From: Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease
Control | PD | PDD | MSA | PSP | Controls that converted to LBD | |
---|---|---|---|---|---|---|
Number | 47 | 50 | 14 | 15 | 15 | 2 |
αSyn RT-QuIC positive (%) | 8 (17%) | 47 (94%) | 14 (100%) | 5 (33%) | 5 (33%) | 2 (100%) |
Sex Female/Male (% Female) | 27/20 (57%) | 25/25 (50%) | 6/8 (43%) | 6/9 (40%) | 8/7 (53%) | 1/1 (50%) |
Age in years | 66.6 (8.9) | 68.0 (6.9) | 71.1 (6.2) | 66.6 (6.6) | 72.3 (5.5) c, d, i | 65.0 (4.2) |
MMSE | 28.7 (1.3) | 28.9 (1.3) | 21.9 (3.8)c, d | 27.3 (2.9)e, f | 24.8 (4.8)c, d | 28.5 (2.1)h |
Disease Duration in years | NA | 6.8 (3.8) | 16.8 (6.9)d | 6.9 (2.7)f | 6.8 (3.8)f | NA |
UPDRS III | 1.9 (2.7) | 13.1 (7.9)a | 38.4 (11.0)a, d | 44.5 (17.5)a, d | 47.5 (14.3)a, d | 0.5 (0.7)e, h, i, j |
Hoehn & Yahr | NA | 2.1 (0.6) | 3.3 (0.7)d | 4.1 (0.89) d, h | 4.3 (0.7) d, g | 0 (0)e, h, I, j |