Categorization of multiple sclerosis relapse subtypes by B cell profiling in the blood

Table 2 Distribution of B cell response patterns in patients experiencing an acute MS relapse ^*

Variable	Pattern I	Pattern II	Pattern III
No. of patients	9	6	15
Age – yrs
Mean	27.9 ± 7.4	41.8 ± 13.7	42.4 ± 12.4
Range	18-42	22-59	18-61
Female sex – no. (%)	9 (100)	5 (83.3)	10 (66.7)
EDSS in remission^†
Mean	3.1 ± 1.1	3.5 ± 1.7^‡	3.5 ± 2.0^‡
Range	1.5-5.0	2.0-5.5	1.0-7.0
MS severity^¶
Mean	73.9 ± 16.0	81.8 ± 10.1^‡	71.4 ± 20.2^‡
Range	51-91	72-93	37-94
RRMS/SPMS	8/1	4/2	12/3

EDSS = Expanded Disability Status Scale; RRMS = relapsing-remitting MS; SPMS = secondary progressive MS; SD = standard deviation.
^*Plus-minus values are means ± SD.
^†Scores on the EDSS range from 0 to 10, with higher scores indicating a greater degree of disability.
^‡One patient was lost to follow-up.
^¶MS severity refers to the percentile rank of each individual study patient compared to a matched MS cohort of the MSBase Registry. Values were determined using MS Curves[18].

ISSN: 2051-5960