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Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis
Acta Neuropathologica Communications volume 7, Article number: 123 (2019)
Medulloblastoma (MB) is the most common malignant brain tumour in children but also rarely occur in adults. Sonic Hedgehog (SHH) driven MB is associated with aberrant activation of the SHH signalling pathway. SMO inhibitors, sonidegib and vismodegib, have been used as selective antagonist of the hedgehog pathway that acts by binding to SMO, and inhibits activation of the downstream hedgehog target genes. Several clinical trials investigating SMO inhibitors for the treatment of relapsed MB patients have been published.
We conducted a systemic review and meta-analysis among these Phase I and II clinical trials. The pooled effect of SMO inhibitors in relapsed MB were analysed using Reviewer Manager 5.3 software. The clinical efficacy of SMO inhibitors on SHH subtype of MB were measured by the objective response rate. The risk difference was obtained by comparing the ORR between SHH and non-SHH subtypes of MB.
The five studies all had clear criteria for patient recruitment, adequate follow-up time for endpoint assessment and clear definition of tumour responses. MB patients had good compliance in the trials. The pooled objective response rate (ORR) of SMO inhibitor was 37% and 0 against SHH-driven and other MBs. The pooled ORR of sonidegib was 55% among MBSHH and 0 among MBnon-SHH subgroup. Vismodegib also had no efficacy on non-SHH subtype of MB. The sonidegib against SHH-driven MB produced the ORR 1.87-fold higher than that of vismodegib (95%CI 1.23, 6.69). Among paediatric patients, the efficacy of sonidegib was 3.67-fold higher than vismodegib (p < 0.05). A total of 320 cases received SMO inhibitor therapy and 36 cases reported grade 3/4 dose-limiting toxicity (DLT). The rate of grade 3/4 DLT was similar between patients receiving vismodegib and sonidegib (11.6% vs. 11.2%).
Sonidegib and vismodegib were well tolerated and demonstrated anti-tumour activity in SHH-driven paediatric and adult MB by effectively inhibiting Hh signalling. These results support the ongoing clinical trials using SMO inhibitors in combination with conventional chemotherapies for the treatment of relapsed MBSHH.
Medulloblastoma (MB) is the most frequent malignant brain tumour (WHO grade IV) to occur in children and remains the leading cause of cancer-related mortality in childhood. The peak age of diagnosis is approximately 7 years of age, tumours can also rarely occur during adulthood in some individuals . International consensus recognises four distinct MB molecular subgroups: WNT (MBWNT), SHH (MBSHH), Group 3 (MBGrp3) and Group 4 (MBGrp4) . This review will focus largely on the SHH subgroup which accounts for approximately 30% of all MB cases . MBGrp3 and MBGrp4 have the worst prognosis while MBWNT is the most favourable . MBSHH falls in between, with a 5-year overall survival (OS) rate of approximately 70% . Despite a relatively good prognosis for MBWNT and MBSHH tumours, patients experience severe long-term side effects, and the development of secondary, therapy-induced, malignancies in later life [17, 30]. Therefore, more specific and less toxic therapies are required to treat these tumours. Here, we review the current clinical progress to-date of two novel SMO inhibitors, sonidegib (LDE225) and vismodegib (GDC-0449) for the treatment of MBSHH.
Aberrant activation of the Sonic Hedgehog (SHH) signalling pathway has been found in familial and sporadic MB patients . Genetic alterations lead to constitutive activation of the hedgehog pathway in MB . Moreover, overexpression of the hedgehog ligand has been linked with the pathogenesis of a number of sporadic cancers, such as pancreatic, colorectal, prostate, prostate, breast and lung . Inhibition of the hedgehog pathway has been reported by using two novel SMO inhibitors in MB, sonidegib (LDE225) and vismodegib (GDC-0449). Both agents are selective antagonists of the hedgehog pathway that act by binding to SMO, and inhibit activation of downstream hedgehog target genes [9, 12]. Vismodegib has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of metastatic or locally advanced non-resectable basal cell carcinoma (BCC) . A Phase I clinical trials of vismodegib has demonstrated a 60% response rate in locally advanced or metastatic BCC . Furthermore, one case study indicated a transient and incomplete response in a patient with metastatic MB . Current clinical trial data has shown varying responses to the efficacy of SMO inhibitors in relapsed or refractory paediatric and adult MB. We therefore performed a systemic review and meta-analysis of clinical trial cohort data to assess their safety and response rate for the treatment of patients with MB.
We searched articles from PubMed (https://www.ncbi.nlm.nih.gov/pubmed/), the Cochrane Library (https://www.cochranelibrary.com/search) and the Embase database (https://www-embase-com.ezproxy.library.uq.edu.au/#search) accessed from the University of Queensland library. Clinical trial data with a publication date before May 2019 were included in this review.
Search terms and strategies
The search terms included medulloblastoma or MB or brain tumour or CNS tumour and SMO or smoothened or vismodegib or sonic hedgehog or sonidegib or SHH. In PubMed, the additional filters were ‘clinical trial’. In the Cochrane Library database, the additional filter was ‘trials’. In Embase database, the filter was ‘randomized controlled trial’.
The study design was defined as a clinical trial, and the excluded designs were prospective studies, reviews, animal studies and other basic science studies. The included studies were either phase I or phase II clinical trials, which had to provide dose-limited toxicity (DLT) and response rates (RR). This study focused on original clinical trials but not the re-analysis of previous data review and comments.
A double-blind extraction of the data was conducted by two health professionals. The extracted data included the phase of trials, authors, publication year, drug, number of patients, the eligible disease, and daily dose of the drug, tumour responses, dose-limiting toxicity (DLT) and safety. The tumour responses were determined according to the RESIST v1.0 criteria and/ or Neuro-Oncology criteria of tumour response, including complete response (CR), partial response (PR), stable disease (SD) and progressed disease (PD). The outcome events were defined as CR and PR.
The pooled effect of SMO inhibitors in relapsed MB were synthesized using Reviewer Manager 5.3 software. The clinical efficacy of SMO inhibitors on SHH subtype of MB were measured by the objective response rate (ORR, CR + PR/all cases). The risk difference was obtained by comparing the ORR between SHH and non-SHH subtypes of MB. The difference of clinical efficacy between vismodegib and sonidegib was estimated by risk ratio with reference of vismodegib. The heterogeneity of pooled effects was indicated by I2. The pooled effect was synthesized under the fixed model with the non-significant heterogeneity (p > 0.05) or the random model with a significant heterogeneity (p < 0.05).
Forty-nine articles were obtained from PubMed, the Cochran Library and Embase database with 10 duplicates removed (Fig. 1). Thirty-four articles were excluded as they were conference abstracts, unrelated to SMO inhibitors, not designed as clinical trial, or did not include MB patients in clinical trials (Fig. 1). Five articles were assessed for eligibility and included into the meta-analysis for safety and response rate evaluation of vismodegib and sonidegib in MB treatment (Fig. 1).
The included trials are composed of four phase I and two phase II trials (Table 1). Among the 320 subjects recruited in the trials, 138 cases were diagnosed as MB (Table 1). The trials recruited relapsed/refractory MB patients and the research endpoints contained safety and tumour responses (Table 1).
The five studies all had clear criteria for patient recruitment, adequate follow-up time for endpoint assessment and clear definition of tumour responses (Table 2). The MB patients had good compliance in the trials and signed consent for MB subtyping classification (Table 2).
There were 14 MBSHH patients and 60 MBnon-SHH patients studied for sonidegib and 32 patients and 22 MBnon-SHH patients studied for vismodegib (Fig. 2). The pooled ORR of SMO inhibitor was 37% for SHH-driven disease, but zero for other MB subtypes (Fig. 2). The pooled ORR of sonidegib was 55% among MBSHH and 0 among MBnon-SHH subgroup (Fig. 2). Vismodegib also had no efficacy on non-SHH subtype of MB. Though vismodegib produced a 17% ORR, the effect size was not significant (Fig. 2). The heterogeneity was not significant between included studies (Fig. 2).
The sonidegib against SHH-driven MB produced the ORR 1.87-fold higher than that of vismodegib (95%CI 1.23, 6.69, Fig. 3). There were 11 adult MBSHH patients who received sonidegib and 18 adult MBSHH patients who received vismodegib, respectively (Fig. 3). Among adult patients, sonidegib had a 1.45-fold higher effect than vismodegib, but the difference was not significant (Fig. 3). There were 3 paediatric SHH-driven MB patients who received sonidegib and 14 paediatric MBSHH patients who were given vismodegib, respectively (Fig. 3). However, among paediatric patients, the efficacy of sonidegib was 3.67-fold higher than vismodegib (p < 0.05, Fig. 3).
A total of 320 cases received SMO inhibitor therapy and 36 cases reported grade 3/4 DLT, including γ-glutamyl transferase, hypokalemia and thrombocytopenia. 16 cases received vismodegib at doses of ≥150 mg/kg reported grade 3/4 DLT. One paediatric patient received sonidegib at doses of 372 mg/kg and the 19 adult patients that received sonidegib ≥800 mg/kg were reported to have grade 3/4 DLT. The rate of grade 3/4 DLT was similar between patients receiving vismodegib and sonidegib (11.6% vs. 11.2%).
The standard of care for MB patients consists of surgical resection followed by craniospinal irradiation and adjuvant chemotherapy, including cyclophosphamide, cisplatin, vincristine, lomustine, etoposide, either alone or in combination [3, 20]. Recently, MB has been further stratified into 12 subtypes demonstrating the extent of heterogeneity that exists within this disease entity. With respect to MBSHH, four clinically and cytogenetically distinct groups have been identified: α, β, γ and δ. SHH- α tumours mainly affect children (age 3–16), and are enriched for MYCN amplification, GLI2 amplification, and TP53 mutations, and have the worst prognosis [2, 28]. They also have specific copy-number aberrations (CNAs), such as 9q loss, 10q loss, 17p loss, and YAP1 amplifications . SHH-β and γ are enriched in infant MB patients (age < 3). However, the prognosis of β tumours is worse than γ tumours because of the high frequency of metastasis in SHH-β. Adult SHH is defined as SHH-δ and is enriched for either PTCH1, SMO or TERT promoter mutations, and have a favourable prognosis [2, 10]. Compared to other subgroups, SHH tumours more frequently recur locally in the original resection cavity . The recent WHO classification defined young children and TP53 wild type patients as low risk and average risk patients , while patients with TP53-mutated MBSHH have a worse prognosis .
Aberrant activation of the SHH signalling pathway has been found in familial and sporadic MB patients . Genetic alterations, including mutations in PTCH, SUFU, and SMO lead to constitutive activation of the hedgehog pathway in BCC, rhabdomyosarcoma and MB . Moreover, overexpression and/or inappropriate expression of the hedgehog ligand has been linked with the pathogenesis of a number of sporadic cancers, such as pancreatic, colorectal, prostate, breast and lung . Therefore, hedgehog pathway signalling has emerged as a legitimate targetable pathway in a number of cancers including SHH-driven MB.
In the absence of hedgehog ligand binding, its receptor PTCH inhibits Smoothed (SMO) and acts as a negative regulator of the hedgehog signalling pathway. Hedgehog signalling is activated when the extracellular Hh protein binds to PTCH, preventing its inhibition of SMO (Fig. 4). Activated SMO localises to cilium and initiates a downstream signalling cascade, involving suppressor of fused (SUFU), also activation of glioma-associated oncogene (GLI) transcription factors that translocate to the nucleus and induce hedgehog pathway target gene expression . Both vismodegib and sonidegib bind to SMO, where they act as antagonists, markedly inhibiting downstream activation of Hh pathway signalling, even in the absence of PTCH1. Earlier preclinical studies have shown anti-tumour activity in MB mouse models by using vismodegib . It has also been demonstrated that sonidegib effectively penetrates the blood-brain barrier (BBB) in preclinical studies, making these SMO inhibitors potential candidates for MB treatment . Oral administration of the drug in mouse MB genetic engineered models led to complete inhibition of GLI1 and tumour regression . However, the response to SMO inhibitors were variable in these studies, likely reflecting tumour heterogeneity. They were found ineffective in tumours driven by mutations in SHH pathway genes downstream of SMO, while showed great efficacy in MBSHH driven by mutations upstream of SMO [4, 11, 25].
In the Phase I and Phase II clinical trials discussed in this paper, Hh pathway activation was identified by two methods, either by 5-gene signature RT-PCR assay [9, 12, 24] or immunohistochemistry [5, 23]. Though SMO inhibitors introduced an optimistic response rate to MB, the efficacy of sonidegib was better than vismodegib, especially among paediatric SHH-driven MB patients. However, this conclusion was made based on 3 paediatric patients in the trial. More patients need to be recruited to make a final conclusion.
The pharmacokinetics of vismodegib showed a substantial interpatient variability in all aspects of vismodegib disposition, including variable solubility-limited absorption in the intestine after oral administration, limited metabolic elimination, and interactions with plasma protein alpha-1-acid glycoprotein (AAG) [5, 7]. While sonidegib exposure in children is consistent with that observed in adults for equivalent mg/m2 doses [9, 24]. Other possible reasons for why patients have seen variable responses could include mutations associated with Hh signalling pathway. For instance, a mutation in the extracellular domain of SMO, D473H, prevents vismodegib binding . Other resistance mechanisms occurring at the cell surface such as the loss of primary cilia can occur [6, 33]. Cilia is the primary site where activated SMO is trafficked to initiate downstream signalling, cilia loss enables low but constitutive Hh signalling protecting tumour cells from the action of vismodegib or sonidegib [6, 33].
A vismodegib Phase II trial demonstrated a potential benefit of prolonged PFS in SHH-driven MB patients with somatic loss of heterozygosity (LOH) of PTCH1 compared to MBnon-SHH and MBunknown patients , suggesting that activity is not limited to objective response. However, SMO inhibitors response variability is based on the position of mutations relative to SMO. Aberrations in PTCH1 results in favourable outcomes, whereas aberrations in downstream of SMO, GLI2 or SUFU, are associated with no response to SMO inhibitors . From DNA methylation and next-generation sequencing data of SHH-driven MB patients, researchers reported that adult MBSHH (SHH-δ) patients will most likely benefit from the SMO inhibitors since they harbour mutations in either PTCH1 or SMO . In contrast, infant (SHH-β and γ) and children (SHH-α) SHH-driven MB frequently have mutations downstream of SMO and will unlikely benefit from treatment . Furthermore, MBSHH in children with strong diffuse staining of P53 also respond poorly to SMO inhibitors . Therefore, it is critical to identify MBSHH patients with mutations upstream of PTCH1 that respond to vismodegib and sonidegib and stratify MBSHH patients for treatment. At present, this testing requires specialist services and is reliant on the availability of quality tissue for analysis.
Irrespective of tumour type, 36 patients were reported experiencing grade 3/4 DLT when receiving SMO inhibitors. Sonidegib and vismodegib are well tolerated and safe in MB patients. All clinical trials demonstrated the safety and feasibility of both drugs in children and adult MB patients. Vismodegib is as effective as sonidegib, but it seems to provoke more severe adverse events including grade 3 muscle spasms and atrial fibrillation . Increased creatine phosphokinase (CPK) elevation was observed in paediatric patients more so than in adults following administration of sonidegib , but the underlining reasons were not elaborated. The Phase I/II study of sonidegib also demonstrated permanent bone growth defects in paediatric patients, which were not reported in the clinical trial of vismodegib [9, 23]. Since SHH-driven MB is common in infants and children, the potential risks of using Hh pathway inhibitors should be advised to patients and their families.
There is one registered Phase I clinical trial with sonidegib for the treatment of MB which is currently recruiting (NCT03434262). The trial is being conducted at St. Jude Children’s Research Hospital evaluating sonidegib in combination with ribociclib for the treatment of refractory or recurrent MBSHH patients with 9q loss or a PTCH1 mutation. This study will primarily determine the safety and tolerability of the modalities. Another ongoing trial (NCT01878617) is a Phase II clinical trial of vismodegib in combination with chemotherapy (cisplatin, vincristine, cyclophosphamide) for the treatment of standard and high risk newly diagnosed MBSHH patients. This study will evaluate the feasibility and toxicity of oral maintenance therapy with vismodegib following conventional adjuvant chemotherapy.
Small sample size was the main limitation of this study. The comparisons between clinical efficacy of sonidegib and vismodegib were not adjusted for the confounding factors existing across the studies. The two-arm randomized control trial should be proposed by comparing sonidegib and vismodegib. MBSHH tumours recur mostly in the local tumour bed , and the molecular subgroup of the tumour is not significantly altered at recurrence . Currently, there are lack of treatment regimens for relapsed or refractory MB. SMO inhibitors might provide a useful therapeutic option to further extend survival in this treatment refractory group. To avoid and overcome SMO inhibitor resistance, combination therapies will likely be needed. Frequent aberrations in genes involved in phosphoinositide 3-kinase (PI3K) signalling are commonly found in MBSHH, therefore the use of a PI3K inhibitor in combination with SMO inhibitor may decrease drug resistance and recurrence [1, 10, 22]. Genome sequencing and complete molecular profiling are needed to further identify patients who will benefit from SMO inhibitors and to study mechanisms of resistance in these patients. In summary, this review highlights that sonidegib and vismodegib were well tolerated and demonstrated anti-tumour activity in SHH-driven MB by effectively inhibiting Hh signalling. These results support the ongoing clinical trials of using SMO inhibitors in combination with conventional chemotherapies for the treatment of relapsed MBSHH.
Blood brain barrier
Basal cell carcinoma
Loss of heterozygosity
Objective response rate
Suppressor of fused
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Li, Y., Song, Q. & Day, B.W. Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis. acta neuropathol commun 7, 123 (2019). https://doi.org/10.1186/s40478-019-0773-8
- Sonic hedgehog pathway
- SMO inhibitor
- And vismodegib