Blümke I: History of Neuroscience:Alois Alzheimer's First Report on Cortical Neurodegeneration. IBRO History of Neuroscience Accessed: 11 Oct 2013 at http://www.ibro.info/Pub/Pub_Main_Display.asp?LC_Docs_ID=3531
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Diseases. Neurology 1984, 34: 939–944. 10.1212/WNL.34.7.939
Article
CAS
PubMed
Google Scholar
Beach TG, Monsell SE, Phillips LE, Kukull W: Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010. J Neuropathol Exp Neurol 2012, 71: 266–273. 10.1097/NEN.0b013e31824b211b
Article
PubMed
PubMed Central
Google Scholar
Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Peteresen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH: The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011, 7: 270–279. 10.1016/j.jalz.2011.03.008
Article
PubMed
PubMed Central
Google Scholar
Jack CR Jr, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, Thies B, Phelps CH: Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011, 7: 257–262. 10.1016/j.jalz.2011.03.004
Article
PubMed
PubMed Central
Google Scholar
McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011, 7: 263–269. 10.1016/j.jalz.2011.03.005
Article
PubMed
PubMed Central
Google Scholar
Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR Jr, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH: Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011, 7: 280–292. 10.1016/j.jalz.2011.03.003
Article
PubMed
PubMed Central
Google Scholar
Penn RD, Basati S, Sweetman B, Guo X, Linninger A: Ventricle wall movements and cerebrospinal fluid flow in hydrocephalus. J Neurosurg 2011, 115: 159–164. 10.3171/2010.12.JNS10926
Article
PubMed
Google Scholar
Albrechtsen M, Sørensen PS, Gjerris F, Bock E: High cerebrospinal fluid concentration of glial fibrillary acidic protein (GFAP) in patients with normal pressure hydrocephalus. J Neurol Sci 1985, 70: 269–274. 10.1016/0022-510X(85)90168-6
Article
CAS
PubMed
Google Scholar
Gjerris A, Werdelin L, Gjerris F, Sørensen PS, Rafaelson OJ, Alling C: CSF-amine metabolites in depression, dementia and controls. Acta Psychiatr Scand 1987, 75: 619–628. 10.1111/j.1600-0447.1987.tb02846.x
Article
CAS
PubMed
Google Scholar
Jeppsson A, Zetterberg H, Blennow K, Wikkelsø C: Idiopathic normal-pressure hydrocephalus: pathophysiology and diagnosis by CSF biomarkers. Neurology 2013, 80: 1385–1392. 10.1212/WNL.0b013e31828c2fda
Article
CAS
PubMed
Google Scholar
Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka SK: CSF biomarkers for Alzheimer’s disease correlate with cortical brain biopsy findings. Neurology 2012, 78: 1568–1575. 10.1212/WNL.0b013e3182563bd0
Article
PubMed
Google Scholar
Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT, Jones BW, Fernandez SJ, Lacor PN, Horowitz P, Finch CE, Krafft GA, Klein WL: Self-assembly of Abeta(1–42) into globular neurotoxins. Biochemistry 2003, 42: 12749–12760. 10.1021/bi030029q
Article
CAS
PubMed
Google Scholar
Herskovits AZ, Locascio JJ, Peskind ER, Li G, Hyman BT: A Luminex assay detects amyloid β oligomers in Alzheimer’s disease cerebrospinal fluid. PLoS One 2013, 8: e67898. 10.1371/journal.pone.0067898
Article
CAS
PubMed
PubMed Central
Google Scholar
Andrén K, Wikkelsø C, Tisell M, Hellström P: Natural course of idiopathic normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry 2013. Doi:10.1136/jnnp-2013–306117
Google Scholar
Koivisto AM, Alafuzoff I, Savolainen S, Sutela A, Rummukainen J, Kurki MI, Jääskeläinen JE, Soininen H, Rinne J, Leinonen V: Subsequent dementia in shunt responsive idiopathic normal pressure hydrocephalus. Neurosurgery 2013, 72: 1–8.
Article
PubMed
Google Scholar
Golomb J, Wisoff J, Miller DC, Boksay I, Kluger A, Weiner H, Salton J, Graves W: Alzheimer’s disease comorbidity in normal pressure hydrocephauls: prevalence and shunt response. J Neurol Neurosurg Psychiatry 2000, 68: 778–781. 10.1136/jnnp.68.6.778
Article
CAS
PubMed
PubMed Central
Google Scholar
Hamilton R, Patel S, Lee EB, Jackson EM, Lopinto J, Arnold SE, Clark CM, Basil A, Shaw LM, Xie SX, Grady MS, Trojanowski JQ: Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology. Ann Neurol 2010, 68: 535–540. 10.1002/ana.22015
Article
PubMed
PubMed Central
Google Scholar
Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Tamminen JN, Tillgren T, Vainikka S, Pyykkö OT, Mölsä J, Fraunberg M, Pirttilä T, Jääskeläinen JE, Soininen H, Rinne J, Alafuzoff I: Amyloid and tau proteins in cortical brain biopsy and Alzheimer’s disease. Ann Neurol 2010, 68: 446–453. 10.1002/ana.22100
Article
CAS
PubMed
Google Scholar
Wolk DA, Grachev ID, Buckley C, Kazi H, Grady MS, Trojanowski JQ, Hamilton RH, Sherwin P, McLain R, Arnold SE: Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology. Arch Neurol 2011, 68: 1398–1403. 10.1001/archneurol.2011.153
Article
PubMed
PubMed Central
Google Scholar
Mathis CA, Mason NS, Lopresti BJ, Klunk WE: Development of positron emission tompography B-amyloid plaque imaging agents. Semin Nucl Med 2012, 42: 423–432. 10.1053/j.semnuclmed.2012.07.001
Article
PubMed
PubMed Central
Google Scholar
Ikonomovic MD, Klunk WE, Abrahamson EE, Mathis CA, Price JC, Tsopelas ND, Lopresti BJ, Ziolko S, Bi W, Paljug WR, Debnath ML, Hope CE, Isanski BA, Hamilton RL, DeKosky ST: Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer’s disease. Brain 2008, 131: 1630–1645. 10.1093/brain/awn016
Article
PubMed
PubMed Central
Google Scholar
Klunk WE: Biopsy support for the validity of Pittsburgh compound B positron emission tomography with a twist. Arch Neurol 2008, 65: 1281–1283.
Article
PubMed
PubMed Central
Google Scholar
Leinonen V, Alafuzoff I, Aalto S, Suotunen T, Savolainen S, Någren K, Tapiola T, Pirttilä T, Rinne J, Jääskeläinen JE, Soininen H, Rinne JO: Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with 11-labeled Pittsburgh Compund B. Arch Neurol 2008, 65: 1304–1309. 10.1001/archneur.65.10.noc80013
Article
PubMed
Google Scholar
Vizamyl [package insert]. Arlington Heights, IL: GE Healthcare; 2013. http://www3.gehealthcare.com/en/Products/Categories/~/media/Downloads/us/Product/Product-Categories/Nuclear-Imaging-Agents_Non-Gatekeeper/Vizamyl/GEHealthcare-Vizamyl-Prescribing-Information.pdf
Amyvid [package insert]. Indianapolis, IN: Eli Lilly and Company; 2012. http://pi.lilly.com/us/amyvid-uspi.pdf
Ni R, Gillberg P, Bergfors A, Marutle A, Nordberg A: Amyloid tracers detect multiple binding sites in Alzheimer’s disease brain tissue. Brain 2013, 136: 2217–2227. 10.1093/brain/awt142
Article
PubMed
Google Scholar
Nelisson N, Van Laere K, Thurfjell L, Owenius R, Vandenbulcke M, Koole M, Guy B, Brooks DJ, Vandenberghe R: Phase 1 study of the Pittsburgh Compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease. J Nucl Med 2009, 50: 1251–1259. 10.2967/jnumed.109.063305
Article
Google Scholar
Wong DF, Moghekar AR, Rigamonti D, Brašić JR, Rousset O, Willis W, Buckley C, Smith A, Gok B, Sherwin P, Grachev ID: An in vivo evaluation of cerebral cortical amyloid with [18F]flutemetamol using positron emission tomography compared with parietal biopsy samples in living normal pressure hydrocephalus patients. Mol Imaging Biol 2013, 15: 230–237. 10.1007/s11307-012-0583-x
Article
PubMed
PubMed Central
Google Scholar
Leinonen V, Rinne JO, Virtanen KA, Eskola O, Rummukainen J, Huttenen J, Von und zu Fraunberg M, Nerg O, Koivisto AM, Rinne J, Jääskeläinen JE, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McClain R, Kailajärvi M, Heurling K, Grachev ID: Positron emission tomography with [18F]flutemetamol and [11 C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients. Eur J Neurol 2013, 20: 1043–1052. 10.1111/ene.12102
Article
CAS
PubMed
Google Scholar
Rinne JO, Frantzen J, Leinonen V, Lonrot K, Laasko A, Virtanen KA, Solin O, Kotkansalo A, Koivisto A, Sajanti J, Karppinen A, Lehto H, Rummukainen J, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajarvi M, Grachev ID: Prospective flutemetamol PET and histopathology in normal pressure hydrocephalus. Neurodegener Dis 2013. Doi:10.1159/000355256
Google Scholar
Rinne JO, Wong DF, Wolk DA, Leinonen V, Arnold SE, Buckley C, Smith A, McLain R, Sherwin PF, Farrar G, Kailajärvi M, Grachev ID: [18F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid B detection in living subjects with normal pressure hydrochephalus: pooled analysis of four studies. Acta Neuropathol 2012, 124: 833–845. 10.1007/s00401-012-1051-z
Article
CAS
PubMed
Google Scholar
Clark CM, Schneider JA, Bedell BJ, Beach TG, Bilker WB, Minyun MA, Pontecorvo MJ, Hefti F, Carpenter AP, Flitter ML, Krautkramer MJ, Kung HF, Coleman RE, Doraiswamy PM, Fleisher A, Sabbagh MN, Sadowsky CH, Reiman EM, Zehntner SP, Skovronsky DM, for the AV45-A07 Study Group: Use of florbetapir-PET for imaging B-amyloid pathology. JAMA 2011, 305: 275–283. 10.1001/jama.2010.2008
Article
CAS
PubMed
Google Scholar
Kepe V, Moghbel MC, Långström B, Zaidi H, Vinters HV, Huang S, Satyamurthy N, Doudet D, Mishani E, Cohen RM, Høilend-Carlsen PF, Alavi A, Barrio JR: Amyloid-β positron emission tomography probes: a critical review. J Alzheimers Dis 2013, 36: 613–631.
CAS
PubMed
PubMed Central
Google Scholar
Raji CA, Becker JT, Tsopelas ND, Price JC, Mathis CA, Saxton JA, Lopresti BJ, Hoge JA, Ziolko SK, DeKosky ST, Klunk WE: Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer’s disease with Pittsburgh Compound B. J Neurosci Meth 2008, 172: 277–282. 10.1016/j.jneumeth.2008.05.005
Article
CAS
Google Scholar
Vandenberghe R, Van Laere K, Ivanoiu A, Salmon E, Bastin C, Triau E, Hasselbalch S, Law I, Andersen A, Korner A, Minthon L: 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial. Ann Neurol 2010, 68: 319–329. 10.1002/ana.22068
Article
PubMed
Google Scholar
Thal DR, Rüb U, Orantes M, Braak H: Phases of Aβ-deposition in the human brain and its relevance for the development of AD. Neurology 2002, 58: 1791–1800. 10.1212/WNL.58.12.1791
Article
PubMed
Google Scholar
Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah EM, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, Trojanowski JQ, Vinters HV, Montine TJ: National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease. Alzheimers Dement 2012, 8: 1–13. 10.1016/j.jalz.2011.10.007
Article
PubMed
PubMed Central
Google Scholar
Lopresti B, Klunk WE, Mathis CA, Hoge JA, Ziolko SK, Lu X, Meltzer CC, Schimmel K, Tsopelas ND, DeKosky ST, Price JC: Simplified quantification of Pittsburgh Compund B amyloid imaging PET studies: a comparative analysis. J Nucl Med 2005, 46: 1959–1972.
CAS
PubMed
Google Scholar
Rowe CC, Ackerman U, Browne W, Mulligan R, Pike KL, O’Keefe G, Tochon-Danguy H, Chan G, Berlangieri SU, Jones G, Dickinson-Rowe KL, Kung HP, Zhang W, Kung MP, Skovronsky D, Dyrks T, Holl G, Krause S, Friebe M, Lehman L, Lindemann S, Dinkelborg LM, Masters CL, Villemagne VL: Imaging of amyloid β in Alzheimer’s disease with 18F-BAY94–9172, a novel PET tracer: proof of mechanism. Lancet Neurol 2008, 7: 129–135. 10.1016/S1474-4422(08)70001-2
Article
CAS
PubMed
Google Scholar
Rinne JO, Brooks DJ, Rossor MN, Fox NC, Bullock R, Klunk WE, Mathis CA, Blennow K, Barakos J, Okello AA, Rodriguez Martinez de Liano S, Liu E, Koller M, Gregg KM, Schenk D, Black R, Grundman M: 11 C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer’s disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol 2010, 9: 363–372. 10.1016/S1474-4422(10)70043-0
Article
CAS
PubMed
Google Scholar
Jack CR Jr, Lowe VJ, Senjem ML, Weigand SD, Kemp BJ, Shiung MM, Knopman DS, Boeve BF, Klunk WE, Mathis CA, Petersen RC: 11C PiB and structural MRI provide complementary information in imaging of Alzheimer’s disease and amnestic mild cognitive impairment. Brain 2008, 131: 665–680. 10.1093/brain/awm336
Article
PubMed
PubMed Central
Google Scholar
Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, vogel FS, Hughes JP, van Belle G, Berg L, and participating CERAD neuropathologists: The consortium to establish a registry for Alzheimer’s diseases (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer’s disease. Neurology 1991, 41: 479–486. 10.1212/WNL.41.4.479
Article
CAS
PubMed
Google Scholar
Youden WJ: Index for rating diagnostic tests. Cancer 1950, 3: 32–35. 10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3
Article
CAS
PubMed
Google Scholar
Connell FA, Koepsell TD: Measures of gain in certainty from a diagnostic test. Am J Epidemiol 1985, 121: 744–753. 10.1093/aje/121.5.744
Article
CAS
PubMed
Google Scholar
Meyer PT, Hellwig S, Amtage F, Rottenburger C, Sahm U, Reuland P, Weber WA, Hüll M: Dual-biomarker imaging of regional cerebral amyloid load and neuronal activity in dementia with PET and 11 C-labeled Pittsburgh Compound B. J Nucl Med 2011, 52: 393–400. 10.2967/jnumed.110.083683
Article
PubMed
Google Scholar
Selkoe DJ: Alzheimer’s disease. Cold Spring Harb Perspect Biol. In Edited by: Morimoto R, Kelly J, Selkoe D, vol 3. 2011, a004457.
King A, Maekawa S, Bodi I, Troakes C, Curran O, Ashkan K, Al-Sarraj S: Simulated surgical-type cerebral biopsies from post-mortem brains allows accurate neuropathological diagnoses in the majority of neurodegenerative disease groups. Acta Neuropathol Comm 2013, 1: 53. 10.1186/2051-5960-1-53
Article
Google Scholar
Thal DR, Sassin I, Schultz C, Haass C, Braak E, Braak H: Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta. J Neuropathol Exp Neurol 1999, 58: 210–216. 10.1097/00005072-199902000-00010
Article
CAS
PubMed
Google Scholar
Spillantini MG, Goedert M, Jakes R, Klug A: Topographical relationship between β-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer’s disease. Proc Natl Acad Sci U S A 1990, 87: 3952–3956. 10.1073/pnas.87.10.3952
Article
CAS
PubMed
PubMed Central
Google Scholar
Thal DR, Rüb U, Schultz C, Sassin I, Ghebremedhin E, Del Tredici K, Braak E, Braak H: Sequence of Aβ-protein deposition in the human medial temporal lobe. J Neuropath Exp Neurol 2000, 59: 733–748.
Article
CAS
PubMed
Google Scholar
Uchihara T: Silver diagnosis in neuropathology: principles, practice, and revised interpretation. Acta Neuropathol 2007, 113: 483–499. 10.1007/s00401-007-0200-2
Article
PubMed
PubMed Central
Google Scholar
Spillantini MG, Goedert M, Jakes R, Klug A: Different configurational states of β-amyloid and their distributions relative to plaques and tangles in Alzheimer’s disease. Proc Natl Acad Sci U S A 1990, 87: 3947–3951. 10.1073/pnas.87.10.3947
Article
CAS
PubMed
PubMed Central
Google Scholar
Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ: Amyloid β-protein dimers isolated directly from Alzheimer brains impair synaptic platicity and memory. Nat Med 2008, 14: 837–842. 10.1038/nm1782
Article
CAS
PubMed
PubMed Central
Google Scholar
Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL: Oligomeric amyloid B associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci U S A 2009, 106: 4012–4017. 10.1073/pnas.0811698106
Article
CAS
PubMed
PubMed Central
Google Scholar
Braak H, Braak E: Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging 1997, 18: 351–357. 10.1016/S0197-4580(97)00056-0
Article
CAS
PubMed
Google Scholar
Vandenberghe R, Adamczuk K, Dupont P, Van Laere K, Chételat G: Amyloid PET in clinical practice: its place in the multidimensional space of Alzheimer’s disease. NeuroImage: Clin 2013, 2: 497–511.
Article
Google Scholar
Choi SR, Schneider JA, Bennett DA, Beach TG, Bedell BJ, Zehntner SP, Krautkramer M, Kung HF, Skovronsky DM, Hefti F, Clark CM: Correlation of amyloid PET ligand florbetapir F 18 (18 F-AV-45) binding with β-amyloid aggregation and neuritic plaque deposition in postmortem brain tissue. Alzheimer Dis Assoc Disord 2012, 26: 8–16. 10.1097/WAD.0b013e31821300bc
Article
CAS
PubMed
PubMed Central
Google Scholar
Braak H, Del Tredici K: The pathological process underlying Alzheimer’s disease in individuals under thirty. Acta Neuropathol 2011, 121: 171–181. 10.1007/s00401-010-0789-4
Article
PubMed
Google Scholar
Alafuzoff I, Pikkarainen M, Arzbereger T, Dietmar RT, Al-Sarraj S, Bell J, Bodi I, Budka H, Capetillo-Zarate E, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Parchi P, Patsouris E, Roggendorf W, Stadelmann C, Streichenberger N, Tagliavani F, Kretzchmar H: Inter-laboratory comparison of neuropathological assessments of B-amyloid protein: a study of the BrainNet Europe consortium. Acta Neuropathol 2008, 115: 533–546. 10.1007/s00401-008-0358-2
Article
CAS
PubMed
Google Scholar
Kohannim O, Hua X, Rajagopalan P, Hibar DP, Jahanshad N, Grill JD, Apostolova LG, Toga AW, Jack CR, Weiner MW, Thompson PM, for the Alzheimer Disease Neuroimaging Initiative: Multilocus genetic profiling to empower drug trials and predict brain atrophy. NeuroImage: Clin 2013, 2: 827–835.
Article
Google Scholar
Barthel H, Gertz H, Dresel S, Peters O, Bartenstein P, Buerger K, Hiemeyer F, Wittemer-Rump SM, Seibyl J, Reininger C, Sabri O: Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer’s disease and healthy controls: a multicentre phase 2 diagnostic study. Lancet Neurol 2011, 10: 424–435. 10.1016/S1474-4422(11)70077-1
Article
CAS
PubMed
Google Scholar
United States Department of Health and Human Services, Food and Drug Administration, CDER; CBER; CDRH: Draft Guidance: Enrichment Strategies for Clinical Trials to Support Approval of Human Drugs and Biological Products (dated December 2012). Accessed 15 July 2012 at http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM332181.pdf
Pyykö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka S, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V: Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus. PLoS One 2014, 9(3):e91974. doi:10.1371/journal.pone.0091974 10.1371/journal.pone.0091974
Article
Google Scholar