Niedowicz DM, Nelson PT, Murphy MP: Alzheimer’s disease: pathological mechanisms and recent insights. Curr Neuropharmacol 2011, 9(4):674–684. doi:10.2174/157015911798376181 10.2174/157015911798376181
Article
CAS
PubMed
PubMed Central
Google Scholar
Ferreira ST, Klein WL: The Abeta oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease. Neurobiol Learn Mem 2011, 96(4):529–543. doi:10.1016/j.nlm.2011.08.003 10.1016/j.nlm.2011.08.003
Article
CAS
PubMed
PubMed Central
Google Scholar
LaFerla FM, Oddo S: Alzheimer’s disease: Abeta, tau and synaptic dysfunction. Trends Mol Med 2005, 11(4):170–176. doi:10.1016/j.molmed.2005.02.009 10.1016/j.molmed.2005.02.009
Article
CAS
PubMed
Google Scholar
Selkoe DJ: Alzheimer’s disease is a synaptic failure. Science 2002, 298(5594):789–791. doi:10.1126/science.1074069 10.1126/science.1074069
Article
CAS
PubMed
Google Scholar
Biessels GJ, Kamal A, Urban IJ, Spruijt BM, Erkelens DW, Gispen WH: Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment. Brain Res 1998, 800(1):125–135. 10.1016/S0006-8993(98)00510-1
Article
CAS
PubMed
Google Scholar
Li XL, Aou S, Oomura Y, Hori N, Fukunaga K, Hori T: Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience 2002, 113(3):607–615. 10.1016/S0306-4522(02)00162-8
Article
CAS
PubMed
Google Scholar
Messier C: Impact of impaired glucose tolerance and type 2 diabetes on cognitive aging. Neurobiol Aging 2005, 26(Suppl 1):26–30. doi:10.1016/j.neurobiolaging.2005.09.014
Article
PubMed
Google Scholar
Luchsinger JA, Gustafson DR: Adiposity, type 2 diabetes, and Alzheimer’s disease. J Alzheimers Dis 2009, 16(4):693–704. doi:10.3233/JAD-2009–1022
PubMed
PubMed Central
Google Scholar
Ahtiluoto S, Polvikoski T, Peltonen M, Solomon A, Tuomilehto J, Winblad B, Sulkava R, Kivipelto M: Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study. Neurology 2010, 75(13):1195–1202. doi:10.1212/WNL.0b013e3181f4d7f8 10.1212/WNL.0b013e3181f4d7f8
Article
CAS
PubMed
Google Scholar
Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW: Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies. Acta Neuropathol 2011, 121(5):571–587. doi:10.1007/s00401–011–0826-y 10.1007/s00401-011-0826-y
Article
PubMed
PubMed Central
Google Scholar
Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP: Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996, 84(3):491–495. 10.1016/S0092-8674(00)81294-5
Article
CAS
PubMed
Google Scholar
Coleman DL: Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978, 14(3):141–148. 10.1007/BF00429772
Article
CAS
PubMed
Google Scholar
Srinivasan K, Ramarao P: Animal models in type 2 diabetes research: an overview. Indian J Med Res 2007, 125(3):451–472.
CAS
PubMed
Google Scholar
Reaume AG, Howland DS, Trusko SP, Savage MJ, Lang DM, Greenberg BD, Siman R, Scott RW: Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer’s disease mutations and a “humanized” Abeta sequence. J Biol Chem 1996, 271(38):23380–23388. 10.1074/jbc.271.38.23380
Article
CAS
PubMed
Google Scholar
Siman R, Reaume AG, Savage MJ, Trusko S, Lin YG, Scott RW, Flood DG: Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability. J Neurosci 2000, 20(23):8717–8726.
CAS
PubMed
Google Scholar
Anantharaman M, Tangpong J, Keller JN, Murphy MP, Markesbery WR, Kiningham KK, St Clair DK: Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer’s disease. Am J Pathol 2006, 168(5):1608–1618. 10.2353/ajpath.2006.051223
Article
CAS
PubMed
PubMed Central
Google Scholar
Murphy MP, Beckett TL, Ding Q, Patel E, Markesbery WR, St Clair DK, LeVine H 3rd, Keller JN: Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice. Neurobiol Dis 2007, 27(3):301–311. doi:10.1016/j.nbd.2007.06.002 10.1016/j.nbd.2007.06.002
Article
CAS
PubMed
Google Scholar
Niedowicz DM, Beckett TL, Matveev S, Weidner AM, Baig I, Kryscio RJ, Mendiondo MS, LeVine H 3rd, Keller JN, Murphy MP: Pittsburgh compound B and the postmortem diagnosis of Alzheimer disease. Ann Neurol 2012, 72(4):564–570. doi:10.1002/ana.23633 10.1002/ana.23633
Article
CAS
PubMed
PubMed Central
Google Scholar
Beckett TL, Niedowicz DM, Studzinski CM, Weidner AM, Webb RL, Holler CJ, Ahmed RR, LeVine H 3rd, Murphy MP: Effects of nonsteroidal anti-inflammatory drugs on amyloid-beta pathology in mouse skeletal muscle. Neurobiol Dis 2010, 39(3):449–456. doi:10.1016/j.nbd.2010.05.018 10.1016/j.nbd.2010.05.018
Article
CAS
PubMed
PubMed Central
Google Scholar
LeVine H 3rd: Alzheimer’s beta-peptide oligomer formation at physiologic concentrations. Anal Biochem 2004, 335(1):81–90. doi:10.1016/j.ab.2004.08.014 10.1016/j.ab.2004.08.014
Article
CAS
PubMed
Google Scholar
Resende R, Ferreiro E, Pereira C, Oliveira CR: ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation. J Neurosci Res 2008, 86(9):2091–2099. doi:10.1002/jnr.21648 10.1002/jnr.21648
Article
CAS
PubMed
Google Scholar
Vale C, Alonso E, Rubiolo JA, Vieytes MR, LaFerla FM, Gimenez-Llort L, Botana LM: Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice. Cell Mol Neurobiol 2010, 30(4):577–590. doi:10.1007/s10571–009–9482–3 10.1007/s10571-009-9482-3
Article
CAS
PubMed
Google Scholar
Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, Hersh LB: Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer’s disease. J Neurosci Res 2009, 87(6):1462–1473. doi:10.1002/jnr.21944 10.1002/jnr.21944
Article
CAS
PubMed
PubMed Central
Google Scholar
Latimer CS, Searcy JL, Bridges MT, Brewer LD, Popovic J, Blalock EM, Landfield PW, Thibault O, Porter NM: Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice. PLoS ONE 2011, 6(10):e26812. doi:10.1371/journal.pone.0026812 10.1371/journal.pone.0026812
Article
CAS
PubMed
PubMed Central
Google Scholar
Wilcock DM, Rojiani A, Rosenthal A, Subbarao S, Freeman MJ, Gordon MN, Morgan D: Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage. J Neuroinflammation 2004, 1(1):24. doi:10.1186/1742–2094–1-24 10.1186/1742-2094-1-24
Article
PubMed
PubMed Central
Google Scholar
Han BH, Zhou ML, Vellimana AK, Milner E, Kim DH, Greenberg JK, Chu W, Mach RH, Zipfel GJ: Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy. Mol Neurodegener 2011, 6: 86. doi:10.1186/1750–1326–6-86 10.1186/1750-1326-6-86
Article
CAS
PubMed
PubMed Central
Google Scholar
Holm S: A simple sequentially rejective multiple test procedure. Scand J Statist 1979, 6: 65–70.
Google Scholar
Niedowicz DM, Studzinski CM, Weidner AM, Platt TL, Kingry KN, Beckett TL, Bruce-Keller AJ, Keller JN, Murphy MP: Leptin regulates amyloid beta production via the gamma-secretase complex. Biochim Biophys Acta 2013, 1832(3):439–444. doi:10.1016/j.bbadis.2012.12.009 10.1016/j.bbadis.2012.12.009
Article
CAS
PubMed
Google Scholar
Thal DR, Ghebremedhin E, Orantes M, Wiestler OD: Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline. J Neuropathol Exp Neurol 2003, 62(12):1287–1301.
Article
PubMed
Google Scholar
Boulton ME, Cai J, Grant MB: gamma-Secretase: a multifaceted regulator of angiogenesis. J Cell Mol Med 2008, 12(3):781–795. doi:10.1111/j.1582–4934.2008.00274.x 10.1111/j.1582-4934.2008.00274.x
Article
CAS
PubMed
PubMed Central
Google Scholar
Cai J, Chen Z, Ruan Q, Han S, Liu L, Qi X, Boye SL, Hauswirth WW, Grant MB, Boulton ME: gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1. J Biol Chem 2011, 286(49):42514–42523. doi:10.1074/jbc.M111.296590 10.1074/jbc.M111.296590
Article
CAS
PubMed
PubMed Central
Google Scholar
Vartanian A, Gatsina G, Grigorieva I, Solomko E, Dombrovsky V, Baryshnikov A, Stepanova E: The involvement of Notch signaling in melanoma vasculogenic mimicry. Clin Exp Med 2012. doi:10.1007/s10238–012–0190–9
Google Scholar
Clinton LK, Billings LM, Green KN, Caccamo A, Ngo J, Oddo S, McGaugh JL, LaFerla FM: Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice. Neurobiol Dis 2007, 28(1):76–82. doi:10.1016/j.nbd.2007.06.013 10.1016/j.nbd.2007.06.013
Article
CAS
PubMed
PubMed Central
Google Scholar
Melnikova T, Savonenko A, Wang Q, Liang X, Hand T, Wu L, Kaufmann WE, Vehmas A, Andreasson KI: Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer’s disease in a sex-dimorphic pattern. Neuroscience 2006, 141(3):1149–1162. doi:10.1016/j.neuroscience.2006.05.001 10.1016/j.neuroscience.2006.05.001
Article
CAS
PubMed
Google Scholar
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM: Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003, 39(3):409–421. 10.1016/S0896-6273(03)00434-3
Article
CAS
PubMed
Google Scholar
Sweetnam D, Holmes A, Tennant KA, Zamani A, Walle M, Jones P, Wong C, Brown CE: Diabetes impairs cortical plasticity and functional recovery following ischemic stroke. J Neurosci 2012, 32(15):5132–5143. doi:10.1523/JNEUROSCI.5075–11.2012 10.1523/JNEUROSCI.5075-11.2012
Article
CAS
PubMed
Google Scholar
Wang CY, Kim HH, Hiroi Y, Sawada N, Salomone S, Benjamin LE, Walsh K, Moskowitz MA, Liao JK: Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Sci Signal 2009, 2(62):ra11. doi:10.1126/scisignal.2000143
Article
PubMed
PubMed Central
Google Scholar
Buee L, Hof PR, Bouras C, Delacourte A, Perl DP, Morrison JH, Fillit HM: Pathological alterations of the cerebral microvasculature in Alzheimer’s disease and related dementing disorders. Acta Neuropathol 1994, 87(5):469–480. 10.1007/BF00294173
Article
CAS
PubMed
Google Scholar
de la Torre JC: Hemodynamic consequences of deformed microvessels in the brain in Alzheimer’s disease. Ann N Y Acad Sci 1997, 826: 75–91.
Article
CAS
PubMed
Google Scholar
Loeys BL, Schwarze U, Holm T, Callewaert BL, Thomas GH, Pannu H, De Backer JF, Oswald GL, Symoens S, Manouvrier S, Roberts AE, Faravelli F, Greco MA, Pyeritz RE, Milewicz DM, Coucke PJ, Cameron DE, Braverman AC, Byers PH, De Paepe AM, Dietz HC: Aneurysm syndromes caused by mutations in the TGF-beta receptor. N Engl J Med 2006, 355(8):788–798. doi:10.1056/NEJMoa055695 10.1056/NEJMoa055695
Article
CAS
PubMed
Google Scholar
Moltzer E, Essers J, van Esch JH, Roos-Hesselink JW, Danser AH: The role of the renin-angiotensin system in thoracic aortic aneurysms: clinical implications. Pharmacol Ther 2011, 131(1):50–60. doi:10.1016/j.pharmthera.2011.04.002 10.1016/j.pharmthera.2011.04.002
Article
CAS
PubMed
Google Scholar
Ergul A: Endothelin-1 and diabetic complications: focus on the vasculature. Pharmacol Res 2011, 63(6):477–482. doi:10.1016/j.phrs.2011.01.012 10.1016/j.phrs.2011.01.012
Article
CAS
PubMed
Google Scholar
Li W, Prakash R, Kelly-Cobbs AI, Ogbi S, Kozak A, El-Remessy AB, Schreihofer DA, Fagan SC, Ergul A: Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia. Diabetes 2010, 59(1):228–235. doi:10.2337/db09–0902 10.2337/db09-0902
Article
PubMed
Google Scholar
Prakash R, Johnson M, Fagan SC, Ergul A: Cerebral neovascularization and remodeling patterns in two different models of type 2 diabetes. PLoS ONE 2013, 8(2):e56264. doi:10.1371/journal.pone.0056264 10.1371/journal.pone.0056264
Article
CAS
PubMed
PubMed Central
Google Scholar
Prakash R, Somanath PR, El-Remessy AB, Kelly-Cobbs A, Stern JE, Dore-Duffy P, Johnson M, Fagan SC, Ergul A: Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling. Diabetes 2012, 61(6):1533–1542. doi:10.2337/db11–1528 10.2337/db11-1528
Article
CAS
PubMed
PubMed Central
Google Scholar
Cai J, Wu L, Qi X, Li Calzi S, Caballero S, Shaw L, Ruan Q, Grant MB, Boulton ME: PEDF regulates vascular permeability by a gamma-secretase-mediated pathway. PLoS ONE 2011, 6(6):e21164. doi:10.1371/journal.pone.0021164 10.1371/journal.pone.0021164
Article
CAS
PubMed
PubMed Central
Google Scholar
Park SA: A common pathogenic mechanism linking type-2 diabetes and Alzheimer’s disease: evidence from animal models. J Clin Neurol 2011, 7(1):10–18. doi:10.3988/jcn.2011.7.1.10 10.3988/jcn.2011.7.1.10
Article
PubMed
PubMed Central
Google Scholar
Thibault O, Anderson KL, DeMoll C, Brewer LD, Landfield PW, Porter NM: Hippocampal calcium dysregulation at the nexus of diabetes and brain aging. Eur J Pharmacol 2013, 719(1–3):34–43. doi:10.1016/j.ejphar.2013.07.024
Article
CAS
PubMed
Google Scholar
Studzinski CM, Li F, Bruce-Keller AJ, Fernandez-Kim OS, Le Z, Weidner AM, Markesbery WR, Paul Murphy M, Keller JN: Effects of short term western diet on cerebral oxidative stress and diabetes related factors in APP x PS-1 knock-in mice. J Neurochem 2008. doi:10.1111/j.1471–4159.2008.05798.x
Google Scholar
Kohjima M, Sun Y, Chan L: Increased food intake leads to obesity and insulin resistance in the tg2576 Alzheimer’s disease mouse model. Endocrinology 2010, 151(4):1532–1540. doi:10.1210/en.2009–1196 10.1210/en.2009-1196
Article
CAS
PubMed
PubMed Central
Google Scholar
Julien C, Tremblay C, Phivilay A, Berthiaume L, Emond V, Julien P, Calon F: High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model. Neurobiol Aging 2010, 31(9):1516–1531. doi:10.1016/j.neurobiolaging.2008.08.022 10.1016/j.neurobiolaging.2008.08.022
Article
CAS
PubMed
Google Scholar
Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Freeman LR, Pepping JK, Beckett C, Murphy MP, Keller JN: Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice. Biochim Biophys Acta 2013, 1832: 1456–1462. doi:10.1016/j.bbadis.2013.01.002 10.1016/j.bbadis.2013.01.002
Article
CAS
PubMed
PubMed Central
Google Scholar
Killick R, Scales G, Leroy K, Causevic M, Hooper C, Irvine EE, Choudhury AI, Drinkwater L, Kerr F, Al-Qassab H, Stephenson J, Yilmaz Z, Giese KP, Brion JP, Withers DJ, Lovestone S: Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochem Biophys Res Commun 2009, 386(1):257–262. doi:10.1016/j.bbrc.2009.06.032 10.1016/j.bbrc.2009.06.032
Article
CAS
PubMed
PubMed Central
Google Scholar
Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R: Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci U S A 2010, 107(15):7036–7041. doi:10.1073/pnas.1000645107 10.1073/pnas.1000645107
Article
CAS
PubMed
PubMed Central
Google Scholar
Lubitz I, Haroutunian V, Katsel P, Leroith D, Landa N, Castel D, Shaish A, Shnerb R, Schnaider-Beeri M: Non-viability of crossing the Alzheimer’s mouse model Tg2576 with the type 2 diabetes mouse model ob/ob. Neurobiol Aging 2014, 35(7):e19-e20. 10.1016/j.neurobiolaging.2014.01.138
Article
PubMed
Google Scholar