Fig. 4
From: Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions
PDH, αKGDH and MDH expression in MS lesions. PDH (a, b), αKGDH (d,e) and MDH (g,h) expression was increased in active MS lesions as compared to NAWM. Insets show that GFAP-positive astrocytes (red) colocalize with respectively PDH (b), αKGDH (e) and MDH (i, green). PDH (c) and αKGDH (f) expression was relatively low in inactive MS lesions, whereas MDH (i) expression was increased as compared to NAWM. The staining intensity of PDH, αKGDH, and MDH was significantly reduced in inactive lesions and the inactive center of chronic active lesions as compared to active lesions and the active rim of chronic active lesions (j). PDH, αKGDH, and MDH immunoreactivity correlates with disease duration (k). -- = strongly reduced immunoreactivity as compared to NAWM; − = reduced immunoreactivity as compared to NAWM; +/− = similar immunoreactivity as compared to NAWM, + = increased immunoreactivity as compared to NAWM, ++ = strongly increased immunoreactivity as compared to NAWM. *P < 0.05, ***P < 0.001