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Table 3 Distribution of neuropathological diagnosis in the (AZSAND/BBDP) cohort

From: Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease

Diagnostic category

NP diagnosis

N

αSyn RT-QuIC positive

αSyn RT-QuIC negative

Sensitivity

Specificity

Standard LBD

25

25

 

100%

 

DLB-AD

4

4

 

100%

 

PD

16

16

 

100%

 

PD-AD

4

4

 

100%

 

PD-PSP*

1

1

 

100%

 

Non-standard LBD

23

13

10

57%

 

ADLB

14

9

5

64%

 

ILBD

4

2

2

50%

 

LBS-PSP

1

 

1

0%

 

LBS-VaD

2

 

2

0%

 

LBS-VaD-PSP **

1

1

 

100%

 

LBS-Astrocytoma

1

1

 

100%

 

Lewy Body negative

53

3

50

 

94%

PSP

2

1

1

 

50%

PSP-AD

2

 

2

 

100%

VaD-CBD

1

 

1

 

100%

MSA

1

 

1

 

100%

AD

7

2

5

 

71%

VaD-AD

7

 

7

 

100%

Controls

25

 

25

 

100%

Other

8

 

8

 

100%

  1. *Included as PD in statistical analyses
  2. **Microscopic changes of PSP, not included as clinicopathological PSP in statistical analyses. Abbreviations: AD = Alzheimers disease; ADLB = Alzheimer’s disease with Lewy bodies, not meeting criteria for DLB;
  3. CBD = Corticobasal degeneration; DLB = Dementia with Lewy Bodies; LBS = Lewy Bodies, LBD = Lewy Body Disorders; ILBD = Incidental Lewy Body Disease; VaD = Vascular dementia; MSA = Multiple System Atrophy; PSP = Supranuclear Palsy
  4. Bold is for total Standard LBD/Non-standard LBD/Lewy body negative
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Acta Neuropathologica Communications

ISSN: 2051-5960

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