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  1. Transgenic overexpression of amyloid precursor protein (APP) genes that are either entirely human in sequence or have humanized Aβ sequences can produce Alzheimer-type amyloidosis in mice, provided the transge...

    Authors: Guilian Xu, Yong Ran, Susan E. Fromholt, Chunhua Fu, Anthony T. Yachnis, Todd E. Golde and David R. Borchelt
    Citation: Acta Neuropathologica Communications 2015 3:72
  2. In Alzheimer’s disease, accumulation and pathological aggregation of amyloid β-peptide is accompanied by the induction of complex immune responses, which have been attributed both beneficial and detrimental pr...

    Authors: Claudia Späni, Tobias Suter, Rebecca Derungs, Maria Teresa Ferretti, Tobias Welt, Fabian Wirth, Christoph Gericke, Roger M. Nitsch and Luka Kulic
    Citation: Acta Neuropathologica Communications 2015 3:71
  3. Amyloid β (Aβ) accumulates in the extracellular space as diffuse and neuritic plaques in Alzheimer’s disease (AD). Aβ also deposits on the walls of arterioles as cerebral amyloid angiopathy (CAA) in most cases...

    Authors: Fan Liao, Tony J. Zhang, Hong Jiang, Katheryn B. Lefton, Grace O. Robinson, Robert Vassar, Patrick M. Sullivan and David M. Holtzman
    Citation: Acta Neuropathologica Communications 2015 3:70
  4. TAR DNA-binding protein 43 (TDP-43) inclusions are pathological hallmarks of patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Loss of TDP-43 in zebrafish engender...

    Authors: Jonathan Janssens, Stéphanie Philtjens, Gernot Kleinberger, Sara Van Mossevelde, Julie van der Zee, Rita Cacace, Sebastiaan Engelborghs, Anne Sieben, Julia Banzhaf-Strathmann, Lubina Dillen, Céline Merlin, Ivy Cuijt, Caroline Robberecht, Bettina Schmid, Patrick Santens, Adrian Ivanoiu…
    Citation: Acta Neuropathologica Communications 2015 3:68
  5. Septic encephalopathy is associated with rapid deterioration of cortical functions. Using magnetic resonance imaging (MRI) we detected functional abnormalities in the hippocampal formation of patients with sep...

    Authors: Aleksandar R. Zivkovic, Oliver Sedlaczek, Rebecca von Haken, Karsten Schmidt, Thorsten Brenner, Markus A. Weigand, Hilmar Bading, C. Peter Bengtson and Stefan Hofer
    Citation: Acta Neuropathologica Communications 2015 3:67
  6. The A673T mutation in the amyloid precursor protein (APP) protects against Alzheimer’s disease by reducing β-amyloid protein (Aβ) production. This mutation reduced the release of the soluble APP fragment (sAPP...

    Authors: Asuka Kokawa, Seiko Ishihara, Hitomi Fujiwara, Mika Nobuhara, Minori Iwata, Yasuo Ihara and Satoru Funamoto
    Citation: Acta Neuropathologica Communications 2015 3:66
  7. Muscle stem cells termed satellite cells are essential for muscle regeneration. A central question in many neuromuscular disorders is why satellite cells are unable to prevent progressive muscle wasting. We ha...

    Authors: Gerben J. Schaaf, Tom JM van Gestel, Esther Brusse, Robert M. Verdijk, Irenaeus FM de Coo, Pieter A. van Doorn, Ans T. van der Ploeg and WWM Pim Pijnappel
    Citation: Acta Neuropathologica Communications 2015 3:65
  8. Autism is diagnosed in numerous genetic and genomic developmental disorders associated with an overlap in high-risk genes and loci that underlie intellectual disability (ID) and epilepsy. The aim of this stere...

    Authors: Jerzy Wegiel, Michael Flory, N. Carolyn Schanen, Edwin H. Cook, Krzysztof Nowicki, Izabela Kuchna, Humi Imaki, Shuang Yong Ma, Jarek Wegiel, Eric London, Manuel F. Casanova, Thomas Wisniewski and W. Ted Brown
    Citation: Acta Neuropathologica Communications 2015 3:63
  9. Mutations in the FUS gene have been shown to be a rare cause of amyotrophic lateral sclerosis (ALS-FUS) and whilst well documented clinically and genetically there have been relatively few neuropathological studi...

    Authors: Andrew King, Claire Troakes, Bradley Smith, Matthew Nolan, Olimpia Curran, Caroline Vance, Christopher E. Shaw and Safa Al-Sarraj
    Citation: Acta Neuropathologica Communications 2015 3:62
  10. Ischemic stroke, a major cause of mortality, is frequently accompanied by life-threatening cerebral edema. Aquaporin-4 (Aqp4), an astrocytic transmembrane water channel, is an important molecular contributor t...

    Authors: Jesse A. Stokum, Rupal I. Mehta, Svetlana Ivanova, Edward Yu, Volodymyr Gerzanich and J. Marc Simard
    Citation: Acta Neuropathologica Communications 2015 3:61
  11. Cerebral white matter lesions (WML), visualized as white matter hyperintensities (WMH) on T2-weighted MRI, encompass structural damage and loss of integrity of the cerebral white matter (WM) and are commonly a...

    Authors: Kirsty E. McAleese, Michael Firbank, Madhurima Dey, Sean J. Colloby, Lauren Walker, Mary Johnson, Joshua R. Beverley, John Paul Taylor, Alan J. Thomas, John T. O’Brien and Johannes Attems
    Citation: Acta Neuropathologica Communications 2015 3:60
  12. A majority of familial frontotemporal lobar dementia and amyotrophic lateral sclerosis cases are associated with a large repeat expansion in a non-coding region of the C9ORF72 gene. Currently, little is known abo...

    Authors: Rachel A K Atkinson, Carmen M. Fernandez-Martos, Julie D. Atkin, James C. Vickers and Anna E. King
    Citation: Acta Neuropathologica Communications 2015 3:59

    The Erratum to this article has been published in Acta Neuropathologica Communications 2016 4:2

  13. The application of high-throughput genomic approaches has revealed 24 novel risk loci for Alzheimer’s disease (AD). We recently reported that the bridging integrator 1 (BIN1) risk gene is linked to Tau pathology.

    Authors: Yoann Sottejeau, Alexis Bretteville, François-Xavier Cantrelle, Nicolas Malmanche, Florie Demiaute, Tiago Mendes, Charlotte Delay, Harmony Alves Dos Alves, Amandine Flaig, Peter Davies, Pierre Dourlen, Bart Dermaut, Jocelyn Laporte, Philippe Amouyel, Guy Lippens, Julien Chapuis…
    Citation: Acta Neuropathologica Communications 2015 3:58
  14. Lewy body–related α-synucleinopathy (LBAS, the abnormal accumulation of pathologic α-synuclein) is found in the central and peripheral nervous systems, including the spinal cord, dorsal root ganglia, and sympa...

    Authors: Hiroyuki Sumikura, Masaki Takao, Hiroyuki Hatsuta, Shinji Ito, Yuta Nakano, Akiko Uchino, Akane Nogami, Yuko Saito, Hideki Mochizuki and Shigeo Murayama
    Citation: Acta Neuropathologica Communications 2015 3:57
  15. Several studies have indicated that autoimmune and neuroinflammatory processes contribute to the neurodegeneration of retinal ganglion cells in human glaucoma patients and in animal models. To test the involve...

    Authors: Oliver W. Gramlich, Qiong J. Ding, Wei Zhu, Amy Cook, Michael G. Anderson and Markus H. Kuehn
    Citation: Acta Neuropathologica Communications 2015 3:56
  16. The term motor neuron disease encompasses a spectrum of disorders in which motor neurons are the lost. Importantly, while some motor neurons are lost early in disease and others remain intact at disease end-st...

    Authors: Lyndsay M. Murray, Ariane Beauvais, Sabrina Gibeault, Natalie L. Courtney and Rashmi Kothary
    Citation: Acta Neuropathologica Communications 2015 3:55
  17. Substantial data has shown that the lectican group of chondroitin sulfate proteoglycans are involved in inhibition of axonal plasticity in response to injury in the central nervous system. Increasing evidence ...

    Authors: Matthew D. Howell, Lauren A. Bailey, Michael A. Cozart, Brenda M. Gannon and Paul E. Gottschall
    Citation: Acta Neuropathologica Communications 2015 3:54
  18. Non-pathological, age-related cognitive decline varies markedly between individuals and places significant financial and emotional strain on people, their families and society as a whole. Understanding the dif...

    Authors: Christopher M. Henstridge, Rosemary J. Jackson, JeeSoo M. Kim, Abigail G. Herrmann, Ann K. Wright, Sarah E. Harris, Mark E. Bastin, John M. Starr, Joanna Wardlaw, Thomas H. Gillingwater, Colin Smith, Chris-Anne McKenzie, Simon R. Cox, Ian J. Deary and Tara L. Spires-Jones
    Citation: Acta Neuropathologica Communications 2015 3:53

    The Erratum to this article has been published in Acta Neuropathologica Communications 2015 3:83

  19. Numerous pathogenic mutations responsible for mitochondrial diseases have been identified in mitochondrial DNA (mtDNA)-encoded tRNA genes. In most cases, however, the detailed molecular pathomechanisms and cel...

    Authors: Hideyuki Hatakeyama, Ayako Katayama, Hirofumi Komaki, Ichizo Nishino and Yu-ichi Goto
    Citation: Acta Neuropathologica Communications 2015 3:52
  20. Synaptic dysfunction and intracellular transport defects are early events in Alzheimer’s disease (AD). Extracellular amyloid β (Aβ) oligomers cause spine alterations and impede the transport of proteins and or...

    Authors: Tomohiro Umeda, Elisa M. Ramser, Minato Yamashita, Koichi Nakajima, Hiroshi Mori, Michael A. Silverman and Takami Tomiyama
    Citation: Acta Neuropathologica Communications 2015 3:51

    The Erratum to this article has been published in Acta Neuropathologica Communications 2016 4:7

  21. The term atypical pituitary adenoma (APA) was revised in the 2004 World Health Organization (WHO) classification of pituitary tumors. However, two of the four parameters required for the diagnosis of APAs were fo...

    Authors: Christian P. Miermeister, Stephan Petersenn, Michael Buchfelder, Rudolf Fahlbusch, Dieter K. Lüdecke, Annett Hölsken, Markus Bergmann, Hans Ulrich Knappe, Volkmar H. Hans, Jörg Flitsch, Wolfgang Saeger and Rolf Buslei
    Citation: Acta Neuropathologica Communications 2015 3:50

    The Erratum to this article has been published in Acta Neuropathologica Communications 2016 4:21

  22. Cerebral microbleeds correspond to blood breakdown products, including hemosiderin-containing macrophages around small vessels on histological examination. Superficial lobar cerebral microbleeds are increasing...

    Authors: Enikö Kövari, Andreas Charidimou, François R. Herrmann, Panteleimon Giannakopoulos, Constantin Bouras and Gabriel Gold
    Citation: Acta Neuropathologica Communications 2015 3:49
  23. Tuberous sclerosis complex (TSC) is a genetic disease resulting from mutation in TSC1 or TSC2 and subsequent hyperactivation of mammalian Target of Rapamycin (mTOR). Common TSC features include brain lesions, suc...

    Authors: Anna R. Malik, Ewa Liszewska, Agnieszka Skalecka, Malgorzata Urbanska, Anand M. Iyer, Lukasz J. Swiech, Malgorzata Perycz, Kamil Parobczak, Patrycja Pietruszka, Malgorzata M. Zarebska, Matylda Macias, Katarzyna Kotulska, Julita Borkowska, Wieslawa Grajkowska, Magdalena E. Tyburczy, Sergiusz Jozwiak…
    Citation: Acta Neuropathologica Communications 2015 3:48
  24. The progression of amyotrophic lateral sclerosis (ALS) through the brain has recently been staged using independent neuropathological and neuroimaging modalities. The two schemes tie into the concept of pathol...

    Authors: Manaal Fatima, Rachel Tan, Glenda M. Halliday and Jillian J. Kril
    Citation: Acta Neuropathologica Communications 2015 3:47
  25. Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons as well as the presence of proteinaceous inclusions named Lewy bodies. α-synuclein (α-syn)...

    Authors: Mathieu Bourdenx, Sandra Dovero, Michel Engeln, Simone Bido, Matthieu F. Bastide, Nathalie Dutheil, Isabel Vollenweider, Laetitia Baud, Camille Piron, Virginie Grouthier, Thomas Boraud, Grégory Porras, Qin Li, Veerle Baekelandt, Dieter Scheller, Anne Michel…
    Citation: Acta Neuropathologica Communications 2015 3:46
  26. The inverse correlation between prevalence of auto-immune disorders like the chronic neuro-inflammatory disease multiple sclerosis (MS) and the occurrence of helminth (worm) infections, suggests that the helmi...

    Authors: Gijs Kooij, Rens Braster, Jasper J. Koning, Lisa C. Laan, Sandra J. van Vliet, Tamara Los, Anne Marieke Eveleens, Susanne M. A. van der Pol, Elisabeth Förster-Waldl, Kaan Boztug, Alexandre Belot, Katka Szilagyi, Timo K. van den Berg, Jaap D. van Buul, Marjolein van Egmond, Helga E. de Vries…
    Citation: Acta Neuropathologica Communications 2015 3:45
  27. Protein aggregation is a common cause of neuropathology. The protein aggregation myopathy Limb-Girdle Muscular Dystrophy 1D (LGMD1D) is caused by mutations of amino acids Phe89 or Phe93 of DNAJB6, a co-chapero...

    Authors: Alessandra Ruggieri, Francesco Brancati, Simona Zanotti, Lorenzo Maggi, Maria Barbara Pasanisi, Simona Saredi, Chiara Terracciano, Carlo Antozzi, Maria Rosaria D′Apice, Federica Sangiuolo, Giuseppe Novelli, Christian R. Marshall, Stephen W. Scherer, Lucia Morandi, Luca Federici, Roberto Massa…
    Citation: Acta Neuropathologica Communications 2015 3:44
  28. Transthyretin/TTR gene mutations usually cause systemic amyloidotic diseases. Few TTR variants preferentially affect the central nervous system, manifesting as oculoleptomeningeal amyloid...

    Authors: Jennifer L. Ziskin, Michael D. Greicius, Wan Zhu, Anna N. Okumu, Christopher M. Adams and Edward D. Plowey
    Citation: Acta Neuropathologica Communications 2015 3:43
  29. Hereditary diffuse leukoencephalopathy with spheroids (HDLS) presents with a variety of clinical phenotypes including motor impairments such as gait dysfunction, rigidity, tremor and bradykinesia as well as co...

    Authors: John L. Robinson, EunRan Suh, Elisabeth M. Wood, Edward B. Lee, H. Branch Coslett, Kevin Raible, Virginia M.-Y. Lee, John Q. Trojanowski and Vivianna M. Van Deerlin
    Citation: Acta Neuropathologica Communications 2015 3:42
  30. The deposition of the amyloid β protein (Aβ) in the brain is a hallmark of Alzheimer's disease (AD). Removal of Aβ by Aβ-antibody treatment has been developed as a potential treatment strategy against AD. Firs...

    Authors: Karthikeyan Balakrishnan, Ajeet Rijal Upadhaya, Julia Steinmetz, Julia Reichwald, Dorothee Abramowski, Marcus Fändrich, Sathish Kumar, Haruyasu Yamaguchi, Jochen Walter, Matthias Staufenbiel and Dietmar Rudolf Thal
    Citation: Acta Neuropathologica Communications 2015 3:41
  31.  The accumulation of neurofibrillary tangles, composed of aggregated hyperphosphorylated tau protein, starts spreading early in specific regions in the course of Alzheimer’s disease (AD), correlating with the ...

    Authors: Laetitia Lemoine, Laure Saint-Aubert, Amelia Marutle, Gunnar Antoni, Jonas P Eriksson, Bernardino Ghetti, Nobuyuki Okamura, Inger Nennesmo, Per-Göran Gillberg and Agneta Nordberg
    Citation: Acta Neuropathologica Communications 2015 3:40
  32. Beta-propeller protein associated neurodegeneration (BPAN) is associated with mutations in the WD repeat domain 45 (WDR45) gene on chromosome Xp11 resulting in reduced autophagic flux. This study describes the cl...

    Authors: R. Paudel, A. Li, S. Wiethoff, R. Bandopadhyay, K. Bhatia, R. de Silva, H. Houlden and J. L. Holton
    Citation: Acta Neuropathologica Communications 2015 3:39
  33. Cytoplasmic TDP-43 inclusions are the pathological hallmark of amyotrophic lateral sclerosis (ALS) and tau-negative frontotemporal lobar dementia (FTLD). The G4C2 repeat mutation in C9ORF72 is the most common cau...

    Authors: Jorge Gomez-Deza, Youn-bok Lee, Claire Troakes, Matthew Nolan, Safa Al-Sarraj, Jean-Marc Gallo and Christopher E. Shaw
    Citation: Acta Neuropathologica Communications 2015 3:38
  34. The present study compares the clinical, pathological and molecular features of a United States (US) case of growth hormone (GH)-associated Creutzfeldt-Jakob disease (GH-CJD) (index case) to those of two earli...

    Authors: Ignazio Cali, Cathleen J. Miller, Joseph E. Parisi, Michael D. Geschwind, Pierluigi Gambetti and Lawrence B. Schonberger
    Citation: Acta Neuropathologica Communications 2015 3:37
  35. Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disorder, and cytoplasmic inclusions containing transactive response (TAR) DNA binding protein (TDP-43) are present in ~90 % ...

    Authors: Jacqueline C Mitchell, Remy Constable, Eva So, Caroline Vance, Emma Scotter, Leanne Glover, Tibor Hortobagyi, Eveline S. Arnold, Shuo-Chien Ling, Melissa McAlonis, Sandrine Da Cruz, Magda Polymenidou, Lino Tessarolo, Don W Cleveland and Christopher E Shaw
    Citation: Acta Neuropathologica Communications 2015 3:36
  36. The transactivation response element DNA-binding protein 43 kDa (TDP-43) is a major component of the ubiquitin-positive and tau-negative inclusions in frontotemporal lobar degeneration and sporadic amyotrophic...

    Authors: Akiko Uchino, Masaki Takao, Hiroyuki Hatsuta, Hiroyuki Sumikura, Yuta Nakano, Akane Nogami, Yuko Saito, Tomio Arai, Kazutoshi Nishiyama and Shigeo Murayama
    Citation: Acta Neuropathologica Communications 2015 3:35
  37. Isocitrate dehydrogenase (IDH) mutation status and grade define subgroups of diffuse gliomas differing based on age, tumor location, presentation, and prognosis. While some biologic differences between IDH mutate...

    Authors: Adam Cohen, Mariko Sato, Kenneth Aldape, Clinton C. Mason, Kristin Alfaro-Munoz, Lindsey Heathcock, Sarah T. South, Lisa M. Abegglen, Joshua D. Schiffman and Howard Colman
    Citation: Acta Neuropathologica Communications 2015 3:34
  38. Accumulation of insoluble conformationally altered hyperphosphorylated tau occurs as part of the pathogenic process in Alzheimer’s disease (AD) and other tauopathies. In most AD subjects, wild-type (WT) tau ag...

    Authors: Jeanna M. Wheeler, Pamela J. McMillan, Michele Hawk, Michiyo Iba, Linda Robinson, George J. Xu, Beth A. Dombroski, Doori Jeong, Marc A. Dichter, Halvor Juul, Elaine Loomis, Murray Raskind, James B. Leverenz, John Q. Trojanowski, Virginia M.Y. Lee, Gerard D. Schellenberg…
    Citation: Acta Neuropathologica Communications 2015 3:33
  39. Neuropathological, genetic, and biochemical studies have provided support for the hypothesis that microglia participate in Alzheimer’s disease (AD) pathogenesis. Despite the extensive characterization of AD mi...

    Authors: Adam D. Bachstetter, Linda J. Van Eldik, Frederick A. Schmitt, Janna H. Neltner, Eseosa T. Ighodaro, Scott J. Webster, Ela Patel, Erin L. Abner, Richard J, Kryscio and Peter T. Nelson
    Citation: Acta Neuropathologica Communications 2015 3:32
  40. Microglia are tissue macrophages of the central nervous system that monitor brain homeostasis and react upon neuronal damage and stress. Aging and neurodegeneration induce a hypersensitive, pro-inflammatory ph...

    Authors: Inge R Holtman, Divya D Raj, Jeremy A Miller, Wandert Schaafsma, Zhuoran Yin, Nieske Brouwer, Paul D Wes, Thomas Möller, Marie Orre, Willem Kamphuis, Elly M Hol, Erik W G M Boddeke and Bart J L Eggen
    Citation: Acta Neuropathologica Communications 2015 3:31
  41. Pediatric adamantinomatous craniopharyngioma (ACP) is a histologically benign but clinically aggressive brain tumor that arises from the sellar/suprasellar region. Despite a high survival rate with current sur...

    Authors: Jacob M. Gump, Andrew M. Donson, Diane K. Birks, Vladimir M. Amani, Karun K. Rao, Andrea M. Griesinger, B. K. Kleinschmidt-DeMasters, James M. Johnston, Richard C. E. Anderson, Amy Rosenfeld, Michael Handler, Lia Gore, Nicholas Foreman and Todd C. Hankinson
    Citation: Acta Neuropathologica Communications 2015 3:30
  42. The histological hallmark of multiple system atrophy (MSA) is the presence of filamentous aggregations of phosphorylated α-synuclein in oligodendrocytes, referred to as glial cytoplasmic inclusions (GCIs). Alt...

    Authors: Keiko Nakamura, Fumiaki Mori, Tomoya Kon, Kunikazu Tanji, Yasuo Miki, Masahiko Tomiyama, Hidekachi Kurotaki, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Masahito Yamada and Koichi Wakabayashi
    Citation: Acta Neuropathologica Communications 2015 3:29
  43. Neuromyelitis Optica (NMO) is an autoimmune disease primarily targeting the spinal cord and optic nerve leading to paralysis and blindness. The discovery of an antibody against the astrocytic water channel, aq...

    Authors: Melina V. Jones, Hwa Huang, Peter A. Calabresi and Michael Levy
    Citation: Acta Neuropathologica Communications 2015 3:28
  44. Several data suggest that excitotoxicity due to excessive glutamatergic neurotransmission may be an important factor in the mechanisms of motor neuron (MN) death occurring in amyotrophic lateral sclerosis (ALS...

    Authors: Citlalli Netzahualcoyotzi and Ricardo Tapia
    Citation: Acta Neuropathologica Communications 2015 3:27
  45. Neurofibrillary tangles (NFT) composed of Tau are hallmarks of neurodegeneration in Alzheimer disease. Transgenic mice expressing full-length pro-aggregant human Tau (2N4R Tau-ΔK280, termed TauΔK) or its repeat d...

    Authors: Katja Hochgräfe, Astrid Sydow, Dorthe Matenia, Daniela Cadinu, Stefanie Könen, Olga Petrova, Marcus Pickhardt, Petra Goll, Fabio Morellini, Eckhard Mandelkow and Eva-Maria Mandelkow
    Citation: Acta Neuropathologica Communications 2015 3:25
  46. FUS/TLS is an RNA-binding protein whose genetic mutations or pathological inclusions are associated with neurological diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration, ...

    Authors: Yoshihiro Kino, Chika Washizu, Masaru Kurosawa, Mizuki Yamada, Haruko Miyazaki, Takumi Akagi, Tsutomu Hashikawa, Hiroshi Doi, Toru Takumi, Geoffrey G Hicks, Nobutaka Hattori, Tomomi Shimogori and Nobuyuki Nukina
    Citation: Acta Neuropathologica Communications 2015 3:24
  47. Although TDP-43 is the main constituent of the ubiquitinated cytoplasmic inclusions in the most common forms of frontotemporal lobar degeneration, TARDBP mutations are not a common cause of familial frontotempora...

    Authors: Fermin Moreno, Gil D Rabinovici, Anna Karydas, Zachary Miller, Sandy Chan Hsu, Andrea Legati, Jamie Fong, Daniel Schonhaut, Hermann Esselmann, Christa Watson, Melanie L Stephens, Joel Kramer, Jens Wiltfang, William W Seeley, Bruce L Miller, Giovanni Coppola…
    Citation: Acta Neuropathologica Communications 2015 3:19

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