Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG: Multiple sclerosis. N Engl J Med 2000, 343: 938–952. 10.1056/NEJM200009283431307
Article
CAS
PubMed
Google Scholar
Compston A, Coles A: Multiple sclerosis. Lancet 2008, 372: 1502–1517. 10.1016/S0140-6736(08)61620-7
Article
CAS
PubMed
Google Scholar
Weber MS, Hemmer B, Cepok S: The role of antibodies in multiple sclerosis. Biochim Biophys Acta 2011, 1812: 239–245. 10.1016/j.bbadis.2010.06.009
Article
CAS
PubMed
Google Scholar
Reindl M, Linington C, Brehm U, Egg R, Dilitz E, Deisenhammer F, Poewe W, Berger T: Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study. Brain 1999, 122: 2047–2056. 10.1093/brain/122.11.2047
Article
PubMed
Google Scholar
Storch MK, Piddlesden S, Haltia M, Ilivanainen M, Morgan P, Lassmann H: Multiple sclerosis: in situ evidence for antibody- and complement-mediated demyelination. Ann Neurol 1998, 43: 465–471. 10.1002/ana.410430409
Article
CAS
PubMed
Google Scholar
Stangel M, Fredrikson S, Meinl E, Petzold A, Stüve O, Tumani H: The utility of cerebrospinal fluid analysis in patients with multiple sclerosis. Nat Rev Neurol 2013, 9: 267–276. 10.1038/nrneurol.2013.41
Article
CAS
PubMed
Google Scholar
Krumbholz M, Derfuss T, Hohlfeld R, Meinl E: B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat Rev Neurol 2012, 8: 613–623. 10.1038/nrneurol.2012.203
Article
CAS
PubMed
Google Scholar
Lucchinetti C, Brueck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H: Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000, 47: 707–717. 10.1002/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q
Article
CAS
PubMed
Google Scholar
Cortese I, Chaudhry V, So YT, Cantor F, Cornblath DR, Rae-Grant A: Evidence-based guideline update: Plasmapheresis in neurologic disorders: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2011, 3: 294–300. 10.1212/WNL.0b013e318207b1f6
Article
Google Scholar
Srivastava R, Aslam M, Kalluri SR, Schirmer L, Buck D, Tackenberg B, Rothhammer V, Chan A, Gold R, Berthele A, Bennett JL, Korn T, Hemmer B: Potassium channel KIR4.1 as an immune target in multiple sclerosis. N Engl J Med 2012, 367: 115–123. 10.1056/NEJMoa1110740
Article
CAS
PubMed
Google Scholar
Pierson ER, Stromnes IM, Goverman JM: B cells promote induction of experimental autoimmune encephalomyelitis by facilitating reactivation of T cells in the central nervous system. J Immunol 2014, 3: 929–939. 10.4049/jimmunol.1302171
Article
Google Scholar
Hauser SL, Waubant E, Arnold DL: B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med 2008, 358: 676–688. 10.1056/NEJMoa0706383
Article
CAS
PubMed
Google Scholar
Freedman MS, Kaplan JM, Markovic-Plese S: Insights into the mechanisms of the therapeutic efficacy of alemtuzumab in multiple sclerosis. J Clin Cell Immunol 2013, 4: 1000152. 10.4172/2155-9899.1000152
Article
PubMed
PubMed Central
Google Scholar
Sorensen PS, Lisby S, Grove R, Derosier F, Shackelford S, Havrdova E, Drulovic J, Filippi M: Safety and efficacy of ofatumumab in relapsing-remitting multiple sclerosis: a phase 2 study. Neurology 2014, 82: 573–581. 10.1212/WNL.0000000000000125
Article
CAS
PubMed
Google Scholar
Kuerten S, Pommerschein G, Barth SK, Hohmann C, Milles B, Sammer FW, Duffy CE, Wunsch M, Rovituso DM, Schroeter M, Addicks K, Kaiser CC, Lehmann PV: Identification of a B cell-dependent subpopulation of multiple sclerosis by measurements of brain-reactive B cells in the blood. Clin Immunol 2014, 152: 20–24. 10.1016/j.clim.2014.02.014
Article
CAS
PubMed
Google Scholar
Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O’Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B, Wolinsky JS: Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011, 69: 292–302. 10.1002/ana.22366
Article
PubMed
PubMed Central
Google Scholar
Kurtzke JF: Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983, 33: 1444–1452. 10.1212/WNL.33.11.1444
Article
CAS
PubMed
Google Scholar
MSBase Foundation Ltd. The MS Severity Rank Calculator MS Curves. Accessed March 29, 2014, 2:25 p.m., at , [http://www.msbase.org]
Pinna D, Corti D, Jarrossay D, Sallusto F, Lanzavecchia A: Clonal dissection of the human memory B-cell repertoire following infection and vaccination. Eur J Immunol 2009, 39: 1260–1270. 10.1002/eji.200839129
Article
CAS
PubMed
Google Scholar
Lill-Elghanian D, Schwartz K, King L, Fraker P: Glucocorticoid-induced apoptosis in early B cells from human bone marrow. Exp Biol Med (Maywood) 2002, 227: 763–770.
CAS
Google Scholar
Meinl E, Krumbholz M, Hohlfeld R: B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation. Ann Neurol 2006, 59: 880–892. 10.1002/ana.20890
Article
CAS
PubMed
Google Scholar
Qin Y, Duquette P, Zhang Y, Talbot P, Poole R, Antel J: Clonal expansion and somatic hypermutation of V (H) genes of B cells from cerebrospinal fluid in multiple sclerosis. J Clin Invest 1998, 102: 1045–1050. 10.1172/JCI3568
Article
CAS
PubMed
PubMed Central
Google Scholar
Genain CP, Cannella B, Hauser SL, Raine CS: Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 1999, 5: 170–175. 10.1038/5532
Article
CAS
PubMed
Google Scholar
Reindl M, Khalil M, Berger T: Antibodies as biological markers for pathophysiological processes in MS. J Neuroimmunol 2006, 180: 50–62. 10.1016/j.jneuroim.2006.06.028
Article
CAS
PubMed
Google Scholar
Karni A, Bakimer-Kleiner R, Abramsky O, Ben-Nun A: Elevated levels of antibody to myelin oligodendrocyte glycoprotein is not specific for patients with multiple sclerosis. Arch Neurol 1999, 56: 311–315. 10.1001/archneur.56.3.311
Article
CAS
PubMed
Google Scholar
Keegan M, Konig F, McClelland R, Brück W, Morales Y, Bitsch A, Panitch H, Lassmann H, Weinshenker B, Rodriguez M, Parisi J, Lucchinetti CF: Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange. Lancet 2005, 366: 579–582. 10.1016/S0140-6736(05)67102-4
Article
PubMed
Google Scholar
Berger T, Rubner P, Schautzer F, Egg R, Ulmer H, Mayringer I, Dilitz E, Deisenhammer F, Reindl M: Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. N Engl J Med 2003, 349: 139–145. 10.1056/NEJMoa022328
Article
CAS
PubMed
Google Scholar
Kuhle J, Pohl C, Mehling M, Edan G, Freedman MS, Hartung HP, Polman CH, Miller DH, Montalban X, Barkhof F, Bauer L, Dahms S, Lindberg R, Kappos L, Sandbrink R: Lack of association between antimyelin antibodies and progression to multiple sclerosis. N Engl J Med 2007, 356: 371–378. 10.1056/NEJMoa063602
Article
CAS
PubMed
Google Scholar
Sun J, Link H, Olsson T, Xiao BG, Andersson G, Ekre HP, Linington C, Diener P: T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J Immunol 1991, 146: 1490–1495.
CAS
PubMed
Google Scholar
Sun JB, Olsson T, Wang WZ, Xiao BG, Kostulas V, Fredrikson S, Ekre HP, Link H: Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur J Immunol 1991, 21: 1461–1468. 10.1002/eji.1830210620
Article
CAS
PubMed
Google Scholar