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Table 2 Summary of methods by study: MRI and [ 18 F]flutemetamol PET image acquisition

From: Diagnostic effectiveness of quantitative [18F]flutemetamol PET imaging for detection of fibrillar amyloid β using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus

 

Study A

Study B

Study C

Study D

Injected activity/dose of [ 18 F]flutemetamol (MBq)

Approximately 185; range, 111 to 197

Mean 200; range, 178 to 252

Mean (SD, 178 (3.4); range, 174 to 185

Mean 176; range, 169 to 184

MRI image equipment

3 T Siemens Trio whole-body scanner (Siemens, Erlangen Germany) equipped with a product 8-channel array coil

Siemens 3 T TRIO (Milwaukee, WI, USA)

1.5 T Philips MRI scanner Gyroscan Intera CV Nova Dual system (Philips Medical Systems, Best, The Netherlands)

PET imaging equipment

Allegro whole-body PET scanner (Philips, Andover, MA, USA) obtained in a single FOV

GE Advance PET scanner (GE Medical Systems, Milwaukee, WI, USA) in 3D modes with a 14.875-cm axial FOV obtained in a single FOV

ECAT EXACT HR + scanner (Siemens-CTI, Knoxville, TN, USA)

Reconstruction

Reconstructed by a 3-dimensional row-action maximum likelihood algorithm. Approximate spatial resolution was 6 mm.

Reconstructed to 35 transaxial images of 128 x 128 voxels by a back-projection algorithm using manufacturer-provided software correcting for attenuation, scatter, and dead time. Resolution was approximately 6 mm at full width at half maximum.

Not stated.

Not stated.

  1. FOV = field of view; MRI = magnetic resonance imaging; PET = positron emission tomography.
  2. Note: Information in this table was extracted from the original study publications (refer to text) and supplemented with data from the clinical trial submission documents.