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Table 1 Patient characteristics, BioFINDER cohort

From: Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease

 

Control

PD

PDD

MSA

PSP

Controls that converted to LBD

Number

47

50

14

15

15

2

αSyn RT-QuIC positive (%)

8

(17%)

47

(94%)

14

(100%)

5

(33%)

5

(33%)

2

(100%)

Sex Female/Male

(% Female)

27/20

(57%)

25/25

(50%)

6/8

(43%)

6/9

(40%)

8/7

(53%)

1/1

(50%)

Age in years

66.6 (8.9)

68.0 (6.9)

71.1

(6.2)

66.6

(6.6)

72.3

(5.5) c, d, i

65.0

(4.2)

MMSE

28.7

(1.3)

28.9

(1.3)

21.9

(3.8)c, d

27.3

(2.9)e, f

24.8

(4.8)c, d

28.5

(2.1)h

Disease Duration in years

NA

6.8 (3.8)

16.8 (6.9)d

6.9

(2.7)f

6.8

(3.8)f

NA

UPDRS III

1.9

(2.7)

13.1

(7.9)a

38.4

(11.0)a, d

44.5

(17.5)a, d

47.5

(14.3)a, d

0.5

(0.7)e, h, i, j

Hoehn & Yahr

NA

2.1

(0.6)

3.3

(0.7)d

4.1

(0.89) d, h

4.3

(0.7) d, g

0

(0)e, h, I, j

  1. Data is given as mean and standard deviation (SD) except for in dichotomized values. Significances were analyzed using Mann–Whitney or in the case of dichotomized values Chi-square. a) p < 0.001 vs. control; b) p < 0.01 vs. control; c) p < 0.05 vs. control; d) p < 0.001 vs. PD; e) p < 0.05 vs. PD; f) p < 0.001 vs. PDD; g) p < 0.01 vs. PDD; h) p < 0.05 vs. PDD) i: p < 0.05 vs. MSA; j) p > 0.05 vs. PSP