Adermark L, Bowers MS (2016) Disentangling the Role of Astrocytes in Alcohol Use Disorder. Alcohol Clin Exp Res 40:1802–1816. https://doi.org/10.1111/acer.13168
Article
PubMed
PubMed Central
Google Scholar
Ando Y, Brannstrom T, Uchida K, Nyhlin N, Nasman B, Suhr O, Yamashita T, Olsson T, El Salhy M, Uchino M et al (1998) Histochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid. J Neurol Sci 156:172–176. https://doi.org/10.1016/s0022-510x(98)00042-2
Article
CAS
PubMed
Google Scholar
Brooks PJ, Enoch MA, Goldman D, Li TK, Yokoyama A (2009) The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med 6:e50. https://doi.org/10.1371/journal.pmed.1000050
Article
CAS
PubMed
Google Scholar
Butterfield DA, Bader Lange ML, Sultana R (2010) Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease. Biochimica et biophysica acta 1801:924–929. https://doi.org/10.1016/j.bbalip.2010.02.005
Article
CAS
PubMed
PubMed Central
Google Scholar
Butterfield DA, Castegna A, Lauderback CM, Drake J (2002) Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death. Neurobiol Aging 23:655–664
Article
Google Scholar
Cederbaum AI (2012) Alcohol metabolism. Clin Liver Dis 16:667–685. https://doi.org/10.1016/j.cld.2012.08.002
Article
PubMed
PubMed Central
Google Scholar
Cheignon C, Tomas M, Bonnefont-Rousselot D, Faller P, Hureau C, Collin F (2018) Oxidative stress and the amyloid beta peptide in Alzheimer's disease. Redox Biol 14:450–464. https://doi.org/10.1016/j.redox.2017.10.014
Article
CAS
PubMed
Google Scholar
Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D (2008) Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321:1493–1495. https://doi.org/10.1126/science.1158554
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen CH, Cruz LA, Mochly-Rosen D (2015) Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo. Proc Natl Acad Sci U S A 112:3074–3079. https://doi.org/10.1073/pnas.1414657112
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen J, Huang W, Cheng CH, Zhou L, Jiang GB, Hu YY (2019) Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals. Front Neurol 10:290. https://doi.org/10.3389/fneur.2019.00290
Article
PubMed
PubMed Central
Google Scholar
Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA (2009) S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 324:102–105. https://doi.org/10.1126/science.1171091
Article
CAS
PubMed
PubMed Central
Google Scholar
Collaborators GBDA (2018) Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 392:1015–1035. https://doi.org/10.1016/S0140-6736(18)31310-2
Article
Google Scholar
Collaborators GBDD (2019) Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 18:88–106. https://doi.org/10.1016/S1474-4422(18)30403-4
Article
Google Scholar
D'Souza Y, Elharram A, Soon-Shiong R, Andrew RD, Bennett BM (2015) Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's disease. Molecular brain 8:27. https://doi.org/10.1186/s13041-015-0117-y
Article
CAS
PubMed
PubMed Central
Google Scholar
Du H, Yan SS (2010) Mitochondrial permeability transition pore in Alzheimer's disease: cyclophilin D and amyloid beta. Biochim Biophys Acta 1802:198–204. https://doi.org/10.1016/j.bbadis.2009.07.005
Article
CAS
PubMed
Google Scholar
Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan Fet al (2014) Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Sci Transl Med 6: 255ra130 Doi https://doi.org/10.1126/scitranslmed.3009027
Article
Google Scholar
Edenberg HJ (2007) The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health 30:5–13
PubMed
PubMed Central
Google Scholar
Fernandez-Lizarbe S, Pascual M, Guerri C (2009) Critical role of TLR4 response in the activation of microglia induced by ethanol. J Immunol 183:4733–4744. https://doi.org/10.4049/jimmunol.0803590
Article
CAS
PubMed
Google Scholar
Forstermann U, Sessa WC (2012) Nitric oxide synthases: regulation and function. Eur Heart J 33: 829-837, 837a-837d. https://doi.org/10.1093/eurheartj/ehr304
Article
Google Scholar
Frost GR, Li YM (2017) The role of astrocytes in amyloid production and Alzheimer's disease. Open Biol 7. https://doi.org/10.1098/rsob.170228
Article
Google Scholar
Gabr AA, Lee HJ, Onphachanh X, Jung YH, Kim JS, Chae CW, Han HJ (2017) Ethanol-induced PGE2 up-regulates Abeta production through PKA/CREB signaling pathway. Biochim Biophys Acta Mol Basis Dis 1863:2942–2953. https://doi.org/10.1016/j.bbadis.2017.06.020
Article
CAS
PubMed
Google Scholar
Godyn J, Jonczyk J, Panek D, Malawska B (2016) Therapeutic strategies for Alzheimer's disease in clinical trials. Pharmacol Rep 68:127–138. https://doi.org/10.1016/j.pharep.2015.07.006
Article
CAS
PubMed
Google Scholar
Gomes KM, Campos JC, Bechara LR, Queliconi B, Lima VM, Disatnik MH, Magno P, Chen CH, Brum PC, Kowaltowski AJ et al (2014) Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling. Cardiovasc Res 103:498–508. https://doi.org/10.1093/cvr/cvu125
Article
CAS
PubMed
PubMed Central
Google Scholar
Gonzalez A, Pariente JA, Salido GM (2007) Ethanol stimulates ROS generation by mitochondria through Ca2+ mobilization and increases GFAP content in rat hippocampal astrocytes. Brain Res 1178:28–37. https://doi.org/10.1016/j.brainres.2007.08.040
Article
CAS
PubMed
Google Scholar
Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X (2013) Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. J Clin Invest 123:5371–5388. https://doi.org/10.1172/JCI70911
Article
CAS
PubMed
PubMed Central
Google Scholar
Hardy JA, Higgins GA (1992) Alzheimer's disease: the amyloid cascade hypothesis. Science 256:184–185
Article
CAS
Google Scholar
Huang D, Yu M, Yang S, Lou D, Zhou W, Zheng L, Wang Z, Cai F, Zhou W, Li T et al (2018) Ethanol Alters APP Processing and Aggravates Alzheimer-Associated Phenotypes. Mol Neurobiol 55:5006–5018. https://doi.org/10.1007/s12035-017-0703-3
Article
CAS
PubMed
Google Scholar
Hung SY, Fu WM (2017) Drug candidates in clinical trials for Alzheimer's disease. J Biomed Sci 24:47. https://doi.org/10.1186/s12929-017-0355-7
Article
CAS
PubMed
PubMed Central
Google Scholar
Iqbal K, Liu F, Gong CX, Grundke-Iqbal I (2010) Tau in Alzheimer disease and related tauopathies. Curr Alzheimer Res 7:656–664
Article
CAS
Google Scholar
Jamal M, Ameno K, Tanaka N, Ito A, Takakura A, Kumihashi M, Kinoshita H (2016) Ethanol and Acetaldehyde After Intraperitoneal Administration to Aldh2-Knockout Mice-22 Reflection in Blood and Brain Levels. Neurochem Res 41:1029–1034. https://doi.org/10.1007/s11064-015-1788-6
Article
CAS
PubMed
Google Scholar
Joshi AU, Minhas PS, Liddelow SA, Haileselassie B, Andreasson KI, Dorn GW 2nd, Mochly-Rosen D (2019) Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nature Neurosci 22:1635–1648. https://doi.org/10.1038/s41593-019-0486-0
Article
CAS
PubMed
Google Scholar
Joshi AU, Saw NL, Shamloo M, Mochly-Rosen D (2018) Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease. Oncotarget 9:6128–6143. https://doi.org/10.18632/oncotarget.23640
Article
PubMed
Google Scholar
Joshi AU, Saw NL, Vogel H, Cunnigham AD, Shamloo M, Mochly-Rosen D (2018) Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis. EMBO Mol Med 10: Doi https://doi.org/10.15252/emmm.201708166
Kamino K, Nagasaka K, Imagawa M, Yamamoto H, Yoneda H, Ueki A, Kitamura S, Namekata K, Miki T, Ohta S (2000) Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population. Biochem Biophys Res Commun 273:192–196. https://doi.org/10.1006/bbrc.2000.2923
Article
CAS
PubMed
Google Scholar
Kim GH, Kim JE, Rhie SJ, Yoon S (2015) The Role of Oxidative Stress in Neurodegenerative Diseases. Exp Neurobiol 24:325–340. https://doi.org/10.5607/en.2015.24.4.325
Article
PubMed
PubMed Central
Google Scholar
Lachenmeier DW, Kanteres F, Rehm J (2009) Carcinogenicity of acetaldehyde in alcoholic beverages: risk assessment outside ethanol metabolism. Addiction 104:533–550. https://doi.org/10.1111/j.1360-0443.2009.02516.x
Article
PubMed
Google Scholar
Liu J, Yang HI, Lee MH, Jen CL, Hu HH, Lu SN, Wang LY, You SL, Huang YT, Chen CJ (2016) Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma. Cancer Epidemiol Biomarkers Prev 25:693–699. https://doi.org/10.1158/1055-9965.EPI-15-0961
Article
CAS
PubMed
Google Scholar
Manzo-Avalos S, Saavedra-Molina A (2010) Cellular and mitochondrial effects of alcohol consumption. Int J Environ Res Public Health 7:4281–4304. https://doi.org/10.3390/ijerph7124281
Article
CAS
PubMed
PubMed Central
Google Scholar
Meagher EA, Barry OP, Burke A, Lucey MR, Lawson JA, Rokach J, FitzGerald GA (1999) Alcohol-induced generation of lipid peroxidation products in humans. J Clin Invest 104:805–813. https://doi.org/10.1172/JCI5584
Article
CAS
PubMed
PubMed Central
Google Scholar
Mekada K, Abe K, Murakami A, Nakamura S, Nakata H, Moriwaki K, Obata Y, Yoshiki A (2009) Genetic differences among C57BL/6 substrains. Exp Anim 58:141–149. https://doi.org/10.1538/expanim.58.141
Article
CAS
PubMed
Google Scholar
Muggironi G, Fois GR, Diana M (2013) Ethanol-derived acetaldehyde: pleasure and pain of alcohol mechanism of action. Front Behav Neurosci 7:87. https://doi.org/10.3389/fnbeh.2013.00087
Article
CAS
PubMed
PubMed Central
Google Scholar
Naik E, Dixit VM (2011) Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J Exp Med 208:417–420. https://doi.org/10.1084/jem.20110367
Article
CAS
PubMed
PubMed Central
Google Scholar
Ohsawa I, Nishimaki K, Murakami Y, Suzuki Y, Ishikawa M, Ohta S (2008) Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci 28:6239–6249. https://doi.org/10.1523/JNEUROSCI.4956-07.2008
Article
CAS
PubMed
PubMed Central
Google Scholar
Pagani L, Eckert A (2011) Amyloid-Beta interaction with mitochondria. Int J Alzheimers Dis 2011:925050. https://doi.org/10.4061/2011/925050
Article
CAS
PubMed
PubMed Central
Google Scholar
Pascual M, Fernandez-Lizarbe S, Guerri C (2011) Role of TLR4 in ethanol effects on innate and adaptive immune responses in peritoneal macrophages. Immunol Cell Biol 89:716–727. https://doi.org/10.1038/icb.2010.163
Article
CAS
PubMed
Google Scholar
Patterson C (2018) Patterson C. World Alzheimer Report 2018. The state of the art of dementia research: New frontiers. London: Alzheimer’s Disease International., City
Perez MJ, Ponce DP, Osorio-Fuentealba C, Behrens MI, Quintanilla RA (2017) Mitochondrial Bioenergetics Is Altered in Fibroblasts from Patients with Sporadic Alzheimer's Disease. Front Neurosci 11:553. https://doi.org/10.3389/fnins.2017.00553
Article
PubMed
PubMed Central
Google Scholar
Ramamoorthy M, Sykora P, Scheibye-Knudsen M, Dunn C, Kasmer C, Zhang Y, Becker KG, Croteau DL, Bohr VA (2012) Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype. Free Radic Biol Med 53:1371–1380. https://doi.org/10.1016/j.freeradbiomed.2012.07.018
Article
CAS
PubMed
PubMed Central
Google Scholar
Sabia S, Fayosse A, Dumurgier J, Dugravot A, Akbaraly T, Britton A, Kivimaki M, Singh-Manoux A (2018) Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study. BMJ 362:k2927. https://doi.org/10.1136/bmj.k2927
Article
PubMed
PubMed Central
Google Scholar
Saito M, Chakraborty G, Hui M, Masiello K, Saito M (2016) Ethanol-Induced Neurodegeneration and Glial Activation in the Developing Brain. Brain Sci 6: Doi https://doi.org/10.3390/brainsci6030031
Article
Google Scholar
Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG, Smith MA (1997) 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem 68:2092–2097. https://doi.org/10.1046/j.1471-4159.1997.68052092.x
Article
CAS
PubMed
Google Scholar
Siegel SJ, Bieschke J, Powers ET, Kelly JW (2007) The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation. Biochemistry 46:1503–1510. https://doi.org/10.1021/bi061853s
Article
CAS
PubMed
PubMed Central
Google Scholar
Swerdlow RH (2018) Mitochondria and Mitochondrial Cascades in Alzheimer's Disease. J Alzheimers Dis 62:1403–1416. https://doi.org/10.3233/JAD-170585
Article
CAS
PubMed
PubMed Central
Google Scholar
Uttara B, Singh AV, Zamboni P, Mahajan RT (2009) Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 7:65–74. https://doi.org/10.2174/157015909787602823
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang B, Wang J, Zhou S, Tan S, He X, Yang Z, Xie YC, Li S, Zheng C, Ma X (2008) The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese. J Neurol Sci 268:172–175. https://doi.org/10.1016/j.jns.2007.12.006
Article
CAS
PubMed
Google Scholar
Wang X, Wang W, Li L, Perry G, Lee HG, Zhu X (2014) Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. Biochim Biophys Acta 1842:1240–1247. https://doi.org/10.1016/j.bbadis.2013.10.015
Article
CAS
PubMed
Google Scholar
Williams TI, Lynn BC, Markesbery WR, Lovell MA (2006) Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in 4 Mild Cognitive Impairment and early Alzheimer's disease. Neurobiology of aging 27:1094–1099. https://doi.org/10.1016/j.neurobiolaging.2005.06.004
Article
CAS
PubMed
Google Scholar
Wu D, Cederbaum AI (2003) Alcohol, oxidative stress, and free radical damage. Alcohol Res Health 27:277–284
PubMed
PubMed Central
Google Scholar
Xiao Q, Weiner H, Johnston T, Crabb DW (1995) The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells. J Clin Invest 96:2180–2186. https://doi.org/10.1172/JCI118272
Article
CAS
PubMed
PubMed Central
Google Scholar
Zambelli VO, Gross ER, Chen CH, Gutierrez VP, Cury Y, Mochly-Rosen D (2014) Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain. Sci Transl Med 6: 251ra118. https://doi.org/10.1126/scitranslmed.3009539
Article
Google Scholar
Zhong H, Yin H (2015) Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol 4:193–199. https://doi.org/10.1016/j.redox.2014.12.011
Article
CAS
PubMed
Google Scholar