Table 2 Patient characteristics, AZSAND/BBDP cohort
From: Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease
αSyn RT-QuIC positive | αSyn RT-QuIC negative | p-value | |
|---|---|---|---|
Number | 41 | 60 | |
Age at death, Mean (SD) | 83 (7.0) | 86 (8.6) | 0.002 |
Sex Male/Female | 31/10 | 35/25 | 0.073 |
Lewy Body positive | 38 (93%) | 10 (17%) | < 0.001 |
Lewy Body density total score (max 40) Mean (SD) | 21 (11) 1 missing | 1.05 (2.9) | < 0.001 |
Lewy Body stage | |||
0 | 3 | 50 | |
I (olfactory bulb only) | 1 | 2 | |
IIa (brainstem predominant) | 2 | 3 | |
IIb (limbic predominant) | 7 | 4 | |
III (brainstem/limbic) | 16 | 1 | |
IV (neocortical) | 12 | 0 | |
Total senile plaque density score (0–15) Mean (SD) | 8.05 (6.19) | 7.16 (6.25) | p = 0.427 |
Total neurofibrillary tangle density score (0–15), Mean (SD) | 7.70 (3.73) | 6.95 (2.94) | p = 0.703 |
TDP-43 pathology Yes/No (missing) | 3/10 (28) | 7/18 (35) | p = 0.744 |