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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis

Fig. 3

The pooled clinical efficacy of sonidegib and vismodegib in paediatric versus adult SHH-driven MB. Efficacy was analysed using Reviewer Manager 5.3 software. In adult patients, sonidegib had a 1.45-fold higher effect, but the difference was not significant. In contrast, the efficacy of sonidegib was significant showing a 3.67-fold higher effect than vismodegib in paediatric patients (p < 0.05)

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