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  1. Tauopathies such as Alzheimer’s disease (AD) feature progressive intraneuronal deposition of aggregated tau protein. The cause is unknown, but in experimental systems trans-cellular propagation of tau patholog...

    Authors: Sarah K. Kaufman, Talitha L. Thomas, Kelly Del Tredici, Heiko Braak and Marc I. Diamond
    Citation: Acta Neuropathologica Communications 2017 5:41
  2. Missense somatic mutations affecting histone H3.1 and H3.3 proteins are now accepted as the hallmark of paediatric diffuse intrinsic pontine gliomas (DIPG), non-brain stem paediatric high grade gliomas (pHGG) ...

    Authors: Farhana Haque, Pascale Varlet, Julien Puntonet, Lisa Storer, Aikaterini Bountali, Ruman Rahman, Jacques Grill, Angel M Carcaboso, Chris Jones, Robert Layfield and Richard G Grundy
    Citation: Acta Neuropathologica Communications 2017 5:45
  3. Most children with in utero alcohol exposure do not exhibit all features of fetal alcohol syndrome (FAS), and a challenge for clinicians is to make an early diagnosis of fetal alcohol spectrum disorders (FASD)...

    Authors: Matthieu Lecuyer, Annie Laquerrière, Soumeya Bekri, Céline Lesueur, Yasmina Ramdani, Sylvie Jégou, Arnaud Uguen, Pascale Marcorelles, Stéphane Marret and Bruno J. Gonzalez
    Citation: Acta Neuropathologica Communications 2017 5:44
  4. Bioactive lipids contribute to the pathophysiology of multiple sclerosis. Here, we show that lysophosphatidic acids (LPAs) are dysregulated in multiple sclerosis (MS) and are functionally relevant in this dise...

    Authors: K. Schmitz, R. Brunkhorst, N. de Bruin, C. A. Mayer, A. Häussler, N. Ferreiros, S. Schiffmann, M. J. Parnham, S. Tunaru, J. Chun, S. Offermanns, C. Foerch, K. Scholich, J. Vogt, S. Wicker, J. Lötsch…
    Citation: Acta Neuropathologica Communications 2017 5:42
  5. Onconeural antibodies are associated with cancer and paraneoplastic encephalitis. While their pathogenic role is still largely unknown, their high diagnostic value is undisputed. In this study we describe the ...

    Authors: Stoyan Popkirov, Ilya Ayzenberg, Stefanie Hahn, Jan Bauer, Yvonne Denno, Nicole Rieckhoff, Christiane Radzimski, Volkmar H. Hans, Sebastian Berg, Florian Roghmann, Joachim Noldus, Christian G. Bien, Sabine Skodda, Jörg Wellmer, Winfried Stöcker, Christos Krogias…
    Citation: Acta Neuropathologica Communications 2017 5:40
  6. Recent updating of the World Health Organization (WHO) classification of central nervous system (CNS) tumors in 2016 demonstrates the first organized effort to restructure brain tumor classification by incorpo...

    Authors: Patrick J. Cimino, Michael Zager, Lisa McFerrin, Hans-Georg Wirsching, Hamid Bolouri, Bettina Hentschel, Andreas von Deimling, David Jones, Guido Reifenberger, Michael Weller and Eric C. Holland
    Citation: Acta Neuropathologica Communications 2017 5:39
  7. α-Synuclein is a protein involved in the pathogenesis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). We investigated the role of ne...

    Authors: Jessica Grigoletto, Katharina Pukaß, Ayelet Gamliel, Dana Davidi, Rachel Katz-Brull, Christiane Richter-Landsberg and Ronit Sharon
    Citation: Acta Neuropathologica Communications 2017 5:37
  8. Congenital hydrocephalus is considered as either acquired due to haemorrhage, infection or neoplasia or as of developmental nature and is divided into two subgroups, communicating and obstructive. Congenital h...

    Authors: Pascale Saugier-Veber, Florent Marguet, François Lecoquierre, Homa Adle-Biassette, Fabien Guimiot, Sara Cipriani, Sophie Patrier, Marie Brasseur-Daudruy, Alice Goldenberg, Valérie Layet, Yline Capri, Marion Gérard, Thierry Frébourg and Annie Laquerrière
    Citation: Acta Neuropathologica Communications 2017 5:36
  9. Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it is characterized by the presence of neuronal loss, spongiform degeneration, chronic inflammation and the accum...

    Authors: Franc Llorens, Katrin Thüne, Beata Sikorska, Matthias Schmitz, Waqas Tahir, Natalia Fernández-Borges, Maria Cramm, Nadine Gotzmann, Margarita Carmona, Nathalie Streichenberger, Uwe Michel, Saima Zafar, Anna-Lena Schuetz, Ashish Rajput, Olivier Andréoletti, Stefan Bonn…
    Citation: Acta Neuropathologica Communications 2017 5:35
  10. Infectious prion aggregates can propagate from extraneural sites into the brain with remarkable efficiency, likely transported via peripheral nerves. Yet not all prions spread into the brain, and the physical ...

    Authors: Cyrus Bett, Jessica Lawrence, Timothy D. Kurt, Christina Orru, Patricia Aguilar-Calvo, Anthony E. Kincaid, Witold K. Surewicz, Byron Caughey, Chengbiao Wu and Christina J. Sigurdson
    Citation: Acta Neuropathologica Communications 2017 5:32
  11. Frontotemporal Lobar Degeneration (FTLD) encompasses certain related neurodegenerative disorders which alter behaviour, personality and language. Heterogeneous ribonuclear proteins (hnRNPs) maintain RNA metabo...

    Authors: Yvonne S. Davidson, Louis Flood, Andrew C. Robinson, Yoshihiro Nihei, Kohji Mori, Sara Rollinson, Anna Richardson, Bridget C. Benson, Matthew Jones, Julie S. Snowden, Stuart Pickering-Brown, Christian Haass, Tammaryn Lashley and David M. A. Mann
    Citation: Acta Neuropathologica Communications 2017 5:31
  12. Studies in vivo and in vitro have suggested that the mechanism underlying Alzheimer’s disease (AD) neuropathogenesis is initiated by an interaction between the cellular prion protein (PrPC) and amyloid-β oligomer...

    Authors: Richard Rubenstein, Binggong Chang, Natalia Grinkina, Eleanor Drummond, Peter Davies, Meir Ruditzky, Deep Sharma, Kevin Wang and Thomas Wisniewski
    Citation: Acta Neuropathologica Communications 2017 5:30
  13. An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sen...

    Authors: Sarah Mizielinska, Charlotte E. Ridler, Rubika Balendra, Annora Thoeng, Nathan S. Woodling, Friedrich A. Grässer, Vincent Plagnol, Tammaryn Lashley, Linda Partridge and Adrian M. Isaacs
    Citation: Acta Neuropathologica Communications 2017 5:29
  14. Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise in young children and are not surgically resectabl...

    Authors: Tina Y. Huang, Andrea Piunti, Rishi R. Lulla, Jin Qi, Craig M. Horbinski, Tadanori Tomita, C. David James, Ali Shilatifard and Amanda M. Saratsis
    Citation: Acta Neuropathologica Communications 2017 5:28
  15. Cerebral amyloid angiopathy (CAA) induces various forms of cerebral infarcts and hemorrhages from vascular amyloid-β accumulation, resulting in acceleration of cognitive impairment, which is currently untreata...

    Authors: Satoshi Saito, Yumi Yamamoto, Takakuni Maki, Yorito Hattori, Hideki Ito, Katsuhiko Mizuno, Mariko Harada-Shiba, Raj N. Kalaria, Masanori Fukushima, Ryosuke Takahashi and Masafumi Ihara
    Citation: Acta Neuropathologica Communications 2017 5:26
  16. Rosenthal fibers (RFs) are cytoplasmic, proteinaceous aggregates. They are the pathognomonic feature of the astrocyte pathology in Alexander Disease (AxD), a neurodegenerative disorder caused by heterozygous m...

    Authors: Alexander A. Sosunov, Guy M. McKhann II and James E. Goldman
    Citation: Acta Neuropathologica Communications 2017 5:27
  17. Intrathecal immunoglobulin G (IgG) synthesis, cerebrospinal fluid (CSF) oligoclonal IgG bands and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease pathology. Both the specific ta...

    Authors: Yiting Liu, Katherine S. Given, Danielle E. Harlow, Adeline M. Matschulat, Wendy B. Macklin, Jeffrey L. Bennett and Gregory P. Owens
    Citation: Acta Neuropathologica Communications 2017 5:25
  18. Sporadic inclusion body myositis (IBM) is the most common primary myopathy in the elderly, but its pathoetiology is still unclear. Perturbed myocellular calcium (Ca2+) homeostasis can exacerbate many of the facto...

    Authors: David R. Amici, Iago Pinal-Fernandez, Davi A. G. Mázala, Thomas E. Lloyd, Andrea M. Corse, Lisa Christopher-Stine, Andrew L. Mammen and Eva R. Chin
    Citation: Acta Neuropathologica Communications 2017 5:24
  19. Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks a predictive and broadly applicable biomarker. Continued focus on mutation-specific upstream mechanisms has yet to pred...

    Authors: Johnathan Cooper-Knock, Claire Green, Gabriel Altschuler, Wenbin Wei, Joanna J. Bury, Paul R. Heath, Matthew Wyles, Catherine Gelsthorpe, J. Robin Highley, Alejandro Lorente-Pons, Tim Beck, Kathryn Doyle, Karel Otero, Bryan Traynor, Janine Kirby, Pamela J. Shaw…
    Citation: Acta Neuropathologica Communications 2017 5:23
  20. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson’s disease. Here, we investigated whether the G2019S LRRK2 mutation causes morphological and/or function...

    Authors: Francesco Longo, Daniela Mercatelli, Salvatore Novello, Ludovico Arcuri, Alberto Brugnoli, Fabrizio Vincenzi, Isabella Russo, Giulia Berti, Omar S. Mabrouk, Robert T. Kennedy, Derya R. Shimshek, Katia Varani, Luigi Bubacco, Elisa Greggio and Michele Morari
    Citation: Acta Neuropathologica Communications 2017 5:22
  21. We previously demonstrated that transplantation of murine neural stem cells (NSCs) can improve motor and cognitive function in a transgenic model of Dementia with Lewy Bodies (DLB). These benefits occurred wit...

    Authors: Anita Lakatos, Natalie R. S. Goldberg and Mathew Blurton-Jones
    Citation: Acta Neuropathologica Communications 2017 5:21
  22. We previously reported transcriptional repression-induced atypical cell death of neuron (TRIAD), a new type of necrosis that is mainly regulated by Hippo pathway signaling and distinct from necroptosis regulat...

    Authors: Emiko Yamanishi, Kazuko Hasegawa, Kyota Fujita, Shizuko Ichinose, Saburo Yagishita, Miho Murata, Kazuhiko Tagawa, Takumi Akashi, Yoshinobu Eishi and Hitoshi Okazawa
    Citation: Acta Neuropathologica Communications 2017 5:19
  23. Among diffuse gliomas, oligodendrogliomas show relatively better prognosis, respond well to radiotherapy and chemotherapy, and seldom progress to very aggressive tumors. To elucidate the genetic and epigenetic...

    Authors: Koki Aihara, Akitake Mukasa, Genta Nagae, Masashi Nomura, Shogo Yamamoto, Hiroki Ueda, Kenji Tatsuno, Junji Shibahara, Miwako Takahashi, Toshimitsu Momose, Shota Tanaka, Shunsaku Takayanagi, Shunsuke Yanagisawa, Takahide Nejo, Satoshi Takahashi, Mayu Omata…
    Citation: Acta Neuropathologica Communications 2017 5:18
  24. Authors: Wei Wei, Michael J. Keogh, Ian Wilson, Jonathan Coxhead, Sarah Ryan, Sara Rollinson, Helen Griffin, Marzena Kurzawa-Akanbi, Mauro Santibanez-Koref, Kevin Talbot, Martin R. Turner, Chris-Anne McKenzie, Claire Troakes, Johannes Attems, Colin Smith, Safa Al Sarraj…
    Citation: Acta Neuropathologica Communications 2017 5:17

    The original article was published in Acta Neuropathologica Communications 2017 5:13

  25. Microglia are key players in the central nervous system in health and disease. Much pioneering research on microglia function has been carried out in vivo with the use of genetic animal models. However, to ful...

    Authors: Mark R. Mizee, Suzanne S. M. Miedema, Marlijn van der Poel, Adelia, Karianne G. Schuurman, Miriam E. van Strien, Jeroen Melief, Joost Smolders, Debbie A. Hendrickx, Kirstin M. Heutinck, Jörg Hamann and Inge Huitinga
    Citation: Acta Neuropathologica Communications 2017 5:16
  26. Neuromyelitis optica spectrum disorders (herein called NMO) is an inflammatory demyelinating disease of the central nervous system in which pathogenesis involves complement-dependent cytotoxicity (CDC) produce...

    Authors: Xiaoming Yao and Alan S. Verkman
    Citation: Acta Neuropathologica Communications 2017 5:15
  27. Axonal dystrophies (AxDs) are swollen and tortuous neuronal processes that are associated with extracellular depositions of amyloid β (Aβ) and have been observed to contribute to synaptic alterations occurring...

    Authors: Lidia Blazquez-Llorca, Susana Valero-Freitag, Eva Ferreira Rodrigues, Ángel Merchán-Pérez, J. Rodrigo Rodríguez, Mario M. Dorostkar, Javier DeFelipe and Jochen Herms
    Citation: Acta Neuropathologica Communications 2017 5:14
  28. Mitochondria play a key role in common neurodegenerative diseases and contain their own genome: mtDNA. Common inherited polymorphic variants of mtDNA have been associated with several neurodegenerative disease...

    Authors: Wei Wei, Michael J. Keogh, Ian Wilson, Jonathan Coxhead, Sarah Ryan, Sara Rollinson, Helen Griffin, Marzena Kurzawa-Akanbi, Mauro Santibanez-Koref, Kevin Talbot, Martin R. Turner, Chris-Anne McKenzie, Claire Troakes, Johannes Attems, Colin Smith, Safa Al Sarraj…
    Citation: Acta Neuropathologica Communications 2017 5:13

    The Erratum to this article has been published in Acta Neuropathologica Communications 2017 5:17

    The Letter to the Editor to this article has been published in Acta Neuropathologica Communications 2017 5:33

    The Letter to the Editor to this article has been published in Acta Neuropathologica Communications 2017 5:34

  29. α-Synuclein is a defining, key component of Lewy bodies and Lewy neurites in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), as well as glial cytoplasmic inclusions in multiple system atrophy (MS...

    Authors: Aki Shimozawa, Maiko Ono, Daisuke Takahara, Airi Tarutani, Sei Imura, Masami Masuda-Suzukake, Makoto Higuchi, Kazuhiko Yanai, Shin-ichi Hisanaga and Masato Hasegawa
    Citation: Acta Neuropathologica Communications 2017 5:12
  30. α-Synuclein is a protein implicated in the etiopathogenesis of Parkinson’s disease (PD). AAV1/2-driven overexpression of human mutated A53T-α-synuclein in rat and monkey substantia nigra (SN) induces degenerat...

    Authors: Chi Wang Ip, Laura-Christin Klaus, Akua A. Karikari, Naomi P. Visanji, Jonathan M. Brotchie, Anthony E. Lang, Jens Volkmann and James B. Koprich
    Citation: Acta Neuropathologica Communications 2017 5:11
  31. MicroRNAs (miRNAs) are attractive molecules to utilize as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer’s disease (AD) because miRNAs are relatively stable in biofluid, in...

    Authors: Norikazu Hara, Masataka Kikuchi, Akinori Miyashita, Hiroyuki Hatsuta, Yuko Saito, Kensaku Kasuga, Shigeo Murayama, Takeshi Ikeuchi and Ryozo Kuwano
    Citation: Acta Neuropathologica Communications 2017 5:10
  32. Mutations resulting in haploinsufficiency of progranulin (PGRN) cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease. Accumulating evidenc...

    Authors: Xiaolai Zhou, Lirong Sun, Owen Adam Brady, Kira A. Murphy and Fenghua Hu
    Citation: Acta Neuropathologica Communications 2017 5:9
  33. A major feature of Alzheimer’s disease (AD) is the loss of noradrenergic locus coeruleus (LC) projection neurons that mediate attention, memory, and arousal. However, the extent to which the LC projection syst...

    Authors: Sarah C. Kelly, Bin He, Sylvia E. Perez, Stephen D. Ginsberg, Elliott J. Mufson and Scott E. Counts
    Citation: Acta Neuropathologica Communications 2017 5:8
  34. Neurodegenerative disorders such as Parkinson’s Disease (PD), PD dementia (PDD) and Dementia with Lewy bodies (DLB) are characterized by progressive accumulation of α-synuclein (α-syn) in neurons. Recent studi...

    Authors: Brian Spencer, Elvira Valera, Edward Rockenstein, Cassia Overk, Michael Mante, Anthony Adame, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Dora Games, Robert A. Rissman and Eliezer Masliah
    Citation: Acta Neuropathologica Communications 2017 5:7
  35. Microtubule associated protein tau (tau) deposition is associated with a spectrum of neurodegenerative diseases collectively termed tauopathies. We have previously shown that amyotrophic lateral sclerosis (ALS...

    Authors: Alexander J. Moszczynski, Wencheng Yang, Robert Hammond, Lee Cyn Ang and Michael J. Strong
    Citation: Acta Neuropathologica Communications 2017 5:6
  36. The small heat shock protein HSPB1 (Hsp27) is an ubiquitously expressed molecular chaperone able to regulate various cellular functions like actin dynamics, oxidative stress regulation and anti-apoptosis. So f...

    Authors: Thomas Geuens, Vicky De Winter, Nicholas Rajan, Tilmann Achsel, Ligia Mateiu, Leonardo Almeida-Souza, Bob Asselbergh, Delphine Bouhy, Michaela Auer-Grumbach, Claudia Bagni and Vincent Timmerman
    Citation: Acta Neuropathologica Communications 2017 5:5
  37. The role of resident microglial cells in the pathogenesis and progression of glial tumors is still obscure mainly due to a lack of specific markers. Recently P2RY12, a P2 purinergic receptor, was introduced as...

    Authors: Changbin Zhu, Johan M. Kros, Marcel van der Weiden, PingPin Zheng, Caroline Cheng and Dana A. M. Mustafa
    Citation: Acta Neuropathologica Communications 2017 5:4
  38. Neuropathological and genetic findings suggest that the presynaptic protein α-synuclein (aSyn) is involved in the pathogenesis of synucleinopathy disorders, including Parkinson’s disease (PD), dementia with Le...

    Authors: Daniel Ysselstein, Benjamin Dehay, Isabel M. Costantino, George P. McCabe, Matthew P. Frosch, Julia M. George, Erwan Bezard and Jean-Christophe Rochet
    Citation: Acta Neuropathologica Communications 2017 5:3
  39. Multiple system atrophy (MSA) is a fatal neurodegenerative disorder characterized by the pathological accumulation of alpha-synuclein (α-syn) in oligodendrocytes. Therapeutic efforts to stop or delay the progr...

    Authors: Elvira Valera, Brian Spencer, Jerel A. Fields, Ivy Trinh, Anthony Adame, Michael Mante, Edward Rockenstein, Paula Desplats and Eliezer Masliah
    Citation: Acta Neuropathologica Communications 2017 5:2
  40. Phosphorylated alpha-synuclein (p-α-syn) containing Lewy bodies (LBs) and Lewy neurites (LNs) are neuropathological hallmarks of Parkinson’s disease (PD) in the central nervous system (CNS). Since they have be...

    Authors: Martina Barrenschee, Dimitri Zorenkov, Martina Böttner, Christina Lange, François Cossais, Amelie Bernadette Scharf, Günther Deuschl, Susanne A. Schneider, Mark Ellrichmann, Annette Fritscher-Ravens and Thilo Wedel
    Citation: Acta Neuropathologica Communications 2017 5:1
  41. The over-production of β-amyloid (Aβ) has been strongly correlated to neuronal dysfunction and altered synaptic plasticity in Alzheimer’s disease (AD). Accordingly, it has been proposed that disrupted synaptic...

    Authors: James Gilbert, Shu Shu, Xin Yang, Youming Lu, Ling-Qiang Zhu and Heng-Ye Man
    Citation: Acta Neuropathologica Communications 2016 4:131

    The Erratum to this article has been published in Acta Neuropathologica Communications 2017 5:20

  42. In vivo imaging of fibrillar β-amyloid deposits may assist clinical diagnosis of Alzheimer’s disease (AD), aid treatment selection for patients, assist clinical trials of therapeutic drugs through subject sele...

    Authors: Milos D. Ikonomovic, Chris J. Buckley, Kerstin Heurling, Paul Sherwin, Paul A. Jones, Michelle Zanette, Chester A. Mathis, William E. Klunk, Aruna Chakrabarty, James Ironside, Azzam Ismail, Colin Smith, Dietmar R. Thal, Thomas G. Beach, Gill Farrar and Adrian P. L. Smith
    Citation: Acta Neuropathologica Communications 2016 4:130
  43. Authors: Renate K. Hukema, Fréderike W. Riemslagh, Shamiram Melhem, Herma C. van der Linde, Lies-Anne W. F. M. Severijnen, Dieter Edbauer, Alex Maas, Nicolas Charlet-Berguerand, Rob Willemsen and John C. van Swieten
    Citation: Acta Neuropathologica Communications 2016 4:129

    The original article was published in Acta Neuropathologica Communications 2014 2:166

  44. α-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease. In particular, multiplications a...

    Authors: Diana F. Lázaro, Mariana Castro Dias, Anita Carija, Susanna Navarro, Carolina Silva Madaleno, Sandra Tenreiro, Salvador Ventura and Tiago F. Outeiro
    Citation: Acta Neuropathologica Communications 2016 4:128
  45. Abnormally elevated hippocampal Caspase-6 (Casp6) activity is intimately associated with age-related cognitive impairment in humans and in mice. In humans, these high levels of Casp6 activity are initially loc...

    Authors: Benedicte Foveau, Steffen Albrecht, David A. Bennett, José A. Correa and Andrea C. LeBlanc
    Citation: Acta Neuropathologica Communications 2016 4:127
  46. Anti-Dopamine-2 receptor (D2R) antibodies have been recently identified in a subgroup of children with autoimmune movement and psychiatric disorders, however the epitope(s) and mechanism of pathogenicity remai...

    Authors: Nese Sinmaz, Fiona Tea, Deepti Pilli, Alicia Zou, Mazen Amatoury, Tina Nguyen, Vera Merheb, Sudarshini Ramanathan, Sandra T. Cooper, Russell C. Dale and Fabienne Brilot
    Citation: Acta Neuropathologica Communications 2016 4:126

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  • Citation Impact 2023
    Journal Impact Factor: 6.2
    5-year Journal Impact Factor: 6.8
    Source Normalized Impact per Paper (SNIP): 1.344
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