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Page 15 of 17

  1. Content type: Research

    The self-assembly of Aβ peptides into a range of conformationally heterogeneous amyloid states represents a fundamental event in Alzheimer’s disease. Within these structures oligomeric intermediates are consid...

    Authors: Jessica Wacker, Raik Rönicke, Martin Westermann, Melanie Wulff, Klaus G Reymann, Christopher M Dobson, Uwe Horn, Damian C Crowther, Leila M Luheshi and Marcus Fändrich

    Citation: Acta Neuropathologica Communications 2014 2:43

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  2. Content type: Methodology article

    Abnormal connectivity across brain regions underlies many neurological disorders including multiple sclerosis, schizophrenia and autism, possibly due to atypical axonal organization within white matter. Attemp...

    Authors: Xiao-Bo Liu and Cynthia M Schumann

    Citation: Acta Neuropathologica Communications 2014 2:42

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  3. Content type: Case report

    Neurocutaneous melanosis (NCM) is a rare congenital disorder characterized by the association of large and/or multiple congenital melanocytic nevi (CMN) of the skin with melanocytic lesions of the leptomeninge...

    Authors: Heidi VN Küsters-Vandevelde, Annelieke ECAB Willemsen, Patricia JTA Groenen, Benno Küsters, Martin Lammens, Pieter Wesseling, Melika Djafarihamedani, Jos Rijntjes, Hans Delye, Michel A Willemsen, Carla ML van Herpen and Willeke AM Blokx

    Citation: Acta Neuropathologica Communications 2014 2:41

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  4. Content type: Research

    Tangle-predominant dementia (TPD) is characterized neuropathologically by numerous neurofibrillary tangles in the limbic areas with no or occasional senile plaques throughout the brain. TPD is an under-recogni...

    Authors: Ito Kawakami, Masato Hasegawa, Tetsuaki Arai, Kenji Ikeda, Kenichi Oshima, Kazuhiro Niizato, Naoya Aoki, Katsuse Omi, Shinji Higashi, Masato Hosokawa, Yoshio Hirayasu and Haruhiko Akiyama

    Citation: Acta Neuropathologica Communications 2014 2:40

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  5. Content type: Research

    Medulloblastoma (MB), the most common pediatric malignant brain cancer, typically arises as pathological result of deregulated developmental pathways, including the NOTCH signaling cascade. Unlike the evidence...

    Authors: Giulio Fiaschetti, Christina Schroeder, Deborah Castelletti, Alexandre Arcaro, Frank Westermann, Martin Baumgartner, Tarek Shalaby and Michael A Grotzer

    Citation: Acta Neuropathologica Communications 2014 2:39

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  6. Content type: Research

    Fragmentation of stacked cisterns of the Golgi apparatus into dispersed smaller elements is a feature associated with degeneration of neurons in amyotrophic lateral sclerosis (ALS) and some other neurodegenera...

    Authors: Vera van Dis, Marijn Kuijpers, Elize D Haasdijk, Eva Teuling, Scott A Oakes, Casper C Hoogenraad and Dick Jaarsma

    Citation: Acta Neuropathologica Communications 2014 2:38

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  7. Content type: Research

    Transactive response DNA binding protein 43 (TDP-43) is detected in pathological inclusions in many cases of Alzheimer’s disease (AD) and mild cognitive impairment (MCI), but its pathological role in AD and MC...

    Authors: Yasuyuki Ohta, Cyntia Tremblay, Julie A Schneider, David A Bennett, Frederic Calon and Jean-Pierre Julien

    Citation: Acta Neuropathologica Communications 2014 2:37

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  8. Content type: Research

    Synaptic dysfunction and synapse loss are key features of Alzheimer’s pathogenesis. Previously, we showed an essential function of APP and APLP2 for synaptic plasticity, learning and memory. Here, we used orga...

    Authors: Sascha W Weyer, Marta Zagrebelsky, Ulrike Herrmann, Meike Hick, Lennard Ganss, Julia Gobbert, Morna Gruber, Christine Altmann, Martin Korte, Thomas Deller and Ulrike C Müller

    Citation: Acta Neuropathologica Communications 2014 2:36

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  9. Content type: Research

    Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) are present in some neuromyelitis optica patients who lack antibodies against aquaporin-4 (AQP4-IgG). The effects of neuromyelitis optica MOG-Ig...

    Authors: Samira Saadoun, Patrick Waters, Gregory P Owens, Jeffrey L Bennett, Angela Vincent and Marios C Papadopoulos

    Citation: Acta Neuropathologica Communications 2014 2:35

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  10. Content type: Research

    Intracranial aneurysm (IA) is a socially important disease due to its high incidence in the general public and the severity of resultant subarachnoid hemorrhage that follows rupture. Despite the social importa...

    Authors: Tomohiro Aoki, Miyuki Fukuda, Masaki Nishimura, Kazuhiko Nozaki and Shuh Narumiya

    Citation: Acta Neuropathologica Communications 2014 2:34

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  11. Content type: Research

    The RNA/DNA-binding protein, TDP-43, is the key component of ubiquitinated inclusions characteristic of amyotrophic lateral sclerosis (ALS) and the majority of frontotemporal lobar degeneration (FTLD-TDP) refe...

    Authors: Linda K Kwong, David J Irwin, Adam K Walker, Yan Xu, Dawn M Riddle, John Q Trojanowski and Virginia M Y Lee

    Citation: Acta Neuropathologica Communications 2014 2:33

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  12. Content type: Review

    Dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) can be divided into two subgroups that exhibit distinct clinical and neuropathological features, with the majority represented by a non-plaque-type ...

    Authors: Atsushi Kobayashi, Yuichi Matsuura, Shirou Mohri and Tetsuyuki Kitamoto

    Citation: Acta Neuropathologica Communications 2014 2:32

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  13. Content type: Research

    Notch and Hedgehog signaling have been implicated in the pathogenesis and stem-like characteristics of glioblastomas, and inhibitors of the pathways have been suggested as new therapies for these aggressive tu...

    Authors: Dacheng Ding, Kah Suan Lim and Charles G Eberhart

    Citation: Acta Neuropathologica Communications 2014 2:31

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  14. Content type: Research

    A major neuropathological hallmark of Alzheimer’s disease is the deposition of amyloid plaques in the brains of affected individuals. Amyloid plaques mainly consist of fibrillar β-amyloid, which is a cleavage ...

    Authors: Steffen Burgold, Severin Filser, Mario M Dorostkar, Boris Schmidt and Jochen Herms

    Citation: Acta Neuropathologica Communications 2014 2:30

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  15. Content type: Research

    The accumulation of misfolded proteins appears as a fundamental pathogenic process in human neurodegenerative diseases. In the case of synucleinopathies such as Parkinson’s disease (PD) or dementia with Lewy b...

    Authors: Dominique Bétemps, Jérémy Verchère, Sébastien Brot, Eric Morignat, Luc Bousset, Damien Gaillard, Latifa Lakhdar, Ronald Melki and Thierry Baron

    Citation: Acta Neuropathologica Communications 2014 2:29

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  16. Content type: Research

    Several morphometric studies have revealed smaller than normal neurons in the neocortex of autistic subjects. To test the hypothesis that abnormal neuronal growth is a marker of an autism-associated global enc...

    Authors: Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Shuang Yong Ma, Humi Imaki, Jarek Wegiel, Ira L Cohen, Eric London, W Ted Brown and Thomas Wisniewski

    Citation: Acta Neuropathologica Communications 2014 2:28

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  17. Content type: Research

    Natalizumab blocks α4-integrins and is a prototypic agent for a series of anti-inflammatory drugs that impair trafficking of immune cells into the CNS. However, modulation of the access of immune cells to the ...

    Authors: Veit Rothhammer, Andreas Muschaweckh, Georg Gasteiger, Franziska Petermann, Sylvia Heink, Dirk H Busch, Mathias Heikenwälder, Bernhard Hemmer, Ingo Drexler and Thomas Korn

    Citation: Acta Neuropathologica Communications 2014 2:27

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  18. Content type: Research

    Based on previous studies, a preclinical classification for Alzheimer’s disease (AD) has been proposed. However, 1) specificity of the different neuronal injury (NI) biomarkers has not been studied, 2) subject...

    Authors: Jon B Toledo, Michael W Weiner, David A Wolk, Xiao Da, Kewei Chen, Steven E Arnold, William Jagust, Clifford Jack, Eric M Reiman, Christos Davatzikos, Leslie M Shaw and John Q Trojanowski

    Citation: Acta Neuropathologica Communications 2014 2:26

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  19. Content type: Research

    Aberrant biometal metabolism is a key feature of neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Metal modulating compounds are promising therapeutics for neurodegeneration, but the...

    Authors: Alexandra Grubman, Grace E Lidgerwood, Clare Duncan, Laura Bica, Jiang-Li Tan, Sarah J Parker, Aphrodite Caragounis, Jodi Meyerowitz, Irene Volitakis, Diane Moujalled, Jeffrey R Liddell, James L Hickey, Malcolm Horne, Shoshanah Longmuir, Jari Koistinaho, Paul S Donnelly…

    Citation: Acta Neuropathologica Communications 2014 2:25

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  20. Content type: Case report

    We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60’s followed by memory impairment, low mood and recurrent falls. Examination shortly befo...

    Authors: Helen Ling, Eleanna Kara, Tamas Revesz, Andrew J Lees, Gordon T Plant, Davide Martino, Henry Houlden, John Hardy and Janice L Holton

    Citation: Acta Neuropathologica Communications 2014 2:24

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  21. Content type: Research

    Paediatric high grade glioma (pHGG) is a distinct biological entity to histologically similar tumours arising in older adults, and has differing copy number profiles and driver genetic alterations. As function...

    Authors: Diana Carvalho, Alan Mackay, Lynn Bjerke, Richard G Grundy, Celeste Lopes, Rui M Reis and Chris Jones

    Citation: Acta Neuropathologica Communications 2014 2:23

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  22. Content type: Research

    The progression of Alzheimer’s disease (AD) is associated with an increase of phosphorylated tau in the brain. One of the earliest phosphorylated sites on tau is Ser262 that is preferentially phosphorylated by mi...

    Authors: Harald Lund, Elin Gustafsson, Anne Svensson, Maria Nilsson, Margareta Berg, Dan Sunnemark and Gabriel von Euler

    Citation: Acta Neuropathologica Communications 2014 2:22

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  23. Content type: Research

    Microglial activation is a pathological feature common to both Alzheimer’s and Parkinson’s diseases (AD and PD). The classical activation involves release of pro-inflammatory cytokines and reactive oxygen spec...

    Authors: Peixuan Pey, Ronald KB Pearce, Michail E Kalaitzakis, W Sue T Griffin and Steve M Gentleman

    Citation: Acta Neuropathologica Communications 2014 2:21

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  24. Content type: Research

    Mutations in the gene for alpha-galactosidase A result in Fabry disease, a rare, X-linked lysosomal storage disorder characterized by a loss of alpha-galactosidase A enzymatic activity. The resultant accumulat...

    Authors: Michael P Nelson, Tonia E Tse, Darrel B O’Quinn, Stefanie M Percival, Edgar A Jaimes, David G Warnock and John J Shacka

    Citation: Acta Neuropathologica Communications 2014 2:20

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  25. Content type: Research

    IDH mutations frequently occur in diffuse gliomas and result in a neo-enzymatic activity that results in reduction of α-ketoglutarate to D-2-hydroxyglutarate. In gliomas, the frequency of IDH1 mutations in cod...

    Authors: Stefan Pusch, Leonille Schweizer, Ann-Christin Beck, Johanna-Marie Lehmler, Susanne Weissert, Jörg Balss, Aubry K Miller and Andreas von Deimling

    Citation: Acta Neuropathologica Communications 2014 2:19

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  26. Content type: Research

    Gangliogliomas are low-grade glioneuronal tumors of the central nervous system and the commonest cause of chronic intractable epilepsy. Most gangliogliomas (>70%) arise in the temporal lobe, and infratentorial...

    Authors: Kirti Gupta, Wilda Orisme, Julie H Harreld, Ibrahim Qaddoumi, James D Dalton, Chandanamali Punchihewa, Racquel Collins-Underwood, Thomas Robertson, Ruth G Tatevossian and David W Ellison

    Citation: Acta Neuropathologica Communications 2014 2:18

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  27. Content type: Research

    The progressive development of Alzheimer’s disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the...

    Authors: Sonia George, Annica Rönnbäck, Gunnar K Gouras, Géraldine H Petit, Fiona Grueninger, Bengt Winblad, Caroline Graff and Patrik Brundin

    Citation: Acta Neuropathologica Communications 2014 2:17

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  28. Content type: Research

    Axon degeneration is a characteristic feature of multiple neuropathologic states and is also a mechanism of physiological neurodevelopmental pruning. The vast majority of in vivo studies looking at axon degenerat...

    Authors: Jennifer D Sokolowski, Kanchana K Gamage, Daniel S Heffron, Andrea C LeBlanc, Christopher D Deppmann and James W Mandell

    Citation: Acta Neuropathologica Communications 2014 2:16

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  29. Content type: Review

    Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by the accumulation of α-synuclein protein in the cytoplasm of oligodendrocytes, the myelin-producing support cells of the...

    Authors: Jonathan M Bleasel, Joanna H Wong, Glenda M Halliday and Woojin Scott Kim

    Citation: Acta Neuropathologica Communications 2014 2:15

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  30. Content type: Research

    In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain, the hierarchical pathways of this neurodegeneration ...

    Authors: Simon Dujardin, Katia Lécolle, Raphaëlle Caillierez, Séverine Bégard, Nadège Zommer, Cédrick Lachaud, Sébastien Carrier, Noëlle Dufour, Gwennaëlle Aurégan, Joris Winderickx, Philippe Hantraye, Nicole Déglon, Morvane Colin and Luc Buée

    Citation: Acta Neuropathologica Communications 2014 2:14

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  31. Content type: Research

    Metabolic stroke is the rapid onset of lasting central neurological deficit associated with decompensation of an underlying metabolic disorder. Glutaric aciduria type I (GA1) is an inherited disorder of lysine...

    Authors: William J Zinnanti, Jelena Lazovic, Cathy Housman, David A Antonetti, David M Koeller, James R Connor and Lawrence Steinman

    Citation: Acta Neuropathologica Communications 2014 2:13

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  32. Content type: Research

    The accumulation of beta amyloid (Aβ) peptides, a hallmark of Alzheimer’s disease (AD) is related to mechanisms leading to neurodegeneration. Among its pleiotropic cellular effects, Aβ accumulation has been as...

    Authors: Johnatan Ceccom, Najat Loukh, Valérie Lauwers-Cances, Christian Touriol, Yvan Nicaise, Catherine Gentil, Emmanuelle Uro-Coste, Stuart Pitson, Claude Alain Maurage, Charles Duyckaerts, Olivier Cuvillier and Marie-Bernadette Delisle

    Citation: Acta Neuropathologica Communications 2014 2:12

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  33. Content type: Research

    Fundamental cytological changes of amyotrophic lateral sclerosis (ALS) were looked for by comparing relatively preserved Onuf’s nucleus (ON) and severely affected neighboring motor neuron groups (dorsolateral ...

    Authors: Takahiro Takeda, Toshiki Uchihara, Yuki Nakayama, Ayako Nakamura, Shoichi Sasaki, Shinji Kakei, Shinichiro Uchiyama, Charles Duyckaerts and Mari Yoshida

    Citation: Acta Neuropathologica Communications 2014 2:11

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  34. Content type: Research

    Medulloblastoma is the most common intracranial childhood malignancy and a genetically heterogeneous disease. Despite recent advances, current therapeutic approaches are still associated with high morbidity an...

    Authors: Ashirwad Merve, Adrian M Dubuc, Xinyu Zhang, Marc Remke, Patricia A Baxter, Xiao-Nan Li, Michael D Taylor and Silvia Marino

    Citation: Acta Neuropathologica Communications 2014 2:10

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  35. Content type: Research

    The greatest genetic risk factor for late-onset Alzheimer's disease (AD) is the ϵ4 allele of Apolipoprotein E (ApoE). ApoE regulates secretion of the potent neuroprotective signaling lipid Sphingosine 1-phosph...

    Authors: Timothy A Couttas, Nupur Kain, Benjamin Daniels, Xin Ying Lim, Claire Shepherd, Jillian Kril, Russell Pickford, Hongyun Li, Brett Garner and Anthony S Don

    Citation: Acta Neuropathologica Communications 2014 2:9

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  36. Content type: Research

    In humans and animals, prion protein (PrP) is usually expressed as a glycophosphatidylinositol (GPI)-anchored membrane protein, but anchorless PrP may be pathogenic in humans with certain familial prion diseas...

    Authors: Alejandra Rangel, Brent Race, Katie Phillips, James Striebel, Nancy Kurtz and Bruce Chesebro

    Citation: Acta Neuropathologica Communications 2014 2:8

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  37. Content type: Case report

    An unusual multinodular and vacuolating neuronal tumour (MVNT) has been described in the cerebral hemispheres of ten patients with adult-onset seizures. We report the findings in two cases with similar feature...

    Authors: Istvan Bodi, Olimpia Curran, Richard Selway, Robert Elwes, Juan Burrone, Ross Laxton, Safa Al-Sarraj and Mrinalini Honavar

    Citation: Acta Neuropathologica Communications 2014 2:7

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  38. Content type: Research

    Spontaneous autoimmune peripheral neuropathy including Guillain-Barré Syndrome (GBS) represents as one of the serious emergencies in neurology. Although pathological changes have been well documented, molecula...

    Authors: Mu Yang, Anthony Rainone, Xiang Qun Shi, Sylvie Fournier and Ji Zhang

    Citation: Acta Neuropathologica Communications 2014 2:5

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  39. Content type: Methodology article

    Induced pluripotent stem cells (iPSCs) derived from patients with neurodegenerative disease generally lack neuropathological confirmation, the gold standard for disease classification and grading of severity. ...

    Authors: Andrew A Sproul, Lauren B Vensand, Carmen R Dusenberry, Samson Jacob, Jean Paul G Vonsattel, Daniel J Paull, Michael L Shelanski, John F Crary and Scott A Noggle

    Citation: Acta Neuropathologica Communications 2014 2:4

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  40. Content type: Research

    Multiple sclerosis (MS) is characterized by central nervous system inflammation and demyelination, and increasing evidence demonstrates significant neuronal damage also occurs and is associated with permanent ...

    Authors: Reas S Khan, Kimberly Dine, Jayasri Das Sarma and Kenneth S Shindler

    Citation: Acta Neuropathologica Communications 2014 2:3

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  41. Content type: Research

    Pompe disease, an inherited deficiency of lysosomal acid alpha-glucosidase (GAA), is a metabolic myopathy with heterogeneous clinical presentations. Late-onset Pompe disease (LOPD) is a debilitating progressiv...

    Authors: Erin J Feeney, Stephanie Austin, Yin-Hsiu Chien, Hanna Mandel, Benedikt Schoser, Sean Prater, Wuh-Liang Hwu, Evelyn Ralston, Priya S Kishnani and Nina Raben

    Citation: Acta Neuropathologica Communications 2014 2:2

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  42. Content type: Research

    Mitochondrial DNA (mtDNA) encodes key proteins of the electron transfer chain (ETC), which produces ATP through oxidative phosphorylation (OXPHOS) and is essential for cells to perform specialised functions. T...

    Authors: Ka Yu Yeung, Adam Dickinson, Jacqueline F Donoghue, Galina Polekhina, Stefan J White, Dimitris K Grammatopoulos, Matthew McKenzie, Terrance G Johns and Justin C St John

    Citation: Acta Neuropathologica Communications 2014 2:1

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  43. Content type: Research

    Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system (CNS), which is characterized by the presence of pathogenic serum autoantibodies against aquaporin 4 (AQP4) in ...

    Authors: Maria Pohl, Naoto Kawakami, Maja Kitic, Jan Bauer, Rui Martins, Marie-Therese Fischer, Joana Machado-Santos, Simone Mader, Joachim W Ellwart, Tatsuro Misu, Kazuo Fujihara, Hartmut Wekerle, Markus Reindl, Hans Lassmann and Monika Bradl

    Citation: Acta Neuropathologica Communications 2013 1:85

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  44. Content type: Research

    Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the relapse-remitting stage and neurodegeneration represents the principal sub...

    Authors: David W Hampton, Andrea Serio, Gareth Pryce, Sarah Al-Izki, Robin JM Franklin, Gavin Giovannoni, David Baker and Siddharthan Chandran

    Citation: Acta Neuropathologica Communications 2013 1:84

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  45. Content type: Research

    Alzheimer’s disease (AD) is characterized by the deposition of insoluble amyloid plaques in the neuropil composed of highly stable, self-assembled Amyloid-beta (Aβ) fibrils. Copper has been implicated to play ...

    Authors: Youssra K Al-Hilaly, Thomas L Williams, Maris Stewart-Parker, Lenzie Ford, Eldhose Skaria, Michael Cole, William Grant Bucher, Kyle L Morris, Alaa Abdul Sada, Julian R Thorpe and Louise C Serpell

    Citation: Acta Neuropathologica Communications 2013 1:83

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  46. Content type: Research

    Illuminating the role of the microtubule-associated protein tau in neurodegenerative diseases is of increasing importance, supported by recent studies establishing novel functions of tau in synaptic signalling...

    Authors: Nadine A Hoffmann, Mario M Dorostkar, Sonja Blumenstock, Michel Goedert and Jochen Herms

    Citation: Acta Neuropathologica Communications 2013 1:82

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  47. Content type: Case report

    A novel point mutation resulting in a glutamate-to-glycine substitution in PRNP at codon 200, E200G with codon 129 MV polymorphism (cis valine) and type 2 PrPSc was identified in a patient with a prolonged diseas...

    Authors: Mee-Ohk Kim, Ignazio Cali, Abby Oehler, Jamie C Fong, Katherine Wong, Tricia See, Jonathan S Katz, Pierluigi Gambetti, Brianne M Bettcher, Stephen J DeArmond and Michael D Geschwind

    Citation: Acta Neuropathologica Communications 2013 1:80

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  48. Content type: Review

    Changes in protein metabolism are key to disease onset and progression in many neurodegenerative diseases. As a prime example, in Parkinson’s disease, folding, post-translational modification and recycling of ...

    Authors: Darius Ebrahimi-Fakhari, Laiq-Jan Saidi and Lara Wahlster

    Citation: Acta Neuropathologica Communications 2013 1:79

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