Table 2 The quality check based on MB patients in each study
| Study | Clear criteria of patient recruitment | Adequate follow-up time for endpoints | Clear definition of tumor responses | Good compliance | MB with SHH |
|---|---|---|---|---|---|
| LoRusso 2011 | Yes | Yes | No | Yes | Yes |
| Gajjar 2013 | Yes | Yes | Yes | Yes | Yes |
| Rodon 2014 | Yes | Yes | Yes | Yes | Yes |
| Robinson 2015 | Yes | Yes | Yes | Yes | Yes |
| Kieran 2017 | Yes | Yes | Yes | Yes | Yes |
