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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology

Fig. 4

ALDH2*2/*2 deficiency and daily treatment of mice with ethanol worsen the neuroinflammatory status in their brains. a) Heat map representation of qPCR analysis of genes associated with inflammation, apoptosis, autophagy and mitochondrial health; Veh – Vehicle; A – Alda-1. b) TNFα levels in total brain homogenates were measured using ELISA; Veh – Vehicle; A – Alda-1. c) IL-6 levels in total brain homogenate were measured using ELISA; Veh – Vehicle; A – Alda-1. d) MCP-1 levels in total brain homogenate were measured using mouse MCP1 ELISA kit; Veh – Vehicle; A – Alda-1. e) C1q levels were measured in total brain homogenate using mouse complement C1q ELISA kit; Veh – Vehicle; A – Alda-1. f) IL-1α levels were measured in total brain homogenate using ELISA kit; Veh – Vehicle; A – Alda-1. g) IL-1β levels were measured in total brain homogenate using ELISA kit; Veh – Vehicle; A – Alda-1. Data information: Mean, standard deviation, and p-values are shown. Results are presented as fold of control for e, f and as absolute values for b-d, g. n = 6 per each group; probability by one-way ANOVA (with Holm-Sidak post hoc test)

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