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  1. A total of 38 brain cytoarchitectonic subdivisions, representing subcortical and cortical structures, cerebellum, and brainstem, were examined in 4- to 60-year-old subjects diagnosed with autism and control su...

    Authors: Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Shuang Yong Ma, Humi Imaki, Jarek Wegiel, Ira L Cohen, Eric London, Thomas Wisniewski and William Ted Brown

    Citation: Acta Neuropathologica Communications 2014 2:141

    Content type: Research

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  2. B cells are attracting increasing attention in the pathogenesis of multiple sclerosis (MS). B cell-targeted therapies with monoclonal antibodies or plasmapheresis have been shown to be successful in a subset o...

    Authors: Christopher Hohmann, Bianca Milles, Michael Schinke, Michael Schroeter, Jochen Ulzheimer, Peter Kraft, Christoph Kleinschnitz, Paul V Lehmann and Stefanie Kuerten

    Citation: Acta Neuropathologica Communications 2014 2:138

    Content type: Methodology article

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  3. Axial myopathy can be the underlying cause of rapidly progressive adult-onset scoliosis; however, the pathogenesis of this disorder remains poorly understood. Here we present a case of a 69-year old woman with...

    Authors: Annie Hiniker, Lee-Jun Wong, Sigurd Berven, Cavatina K Truong, Adekunle M Adesina and Marta Margeta

    Citation: Acta Neuropathologica Communications 2014 2:137

    Content type: Case report

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  4. p25α/tubulin polymerization promoting protein (TPPP) is an oligodendroglial protein that plays crucial roles including myelination, and the stabilization of microtubules. In multiple system atrophy (MSA), TPPP...

    Authors: Kiyobumi Ota, Masato Obayashi, Kokoro Ozaki, Shizuko Ichinose, Akiyoshi Kakita, Mari Tada, Hitoshi Takahashi, Noboru Ando, Yoshinobu Eishi, Hidehiro Mizusawa and Kinya Ishikawa

    Citation: Acta Neuropathologica Communications 2014 2:136

    Content type: Research

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  5. Several neurodegenerative diseases are classified as proteopathies as they are associated with the aggregation of misfolded proteins. Synucleinopathies are a group of neurodegenerative disorders associated wit...

    Authors: Irina Surgucheva, Kathy L. Newell, Jeffrey Burns and Andrei Surguchov

    Citation: Acta Neuropathologica Communications 2014 2:132

    Content type: Research

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  6. Mutations in ~100 genes cause muscle diseases with complex and often unexplained genotype/phenotype correlations. Next-generation sequencing studies identify a greater-than-expected number of genetic variation...

    Authors: Marco Savarese, Giuseppina Di Fruscio, Margherita Mutarelli, Annalaura Torella, Francesca Magri, Filippo Maria Santorelli, Giacomo Pietro Comi, Claudio Bruno and Vincenzo Nigro

    Citation: Acta Neuropathologica Communications 2014 2:100

    Content type: Research

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  7. Mucolipidosis IV (MLIV) is caused by mutations in the gene MCOLN1. Patients with MLIV have severe neurologic deficits and very little is known about the brain pathology in this lysosomal disease. Using an accurat...

    Authors: Yulia Grishchuk, Sarmi Sri, Nikita Rudinskiy, Weiyuan Ma, Katherine G. Stember, Matthew W. Cottle, Ellen Sapp, Marian Difiglia, Alona Muzikansky, Rebecca A. Betensky, Andrew M. S. Wong, Brian J. Bacskai, Bradley T. Hyman, Raymond J. Kelleher, Jonathan D. Cooper and Susan A. Slaugenhaupt

    Citation: Acta Neuropathologica Communications 2014 2:133

    Content type: Research

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  8. Neurodegenerative diseases share common pathologic features including neuroinflammation, mitochondrial dysfunction and protein aggregation, suggesting common underlying mechanisms of neurodegeneration. We unde...

    Authors: Matthew D Li, Terry C Burns, Alexander A Morgan and Purvesh Khatri

    Citation: Acta Neuropathologica Communications 2014 2:93

    Content type: Research

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  9. Hirano bodies are actin-rich intracellular inclusions found in the brains of patients with neurodegenerative conditions such as Alzheimer's disease or frontotemporal lobar degeneration-tau. While Hirano body u...

    Authors: Matthew Furgerson, Jason K. Clark, Jonathon D. Crystal, John J. Wagner, Marcus Fechheimer and Ruth Furukawa

    Citation: Acta Neuropathologica Communications 2014 2:131

    Content type: Research

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  10. Alzheimer’s disease (AD) is the most common cause of dementia, and currently, there is no effective treatment. The major neuropathological lesions in AD are accumulation of amyloid β (Aβ) as amyloid plaques an...

    Authors: Henrieta Scholtzova, Peter Chianchiano, Jason Pan, Yanjie Sun, Fernando Goñi, Pankaj D Mehta and Thomas Wisniewski

    Citation: Acta Neuropathologica Communications 2014 2:101

    Content type: Research

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  11. The paraffin-embedded tissue (PET) blot technique followed by limited protease digestion has been established to detect protein aggregates in prion diseases, alpha-synucleopathies, and tauopathies. We analyzed...

    Authors: Petra Steinacker, Christian Berner, Dietmar R Thal, Johannes Attems, Albert C Ludolph and Markus Otto

    Citation: Acta Neuropathologica Communications 2014 2:130

    Content type: Research

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  12. A remarkable pathological difference between grey matter lesions (GML) and white matter lesions (WML) in Multiple Sclerosis (MS) patients is the paucity of infiltrating leukocytes in GML. To better understand ...

    Authors: Marloes Prins, Ranjan Dutta, Bart Baselmans, John J P Brevé, John G J M Bol, Sadie A Deckard, Paul van der Valk, Sandra Amor, Bruce D Trapp, Helga E de Vries, Benjamin Drukarch and Anne-Marie van Dam

    Citation: Acta Neuropathologica Communications 2014 2:98

    Content type: Research

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  13. Alzheimer’s disease (AD) is the most common neurodegenerative disease and the leading cause of dementia. In addition to grey matter pathology, white matter changes are now recognized as an important pathologic...

    Authors: Lyndsey E Collins-Praino, Yitshak I Francis, Erica Y Griffith, Anne F Wiegman, Jonathan Urbach, Arlene Lawton, Lawrence S Honig, Etty Cortes, Jean Paul G Vonsattel, Peter D Canoll, James E Goldman and Adam M Brickman

    Citation: Acta Neuropathologica Communications 2014 2:83

    Content type: Research

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  14. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) represents the most common hereditary form of cerebral small vessel disease characterized by early-onset str...

    Authors: Jessica Kast, Patrizia Hanecker, Nathalie Beaufort, Armin Giese, Anne Joutel, Martin Dichgans, Christian Opherk and Christof Haffner

    Citation: Acta Neuropathologica Communications 2014 2:96

    Content type: Research

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  15. Next to α-synuclein deposition, microglial activation is a prominent pathological feature in the substantia nigra (SN) of Parkinson’s disease (PD) patients. Little is known, however, about the different phenot...

    Authors: Karlijn J Doorn, Tim Moors, Benjamin Drukarch, Wilma DJ van de Berg, Paul J Lucassen and Anne-Marie van Dam

    Citation: Acta Neuropathologica Communications 2014 2:90

    Content type: Research

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  16. We explored the prevalence of syringomyelia in a series of 113 cases of fetal dysraphism and hindbrain crowding, of gestational age ranging from 17.5 to 34 weeks with the vast majority less than 26 weeks gesta...

    Authors: Anne Guo, David Chitayat, Susan Blaser, Sarah Keating and Patrick Shannon

    Citation: Acta Neuropathologica Communications 2014 2:91

    Content type: Research

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  17. α-Synuclein is the major component of filamentous inclusions that constitute the defining characteristic of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy, so-called α-synucleinopat...

    Authors: Masami Masuda-Suzukake, Takashi Nonaka, Masato Hosokawa, Maki Kubo, Aki Shimozawa, Haruhiko Akiyama and Masato Hasegawa

    Citation: Acta Neuropathologica Communications 2014 2:88

    Content type: Research

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  18. In Huntington’s disease (HD), the ratio between normal and mutant Huntingtin (polyQ-hHtt) is crucial in the onset and progression of the disease. As a result, addition of normal Htt was shown to improve polyQ-...

    Authors: Yoan Arribat, Yasmina Talmat-Amar, Alexia Paucard, Pierre Lesport, Nathalie Bonneaud, Caroline Bauer, Nicole Bec, Marie-Laure Parmentier, Lorraine Benigno, Christian Larroque, Patrick Maurel and Florence Maschat

    Citation: Acta Neuropathologica Communications 2014 2:86

    Content type: Research

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  19. Leptomeningeal dissemination (LMD), the metastatic spread of tumor cells via the cerebrospinal fluid to the brain and spinal cord, is an ominous prognostic sign for patients with the pediatric brain tumor medu...

    Authors: Noah C Jenkins, Ricky R Kalra, Adrian Dubuc, Walavan Sivakumar, Carolyn A Pedone, Xiaochong Wu, Michael D Taylor and Daniel W Fults

    Citation: Acta Neuropathologica Communications 2014 2:85

    Content type: Research

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  20. Complex cortical malformations associated with mutations in tubulin genes are commonly referred to as “Tubulinopathies”. To further characterize the mutation frequency and phenotypes associated with tubulin mu...

    Authors: Catherine Fallet-Bianco, Annie Laquerrière, Karine Poirier, Ferechte Razavi, Fabien Guimiot, Patricia Dias, Laurence Loeuillet, Karine Lascelles, Cherif Beldjord, Nathalie Carion, Aurélie Toussaint, Nicole Revencu, Marie-Claude Addor, Benoit Lhermitte, Marie Gonzales, Jelena Martinovich…

    Citation: Acta Neuropathologica Communications 2014 2:69

    Content type: Research

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  21. Angiogenesis, the formation of new vessels, is found in Multiple Sclerosis (MS) demyelinating lesions following Vascular Endothelial Growth Factor (VEGF) release and the production of several other angiogenic ...

    Authors: Francesco Girolamo, Cristiana Coppola, Domenico Ribatti and Maria Trojano

    Citation: Acta Neuropathologica Communications 2014 2:84

    Content type: Review

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  22. Polymicrogyria (PMG) is a complex cortical malformation which has so far defied any mechanistic or genetic explanation. Adopting a broad definition of an abnormally folded or festooned cerebral cortical neuron...

    Authors: Waney Squier and Anna Jansen

    Citation: Acta Neuropathologica Communications 2014 2:80

    Content type: Review

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  23. Current consensus identifies four molecular subtypes of medulloblastoma (MB): WNT, sonic hedgehog (SHH), and groups “3/C” and “4/D”. Group 4 is not well characterized, but harbors the most frequently observed ...

    Authors: Gabriel A Bien-Willner and Robi D Mitra

    Citation: Acta Neuropathologica Communications 2014 2:74

    Content type: Research

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  24. Epilepsy and psychiatric comorbidities are frequently associated, but their common biological substrate is unknown. We have previously reported altered structural elements and neurotrophins (NTs) expression in...

    Authors: Ludmyla Kandratavicius, Jaime Eduardo Hallak, Carlos Gilberto Carlotti, Joao Alberto Assirati and Joao Pereira Leite

    Citation: Acta Neuropathologica Communications 2014 2:81

    Content type: Research

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  25. Synaptic dysfunction occurs early in the progression of Alzheimer’s disease (AD) and correlates with memory decline. There is emerging evidence that deregulation of Erythropoietin-producing hepatocellular (Eph...

    Authors: Andrea FN Rosenberger, Annemieke JM Rozemuller, Wiesje M van der Flier, Philip Scheltens, Saskia M van der Vies and Jeroen JM Hoozemans

    Citation: Acta Neuropathologica Communications 2014 2:79

    Content type: Research

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  26. It has been shown that progranulin (PGRN) deficiency causes age-related neurodegenerative diseases such as frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL), a lysosomal storage...

    Authors: Yoshinori Tanaka, James K Chambers, Takashi Matsuwaki, Keitaro Yamanouchi and Masugi Nishihara

    Citation: Acta Neuropathologica Communications 2014 2:78

    Content type: Research

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  27. In the human demyelinating central nervous system (CNS) disease multiple sclerosis, remyelination promotes recovery and limits neurodegeneration, but this is inefficient and always ultimately fails. Furthermor...

    Authors: Eva Jolanda Münzel, Catherina G Becker, Thomas Becker and Anna Williams

    Citation: Acta Neuropathologica Communications 2014 2:77

    Content type: Research

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  28. Mutagenic loss of the NF2 tumor suppressor gene encoded protein merlin is known to provoke the hereditary neoplasia syndrome, Neurofibromatosis type 2 (NF2). In addition to glial cell-derived tumors in the PNS an...

    Authors: Alexander Schulz, Ansgar Zoch and Helen Morrison

    Citation: Acta Neuropathologica Communications 2014 2:82

    Content type: Review

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  29. Activation of the mTOR pathway has been linked to the cytopathology and epileptogenicity of malformations, specifically Focal Cortical Dysplasia (FCD) and Tuberous Sclerosis (TSC). Experimental and clinical tr...

    Authors: Joan Liu, Cheryl Reeves, Zuzanna Michalak, Antonietta Coppola, Beate Diehl, Sanjay M Sisodiya and Maria Thom

    Citation: Acta Neuropathologica Communications 2014 2:71

    Content type: Research

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  30. Alzheimer’s disease is caused by increased production or reduced clearance of amyloid-β, which results in the formation amyloid-β plaques and triggers a cascade of downstream events leading to progressive neur...

    Authors: Marlene J Végh, Céline M Heldring, Willem Kamphuis, Sara Hijazi, Arie J Timmerman, Ka Wan Li, Pim van Nierop, Huibert D Mansvelder, Elly M Hol, August B Smit and Ronald E van Kesteren

    Citation: Acta Neuropathologica Communications 2014 2:76

    Content type: Research

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  31. Accumulation of β-amyloid (Aβ) in the brain is essential to Alzheimer’s disease (AD) pathogenesis. Carriers of the apolipoprotein E (APOE) ε4 allele demonstrate greatly increased AD risk and enhanced brain Aβ ...

    Authors: Joanna E Pankiewicz, Maitea Guridi, Jungsu Kim, Ayodeji A Asuni, Sandrine Sanchez, Patrick M Sullivan, David M Holtzman and Martin J Sadowski

    Citation: Acta Neuropathologica Communications 2014 2:75

    Content type: Research

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  32. A hexanucleotide (GGGGCC) expansion in C9ORF72 gene is the most common genetic change seen in familial Frontotemporal Lobar Degeneration (FTLD) and familial Motor Neurone Disease (MND). Pathologically, expansion ...

    Authors: Yvonne S Davidson, Holly Barker, Andrew C Robinson, Jennifer C Thompson, Jenny Harris, Claire Troakes, Bradley Smith, Safa Al-Saraj, Chris Shaw, Sara Rollinson, Masami Masuda-Suzukake, Masato Hasegawa, Stuart Pickering-Brown, Julie S Snowden and David M Mann

    Citation: Acta Neuropathologica Communications 2014 2:70

    Content type: Research

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  33. We evaluated the prognostic and predictive value of a range of molecular changes in the setting of a randomised trial comparing standard PCV (procarbazine, CCNU (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea) a...

    Authors: Vincent Peter Collins, Koichi Ichimura, Ying Di, Danita Pearson, Ray Chan, Lindsay C Thompson, Rhian Gabe, Michael Brada and Sally P Stenning

    Citation: Acta Neuropathologica Communications 2014 2:68

    Content type: Research

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  34. Blast-related traumatic brain injury (TBI) is a common cause of injury in the military operations in Iraq and Afghanistan. How the primary blast wave affects the brain is not well understood. The aim of the pr...

    Authors: Miguel A Gama Sosa, Rita De Gasperi, Pierce L Janssen, Frank J Yuk, Pamela C Anazodo, Paul E Pricop, Alejandro J Paulino, Bridget Wicinski, Michael C Shaughness, Eric Maudlin-Jeronimo, Aaron A Hall, Dara L Dickstein, Richard M McCarron, Mikulas Chavko, Patrick R Hof, Stephen T Ahlers…

    Citation: Acta Neuropathologica Communications 2014 2:67

    Content type: Research

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  35. Progressive supranuclear palsy (PSP) is a neurodegenerative tauopathy which is primarily defined by the deposition of tau into globose-type neurofibrillary tangles (NFT). Tau in its native form has important f...

    Authors: Julia E Gerson, Urmi Sengupta, Cristian A Lasagna-Reeves, Marcos J Guerrero-Muñoz, Juan Troncoso and Rakez Kayed

    Citation: Acta Neuropathologica Communications 2014 2:73

    Content type: Research

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  36. In epilepsy, the diagnosis of mild Malformation of Cortical Development type II (mMCD II) predominantly relies on the histopathological assessment of heterotopic neurons in the white matter. The exact diagnost...

    Authors: Joan YW Liu, Matthew Ellis, Hannah Brooke-Ball, Jane de Tisi, Sofia H Eriksson, Sebastian Brandner, Sanjay M Sisodiya and Maria Thom

    Citation: Acta Neuropathologica Communications 2014 2:72

    Content type: Methodology article

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  37. Hallmarks of CNS inflammation, including microglial and astrocyte activation, are prominent features in post-mortem tissue from amyotrophic lateral sclerosis (ALS) patients and in mice overexpressing mutant super...

    Authors: Matthew C Evans, Pieter J Gaillard, Marco de Boer, Chantal Appeldoorn, Rick Dorland, Nicola R Sibson, Martin R Turner, Daniel C Anthony and Helen B Stolp

    Citation: Acta Neuropathologica Communications 2014 2:66

    Content type: Research

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  38. Mid-life obesity and type 2 diabetes mellitus (T2DM) confer a modest, increased risk for Alzheimer’s disease (AD), though the underlying mechanisms are unknown. We have created a novel mouse model that recapit...

    Authors: Dana M Niedowicz, Valerie L Reeves, Thomas L Platt, Katharina Kohler, Tina L Beckett, David K Powell, Tiffany L Lee, Travis R Sexton, Eun Suk Song, Lawrence D Brewer, Caitlin S Latimer, Susan D Kraner, Kara L Larson, Sabire Ozcan, Christopher M Norris, Louis B Hersh…

    Citation: Acta Neuropathologica Communications 2014 2:64

    Content type: Research

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  39. Intraneuronal neurofibrillary tangles (NFTs) – a characteristic pathological feature of Alzheimer’s and several other neurodegenerative diseases – are considered a major target for drug development. Tangle loa...

    Authors: Nikita Rudinskiy, Jonathan M Hawkes, Susanne Wegmann, Kishore V Kuchibhotla, Alona Muzikansky, Rebecca A Betensky, Tara L Spires-Jones and Bradley T Hyman

    Citation: Acta Neuropathologica Communications 2014 2:63

    Content type: Research

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  40. Cancer pain creates a poor quality of life and decreases survival. The basic neurobiology of cancer pain is poorly understood. Adenosine triphosphate (ATP) and the ATP ionotropic receptor subunits, P2X2 and P2...

    Authors: Yi Ye, Kentaro Ono, Daniel G Bernabé, Chi T Viet, Victoria Pickering, John C Dolan, Markus Hardt, Anthony P Ford and Brian L Schmidt

    Citation: Acta Neuropathologica Communications 2014 2:62

    Content type: Research

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  41. Numerous studies have implicated the abnormal accumulation of intraneuronal amyloid-β (Aβ) as an important contributor to Alzheimer’s disease (AD) pathology, capable of triggering neuroinflammation, tau hyperp...

    Authors: M Florencia Iulita, Simon Allard, Luise Richter, Lisa-Marie Munter, Adriana Ducatenzeiler, Christoph Weise, Sonia Do Carmo, William L Klein, Gerhard Multhaup and A Claudio Cuello

    Citation: Acta Neuropathologica Communications 2014 2:61

    Content type: Research

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  42. The pathogenesis of heart failure (HF) in diabetic individuals, called “diabetic cardiomyopathy”, is only partially understood. Alterations in the cardiac autonomic nervous system due to oxidative stress have ...

    Authors: Chantalle E Menard, Melanie Durston, Elena Zherebitskaya, Darrell R Smith, Darren Freed, Gordon W Glazner, Ganghong Tian, Paul Fernyhough and Rakesh C Arora

    Citation: Acta Neuropathologica Communications 2014 2:60

    Content type: Research

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  43. Diffuse intrinsic pontine glioma (DIPG) is a malignant pediatric brain tumor associated with dismal outcome. Recent high-throughput molecular studies have shown a high frequency of mutations in histone-encodin...

    Authors: Sama Ahsan, Eric H Raabe, Michael C Haffner, Ajay Vaghasia, Katherine E Warren, Martha Quezado, Leomar Y Ballester, Javad Nazarian, Charles G Eberhart and Fausto J Rodriguez

    Citation: Acta Neuropathologica Communications 2014 2:59

    Content type: Research

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  44. Mutations in isocitrate dehydrogenase genes IDH1 or IDH2 are frequent in glioma, and IDH mutation status is a strong diagnostic and prognostic marker. Current IDH mutation screening is performed with an immunohis...

    Authors: Aurélie Catteau, Hélène Girardi, Florence Monville, Cécile Poggionovo, Sabrina Carpentier, Véronique Frayssinet, Jesse Voss, Robert Jenkins, Blandine Boisselier, Karima Mokhtari, Marc Sanson, Hélène Peyro-Saint-Paul and Caterina Giannini

    Citation: Acta Neuropathologica Communications 2014 2:58

    Content type: Methodology article

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  45. Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients. We analysed whether circumve...

    Authors: Ramadhan T Othman, Ioanna Kimishi, Tracey D Bradshaw, Lisa CD Storer, Andrey Korshunov, Stefan M Pfister, Richard G Grundy, Ian D Kerr and Beth Coyle

    Citation: Acta Neuropathologica Communications 2014 2:57

    Content type: Research

    Published on:

  46. Pathological aggregation of the microtubule-associated protein tau and subsequent accumulation of neurofibrillary tangles (NFTs) or other tau-containing inclusions are defining histopathological features of ma...

    Authors: Cristian A Lasagna-Reeves, Urmi Sengupta, Diana Castillo-Carranza, Julia E Gerson, Marcos Guerrero-Munoz, Juan C Troncoso, George R Jackson and Rakez Kayed

    Citation: Acta Neuropathologica Communications 2014 2:56

    Content type: Research

    Published on:

  47. Greater than 160 missense mutations in copper-zinc superoxide dismutase-1 (SOD1) can cause amyotrophic lateral sclerosis (ALS). These mutations produce conformational changes that reveal novel antibody binding ep...

    Authors: Jacob I Ayers, Guilian Xu, Olga Pletnikova, Juan C Troncoso, P John Hart and David R Borchelt

    Citation: Acta Neuropathologica Communications 2014 2:55

    Content type: Research

    Published on:

  48. The neuronal ceroid lipofuscinoses constitute a group of fatal inherited lysosomal storage diseases that manifest in profound neurodegeneration in the CNS. Visual impairment usually is an early symptom and sel...

    Authors: Janos Groh, David Stadler, Mathias Buttmann and Rudolf Martini

    Citation: Acta Neuropathologica Communications 2014 2:54

    Content type: Methodology article

    Published on:

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