Table 7 Sensitivity and specificity and their exact 95% CIs for each SUVR type/pathology SoT combination for all 4 studies combined
Cerebellum REF | Pons REF | |||||
|---|---|---|---|---|---|---|
Pathology SoT | Ipsilateral | Contralateral | Composite | Ipsilateral | Contralateral | Composite |
4G8 | ||||||
Sensitivity (95% CI) | 1.0000 (0.6637, 1.0000) | 1.0000 (0.6637, 1.0000) | 0.6667 (0.2993, 0.9251) | 1.0000 (0.6637, 1.0000) | 0.8889 (0.5175, 0.9972) | 0.8889 (0.5175, 0.9972) |
Specificity (95% CI) | 0.6216 (0.4476, 0.7754) | 0.6757 (0.5021, 0.8199) | 0.8649 (0.7123, 0.9546) | 0.5000 (0.3338, 0.6662) | 0.6579 (0.4865, 0.8037) | 0.6316 (0.4599, 0.7819) |
Maximal sum (sensitivity + specificity) | 1.6216 | 1.6757 | 1.5316 | 1.5000 | 1.5468 | 1.5205 |
Bielschowsky | ||||||
Sensitivity (95% CI) | 1.0000 (0.6306, 1.0000) | 1.0000 (0.6306, 1.0000) | 1.0000 (0.6306, 1.0000) | 1.0000 (0.6306, 1.0000) | 1.0000 (0.6306, 1.0000) | 1.0000 (0.6306, 1.0000) |
Specificity (95% CI) | 0.8889 (0.7084, 0.9765) | 0.8889 (0.7084, 0.9765) | 0.9259 (0.7571, 0.9909) | 0.8214 (0.6311, 0.9394) | 0.9286 (0.7650, 0.9912) | 0.8571 (0.6733, 0.9597) |
Maximal sum (sensitivity + specificity) | 1.8889 | 1.8889 | 1.9259 | 1.8214 | 1.9286 | 1.8571 |
Thioflavin S | ||||||
Sensitivity (95% CI) | 0.7778 (0.3999, 0.9719) | 0.8889 (0.5175, 0.9972) | 1.0000 (0.6637, 1.0000) | 0.8889 (0.5175, 0.9972) | 0.8889 (0.5175, 0.9972) | 0.8889 (0.5175, 0.9972) |
Specificity (95% CI) | 0.9688 (0.8378, 0.9992) | 0.9063 (0.7498, 0.9802) | 0.8438 (0.6721, 0.9472) | 0.7576 (0.5774, 0.8891) | 0.9091 (0.7567, 0.9808) | 0.8485 (0.6810, 0.9489) |
Maximal sum (sensitivity + specificity) | 1.7466 | 1.7952 | 1.8438 | 1.6465 | 1.7980 | 1.7374 |
Overall pathology | ||||||
Sensitivity (95% CI) | 0.9286 (0.6613, 0.9982) | 1.0000 (0.7684, 1.0000) | 1.0000 (0.7684, 1.0000) | 0.9286 (0.6613, 0.9982) | 1.0000 (0.7684, 1.0000) | 0.9286 (0.6613, 0.9982) |
Specificity (95% CI) | 1.0000 (0.8972, 1.0000) | 0.9706 (0.8467, 0.9993) | 1.0000 (0.8972, 1.0000) | 0.8571 (0.6974, 0.9519) | 0.8857 (0.7326, 0.9680) | 1.0000 (0.9000, 1.0000) |
Maximal sum (sensitivity + specificity) | 1.9286 | 1.9706 | 2.0000 | 1.7857 | 1.8857 | 1.9286 |