Figure 3
From: Categorization of multiple sclerosis relapse subtypes by B cell profiling in the blood
ELISPOT results of a patient showing a conversion from pattern III to pattern I. Panel A shows the number of B cell spots measured in ELISPOT assays directly ex vivo and after 96 h of polyclonal stimulation in an individual patient on six consecutive time points. The severity of clinical disease is represented by the EDSS score that is referred to by the line graph. Representative well images of four different time points are shown in Panel B depicting the development of a brain antigen-specific B cell response in the course of the disease.