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Table 10 Sensitivity, specificity, and exact 95% CI for each SUVR type/pathology SoT combination in retrospective vs. prospective studies for all 4 studies combined

From: Diagnostic effectiveness of quantitative [18F]flutemetamol PET imaging for detection of fibrillar amyloid β using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus

 

Cerebellum REF

Pons REF

Pathology SoT

Ipsilateral

Contralateral

Composite

Ipsilateral

Contralateral

Composite

4G8

      

   Retrospective

      

   Sensitivity (95% CI)

1.0000 (0.3976, 1.0000)

1.0000 (0.3976, 1.0000)

0.5000 (0.0676, 0.9324)

1.0000 (0.3976, 1.0000)

0.7500 (0.1941, 0.9937)

0.7500 (0.1941, 0.9937)

   Specificity (95% CI)

0.6000 (0.3605, 0.8088)

0.7500 (0.5090, 0.9134)

0.9000 (0.6830, 0.9877)

0.4762 (0.2571, 0.7022)

0.6667 ()0.4303, 0.8541

0.6667 (0.4303, 0.8541)

   Sum (sensitivity + specificity)

1.6000

1.7500

1.4000

1.4762

1.4167

1.4167

   Prospective

      

   Sensitivity (95% CI)

1.0000 (0.4782, 1.0000)

1.0000 (0.4782, 1.0000)

0.8000 (0.2836, 0.9949)

1.0000 (0.4782, 1.0000)

1.0000 (0.4782, 1.0000)

1.0000 (0.4782, 1.0000)

   Specificity (95% CI)

0.6471 (0.3833, 0.8579)

0.5882 (0.3292, 0.8156)

0.8235 (0.5657, 0.9620)

0.5294 (0.2781, 0.7702)

0.6471 (0.3833, 0.8579)

0.5882 (0.3292, 0.8156)

   Sum (sensitivity + specificity)

1.6471

1.5882

1.6235

1.5294

1.6471

1.5882

Bielschowsky

      

   Retrospective

      

   Sensitivity (95% CI)

1.0000 (0.4782, 1.0000)

1.0000 (0.4782, 1.0000)

1.0000 (0.4782, 1.0000)

1.0000 (0.4782, 1.0000)

1.0000 (0.4782, 1.0000)

1.0000 (0.4782, 1.0000)

   Specificity (95% CI)

0.8750 (0.6165, 0.9845)

0.8750 (0.6165, 0.9845)

0.9375 (0.6977, 0.9984)

0.7647 (0.5010, 0.9319)

0.8824 (0.6356, 0.9854)

0.8824 (0.6356, 0.9854)

   Sum (sensitivity + specificity)

1.8750

1.8750

1.9375

1.7647

1.8824

1.8824

   Prospective

      

   Sensitivity (95% CI)

1.0000 (0.2924, 1.0000)

1.0000 (0.2924, 1.0000)

1.0000 (0.2924, 1.0000)

1.0000 (0.2924, 1.0000)

1.0000 (0.2924, 1.0000)

1.0000 (0.2924, 1.0000)

   Specificity (95% CI)

0.9091 (0.5872, 0.9977)

0.9091 (0.5872, 0.9977)

0.9091 (0.5872, 0.9977)

0.9091 (0.5872, 0.9977)

1.0000 (0.7151, 1.000)

0.8182 (0.4822, 0.9772)

   Sum (sensitivity + specificity)

1.9091

1.9091

1.9091

1.9091

2.0000

1.8182

Thioflavin S

      

   Retrospective

      

   Sensitivity (95% CI)

0.8571 (0.4213, 0.9964)

0.8571 (0.4213, 0.9964)

1.0000 (0.5904, 1.0000)

0.8571 (0.4213, 0.9964)

0.8571 (0.4213, 0.9964)

0.8571 (0.4213, 0.9964)

   Specificity (95% CI)

1.0000 (0.8235, 1.0000)

0.9474 (0.7397, 0.9987)

0.8947 (0.6686, 0.9870)

0.7000 (0.4572, 0.8811)

0.9000 (0.6830, 0.9877)

0.9000 (0.6830, 0.9877)

   Sum (sensitivity + specificity)

1.8571

1.8045

1.8947

1.5571

1.7571

1.7571

   Prospective

      

   Sensitivity (95% CI)

0.5000 (0.0126, 0.9874)

1.0000 (0.1581, 1.0000)

1.0000 (0.1581, 1.0000)

1.0000 (0.1581, 1.0000)

1.0000 (0.1581, 1.0000)

1.0000 (0.1581, 1.0000)

   Specificity (95% CI)

0.9231 (0.6397, 0.9981)

0.8462 (0.5455, 0.9808)

0.7692 (0.4619, 0.9496)

0.8462 (0.5455, 0.9808)

0.9231 (0.6397, 0.9981)

0.7692 (0.4619, 0.9496)

   Sum (sensitivity + specificity)

1.4231

1.8462

1.7692

1.8462

1.9231

1.7692

Overall pathology

      

   Retrospective

      

   Sensitivity (95% CI)

1.0000 (0.5407, 1.0000)

1.0000 (0.5407, 1.0000)

1.0000 (0.5407, 1.0000)

1.0000 (0.5407, 1.0000)

1.0000 (0.5407, 1.0000)

1.0000 (0.5407, 1.0000)

   Specificity (95% CI)

1.0000 (0.8316, 1.000)

0.9500 (0.7513, 9987)

1.0000 (0.8316, 1.0000)

0.8095 (0.5809, 0.9455)

0.8571 (0.6366, 0.9695)

1.0000 (0.8389, 1.000)

   Sum (sensitivity + specificity)

2.0000

1.9500

2.0000

1.8095

1.8571

2.0000

   Prospective

      

   Sensitivity (95% CI)

0.8750 (0.4735, 0.9968)

1.0000 (0.6306, 1.0000)

1.0000 (0.6306, 1.0000)

0.8750 (0.4735, 0.9968)

1.0000 (0.6306, 1.0000)

0.8750 (0.4735, 0.9968)

   Specificity (95% CI)

1.0000 (0.7684, 1.000)

1.0000 (0.7684, 1.0000)

1.0000 (0.7684, 1.0000)

0.9286 (0.6613, 0.9982)

0.9286 (0.6613, 0.9982)

1.0000 (0.7684, 1.0000)

   Sum (sensitivity + specificity)

1.8750

2.0000

2.0000

1.8036

1.9286

1.8750

  1. REF = PET imaging brain reference region; SoT = standard of truth, SUVR = standard uptake value ratio. Refer to [32] for a discussion of agreement between readers.