(1997) Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging 18: S1–2
Adler CH, Beach TG, Hentz JG, Shill HA, Caviness JN, Driver-Dunckley E et al (2014) Low clinical diagnostic accuracy of early vs advanced Parkinson disease: clinicopathologic study. Neurology 83:406–412. https://doi.org/10.1212/WNL.0000000000000641
Article
PubMed
PubMed Central
Google Scholar
Adler CH, Beach TG, Zhang N, Shill HA, Driver-Dunckley E, Mehta SH et al (2021) Clinical diagnostic accuracy of early/advanced parkinson disease: an updated clinicopathologic study. Neurol Clin Pract 11:e414–e421. https://doi.org/10.1212/CPJ.0000000000001016
Article
PubMed
Google Scholar
Arnold SJ, Dugger BN, Beach TG (2013) TDP-43 deposition in prospectively followed, cognitively normal elderly individuals: correlation with argyrophilic grains but not other concomitant pathologies. Acta Neuropathol 126:51–57. https://doi.org/10.1007/s00401-013-1110-0
Article
CAS
PubMed
PubMed Central
Google Scholar
Bargar C, Wang W, Gunzler SA, LeFevre A, Wang Z, Lerner AJ et al (2021) Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies. Acta Neuropathol Commun 9:62. https://doi.org/10.1186/s40478-021-01175-w
Article
CAS
PubMed
PubMed Central
Google Scholar
Bassil F, Meymand ES, Brown HJ, Xu H, Cox TO, Pattabhiraman S et al (2021) alpha-Synuclein modulates tau spreading in mouse brains. J Exp Med. https://doi.org/10.1084/jem.20192193
Article
PubMed
Google Scholar
Beach TG, Adler CH (2018) Importance of low diagnostic Accuracy for early Parkinson’s disease. Mov Disord 33:1551–1554. https://doi.org/10.1002/mds.27485
Article
PubMed
PubMed Central
Google Scholar
Beach TG, Adler CH, Lue L, Sue LI, Bachalakuri J, Henry-Watson J et al (2009) Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol 117:613–634. https://doi.org/10.1007/s00401-009-0538-8
Article
PubMed
PubMed Central
Google Scholar
Beach TG, Adler CH, Sue LI, Serrano G, Shill HA, Walker DG et al (2015) Arizona study of aging and neurodegenerative disorders and brain and body donation program. Neuropathology 35:354–389. https://doi.org/10.1111/neup.12189
Article
PubMed
PubMed Central
Google Scholar
Beach TG, Malek-Ahmadi M (2021) Alzheimer’s Disease neuropathological comorbidities are common in the younger-old. J Alzheimers Dis 79:389–400. https://doi.org/10.3233/JAD-201213
Article
CAS
PubMed
PubMed Central
Google Scholar
Beach TG, Sue LI, Walker DG, Roher AE, Lue L, Vedders L et al (2008) The sun health research institute brain donation program: description and experience, 1987–2007. Cell Tissue Bank 9:229–245. https://doi.org/10.1007/s10561-008-9067-2
Article
PubMed
PubMed Central
Google Scholar
Berg D, Postuma RB, Adler CH, Bloem BR, Chan P, Dubois B et al (2015) MDS research criteria for prodromal Parkinson’s disease. Mov Disord 30:1600–1611. https://doi.org/10.1002/mds.26431
Article
PubMed
Google Scholar
Blennow K, Hampel H, Weiner M, Zetterberg H (2010) Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol 6:131–144. https://doi.org/10.1038/nrneurol.2010.4
Article
CAS
PubMed
Google Scholar
Bongianni M, Ladogana A, Capaldi S, Klotz S, Baiardi S, Cagnin A et al (2019) alpha-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies. Ann Clin Transl Neurol 6:2120–2126. https://doi.org/10.1002/acn3.50897
Article
CAS
PubMed
PubMed Central
Google Scholar
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239–259. https://doi.org/10.1007/BF00308809
Article
CAS
PubMed
Google Scholar
Brandner S, Thaler C, Lelental N, Buchfelder M, Kleindienst A, Maler JM et al (2014) Ventricular and lumbar cerebrospinal fluid concentrations of Alzheimer’s disease biomarkers in patients with normal pressure hydrocephalus and posttraumatic hydrocephalus. J Alzheimers Dis 41:1057–1062. https://doi.org/10.3233/JAD-132708
Article
CAS
PubMed
Google Scholar
Brandner S, Thaler C, Lewczuk P, Lelental N, Buchfelder M, Kleindienst A (2013) Neuroprotein dynamics in the cerebrospinal fluid: intraindividual concomitant ventricular and lumbar measurements. Eur Neurol 70:189–194. https://doi.org/10.1159/000352032
Article
PubMed
Google Scholar
Brockmann K, Quadalti C, Lerche S, Rossi M, Wurster I, Baiardi S et al (2021) Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies. Acta Neuropathol Commun 9:175. https://doi.org/10.1186/s40478-021-01276-6
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen-Plotkin AS, Albin R, Alcalay R, Babcock D, Bajaj V, Bowman D et al (2018) Finding useful biomarkers for Parkinson’s disease. Sci Transl Med. https://doi.org/10.1126/scitranslmed.aam6003
Article
PubMed
PubMed Central
Google Scholar
De Pablo-Fernandez E, Lees AJ, Holton JL, Warner TT (2019) Prognosis and neuropathologic correlation of clinical subtypes of parkinson disease. JAMA Neurol 76:470–479. https://doi.org/10.1001/jamaneurol.2018.4377
Article
PubMed
PubMed Central
Google Scholar
Dickson DW (2018) Neuropathology of Parkinson disease. Parkinsonism Relat Disord 46(Suppl 1):S30–S33. https://doi.org/10.1016/j.parkreldis.2017.07.033
Article
PubMed
Google Scholar
Dickson DW (2012) Parkinson’s disease and parkinsonism: neuropathology. Cold Spring Harb Perspect Med. https://doi.org/10.1101/cshperspect.a009258
Article
PubMed
PubMed Central
Google Scholar
Dickson DW, Bergeron C, Chin SS, Duyckaerts C, Horoupian D, Ikeda K et al (2002) Office of rare diseases neuropathologic criteria for corticobasal degeneration. J Neuropathol Exp Neurol 61:935–946. https://doi.org/10.1093/jnen/61.11.935
Article
CAS
PubMed
Google Scholar
Dickson DW, Braak H, Duda JE, Duyckaerts C, Gasser T, Halliday GM et al (2009) Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria. Lancet Neurol 8:1150–1157. https://doi.org/10.1016/S1474-4422(09)70238-8
Article
CAS
PubMed
Google Scholar
Emre M, Aarsland D, Brown R, Burn DJ, Duyckaerts C, Mizuno Y et al (2007) Clinical diagnostic criteria for dementia associated with Parkinson's disease. Movement Disorders: official journal of the Movement Disorder Society 22: 1689–1707; quiz 1837 Doi https://doi.org/10.1002/mds.21507
Fahn S ER (1987) UPDRS Program Members. Unified Parkinson's disease rating scale. In: Fahn S, Marsden CD, Goldstein M, Calne DB (ed) Recent Developments in Parkinson's Disease. Florham Park, NJ: Macmillan Healthcare Information, pp 153–163
Fairfoul G, McGuire LI, Pal S, Ironside JW, Neumann J, Christie S et al (2016) Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies. Ann Clin Transl Neurol 3:812–818. https://doi.org/10.1002/acn3.338
Article
CAS
PubMed
PubMed Central
Google Scholar
Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198
Article
CAS
Google Scholar
Gelb DJ, Oliver E, Gilman S (1999) Diagnostic criteria for Parkinson disease. Arch Neurol 56:33–39
Article
CAS
Google Scholar
Gilman S, Low PA, Quinn N, Albanese A, Ben-Shlomo Y, Fowler CJ et al (1999) Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 163:94–98
Article
CAS
Google Scholar
Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ et al (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71:670–676. https://doi.org/10.1212/01.wnl.0000324625.00404.15
Article
CAS
PubMed
PubMed Central
Google Scholar
Groveman BR, Orru CD, Hughson AG, Raymond LD, Zanusso G, Ghetti B et al (2018) Rapid and ultra-sensitive quantitation of disease-associated alpha-synuclein seeds in brain and cerebrospinal fluid by alphaSyn RT-QuIC. Acta Neuropathol Commun 6:7. https://doi.org/10.1186/s40478-018-0508-2
Article
CAS
PubMed
PubMed Central
Google Scholar
Hall S, Ohrfelt A, Constantinescu R, Andreasson U, Surova Y, Bostrom F et al (2012) Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders. Arch Neurol 69:1445–1452. https://doi.org/10.1001/archneurol.2012.1654
Article
PubMed
Google Scholar
Hall S, Surova Y, Ohrfelt A, Zetterberg H, Lindqvist D, Hansson O (2015) CSF biomarkers and clinical progression of Parkinson disease. Neurology 84:57–63. https://doi.org/10.1212/WNL.0000000000001098
Article
CAS
PubMed
PubMed Central
Google Scholar
Hansson O, Mikulskis A, Fagan AM, Teunissen C, Zetterberg H, Vanderstichele H et al (2018) The impact of preanalytical variables on measuring cerebrospinal fluid biomarkers for Alzheimer’s disease diagnosis: a review. Alzheimers Dement 14:1313–1333. https://doi.org/10.1016/j.jalz.2018.05.008
Article
PubMed
Google Scholar
Hauw JJ, Daniel SE, Dickson D, Horoupian DS, Jellinger K, Lantos PL et al (1994) Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). Neurology 44:2015–2019. https://doi.org/10.1212/wnl.44.11.2015
Article
CAS
PubMed
Google Scholar
Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17:427–442
Article
CAS
Google Scholar
Hoglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE et al (2017) Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord 32:853–864. https://doi.org/10.1002/mds.26987
Article
PubMed
PubMed Central
Google Scholar
Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC et al (2012) National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease. Alzheimers Dement 8:1–13. https://doi.org/10.1016/j.jalz.2011.10.007
Article
PubMed
PubMed Central
Google Scholar
Iranzo A, Fairfoul G, Ayudhaya ACN, Serradell M, Gelpi E, Vilaseca I et al (2021) Detection of alpha-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study. Lancet Neurol 20:203–212. https://doi.org/10.1016/S1474-4422(20)30449-X
Article
CAS
PubMed
Google Scholar
Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX et al (2017) Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. Lancet Neurol 16:55–65. https://doi.org/10.1016/S1474-4422(16)30291-5
Article
PubMed
PubMed Central
Google Scholar
Jecmenica Lukic M, Kurz C, Respondek G, Grau-Rivera O, Compta Y, Gelpi E et al (2020) Copathology in progressive supranuclear palsy: does it matter? Mov Disord 35:984–993. https://doi.org/10.1002/mds.28011
Article
CAS
PubMed
Google Scholar
Jellinger KA (2018) Dementia with Lewy bodies and Parkinson’s disease-dementia: current concepts and controversies. J Neural Transm (Vienna) 125:615–650. https://doi.org/10.1007/s00702-017-1821-9
Article
CAS
Google Scholar
Kang UJ, Boehme AK, Fairfoul G, Shahnawaz M, Ma TC, Hutten SJ et al (2019) Comparative study of cerebrospinal fluid alpha-synuclein seeding aggregation assays for diagnosis of Parkinson’s disease. Mov Disord 34:536–544. https://doi.org/10.1002/mds.27646
Article
CAS
PubMed
PubMed Central
Google Scholar
Koga S, Aoki N, Uitti RJ, van Gerpen JA, Cheshire WP, Josephs KA et al (2015) When DLB, PD, and PSP masquerade as MSA: an autopsy study of 134 patients. Neurology 85:404–412. https://doi.org/10.1212/WNL.0000000000001807
Article
CAS
PubMed
PubMed Central
Google Scholar
Koga S, Li F, Zhao N, Roemer SF, Ferman TJ, Wernick AI et al (2020) Clinicopathologic and genetic features of multiple system atrophy with Lewy body disease. Brain Pathol 30:766–778. https://doi.org/10.1111/bpa.12839
Article
CAS
PubMed
PubMed Central
Google Scholar
Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC et al (1996) Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 47:1–9
Article
CAS
Google Scholar
Martinez-Valbuena I, Visanji NP, Kim A, Lau HHC, So RWL, Alshimemeri S et al (2022) Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy. Transl Neurodegener 11:7. https://doi.org/10.1186/s40035-022-00283-4
Article
CAS
PubMed
PubMed Central
Google Scholar
McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H et al (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65:1863–1872. https://doi.org/10.1212/01.wnl.0000187889.17253.b1
Article
CAS
PubMed
Google Scholar
Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM et al (1991) The consortium to establish a registry for alzheimer’s disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer’s disease. Neurology 41:479–486. https://doi.org/10.1212/wnl.41.4.479
Article
CAS
PubMed
Google Scholar
Mollenhauer B, Locascio JJ, Schulz-Schaeffer W, Sixel-Doring F, Trenkwalder C, Schlossmacher MG (2011) alpha-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study. Lancet Neurol 10:230–240. https://doi.org/10.1016/S1474-4422(11)70014-X
Article
CAS
PubMed
Google Scholar
Orru CD, Ma TC, Hughson AG, Groveman BR, Srivastava A, Galasko D et al (2021) A rapid alpha-synuclein seed assay of Parkinson’s disease CSF panel shows high diagnostic accuracy. Ann Clin Transl Neurol 8:374–384. https://doi.org/10.1002/acn3.51280
Article
CAS
PubMed
Google Scholar
Parnetti L, Gaetani L, Eusebi P, Paciotti S, Hansson O, El-Agnaf O et al (2019) CSF and blood biomarkers for Parkinson’s disease. Lancet Neurol 18:573–586. https://doi.org/10.1016/S1474-4422(19)30024-9
Article
CAS
PubMed
Google Scholar
Peelaerts W, Bousset L, Baekelandt V, Melki R (2018) a-Synuclein strains and seeding in Parkinson’s disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences. Cell Tissue Res 373:195–212. https://doi.org/10.1007/s00441-018-2839-5
Article
CAS
PubMed
Google Scholar
Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL et al (2018) Cellular milieu imparts distinct pathological alpha-synuclein strains in alpha-synucleinopathies. Nature 557:558–563. https://doi.org/10.1038/s41586-018-0104-4
Article
CAS
PubMed
PubMed Central
Google Scholar
Peng C, Trojanowski JQ, Lee VM (2020) Protein transmission in neurodegenerative disease. Nat Rev Neurol 16:199–212. https://doi.org/10.1038/s41582-020-0333-7
Article
CAS
PubMed
Google Scholar
Perra D, Bongianni M, Novi G, Janes F, Bessi V, Capaldi S et al (2021) Alpha-synuclein seeds in olfactory mucosa and cerebrospinal fluid of patients with dementia with Lewy bodies. Brain Commun 3: fcab045, https://doi.org/10.1093/braincomms/fcab045
Rizzo G, Copetti M, Arcuti S, Martino D, Fontana A, Logroscino G (2016) Accuracy of clinical diagnosis of Parkinson disease: a systematic review and meta-analysis. Neurology 86:566–576. https://doi.org/10.1212/WNL.0000000000002350
Article
PubMed
Google Scholar
Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C et al (2018) Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain 141:2181–2193. https://doi.org/10.1093/brain/awy146
Article
PubMed
PubMed Central
Google Scholar
Rossi M, Baiardi S, Teunissen CE, Quadalti C, van de Beek M, Mammana A et al (2021) Diagnostic value of the CSF alpha-synuclein real-time quaking-induced conversion assay at the prodromal MCI stage of dementia with lewy bodies. Neurology 97:e930–e940. https://doi.org/10.1212/WNL.0000000000012438
Article
CAS
PubMed
Google Scholar
Rossi M, Candelise N, Baiardi S, Capellari S, Giannini G, Orru CD et al (2020) Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies. Acta Neuropathol 140:49–62. https://doi.org/10.1007/s00401-020-02160-8
Article
CAS
PubMed
PubMed Central
Google Scholar
Russo MJ, Orru CD, Concha-Marambio L, Giaisi S, Groveman BR, Farris CM et al (2021) High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease. Acta Neuropathol Commun 9:179. https://doi.org/10.1186/s40478-021-01282-8
Article
CAS
PubMed
PubMed Central
Google Scholar
Saijo E, Groveman BR, Kraus A, Metrick M, Orru CD, Hughson AG et al (2019) Ultrasensitive RT-QuIC seed amplification assays for disease-associated tau, alpha-synuclein, and prion aggregates. Methods Mol Biol 1873:19–37. https://doi.org/10.1007/978-1-4939-8820-4_2
Article
CAS
PubMed
Google Scholar
Schapira AH (2009) Molecular and clinical pathways to neuroprotection of dopaminergic drugs in Parkinson disease. Neurology 72:S44-50. https://doi.org/10.1212/WNL.0b013e3181990438
Article
CAS
PubMed
Google Scholar
Serrano-Pozo A, Qian J, Muzikansky A, Monsell SE, Montine TJ, Frosch MP et al (2016) Thal amyloid stages do not significantly impact the correlation between neuropathological change and cognition in the alzheimer disease continuum. J Neuropathol Exp Neurol 75:516–526. https://doi.org/10.1093/jnen/nlw026
Article
CAS
PubMed
PubMed Central
Google Scholar
Shahnawaz M, Mukherjee A, Pritzkow S, Mendez N, Rabadia P, Liu X et al (2020) Discriminating alpha-synuclein strains in Parkinson’s disease and multiple system atrophy. Nature 578:273–277. https://doi.org/10.1038/s41586-020-1984-7
Article
CAS
PubMed
PubMed Central
Google Scholar
Simonsen AH, Bech S, Laursen I, Salvesen L, Winge K, Waldemar G et al (2010) Proteomic investigations of the ventriculo-lumbar gradient in human CSF. J Neurosci Methods 191:244–248. https://doi.org/10.1016/j.jneumeth.2010.06.017
Article
CAS
PubMed
Google Scholar
Singer W, Schmeichel AM, Shahnawaz M, Schmelzer JD, Sletten DM, Gehrking TL et al (2021) Alpha-synuclein oligomers and neurofilament light chain predict phenoconversion of pure autonomic failure. Ann Neurol 89:1212–1220. https://doi.org/10.1002/ana.26089
Article
CAS
PubMed
PubMed Central
Google Scholar
Van der Perren A, Gelders G, Fenyi A, Bousset L, Brito F, Peelaerts W et al (2020) The structural differences between patient-derived alpha-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies. Acta Neuropathol 139:977–1000. https://doi.org/10.1007/s00401-020-02157-3
Article
CAS
PubMed
PubMed Central
Google Scholar
van Rumund A, Green AJE, Fairfoul G, Esselink RAJ, Bloem BR, Verbeek MM (2019) alpha-Synuclein real-time quaking-induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism. Ann Neurol 85:777–781. https://doi.org/10.1002/ana.25447
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang Z, Becker K, Donadio V, Siedlak S, Yuan J, Rezaee M et al (2020) Skin alpha-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease. JAMA Neurol, https://doi.org/10.1001/jamaneurol.2020.3311