rodenburg RJ, Belien JA, Musters R, Hazes T, et al. Enhanced number and activity of mitochondria in multiple sclerosis lesions. J Pathol. 2009;219:193–204.
Article
PubMed
Google Scholar
Witte ME, Mahad DJ, Lassmann H, van Horssen J. Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis. Trends Mol Med. 2014;20:179–87.
Article
PubMed
Google Scholar
Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R, et al. Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med. 2011;208:313–26.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, et al. PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis. Cell. 2012;150:685–96.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zaaraoui W, Rico A, Audoin B, Reuter F, Malikova I, Soulier E, et al. Unfolding the long-term pathophysiological processes following an acute inflammatory demyelinating lesion of multiple sclerosis. Magn Reson Imaging. 2010;28(4):477–86.
Article
CAS
PubMed
Google Scholar