Figure 2
From: Categorization of multiple sclerosis relapse subtypes by B cell profiling in the blood
Representative ELISPOT wells of the three different CNS antigen-specific B cell response patterns. Pattern I: positive brain antigen-specific B cell response directly ex vivo and after polyclonal stimulation during relapse, persisting memory B cell response in remission. Pattern II: positive brain antigen-specific B cell response only after polyclonal stimulation both in relapse and remission. Pattern III: absence of brain antigen-specific B cell responses at any time point. Images and pattern classifications are representative for a study cohort of 30 patients.