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Table 6 ROC AUC, Youden index, and Optimal SUVR thresholds by SUVR type and pathology SoT for all 4 studies combined

From: Diagnostic effectiveness of quantitative [18F]flutemetamol PET imaging for detection of fibrillar amyloid β using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus

Pathology standard of truth

   

SUVR type

   

SUVR brain region

REF

ROC AUC

Maximal Youden index

SUVR cut-off criterion

4G8

   

   Ipsilateral

Cerebellum

0.8544

0.6216

>1.25

   Contralateral

Cerebellum

0.8529

0.6757

>1.24

   Composite

Cerebellum

0.7508

0.5315

>1.79

   Ipsilateral

Pons

0.7763

0.5000

>0.42

   Contralateral

Pons

0.7853

0.5468

>0.44

   Composite

Pons

0.7583

0.5205

>0.45

Bielschowsky

   

   Ipsilateral

Cerebellum

0.9769

0.8889

>1.31

   Contralateral

Cerebellum

0.9769

0.8889

>1.31

   Composite

Cerebellum

0.9815

0.9259

>1.38

   Ipsilateral

Pons

0.9699

0.8214

>0.46

   Contralateral

Pons

0.9815

0.9286

>0.48

   Composite

Pons

0.9792

0.8571

>0.48

Thioflavin S

   

   Ipsilateral

Cerebellum

0.9288

0.7465

>1.62

   Contralateral

Cerebellum

0.9253

0.7951

>1.31

   Composite

Cerebellum

0.9462

0.8438

>1.34

   Ipsilateral

Pons

0.8767

0.6465

>0.46

   Contralateral

Pons

0.9132

0.7980

>0.48

   Composite

Pons

0.9236

0.7374

>0.5

Overall pathology

   

   Ipsilateral

Cerebellum

0.9916

0.9286

>1.5

   Contralateral

Cerebellum

0.9979

0.9706

>1.31

   Composite

Cerebellum

1.0000

1.0000

>1.46

   Ipsilateral

Pons

0.9433

0.7857

>0.472

   Contralateral

Pons

0.9842

0.8857

>0.479

   Composite

Pons

0.9947

0.9286

>0.53

  1. AUC = area under the curve; REF = brain reference region; ROC = receiver-operator curve; SUVR = standard uptake value ratio; SoT = standard of truth; VOI = volume of interest.
  2. Note: SUVR cut-off criterion is the SUVR value that maximizes the value of the Youden index. The SUVR cut-off value is the SUVR value above which lies a reading of abnormal and below or equal to which is a reading of normal.