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Table 2 Distribution of B cell response patterns in patients experiencing an acute MS relapse *

From: Categorization of multiple sclerosis relapse subtypes by B cell profiling in the blood

Variable Pattern I Pattern II Pattern III
No. of patients 9 6 15
Age – yrs    
  Mean 27.9 ± 7.4 41.8 ± 13.7 42.4 ± 12.4
  Range 18-42 22-59 18-61
Female sex – no. (%) 9 (100) 5 (83.3) 10 (66.7)
EDSS in remission    
  Mean 3.1 ± 1.1 3.5 ± 1.7 3.5 ± 2.0
  Range 1.5-5.0 2.0-5.5 1.0-7.0
MS severity    
  Mean 73.9 ± 16.0 81.8 ± 10.1 71.4 ± 20.2
  Range 51-91 72-93 37-94
RRMS/SPMS 8/1 4/2 12/3
  1. EDSS = Expanded Disability Status Scale; RRMS = relapsing-remitting MS; SPMS = secondary progressive MS; SD = standard deviation.
  2. *Plus-minus values are means ± SD.
  3. Scores on the EDSS range from 0 to 10, with higher scores indicating a greater degree of disability.
  4. One patient was lost to follow-up.
  5. MS severity refers to the percentile rank of each individual study patient compared to a matched MS cohort of the MSBase Registry. Values were determined using MS Curves[18].